BP

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.

ISS

BP

GO:0000165

MAPK cascade

An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

IEA

BP

GO:0000188

inactivation of MAPK activity

Any process that terminates the activity of the active enzyme MAP kinase.

ISS

BP

GO:0001525

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

IEA

BP

GO:0001570

vasculogenesis

The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.

ISS

BP

GO:0001666

response to hypoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.

ISS

BP

GO:0001937

negative regulation of endothelial cell proliferation

Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.

ISS

BP

GO:0001960

negative regulation of cytokine-mediated signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.

IEA

BP

GO:0002931

response to ischemia

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.

IEA

BP

GO:0003057

regulation of the force of heart contraction by chemical signal

The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.

IEA

BP

GO:0006641

triglyceride metabolic process

The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.

ISS

BP

GO:0006816

calcium ion transport

The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

ISS

BP

GO:0006874

cellular calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.

ISS

BP

GO:0006940

regulation of smooth muscle contraction

Any process that modulates the frequency, rate or extent of smooth muscle contraction.

ISS

BP

GO:0007519

skeletal muscle tissue development

The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.

ISS

BP

GO:0007595

lactation

The secretion of milk by the mammary gland.

IEA

BP

GO:0008104

protein localization

Any process in which a protein is transported to, or maintained in, a specific location.

ISS

BP

GO:0009617

response to bacterium

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.

IDA

BP

GO:0010524

positive regulation of calcium ion transport into cytosol

Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.

ISS

BP

GO:0010608

posttranscriptional regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.

IEA

BP

GO:0010628

positive regulation of gene expression

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

IEA

BP

GO:0010952

positive regulation of peptidase activity

Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.

IEA

BP

GO:0016050

vesicle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.

ISS

BP

GO:0019065

receptor-mediated endocytosis of virus by host cell

Any receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell.

IGI

BP

GO:0019217

regulation of fatty acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.

ISS

BP

GO:0019915

lipid storage

The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.

ISS

BP

GO:0030193

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

IMP

BP

GO:0030301

cholesterol transport

The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

TAS

BP

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.

IDA

BP

GO:0030857

negative regulation of epithelial cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation.

ISS

BP

GO:0030879

mammary gland development

The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.

ISS

BP

GO:0031295

T cell costimulation

The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.

IDA

BP

GO:0031397

negative regulation of protein ubiquitination

Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.

IMP

BP

GO:0031398

positive regulation of protein ubiquitination

Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.

IMP

BP

GO:0031623

receptor internalization

A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.

IDA

BP

GO:0032091

negative regulation of protein binding

Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.

IDA

BP

GO:0032092

positive regulation of protein binding

Any process that activates or increases the frequency, rate or extent of protein binding.

IMP

BP

GO:0032507

maintenance of protein location in cell

Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.

ISS

BP

GO:0032570

response to progesterone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.

IDA

BP

GO:0033137

negative regulation of peptidyl-serine phosphorylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine.

IDA

BP

GO:0033138

positive regulation of peptidyl-serine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.

IDA

BP

GO:0033484

nitric oxide homeostasis

A homeostatic process involved in the maintenance of an internal steady state of nitric oxide within an organism or cell.

ISS

BP

GO:0034141

positive regulation of toll-like receptor 3 signaling pathway

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway.

IMP

BP

GO:0042310

vasoconstriction

A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure.

IEA

BP

GO:0042524

negative regulation of tyrosine phosphorylation of Stat5 protein

Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein.

IEA

BP

GO:0042632

cholesterol homeostasis

Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.

ISS|TAS

BP

GO:0043085

positive regulation of catalytic activity

Any process that activates or increases the activity of an enzyme.

ISS

BP

GO:0043409

negative regulation of MAPK cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.

ISS

BP

GO:0043627

response to estrogen

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.

IDA

BP

GO:0044860

protein localization to plasma membrane raft

A process in which a protein is transported to, or maintained in, a location within a plasma membrane raft.

ISS

BP

GO:0045019

negative regulation of nitric oxide biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.

ISS

BP

GO:0045907

positive regulation of vasoconstriction

Any process that activates or increases the frequency, rate or extent of vasoconstriction.

ISS

BP

GO:0046426

negative regulation of JAK-STAT cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity.

ISS

BP

GO:0048550

negative regulation of pinocytosis

Any process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes.

IMP

BP

GO:0050900

leukocyte migration

The movement of a leukocyte within or between different tissues and organs of the body.

TAS

BP

GO:0050999

regulation of nitric-oxide synthase activity

Any process that modulates the activity of the enzyme nitric-oxide synthase.

TAS

BP

GO:0051001

negative regulation of nitric-oxide synthase activity

Any process that stops or reduces the activity of the enzyme nitric-oxide synthase.

IEA

BP

GO:0051260

protein homooligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

ISS

BP

GO:0051480

regulation of cytosolic calcium ion concentration

Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.

IDA

BP

GO:0051592

response to calcium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.

ISS

BP

GO:0051899

membrane depolarization

The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.

ISS

BP

GO:0052547

regulation of peptidase activity

Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.

ISS

BP

GO:0055074

calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.

ISS

BP

GO:0060056

mammary gland involution

The tissue remodeling that removes differentiated mammary epithelia during weaning.

ISS

BP

GO:0060355

positive regulation of cell adhesion molecule production

Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism.

IMP

BP

GO:0060546

negative regulation of necroptotic process

Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.

IEA

BP

GO:0061099

negative regulation of protein tyrosine kinase activity

Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity.

IMP

BP

GO:0070836

caveola assembly

The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane.

