BP

GO:0002826

negative regulation of T-helper 1 type immune response

Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response.

IEA

BP

GO:0006955

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

NAS

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0032689

negative regulation of interferon-gamma production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.

IEA

BP

GO:0032754

positive regulation of interleukin-5 production

Any process that activates or increases the frequency, rate, or extent of interleukin-5 production.

IEA

BP

GO:0038172

interleukin-33-mediated signaling pathway

A series of molecular signals initiated by the binding of interleukin-33 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IEA

BP

GO:0043032

positive regulation of macrophage activation

Any process that stimulates, induces or increases the rate of macrophage activation.

IEA

BP

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.

IEA

BP

GO:0050729

positive regulation of inflammatory response

Any process that activates or increases the frequency, rate or extent of the inflammatory response.

IEA

BP

GO:0090197

positive regulation of chemokine secretion

Any process that increases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell.

IEA

CC

GO:0005578

proteinaceous extracellular matrix

A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0009897

external side of plasma membrane

The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.

IEA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0002113

interleukin-33 binding

Interacting selectively and non-covalently with interleukin-33.

IEA

MF

GO:0002114

interleukin-33 receptor activity

Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IEA

MF

GO:0004896

cytokine receptor activity

Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

TAS

MF

GO:0004908

interleukin-1 receptor activity

Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.

IEA

MF

GO:0005057

receptor signaling protein activity

Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI