Gene Symbol | PLAA |
Entrez ID | 9373 |
Uniprot ID | Q9Y263 |
Description | phospholipase A2-activating protein |
Chromosomal Location | chr9: 26,904,083-26,947,463 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006644 |
phospholipid metabolic process |
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
TAS |
BP |
GO:0006954 |
inflammatory response |
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
IEA |
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
TAS |
BP |
GO:0043085 |
positive regulation of catalytic activity |
Any process that activates or increases the activity of an enzyme. |
IEA |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0016005 |
phospholipase A2 activator activity |
Increases the activity of the enzyme phospholipase A2. |
IEA |
Domain ID | Description |
---|---|
IPR001680 |
WD40 repeat |
IPR011989 |
Armadillo-like helical |
IPR013535 |
PUL domain |
IPR015155 |
PLAA family ubiquitin binding, PFU |
IPR015943 |
WD40/YVTN repeat-like-containing domain |
IPR016024 |
Armadillo-type fold |
IPR017986 |
WD40-repeat-containing domain |
IPR033510 |
PLAA/Doa1/Lub1 |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04141 |
Protein processing in endoplasmic reticulum |
KEGG |
UMLS CUI | UMLS Term |
---|---|
C0021368 |
Inflammation |
Tissue | Cell Type |
---|---|
bone marrow |
hematopoietic cells |
cerebral cortex |
neuronal cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
CSE1L |
1434 |
P55060 |
0.49 |
FDPS |
2224 |
P14324 |
0.49 |
PAK2 |
5062 |
Q13177 |
0.49 |
XPNPEP1 |
7511 |
Q9NQW7 |
0.49 |
SF1 |
7536 |
Q15637 |
0.49 |
BASP1 |
10409 |
P80723 |
0.49 |
PLA2G1B |
5319 |
P04054 |
0.62 |
CAV1 |
857 |
Q03135 |
0.63 |
PDIA3 |
2923 |
P30101 |
0.63 |
PCNA |
5111 |
P12004 |
0.63 |
TUBB2A |
7280 |
Q13885 |
0.63 |
TUFM |
7284 |
P49411 |
0.63 |
TWF2 |
11344 |
Q6IBS0 |
0.63 |
PARP6 |
56965 |
Q2NL67 |
0.63 |
NSFL1C |
55968 |
Q9UNZ2 |
0.70 |
HDAC6 |
10013 |
Q9UBN7 |
0.91 |
VCP |
7415 |
P55072 |
0.94 |
RNF169 |
254225 |
Q8NCN4 |
0.07 |
EGFR |
1956 |
P00533 |
0.63 |
HK1 |
3098 |
P19367 |
0.63 |
KPNA3 |
3840 |
O00505 |
0.63 |
NT5E |
4907 |
P21589 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
RNF2 |
6045 |
Q99496 |
0.63 |
SCN2B |
6327 |
O60939 |
0.63 |
FAF1 |
11124 |
Q9UNN5 |
0.63 |
FAF2 |
23197 |
Q96CS3 |
0.63 |
CA14 |
23632 |
Q9ULX7 |
0.63 |
UBXN7 |
26043 |
O94888 |
0.63 |
LYPD3 |
27076 |
O95274 |
0.63 |
SRPRB |
58477 |
Q9Y5M8 |
0.63 |
ASPSCR1 |
79058 |
Q9BZE9 |
0.63 |
UBXN6 |
80700 |
Q9BZV1 |
0.63 |
UNK |
85451 |
Q9C0B0 |
0.63 |
TEX29 |
121793 |
Q8N6K0 |
0.63 |
SUMO2 |
6613 |
P61956 |
0.73 |
UBXN1 |
51035 |
Q04323 |
0.87 |