Gene Symbol | FADS2 |
Entrez ID | 9415 |
Uniprot ID | O95864 |
Description | fatty acid desaturase 2 |
Chromosomal Location | chr11: 61,792,980-61,867,354 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006636 |
unsaturated fatty acid biosynthetic process |
The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. |
IEA |
BP |
GO:0036109 |
alpha-linolenic acid metabolic process |
The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. |
TAS |
BP |
GO:0043651 |
linoleic acid metabolic process |
The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. |
TAS |
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
IEA |
CC |
GO:0005789 |
endoplasmic reticulum membrane |
The lipid bilayer surrounding the endoplasmic reticulum. |
TAS |
CC |
GO:0005887 |
integral component of plasma membrane |
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
TAS |
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
MF |
GO:0004768 |
stearoyl-CoA 9-desaturase activity |
Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O. |
IEA |
MF |
GO:0016213 |
linoleoyl-CoA desaturase activity |
Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O. |
TAS |
Domain ID | Description |
---|---|
IPR001199 |
Cytochrome b5-like heme/steroid binding domain |
IPR005804 |
Fatty acid desaturase domain |
IPR012171 |
Fatty acid desaturase |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00592 |
alpha-Linolenic acid metabolism |
KEGG |
hsa01040 |
Biosynthesis of unsaturated fatty acids |
KEGG |
hsa01212 |
Fatty acid metabolism |
KEGG |
hsa03320 |
PPAR signaling pathway |
KEGG |
WP3942 |
PPAR signaling pathway |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0003873 |
Rheumatoid Arthritis |
C0009404 |
Colorectal Neoplasms |
C0023794 |
Lipoidosis |
C0524620 |
Metabolic Syndrome X |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
appendix |
glandular cells |
cerebellum |
Purkinje cells |
duodenum |
glandular cells |
epididymis |
glandular cells |
esophagus |
squamous epithelial cells |
gallbladder |
glandular cells |
liver |
hepatocytes |
lung |
pneumocytes |
pancreas |
exocrine glandular cells |
placenta |
trophoblastic cells |
rectum |
glandular cells |
seminal vesicle |
glandular cells |
small intestine |
glandular cells |
stomach |
glandular cells |
testis |
Leydig cells |
urinary bladder |
urothelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22344199 |
Chazenbalk et al. |
2012 |
Abnormal Expression of Genes Involved in Inflammation, Lipid Metabolism, and Wnt Signaling in the Adipose Tissue of Polycystic Ovary Syndrome |
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
ATXN1L |
342371 |
P0C7T5 |
0.63 |
TCTN3 |
26123 |
Q6NUS6 |
0.49 |
TCTN2 |
79867 |
Q96GX1 |
0.49 |
ATP1B3 |
483 |
P54709 |
0.63 |
CLN3 |
1201 |
Q13286 |
0.63 |
EGFR |
1956 |
P00533 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
SUMO1 |
7341 |
P63165 |
0.63 |
VSIG4 |
11326 |
Q9Y279 |
0.63 |