Protein Description

Gene Symbol SLC16A3
Entrez ID 9123
Uniprot ID O15427
Description solute carrier family 16 (monocarboxylate transporter), member 3
Chromosomal Location chr17: 82,228,397-82,261,129
Ontology GO ID GO Term Definition Evidence

BP

GO:0006090

pyruvate metabolic process

The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.

TAS

BP

GO:0015718

monocarboxylic acid transport

The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

TAS

BP

GO:0035879

plasma membrane lactate transport

The directed movement of lactate across a plasma membrane.

IBA

BP

GO:0050900

leukocyte migration

The movement of a leukocyte within or between different tissues and organs of the body.

TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA|TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

CC

GO:0015629

actin cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.

IDA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

TAS

CC

GO:0031965

nuclear membrane

Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

IDA

MF

GO:0008028

monocarboxylic acid transmembrane transporter activity

Enables the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group.

TAS

MF

GO:0015129

lactate transmembrane transporter activity

Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.

EXP|IBA

MF

GO:0015293

symporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

IEA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

Domain ID Description

IPR004743

Monocarboxylate transporter

IPR011701

Major facilitator superfamily

IPR020846

Major facilitator superfamily domain

IPR030756

Monocarboxylate transporter 4

Pathway ID Pathway Term Pathway Source

hsa05230

Central carbon metabolism in cancer

KEGG

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

bone marrow

hematopoietic cells

breast

glandular cells

bronchus

respiratory epithelial cells

cerebellum

Purkinje cells

colon

glandular cells

duodenum

glandular cells

endometrium

glandular cells

esophagus

squamous epithelial cells

lymph node

germinal center cells

lymph node

non-germinal center cells

nasopharynx

respiratory epithelial cells

placenta

trophoblastic cells

rectum

glandular cells

salivary gland

glandular cells

skeletal muscle

myocytes

small intestine

glandular cells

stomach

glandular cells

thyroid gland

glandular cells

tonsil

germinal center cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

BSG

682

P35613

0.52

BANP

54971

Q8N9N5

0.63

NR2C2AP

126382

Q86WQ0

0.63

FAM9B

171483

Q8IZU0

0.63

E2F3

1871

O00716

0.07

DIAPH1

1729

O60610

0.72

TSNAX

7257

Q99598

0.72

TERF2IP

54386

Q9NYB0

0.72