| Gene Symbol | SLC16A3 |
| Entrez ID | 9123 |
| Uniprot ID | O15427 |
| Description | solute carrier family 16 (monocarboxylate transporter), member 3 |
| Chromosomal Location | chr17: 82,228,397-82,261,129 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006090 |
pyruvate metabolic process |
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. |
TAS |
|
BP |
GO:0015718 |
monocarboxylic acid transport |
The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
TAS |
|
BP |
GO:0035879 |
plasma membrane lactate transport |
The directed movement of lactate across a plasma membrane. |
IBA |
|
BP |
GO:0050900 |
leukocyte migration |
The movement of a leukocyte within or between different tissues and organs of the body. |
TAS |
|
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IDA|TAS |
|
CC |
GO:0005887 |
integral component of plasma membrane |
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
|
CC |
GO:0015629 |
actin cytoskeleton |
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
IDA |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
TAS |
|
CC |
GO:0031965 |
nuclear membrane |
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
IDA |
|
MF |
GO:0008028 |
monocarboxylic acid transmembrane transporter activity |
Enables the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. |
TAS |
|
MF |
GO:0015129 |
lactate transmembrane transporter activity |
Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. |
EXP|IBA |
|
MF |
GO:0015293 |
symporter activity |
Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
IEA |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR004743 |
Monocarboxylate transporter |
|
IPR011701 |
Major facilitator superfamily |
|
IPR020846 |
Major facilitator superfamily domain |
|
IPR030756 |
Monocarboxylate transporter 4 |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa05230 |
Central carbon metabolism in cancer |
KEGG |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
bronchus |
respiratory epithelial cells |
|
cerebellum |
Purkinje cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
placenta |
trophoblastic cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
skeletal muscle |
myocytes |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
BSG |
682 |
P35613 |
0.52 |
|
BANP |
54971 |
Q8N9N5 |
0.63 |
|
NR2C2AP |
126382 |
Q86WQ0 |
0.63 |
|
FAM9B |
171483 |
Q8IZU0 |
0.63 |
|
E2F3 |
1871 |
O00716 |
0.07 |
|
DIAPH1 |
1729 |
O60610 |
0.72 |
|
TSNAX |
7257 |
Q99598 |
0.72 |
|
TERF2IP |
54386 |
Q9NYB0 |
0.72 |