Gene Symbol | CBS |
Entrez ID | 875 |
Uniprot ID | P35520 |
Description | cystathionine-beta-synthase |
Chromosomal Location | chr21: 43,053,191-43,076,943 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006535 |
cysteine biosynthetic process from serine |
The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. |
IBA|IEA |
BP |
GO:0006563 |
L-serine metabolic process |
The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. |
IDA |
BP |
GO:0006565 |
L-serine catabolic process |
The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. |
IDA |
BP |
GO:0008652 |
cellular amino acid biosynthetic process |
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. |
IEA |
BP |
GO:0019343 |
cysteine biosynthetic process via cystathionine |
The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine. |
IEA |
BP |
GO:0019344 |
cysteine biosynthetic process |
The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. |
IDA |
BP |
GO:0019346 |
transsulfuration |
The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. |
TAS |
BP |
GO:0019448 |
L-cysteine catabolic process |
The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid. |
IDA |
BP |
GO:0042262 |
DNA protection |
Any process in which DNA is protected from damage by, for example, oxidative stress. |
IMP |
BP |
GO:0043418 |
homocysteine catabolic process |
The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. |
IDA |
BP |
GO:0050667 |
homocysteine metabolic process |
The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. |
IDA |
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
IEA |
BP |
GO:0070814 |
hydrogen sulfide biosynthetic process |
The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S. |
IDA|ISS |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA|IEA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA|IEA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
IDA|TAS |
MF |
GO:0004122 |
cystathionine beta-synthase activity |
Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O. |
IDA|TAS|IEA |
MF |
GO:0004124 |
cysteine synthase activity |
Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate. |
IBA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0019825 |
oxygen binding |
Interacting selectively and non-covalently with oxygen (O2). |
IDA |
MF |
GO:0019899 |
enzyme binding |
Interacting selectively and non-covalently with any enzyme. |
IPI |
MF |
GO:0020037 |
heme binding |
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. |
IDA|IMP |
MF |
GO:0030170 |
pyridoxal phosphate binding |
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
IDA |
MF |
GO:0031625 |
ubiquitin protein ligase binding |
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. |
IPI |
MF |
GO:0042803 |
protein homodimerization activity |
Interacting selectively and non-covalently with an identical protein to form a homodimer. |
IDA |
MF |
GO:0046872 |
metal ion binding |
Interacting selectively and non-covalently with any metal ion. |
IEA |
MF |
GO:0050421 |
nitrite reductase (NO-forming) activity |
Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+. |
IDA |
MF |
GO:0070025 |
carbon monoxide binding |
Interacting selectively and non-covalently with carbon monoxide (CO). |
IDA |
MF |
GO:0070026 |
nitric oxide binding |
Interacting selectively and non-covalently with nitric oxide (NO). |
IDA |
MF |
GO:0072341 |
modified amino acid binding |
Interacting selectively and non-covalently with a modified amino acid. |
IDA |
MF |
GO:1904047 |
S-adenosyl-L-methionine binding |
