Gene Symbol | DHRS3 |
Entrez ID | 9249 |
Uniprot ID | O75911 |
Description | dehydrogenase/reductase (SDR family) member 3 |
Chromosomal Location | chr1: 12,567,910-12,617,731 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0001523 |
retinoid metabolic process |
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. |
TAS |
BP |
GO:0003151 |
outflow tract morphogenesis |
The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. |
IEA |
BP |
GO:0007601 |
visual perception |
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
TAS |
BP |
GO:0030278 |
regulation of ossification |
Any process that modulates the frequency, rate or extent of bone formation. |
IEA |
BP |
GO:0042572 |
retinol metabolic process |
The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. |
TAS |
BP |
GO:0048387 |
negative regulation of retinoic acid receptor signaling pathway |
Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity. |
IEA |
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
IEA |
BP |
GO:0060021 |
palate development |
The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities. |
IEA |
BP |
GO:0060349 |
bone morphogenesis |
The process in which bones are generated and organized. |
IEA |
BP |
GO:0060411 |
cardiac septum morphogenesis |
The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. |
IEA |
CC |
GO:0005789 |
endoplasmic reticulum membrane |
The lipid bilayer surrounding the endoplasmic reticulum. |
TAS |
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
CC |
GO:0042622 |
photoreceptor outer segment membrane |
The membrane surrounding the outer segment of a vertebrate photoreceptor. |
TAS |
MF |
GO:0000166 |
nucleotide binding |
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
TAS |
MF |
GO:0004745 |
retinol dehydrogenase activity |
Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. |
IEA |
MF |
GO:0009055 |
electron carrier activity |
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. |
TAS |
MF |
GO:0052650 |
NADP-retinol dehydrogenase activity |
Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+. |
TAS |
Domain ID | Description |
---|---|
IPR002347 |
Short-chain dehydrogenase/reductase SDR |
IPR016040 |
NAD(P)-binding domain |
IPR032969 |
Short-chain dehydrogenase/reductase 3 |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00830 |
Retinol metabolism |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
WP716 |
Vitamin A and Carotenoid Metabolism |
WikiPathways |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
appendix |
glandular cells |
bronchus |
respiratory epithelial cells |
caudate |
neuronal cells |
cerebellum |
cells in granular layer |
cerebellum |
Purkinje cells |
cerebral cortex |
neuronal cells |
cervix, uterine |
glandular cells |
colon |
endothelial cells |
colon |
glandular cells |
colon |
peripheral nerve/ganglion |
duodenum |
glandular cells |
endometrium |
glandular cells |
esophagus |
squamous epithelial cells |
gallbladder |
glandular cells |
heart muscle |
myocytes |
hippocampus |
neuronal cells |
kidney |
cells in tubules |
liver |
hepatocytes |
lung |
macrophages |
nasopharynx |
respiratory epithelial cells |
pancreas |
exocrine glandular cells |
parathyroid gland |
glandular cells |
placenta |
trophoblastic cells |
rectum |
glandular cells |
skin |
fibroblasts |
small intestine |
glandular cells |
smooth muscle |
smooth muscle cells |
stomach |
glandular cells |
thyroid gland |
glandular cells |
tonsil |
germinal center cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
18765015 |
Qiao et al. |
2008 |
Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome |
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
23824412 |
Piltonen et al. |
2013 |
Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
ELAVL1 |
1994 |
Q15717 |
0.63 |