Gene Symbol | IL1RL1 |
Entrez ID | 9173 |
Uniprot ID | Q01638 |
Description | interleukin 1 receptor-like 1 |
Chromosomal Location | chr2: 102,311,502-102,352,037 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0002826 |
negative regulation of T-helper 1 type immune response |
Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response. |
IEA |
BP |
GO:0006955 |
immune response |
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. |
NAS |
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
TAS |
BP |
GO:0032689 |
negative regulation of interferon-gamma production |
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. |
IEA |
BP |
GO:0032754 |
positive regulation of interleukin-5 production |
Any process that activates or increases the frequency, rate, or extent of interleukin-5 production. |
IEA |
BP |
GO:0038172 |
interleukin-33-mediated signaling pathway |
A series of molecular signals initiated by the binding of interleukin-33 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
IEA |
BP |
GO:0043032 |
positive regulation of macrophage activation |
Any process that stimulates, induces or increases the rate of macrophage activation. |
IEA |
BP |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. |
IEA |
BP |
GO:0050729 |
positive regulation of inflammatory response |
Any process that activates or increases the frequency, rate or extent of the inflammatory response. |
IEA |
BP |
GO:0090197 |
positive regulation of chemokine secretion |
Any process that increases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell. |
IEA |
CC |
GO:0005578 |
proteinaceous extracellular matrix |
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. |
IEA |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
TAS |
CC |
GO:0009897 |
external side of plasma membrane |
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
IEA |
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
MF |
GO:0002113 |
interleukin-33 binding |
Interacting selectively and non-covalently with interleukin-33. |
IEA |
MF |
GO:0002114 |
interleukin-33 receptor activity |
Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IEA |
MF |
GO:0004896 |
cytokine receptor activity |
Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
TAS |
MF |
GO:0004908 |
interleukin-1 receptor activity |
Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response. |
IEA |
MF |
GO:0005057 |
receptor signaling protein activity |
Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell. |
TAS |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
Domain ID | Description |
---|---|
IPR000157 |
Toll/interleukin-1 receptor homology (TIR) domain |
IPR003598 |
Immunoglobulin subtype 2 |
IPR003599 |
Immunoglobulin subtype |
IPR004074 |
Interleukin-1 receptor type I/II |
IPR007110 |
Immunoglobulin-like domain |
IPR013098 |
Immunoglobulin I-set |
IPR013783 |
Immunoglobulin-like fold |
IPR015621 |
Interleukin-1 receptor family |
UMLS CUI | UMLS Term |
---|---|
C0004096 |
Asthma |
C0018621 |
Hay Fever |
C0023343 |
Leprosy |
C0242488 |
Acute Lung Injury |
C0993582 |
Arthritis, Experimental |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
TIRAP |
114609 |
P58753 |
0.52 |
APP |
351 |
P05067 |
0.56 |
IL33 |
90865 |
O95760 |
0.59 |
CLEC7A |
64581 |
Q9BXN2 |
0.63 |
IRAK1 |
3654 |
P51617 |
0.70 |
MYD88 |
4615 |
Q99836 |
0.89 |
TRAF6 |
7189 |
Q9Y4K3 |
0.72 |
IRAK4 |
51135 |
Q9NWZ3 |
0.72 |
TMED1 |
11018 |
Q13445 |
0.75 |