Protein Description

Gene Symbol DHRS3
Entrez ID 9249
Uniprot ID O75911
Description dehydrogenase/reductase (SDR family) member 3
Chromosomal Location chr1: 12,567,910-12,617,731
Ontology GO ID GO Term Definition Evidence

BP

GO:0001523

retinoid metabolic process

The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.

TAS

BP

GO:0003151

outflow tract morphogenesis

The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.

IEA

BP

GO:0007601

visual perception

The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

TAS

BP

GO:0030278

regulation of ossification

Any process that modulates the frequency, rate or extent of bone formation.

IEA

BP

GO:0042572

retinol metabolic process

The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.

TAS

BP

GO:0048387

negative regulation of retinoic acid receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity.

IEA

BP

GO:0055114

oxidation-reduction process

A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

IEA

BP

GO:0060021

palate development

The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities.

IEA

BP

GO:0060349

bone morphogenesis

The process in which bones are generated and organized.

IEA

BP

GO:0060411

cardiac septum morphogenesis

The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.

IEA

CC

GO:0005789

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

TAS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

CC

GO:0042622

photoreceptor outer segment membrane

The membrane surrounding the outer segment of a vertebrate photoreceptor.

TAS

MF

GO:0000166

nucleotide binding

Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

TAS

MF

GO:0004745

retinol dehydrogenase activity

Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.

IEA

MF

GO:0009055

electron carrier activity

Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

TAS

MF

GO:0052650

NADP-retinol dehydrogenase activity

Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.

TAS

Domain ID Description

IPR002347

Short-chain dehydrogenase/reductase SDR

IPR016040

NAD(P)-binding domain

IPR032969

Short-chain dehydrogenase/reductase 3

Pathway ID Pathway Term Pathway Source

hsa00830

Retinol metabolism

KEGG

hsa01100

Metabolic pathways

KEGG

WP716

Vitamin A and Carotenoid Metabolism

WikiPathways

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

bronchus

respiratory epithelial cells

caudate

neuronal cells

cerebellum

cells in granular layer

cerebellum

Purkinje cells

cerebral cortex

neuronal cells

cervix, uterine

glandular cells

colon

endothelial cells

colon

glandular cells

colon

peripheral nerve/ganglion

duodenum

glandular cells

endometrium

glandular cells

esophagus

squamous epithelial cells

gallbladder

glandular cells

heart muscle

myocytes

hippocampus

neuronal cells

kidney

cells in tubules

liver

hepatocytes

lung

macrophages

nasopharynx

respiratory epithelial cells

pancreas

exocrine glandular cells

parathyroid gland

glandular cells

placenta

trophoblastic cells

rectum

glandular cells

skin

fibroblasts

small intestine

glandular cells

smooth muscle

smooth muscle cells

stomach

glandular cells

thyroid gland

glandular cells

tonsil

germinal center cells

No databases found.

Pubmed ID Author Year Title

18765015

Qiao et al.

2008

Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

23824412

Piltonen et al.

2013

Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

Gene Symbol Entrez ID Uniprot ID Score

ELAVL1

1994

Q15717

0.63