Protein Description

Gene Symbol HS6ST1
Entrez ID 9394
Uniprot ID O60243
Description heparan sulfate 6-O-sulfotransferase 1
Chromosomal Location chr2: 128,236,716-128,318,577
Ontology GO ID GO Term Definition Evidence

BP

GO:0001525

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

IEA

BP

GO:0006024

glycosaminoglycan biosynthetic process

The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.

TAS

BP

GO:0015015

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization.

IEA

BP

GO:0048286

lung alveolus development

The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.

IEA

BP

GO:0048666

neuron development

The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.

IMP

BP

GO:0060716

labyrinthine layer blood vessel development

The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.

IEA

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

TAS

MF

GO:0008146

sulfotransferase activity

Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.

TAS

MF

GO:0017095

heparan sulfate 6-O-sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate.

IBA|TAS

Domain ID Description

IPR005331

Sulfotransferase

IPR010635

Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase

IPR027417

P-loop containing nucleoside triphosphate hydrolase

Pathway ID Pathway Term Pathway Source

hsa00534

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

KEGG

WP702

Metapathway biotransformation

WikiPathways

UMLS CUI UMLS Term

C0162809

Kallmann Syndrome

No tissues found.

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

NRG1

3084

Q02297

0.63

ITM2B

9445

Q9Y287

0.63

B3GNT3

10331

Q9Y2A9

0.63

CHRNA9

55584

Q9UGM1

0.63