| Gene Symbol | B4GALT5 |
| Entrez ID | 9334 |
| Uniprot ID | O43286 |
| Description | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 |
| Chromosomal Location | chr20: 49,632,945-49,713,878 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0016266 |
O-glycan processing |
The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure. |
TAS |
|
BP |
GO:0018146 |
keratan sulfate biosynthetic process |
The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. |
TAS |
|
CC |
GO:0000139 |
Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
TAS |
|
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
|
CC |
GO:0032580 |
Golgi cisterna membrane |
The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. |
IEA |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0003831 |
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity |
Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide. |
TAS |
|
MF |
GO:0008378 |
galactosyltransferase activity |
Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
TAS |
|
MF |
GO:0046872 |
metal ion binding |
Interacting selectively and non-covalently with any metal ion. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR003859 |
Beta-1,4-galactosyltransferase |
|
IPR027791 |
Galactosyltransferase, C-terminal |
|
IPR027995 |
Galactosyltransferase, N-terminal |
|
IPR029044 |
Nucleotide-diphospho-sugar transferases |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00512 |
Mucin type O-glycan biosynthesis |
KEGG |
| UMLS CUI | UMLS Term |
|---|---|
|
C3495559 |
Juvenile Arthritis |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
12734205 |
Wood et al. |
2003 |
The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis |
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22904171 |
Kaur et al. |
2012 |
Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
HLA-DPA1 |
3113 |
P20036 |
0.63 |
|
TNF |
7124 |
P01375 |
0.63 |
|
NXPH2 |
11249 |
O95156 |
0.63 |
|
IL20RB |
53833 |
Q6UXL0 |
0.63 |
|
GINM1 |
116254 |
Q9NU53 |
0.63 |
|
LIPH |
200879 |
Q8WWY8 |
0.63 |