PCOSBase

Protein Description

Gene Symbol	RPL14
Entrez ID	9045
Uniprot ID	P50914
Description	ribosomal protein L14
Chromosomal Location	chr3: 40,457,292-40,468,587

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.	TAS
BP	GO:0006364	rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.	IMP\|TAS
BP	GO:0006412	translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome.	NAS
BP	GO:0006413	translational initiation	The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.	TAS
BP	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.	TAS
BP	GO:0019083	viral transcription	The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.	TAS
BP	GO:0042273	ribosomal large subunit biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.	IMP
BP	GO:0098609	cell-cell adhesion	The attachment of one cell to another cell via adhesion molecules.	IEA
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IDA
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	TAS
CC	GO:0005913	cell-cell adherens junction	An adherens junction which connects a cell to another cell.	IDA
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0022625	cytosolic large ribosomal subunit	The large subunit of a ribosome located in the cytosol.	IDA
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
MF	GO:0003723	RNA binding	Interacting selectively and non-covalently with an RNA molecule or a portion thereof.	TAS
MF	GO:0003735	structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.	NAS
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA
MF	GO:0098641	cadherin binding involved in cell-cell adhesion	Any cadherin binding that occurs as part of the process of cell-cell adhesion.	IDA

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Domain ID	Description
IPR002784	Ribosomal protein L14e domain
IPR008991	Translation protein SH3-like domain
IPR014722	Ribosomal protein L2 domain 2

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Pathway ID	Pathway Term	Pathway Source
hsa03010	Ribosome	KEGG
WP477	Cytoplasmic Ribosomal Proteins	WikiPathways

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UMLS CUI	UMLS Term
C0007134	Renal Cell Carcinoma
C0030567	Parkinson Disease

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Tissue	Cell Type
appendix	glandular cells
appendix	lymphoid tissue
bone marrow	hematopoietic cells
breast	glandular cells
breast	myoepithelial cells
bronchus	respiratory epithelial cells
caudate	neuronal cells
cerebellum	cells in molecular layer
cerebellum	Purkinje cells
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
cervix, uterine	squamous epithelial cells
colon	glandular cells
duodenum	glandular cells
endometrium	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
hippocampus	neuronal cells
lung	macrophages
lung	pneumocytes
lymph node	germinal center cells
lymph node	non-germinal center cells
nasopharynx	respiratory epithelial cells
pancreas	exocrine glandular cells
placenta	decidual cells
placenta	trophoblastic cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
small intestine	glandular cells
soft tissue	chondrocytes
soft tissue	fibroblasts
spleen	cells in white pulp
stomach	glandular cells
thyroid gland	glandular cells
tonsil	germinal center cells
tonsil	non-germinal center cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells

No databases found.

