Protein Description

Gene Symbol FADS2
Entrez ID 9415
Uniprot ID O95864
Description fatty acid desaturase 2
Chromosomal Location chr11: 61,792,980-61,867,354
Ontology GO ID GO Term Definition Evidence

BP

GO:0006636

unsaturated fatty acid biosynthetic process

The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms.

IEA

BP

GO:0036109

alpha-linolenic acid metabolic process

The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.

TAS

BP

GO:0043651

linoleic acid metabolic process

The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.

TAS

BP

GO:0055114

oxidation-reduction process

A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

IEA

CC

GO:0005789

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

TAS

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

MF

GO:0004768

stearoyl-CoA 9-desaturase activity

Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O.

IEA

MF

GO:0016213

linoleoyl-CoA desaturase activity

Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O.

TAS

Domain ID Description

IPR001199

Cytochrome b5-like heme/steroid binding domain

IPR005804

Fatty acid desaturase domain

IPR012171

Fatty acid desaturase

Pathway ID Pathway Term Pathway Source

hsa00592

alpha-Linolenic acid metabolism

KEGG

hsa01040

Biosynthesis of unsaturated fatty acids

KEGG

hsa01212

Fatty acid metabolism

KEGG

hsa03320

PPAR signaling pathway

KEGG

WP3942

PPAR signaling pathway

WikiPathways

UMLS CUI UMLS Term

C0003873

Rheumatoid Arthritis

C0009404

Colorectal Neoplasms

C0023794

Lipoidosis

C0524620

Metabolic Syndrome X

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

cerebellum

Purkinje cells

duodenum

glandular cells

epididymis

glandular cells

esophagus

squamous epithelial cells

gallbladder

glandular cells

liver

hepatocytes

lung

pneumocytes

pancreas

exocrine glandular cells

placenta

trophoblastic cells

rectum

glandular cells

seminal vesicle

glandular cells

small intestine

glandular cells

stomach

glandular cells

testis

Leydig cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

22344199

Chazenbalk et al.

2012

Abnormal Expression of Genes Involved in Inflammation, Lipid Metabolism, and Wnt Signaling in the Adipose Tissue of Polycystic Ovary Syndrome

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

ATXN1L

342371

P0C7T5

0.63

TCTN3

26123

Q6NUS6

0.49

TCTN2

79867

Q96GX1

0.49

ATP1B3

483

P54709

0.63

CLN3

1201

Q13286

0.63

EGFR

1956

P00533

0.63

NTRK1

4914

P04629

0.63

SUMO1

7341

P63165

0.63

VSIG4

11326

Q9Y279

0.63