| Gene Symbol | PPIG |
| Entrez ID | 9360 |
| Uniprot ID | Q13427 |
| Description | peptidylprolyl isomerase G (cyclophilin G) |
| Chromosomal Location | chr2: 169,584,340-169,641,406 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000413 |
protein peptidyl-prolyl isomerization |
The modification of a protein by cis-trans isomerization of a proline residue. |
IEA |
|
BP |
GO:0006457 |
protein folding |
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
IEA |
|
BP |
GO:0008380 |
RNA splicing |
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
TAS |
|
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
TAS |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
|
CC |
GO:0016363 |
nuclear matrix |
The dense fibrillar network lying on the inner side of the nuclear membrane. |
IEA |
|
CC |
GO:0016607 |
nuclear speck |
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
IEA |
|
MF |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). |
IBA |
|
MF |
GO:0016018 |
cyclosporin A binding |
Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids. |
TAS |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR002130 |
Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
|
IPR020892 |
Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site |
|
IPR024936 |
Cyclophilin-type peptidyl-prolyl cis-trans isomerase |
|
IPR029000 |
Cyclophilin-like domain |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
bone marrow |
hematopoietic cells |
|
breast |
adipocytes |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
endothelial cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
liver |
bile duct cells |
|
liver |
hepatocytes |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
follicle cells |
|
ovary |
ovarian stroma cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
fibroblasts |
|
soft tissue |
adipocytes |
|
soft tissue |
peripheral nerve |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
RBM39 |
9584 |
Q14498 |
0.63 |
|
PNMA2 |
10687 |
Q9UL42 |
0.63 |
|
ZCCHC10 |
54819 |
Q8TBK6 |
0.63 |
|
THAP1 |
55145 |
Q9NVV9 |
0.63 |
|
PPCDC |
60490 |
Q96CD2 |
0.63 |
|
NKAP |
79576 |
Q8N5F7 |
0.63 |
|
CEP70 |
80321 |
Q8NHQ1 |
0.63 |
|
KCTD6 |
200845 |
Q8NC69 |
0.63 |
|
BEND7 |
222389 |
Q8N7W2 |
0.63 |
|
POLR2A |
5430 |
P24928 |
0.67 |
|
SMN1; SMN2 |
6606 |
Q16637 |
0.73 |
|
PCBP1 |
5093 |
Q15365 |
0.76 |
|
PNN |
5411 |
Q9H307 |
0.77 |
|
YWHAG |
7532 |
P61981 |
0.86 |
|
FOS |
2353 |
P01100 |
0.49 |
|
SP1 |
6667 |
P08047 |
0.56 |
|
RHOB |
388 |
P62745 |
0.63 |
|
CACNA1A |
773 |
O00555 |
0.63 |
|
DAB1 |
1600 |
O75553 |
0.63 |
|
DACH1 |
1602 |
Q9UI36 |
0.63 |
|
FHL3 |
2275 |
Q13643 |
0.63 |
|
GRK5 |
2869 |
P34947 |
0.63 |
|
LGALS3 |
3958 |
P17931 |
0.63 |
|
TFCP2 |
7024 |
Q12800 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
SLU7 |
10569 |
O95391 |
0.63 |
|
ZMYND11 |
10771 |
Q15326 |
0.63 |
|
RNPS1 |
10921 |
Q15287 |
0.63 |
|
TRA2A |
29896 |
Q13595 |
0.63 |
|
PRPF40A |
55660 |
O75400 |
0.63 |
|
LUC7L |
55692 |
Q9NQ29 |
0.63 |
|
RRAGD |
58528 |
Q9NQL2 |
0.63 |
|
SNIP1 |
79753 |
Q8TAD8 |
0.63 |
|
PRPF38A |
84950 |
Q8NAV1 |
0.63 |
|
MED19 |
219541 |
A0JLT2 |
0.63 |
|
SRPK1 |
6732 |
Q96SB4 |
0.72 |
|
NUF2 |
83540 |
Q9BZD4 |
0.72 |
|
CLK1 |
1195 |
P49759 |
0.76 |