IGI|IMP|ISS

BP

GO:0071360

cellular response to exogenous dsRNA

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.

IMP

BP

GO:0071375

cellular response to peptide hormone stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.

ISS

BP

GO:0071455

cellular response to hyperoxia

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.

IMP

BP

GO:0071560

cellular response to transforming growth factor beta stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.

IEA

BP

GO:0072584

caveolin-mediated endocytosis

An endocytosis process that begins when material is taken up into plasma membrane caveolae, which then pinch off to form endocytic caveolar carriers.

IDA

BP

GO:0086091

regulation of heart rate by cardiac conduction

A cardiac conduction process that modulates the frequency or rate of heart contraction.

ISS

BP

GO:0086098

angiotensin-activated signaling pathway involved in heart process

An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart.

ISS

BP

GO:0090090

negative regulation of canonical Wnt signaling pathway

Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.

ISS

BP

GO:0090263

positive regulation of canonical Wnt signaling pathway

Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.

IMP

BP

GO:0097190

apoptotic signaling pathway

A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.

IMP

BP

GO:0098903

regulation of membrane repolarization during action potential

Any process that modulates the rate, frequency or extent of membrane repolarization during an action potential. Membrane repolarization is the process in which membrane potential changes in the repolarizing direction, towards the resting potential.

IMP

BP

GO:0098909

regulation of cardiac muscle cell action potential involved in regulation of contraction

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction.

IC

BP

GO:0098911

regulation of ventricular cardiac muscle cell action potential

Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.

ISS

BP

GO:1900027

regulation of ruffle assembly

Any process that modulates the frequency, rate or extent of ruffle assembly.

IDA

BP

GO:1900085

negative regulation of peptidyl-tyrosine autophosphorylation

Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.

IMP

BP

GO:1901380

negative regulation of potassium ion transmembrane transport

Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport.

IMP

BP

GO:1901844

regulation of cell communication by electrical coupling involved in cardiac conduction

Any process that modulates the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction.

ISS

BP

GO:1901979

regulation of inward rectifier potassium channel activity

Any process that modulates the frequency, rate or extent of inward rectifier potassium channel activity.

IMP

BP

GO:1903071

positive regulation of ER-associated ubiquitin-dependent protein catabolic process

Any process that activates or increases the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process.

IC

BP

GO:1903361

protein localization to basolateral plasma membrane

A process in which a protein is transported to, or maintained in, a location within a basolateral plasma membrane.

ISS

BP

GO:1903598

positive regulation of gap junction assembly

Any process that activates or increases the frequency, rate or extent of gap junction assembly.

ISS

BP

GO:1904886

beta-catenin destruction complex disassembly

The disaggregation of a beta-catenin destruction complex into its constituent components.

TAS

BP

GO:2000286

receptor internalization involved in canonical Wnt signaling pathway

A receptor internalization process that contributes to canonical Wnt signaling pathway.

IMP

BP

GO:2000535

regulation of entry of bacterium into host cell

Any process that modulates the frequency, rate or extent of entry of bacterium into host cell.

IDA

BP

GO:2000811

negative regulation of anoikis

Any process that stops, prevents or reduces the frequency, rate or extent of anoikis.

IMP

BP

GO:2001238

positive regulation of extrinsic apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.

IMP

BP

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.

IMP

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IDA|TAS

CC

GO:0002080

acrosomal membrane

The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization.

IEA

CC

GO:0005622

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

IDA

CC

GO:0005768

endosome

A vacuole to which materials ingested by endocytosis are delivered.

IDA

CC

GO:0005783

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

IDA

CC

GO:0005789

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

TAS

CC

GO:0005811

lipid particle

An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA|TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

CC

GO:0005901

caveola

A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.

IDA

CC

GO:0005925

focal adhesion

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

IDA

CC

GO:0005929

cilium

A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.

IEA

CC

GO:0005938

cell cortex

The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.

IEA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0030666

endocytic vesicle membrane

The lipid bilayer surrounding an endocytic vesicle.

TAS

CC

GO:0031410

cytoplasmic vesicle

A vesicle found in the cytoplasm of a cell.

IDA

CC

GO:0031901

early endosome membrane

The lipid bilayer surrounding an early endosome.

TAS

CC

GO:0034098

VCP-NPL4-UFD1 AAA ATPase complex

A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).

IPI

CC

GO:0043234

protein complex

A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.

IDA

CC

GO:0045121

membrane raft

Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.

IDA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IDA|ISS

MF

GO:0005102

receptor binding

Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

IPI

MF

GO:0005113

patched binding

Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins.

NAS

MF

GO:0005198

structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0015485

cholesterol binding

Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

TAS

MF

GO:0016504

peptidase activator activity

Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

ISS

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IPI

MF

GO:0019901

protein kinase binding

Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

IPI

MF

GO:0030674

protein binding, bridging

The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.

IEA

MF

GO:0032947

protein complex scaffold

Functions to provide a physical support for the assembly of a multiprotein complex.

TAS

MF

GO:0042802

identical protein binding

Interacting selectively and non-covalently with an identical protein or proteins.

IPI

MF

GO:0044325

ion channel binding

Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

IPI

MF

GO:0046982

protein heterodimerization activity

Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.

IEA

MF

GO:0048365

Rac GTPase binding

Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.

IPI

MF

GO:0050998

nitric-oxide synthase binding

Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.

IPI

MF

GO:0051117

ATPase binding

Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.

IPI

MF

GO:0070320

inward rectifier potassium channel inhibitor activity

Stops, prevents, or reduces the activity of an inwardly rectifying potassium channel.

IDA