| Gene Symbol | SNRNP40 |
| Entrez ID | 9410 |
| Uniprot ID | Q96DI7 |
| Description | small nuclear ribonucleoprotein, U5 40kDa subunit |
| Chromosomal Location | chr1: 31,259,568-31,296,782 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000375 |
RNA splicing, via transesterification reactions |
Splicing of RNA via a series of two transesterification reactions. |
TAS |
|
BP |
GO:0000398 |
mRNA splicing, via spliceosome |
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
IC|TAS |
|
BP |
GO:0006396 |
RNA processing |
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. |
TAS |
|
BP |
GO:0008380 |
RNA splicing |
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
TAS |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA|TAS |
|
CC |
GO:0005682 |
U5 snRNP |
A ribonucleoprotein complex that contains small nuclear RNA U5. |
TAS |
|
CC |
GO:0005732 |
small nucleolar ribonucleoprotein complex |
A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. |
NAS |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
|
CC |
GO:0071011 |
precatalytic spliceosome |
A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. |
IBA |
|
CC |
GO:0071013 |
catalytic step 2 spliceosome |
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
IDA |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR001680 |
WD40 repeat |
|
IPR015943 |
WD40/YVTN repeat-like-containing domain |
|
IPR017986 |
WD40-repeat-containing domain |
|
IPR019775 |
WD40 repeat, conserved site |
|
IPR020472 |
G-protein beta WD-40 repeat |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa03040 |
Spliceosome |
KEGG |
|
WP411 |
mRNA Processing |
WikiPathways |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
bronchus |
respiratory epithelial cells |
|
cerebellum |
cells in molecular layer |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
kidney |
cells in tubules |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
follicle cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
CHD3 |
1107 |
Q12873 |
0.49 |
|
TBL1X |
6907 |
O60907 |
0.49 |
|
POLR3C |
10623 |
Q9BUI4 |
0.49 |
|
CRNKL1 |
51340 |
Q9BZJ0 |
0.49 |
|
SREK1 |
140890 |
Q8WXA9 |
0.49 |
|
SNRNP40 |
9410 |
Q96DI7 |
0.52 |
|
APP |
351 |
P05067 |
0.56 |
|
ZNHIT2 |
741 |
Q9UHR6 |
0.63 |
|
SNRPD1 |
6632 |
P62314 |
0.63 |
|
SNRPD2 |
6633 |
P62316 |
0.63 |
|
SART1 |
9092 |
O43290 |
0.63 |
|
PRPF3 |
9129 |
O43395 |
0.63 |
|
AQR |
9716 |
O60306 |
0.63 |
|
DHX38 |
9785 |
Q92620 |
0.63 |
|
TXNL4A |
10907 |
P83876 |
0.63 |
|
SNRNP27 |
11017 |
Q8WVK2 |
0.63 |
|
ECD |
11319 |
O95905 |
0.63 |
|
TFIP11 |
24144 |
Q9UBB9 |
0.63 |
|
PRPF31 |
26121 |
Q8WWY3 |
0.63 |
|
ISY1 |
57461 |
Q9ULR0 |
0.63 |
|
RBM42 |
79171 |
Q9BTD8 |
0.63 |
|
GRWD1 |
83743 |
Q9BQ67 |
0.63 |
|
PAXBP1 |
94104 |
Q9Y5B6 |
0.63 |
|
CCDC12 |
151903 |
Q8WUD4 |
0.63 |
|
RNU4ATAC |
100151683 |
N/A |
0.63 |
|
RNU6ATAC |
100151684 |
N/A |
0.63 |
|
DDB1 |
100290337 |
Q16531 |
0.63 |
|
WDR5 |
11091 |
P61964 |
0.72 |
|
MAGEA6 |
4105 |
P43360 |
0.76 |
|
PFDN2 |
5202 |
Q9UHV9 |
0.76 |
|
SNRPB2 |
6629 |
P08579 |
0.76 |
|
SF3B1 |
23451 |
O75533 |
0.76 |
|
PRPF6 |
24148 |
O94906 |
0.86 |
|
SNRNP200 |
23020 |
O75643 |
0.89 |
|
EFTUD2 |
9343 |
Q15029 |
0.90 |
|
PRPF8 |
10594 |
Q6P2Q9 |
0.90 |
|
SNRPE |
6635 |
P62304 |
0.49 |
|
DHX16 |
8449 |
O60231 |
0.49 |
|
RALY |
22913 |
Q9UKM9 |
0.49 |
|
ACP5 |
54 |
P13686 |
0.63 |
|
DDR1 |
780 |
Q08345 |
0.63 |
|
CDC5L |
988 |
Q99459 |
0.63 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
MOV10 |
4343 |
Q9HCE1 |
0.63 |
|
PML |
5371 |
P29590 |
0.63 |
|
RARA |
5914 |
P10276 |
0.63 |
|
RPA1 |
6117 |
P27694 |
0.63 |
|
RPA2 |
6118 |
P15927 |
0.63 |
|
RPA3 |
6119 |
P35244 |
0.63 |
|
XPO1 |
7514 |
O14980 |
0.63 |
|
MDC1 |
9656 |
Q14676 |
0.63 |
|
KIAA0101 |
9768 |
Q15004 |
0.63 |
|
CUL7 |
9820 |
Q14999 |
0.63 |
|
TSSC4 |
10078 |
Q9Y5U2 |
0.63 |
|
SRRM1 |
10250 |
Q8IYB3 |
0.63 |
|
NXF1 |
10482 |
Q9UBU9 |
0.63 |
|
SNW1 |
22938 |
Q13573 |
0.63 |
|
OBSL1 |
23363 |
O75147 |
0.63 |
|
SUZ12 |
23512 |
Q15022 |
0.63 |
|
RSRC1 |
51319 |
Q96IZ7 |
0.63 |
|
DDX41 |
51428 |
Q9UJV9 |
0.63 |
|
MAGOH |
4116 |
P61326 |
0.72 |
|
YWHAZ |
7534 |
P63104 |
0.72 |
|
CUL4B |
8450 |
Q13620 |
0.72 |
|
CUL4A |
8451 |
Q13619 |
0.72 |
|
PRPF4B |
8899 |
Q13523 |
0.72 |
|
EIF4A3 |
9775 |
P38919 |
0.72 |
|
PRPF4 |
9128 |
O43172 |
0.76 |
|
USP39 |
10713 |
Q53GS9 |
0.76 |
|
DDX23 |
9416 |
Q9BUQ8 |
0.82 |
|
CD2BP2 |
10421 |
O95400 |
0.87 |