Interacting selectively and non-covalently with S-adenosyl-L-methionine. |
IDA |
Domain ID | Description |
---|---|
IPR000644 |
CBS domain |
IPR001216 |
Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site |
IPR001926 |
Tryptophan synthase beta subunit-like PLP-dependent enzyme |
IPR005857 |
Cystathionine beta-synthase |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00260 |
Glycine, serine and threonine metabolism |
KEGG |
hsa00270 |
Cysteine and methionine metabolism |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
hsa01230 |
Biosynthesis of amino acids |
KEGG |
WP2333 |
Trans-sulfuration pathway |
WikiPathways |
WP1533 |
Vitamin B12 Metabolism |
WikiPathways |
WP15 |
Selenium Micronutrient Network |
WikiPathways |
WP1589 |
Folate-Alcohol and Cancer Pathway |
WikiPathways |
WP3925 |
Amino Acid metabolism |
WikiPathways |
WP176 |
Folate Metabolism |
WikiPathways |
WP2525 |
Trans-sulfuration and one carbon metabolism |
WikiPathways |
WP3940 |
One carbon metabolism and related pathways |
WikiPathways |
h_methioninepathway |
Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0007222 |
Cardiovascular Diseases |
C0011860 |
Diabetes Mellitus, Non-Insulin-Dependent |
C0019880 |
Homocystinuria |
C0020538 |
Hypertensive Disease |
C0024305 |
Lymphoma, Non-Hodgkin |
C0162429 |
Malnutrition |
C0598608 |
Hyperhomocysteinemia |
C0751202 |
Cystathionine Beta-Synthase Deficiency Disease |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
AP1B1 |
162 |
Q10567 |
0.49 |
CARS |
833 |
P49589 |
0.49 |
CTH |
1491 |
P32929 |
0.49 |
HSPE1 |
3336 |
P61604 |
0.49 |
IARS |
3376 |
P41252 |
0.49 |
QARS |
5859 |
P47897 |
0.49 |
SEC24B |
10427 |
O95487 |
0.49 |
UBE3B |
89910 |
Q7Z3V4 |
0.49 |
SEC31A |
22872 |
O94979 |
0.56 |
NMD3 |
51068 |
Q96D46 |
0.56 |
DAXX |
1616 |
Q9UER7 |
0.63 |
EHHADH |
1962 |
Q08426 |
0.63 |
HSF1 |
3297 |
Q00613 |
0.63 |
IREB2 |
3658 |
P48200 |
0.63 |
PIN1 |
5300 |
Q13526 |
0.63 |
PRKAG1 |
5571 |
P54619 |
0.63 |
PSMA1 |
5682 |
P25786 |
0.63 |
RAD23B |
5887 |
P54727 |
0.63 |
SRP14 |
6727 |
P37108 |
0.63 |
UGP2 |
7360 |
Q16851 |
0.63 |
CBX4 |
8535 |
O00257 |
0.63 |
PIAS1 |
8554 |
O75925 |
0.63 |
RANBP9 |
10048 |
Q96S59 |
0.63 |
UBA2 |
10054 |
Q9UBT2 |
0.63 |
COL4A3BP |
10087 |
Q9Y5P4 |
0.63 |
PIAS3 |
10401 |
Q9Y6X2 |
0.63 |
PDLIM5 |
10611 |
Q96HC4 |
0.63 |
GPSM1 |
26086 |
Q86YR5 |
0.63 |
ERO1A |
30001 |
Q96HE7 |
0.63 |
VTA1 |
51534 |
Q9NP79 |
0.63 |
UBASH3A |
53347 |
P57075 |
0.63 |
PARP6 |
56965 |
Q2NL67 |
0.63 |
GOPC |
57120 |
Q9HD26 |
0.63 |
IPO4 |
79711 |
Q8TEX9 |
0.63 |
UBA5 |
79876 |
Q9GZZ9 |
0.63 |
C14orf142 |
84520 |
Q9BXV9 |
0.63 |
LRSAM1 |
90678 |
Q6UWE0 |
0.63 |
HID1 |
283987 |
Q8IV36 |
0.63 |
GPN1 |
11321 |
Q9HCN4 |
0.70 |
SUMO1 |
7341 |
P63165 |
0.73 |
FXR2 |
9513 |
P51116 |
0.73 |
UBE2I |
7329 |
P63279 |
0.75 |
HTT |
3064 |
P42858 |
0.83 |
CBS |
875 |
P35520 |
0.97 |
ABAT |
18 |
P80404 |
0.49 |
ASNS |
440 |
P08243 |
0.49 |
RSU1 |
6251 |
Q15404 |
0.49 |
SKIV2L |
6499 |
Q15477 |
0.49 |
VBP1 |
7411 |
P61758 |
0.49 |
RTFDC1 |
51507 |
Q9BY42 |
0.49 |
ENOPH1 |
58478 |
Q9UHY7 |
0.49 |
EEF1A1 |
1915 |
P68104 |
0.56 |
OAT |
4942 |
P04181 |
0.56 |
CDK2 |
1017 |
P24941 |
0.63 |
NEDD8 |
4738 |
Q15843 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
NUCB1 |
4924 |
Q02818 |
0.63 |
PKM |
5315 |
P14618 |
0.63 |
PRKAR1A |
5573 |
P10644 |
0.63 |
PLIN3 |
10226 |
O60664 |
0.63 |
GABARAP |
11337 |
O95166 |
0.63 |
ZDHHC17 |
23390 |
Q8IUH5 |
0.63 |
DBNL |
28988 |
Q9UJU6 |
0.63 |
DERA |
51071 |
Q9Y315 |
0.63 |
OTUB1 |
55611 |
Q96FW1 |
0.63 |
NPLOC4 |
55666 |
Q8TAT6 |
0.63 |
HGS |
9146 |
O14964 |
0.75 |