Gene Symbol | HS6ST1 |
Entrez ID | 9394 |
Uniprot ID | O60243 |
Description | heparan sulfate 6-O-sulfotransferase 1 |
Chromosomal Location | chr2: 128,236,716-128,318,577 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0001525 |
angiogenesis |
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
IEA |
BP |
GO:0006024 |
glycosaminoglycan biosynthetic process |
The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. |
TAS |
BP |
GO:0015015 |
heparan sulfate proteoglycan biosynthetic process, enzymatic modification |
The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization. |
IEA |
BP |
GO:0048286 |
lung alveolus development |
The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. |
IEA |
BP |
GO:0048666 |
neuron development |
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. |
IMP |
BP |
GO:0060716 |
labyrinthine layer blood vessel development |
The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply. |
IEA |
CC |
GO:0000139 |
Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
TAS |
CC |
GO:0005887 |
integral component of plasma membrane |
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
TAS |
MF |
GO:0008146 |
sulfotransferase activity |
Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. |
TAS |
MF |
GO:0017095 |
heparan sulfate 6-O-sulfotransferase activity |
Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate. |
IBA|TAS |
Domain ID | Description |
---|---|
IPR005331 |
Sulfotransferase |
IPR010635 |
Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase |
IPR027417 |
P-loop containing nucleoside triphosphate hydrolase |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00534 |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
KEGG |
WP702 |
Metapathway biotransformation |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0162809 |
Kallmann Syndrome |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
NRG1 |
3084 |
Q02297 |
0.63 |
ITM2B |
9445 |
Q9Y287 |
0.63 |
B3GNT3 |
10331 |
Q9Y2A9 |
0.63 |
CHRNA9 |
55584 |
Q9UGM1 |
0.63 |