Protein Description

Gene Symbol CBS
Entrez ID 875
Uniprot ID P35520
Description cystathionine-beta-synthase
Chromosomal Location chr21: 43,053,191-43,076,943
Ontology GO ID GO Term Definition Evidence

BP

GO:0006535

cysteine biosynthetic process from serine

The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine.

IBA|IEA

BP

GO:0006563

L-serine metabolic process

The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.

IDA

BP

GO:0006565

L-serine catabolic process

The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.

IDA

BP

GO:0008652

cellular amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.

IEA

BP

GO:0019343

cysteine biosynthetic process via cystathionine

The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine.

IEA

BP

GO:0019344

cysteine biosynthetic process

The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.

IDA

BP

GO:0019346

transsulfuration

The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes.

TAS

BP

GO:0019448

L-cysteine catabolic process

The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid.

IDA

BP

GO:0042262

DNA protection

Any process in which DNA is protected from damage by, for example, oxidative stress.

IMP

BP

GO:0043418

homocysteine catabolic process

The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid.

IDA

BP

GO:0050667

homocysteine metabolic process

The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.

IDA

BP

GO:0055114

oxidation-reduction process

A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

IEA

BP

GO:0070814

hydrogen sulfide biosynthetic process

The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S.

IDA|ISS

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA|IEA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA|IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IDA|TAS

MF

GO:0004122

cystathionine beta-synthase activity

Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.

IDA|TAS|IEA

MF

GO:0004124

cysteine synthase activity

Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.

IBA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0019825

oxygen binding

Interacting selectively and non-covalently with oxygen (O2).

IDA

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IPI

MF

GO:0020037

heme binding

Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.

IDA|IMP

MF

GO:0030170

pyridoxal phosphate binding

Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

IDA

MF

GO:0031625

ubiquitin protein ligase binding

Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.

IPI

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

IDA

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

MF

GO:0050421

nitrite reductase (NO-forming) activity

Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+.

IDA

MF

GO:0070025

carbon monoxide binding

Interacting selectively and non-covalently with carbon monoxide (CO).

IDA

MF

GO:0070026

nitric oxide binding

Interacting selectively and non-covalently with nitric oxide (NO).

IDA

MF

GO:0072341

modified amino acid binding

Interacting selectively and non-covalently with a modified amino acid.

IDA

MF

GO:1904047

S-adenosyl-L-methionine binding

Interacting selectively and non-covalently with S-adenosyl-L-methionine.

IDA

Domain ID Description

IPR000644

CBS domain

IPR001216

Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site

IPR001926

Tryptophan synthase beta subunit-like PLP-dependent enzyme

IPR005857

Cystathionine beta-synthase

Pathway ID Pathway Term Pathway Source

hsa00260

Glycine, serine and threonine metabolism

KEGG

hsa00270

Cysteine and methionine metabolism

KEGG

hsa01100

Metabolic pathways

KEGG

hsa01230

Biosynthesis of amino acids

KEGG

WP2333

Trans-sulfuration pathway

WikiPathways

WP1533

Vitamin B12 Metabolism

WikiPathways

WP15

Selenium Micronutrient Network

WikiPathways

WP1589

Folate-Alcohol and Cancer Pathway

WikiPathways

WP3925

Amino Acid metabolism

WikiPathways

WP176

Folate Metabolism

WikiPathways

WP2525

Trans-sulfuration and one carbon metabolism

WikiPathways

WP3940

One carbon metabolism and related pathways

WikiPathways

h_methioninepathway

Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine

BioCarta

UMLS CUI UMLS Term

C0007222

Cardiovascular Diseases

C0011860

Diabetes Mellitus, Non-Insulin-Dependent

C0019880

Homocystinuria

C0020538

Hypertensive Disease

C0024305

Lymphoma, Non-Hodgkin

C0162429

Malnutrition

C0598608

Hyperhomocysteinemia

C0751202

Cystathionine Beta-Synthase Deficiency Disease

No tissues found.

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

AP1B1

162

Q10567

0.49

CARS

833

P49589

0.49

CTH

1491

P32929

0.49

HSPE1

3336

P61604

0.49

IARS

3376

P41252

0.49

QARS

5859

P47897

0.49

SEC24B

10427

O95487

0.49

UBE3B

89910

Q7Z3V4

0.49

SEC31A

22872

O94979

0.56

NMD3

51068

Q96D46

0.56

DAXX

1616

Q9UER7

0.63

EHHADH

1962

Q08426

0.63

HSF1

3297

Q00613

0.63

IREB2

3658

P48200

0.63

PIN1

5300

Q13526

0.63

PRKAG1

5571

P54619

0.63

PSMA1

5682

P25786

0.63

RAD23B

5887

P54727

0.63

SRP14

6727

P37108

0.63

UGP2

7360

Q16851

0.63

CBX4

8535

O00257

0.63

PIAS1

8554

O75925

0.63

RANBP9

10048

Q96S59

0.63

UBA2

10054

Q9UBT2

0.63

COL4A3BP

10087

Q9Y5P4

0.63

PIAS3

10401

Q9Y6X2

0.63

PDLIM5

10611

Q96HC4

0.63

GPSM1

26086

Q86YR5

0.63

ERO1A

30001

Q96HE7

0.63

VTA1

51534

Q9NP79

0.63

UBASH3A

53347

P57075

0.63

PARP6

56965

Q2NL67

0.63

GOPC

57120

Q9HD26

0.63

IPO4

79711

Q8TEX9

0.63

UBA5

79876

Q9GZZ9

0.63

C14orf142

84520

Q9BXV9

0.63

LRSAM1

90678

Q6UWE0

0.63

HID1

283987

Q8IV36

0.63

GPN1

11321

Q9HCN4

0.70

SUMO1

7341

P63165

0.73

FXR2

9513

P51116

0.73

UBE2I

7329

P63279

0.75

HTT

3064

P42858

0.83

CBS

875

P35520

0.97

ABAT

18

P80404

0.49

ASNS

440

P08243

0.49

RSU1

6251

Q15404

0.49

SKIV2L

6499

Q15477

0.49

VBP1

7411

P61758

0.49

RTFDC1

51507

Q9BY42

0.49

ENOPH1

58478

Q9UHY7

0.49

EEF1A1

1915

P68104

0.56

OAT

4942

P04181

0.56

CDK2

1017

P24941

0.63

NEDD8

4738

Q15843

0.63

NTRK1

4914

P04629

0.63

NUCB1

4924

Q02818

0.63

PKM

5315

P14618

0.63

PRKAR1A

5573

P10644

0.63

PLIN3

10226

O60664

0.63

GABARAP

11337

O95166

0.63

ZDHHC17

23390

Q8IUH5

0.63

DBNL

28988

Q9UJU6

0.63

DERA

51071

Q9Y315

0.63

OTUB1

55611

Q96FW1

0.63

NPLOC4

55666

Q8TAT6

0.63

HGS

9146

O14964

0.75