Protein Description

Gene Symbol PLAA
Entrez ID 9373
Uniprot ID Q9Y263
Description phospholipase A2-activating protein
Chromosomal Location chr9: 26,904,083-26,947,463
Ontology GO ID GO Term Definition Evidence

BP

GO:0006644

phospholipid metabolic process

The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.

TAS

BP

GO:0006954

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

IEA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0043085

positive regulation of catalytic activity

Any process that activates or increases the activity of an enzyme.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0016005

phospholipase A2 activator activity

Increases the activity of the enzyme phospholipase A2.

IEA

Domain ID Description

IPR001680

WD40 repeat

IPR011989

Armadillo-like helical

IPR013535

PUL domain

IPR015155

PLAA family ubiquitin binding, PFU

IPR015943

WD40/YVTN repeat-like-containing domain

IPR016024

Armadillo-type fold

IPR017986

WD40-repeat-containing domain

IPR033510

PLAA/Doa1/Lub1

Pathway ID Pathway Term Pathway Source

hsa04141

Protein processing in endoplasmic reticulum

KEGG

UMLS CUI UMLS Term

C0021368

Inflammation

Tissue Cell Type

bone marrow

hematopoietic cells

cerebral cortex

neuronal cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

CSE1L

1434

P55060

0.49

FDPS

2224

P14324

0.49

PAK2

5062

Q13177

0.49

XPNPEP1

7511

Q9NQW7

0.49

SF1

7536

Q15637

0.49

BASP1

10409

P80723

0.49

PLA2G1B

5319

P04054

0.62

CAV1

857

Q03135

0.63

PDIA3

2923

P30101

0.63

PCNA

5111

P12004

0.63

TUBB2A

7280

Q13885

0.63

TUFM

7284

P49411

0.63

TWF2

11344

Q6IBS0

0.63

PARP6

56965

Q2NL67

0.63

NSFL1C

55968

Q9UNZ2

0.70

HDAC6

10013

Q9UBN7

0.91

VCP

7415

P55072

0.94

RNF169

254225

Q8NCN4

0.07

EGFR

1956

P00533

0.63

HK1

3098

P19367

0.63

KPNA3

3840

O00505

0.63

NT5E

4907

P21589

0.63

NTRK1

4914

P04629

0.63

RNF2

6045

Q99496

0.63

SCN2B

6327

O60939

0.63

FAF1

11124

Q9UNN5

0.63

FAF2

23197

Q96CS3

0.63

CA14

23632

Q9ULX7

0.63

UBXN7

26043

O94888

0.63

LYPD3

27076

O95274

0.63

SRPRB

58477

Q9Y5M8

0.63

ASPSCR1

79058

Q9BZE9

0.63

UBXN6

80700

Q9BZV1

0.63

UNK

85451

Q9C0B0

0.63

TEX29

121793

Q8N6K0

0.63

SUMO2

6613

P61956

0.73

UBXN1

51035

Q04323

0.87