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Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
RPL17	6139	P18621	0.49
RPL28	6158	P46779	0.49
RPL29	6159	P47914	0.49
RPL35A	6165	P18077	0.49
MRPL12	6182	P52815	0.49
RPS14	6208	P62263	0.49
RPS15	6209	P62841	0.49
RPS17	6218	P08708	0.49
RPS18	6222	P62269	0.49
RPS24	6229	P62847	0.49
RPS27	6232	P42677	0.49
RPS27A	6233	P62979	0.49
RPS28	6234	P62857	0.49
SRP14	6727	P37108	0.49
SSR3	6747	Q9UNL2	0.49
PTGES3	10728	Q15185	0.49
RPS27L	51065	Q71UM5	0.49
RPS10P5	93144	Q9NQ39	0.49
RPLP0P6	220717	Q8NHW5	0.49
RPS21	100291837	P63220	0.49
RPSA	3921	P08865	0.59
RPL4	6124	P36578	0.59
RPL5	6125	P46777	0.59
RPL6	6128	Q02878	0.59
RPL7	6129	P18124	0.59
RPL7A	6130	P62424	0.59
RPL8	6132	P62917	0.59
RPL18	6141	Q07020	0.59
RPL18A	6142	Q02543	0.59
RPL19	6143	P84098	0.59
RPL21	6144	P46778	0.59
RPL22	6146	P35268	0.59
RPL23A	6147	P62750	0.59
RPL24	6152	P83731	0.59
RPL27	6155	P61353	0.59
RPL30	6156	P62888	0.59
RPL27A	6157	P46776	0.59
RPL31	6160	P62899	0.59
RPL37A	6168	P61513	0.59
RPL38	6169	P63173	0.59
RPLP0	6175	P05388	0.59
RPLP2	6181	P05387	0.59
RPS2	6187	P15880	0.59
RPS3	6188	P23396	0.59
RPS3A	6189	P61247	0.59
RPS4X	6191	P62701	0.59
RPS5	6193	P46782	0.59
RPS6	6194	P62753	0.59
RPS7	6201	P62081	0.59
RPS10	6204	P46783	0.59
RPS11	6205	P62280	0.59
RPS12	6206	P25398	0.59
RPS13	6207	P62277	0.59
RPS15A	6210	P62244	0.59
RPS16	6217	P62249	0.59
RPS19	6223	P39019	0.59
RPS20	6224	P60866	0.59
RPS23	6228	P62266	0.59
RPS25	6230	P62851	0.59
RPS26	6231	P62854	0.59
RPL23	9349	P62829	0.59
RPL35	11224	P42766	0.59
RPL36	25873	Q9Y3U8	0.59
RPL9; RPL9P7; RPL9P8; RPL9P9	6133	P32969	0.59
DKC1	1736	O60832	0.63
NOP2	4839	P46087	0.63
NVL	4931	O15381	0.63
RPL36AL	6166	Q969Q0	0.63
SURF6	6838	O75683	0.63
TTF1	7270	Q15361	0.63
WHSC1	7468	O96028	0.63
ZNF22	7570	P17026	0.63
ZKSCAN8	7745	Q15776	0.63
PRPF4B	8899	Q13523	0.63
TAF1C	9013	Q15572	0.63
TAF1A	9015	Q15573	0.63
DDX21	9188	Q9NR30	0.63
TRAF4	9618	Q9BUZ4	0.63
VPRBP	9730	Q9Y4B6	0.63
URB2	9816	Q14146	0.63
ZBTB24	9841	O43167	0.63
URB1	9875	O60287	0.63
PUM3	9933	Q15397	0.63
G3BP1	10146	Q13283	0.63
CEBPZ	10153	Q03701	0.63
SRRM1	10250	Q8IYB3	0.63
UBE2E3	10477	Q969T4	0.63
MYBBP1A	10514	Q9BQG0	0.63
DDX52	11056	Q9Y2R4	0.63
RBM34	23029	P42696	0.63
RRP1B	23076	Q14684	0.63
RRS1	23212	Q15050	0.63
ZNF629	23361	Q9UEG4	0.63
RRP8	23378	O43159	0.63
GTPBP4	23560	Q9BZE4	0.63
STAU2	27067	Q9NUL3	0.63
GNL2	29889	Q13823	0.63
GLTSCR2	29997	Q9NZM5	0.63
KCNK4	50801	Q9NYG8	0.63
MYEF2	50804	Q9P2K5	0.63
HP1BP3	50809	Q5SSJ5	0.63
HERC5	51191	Q9UII4	0.63
C9orf114	51490	Q5T280	0.63
RBMX2	51634	Q9Y388	0.63
CDK12	51755	Q9NYV4	0.63
DDX56	54606	Q9NY93	0.63
ZNF770	54989	Q6IQ21	0.63
PAK1IP1	55003	Q9NWT1	0.63
ARGLU1	55082	Q9NWB6	0.63
RBM28	55131	Q9NW13	0.63
BRIX1	55299	Q8TDN6	0.63
DDX27	55661	Q96GQ7	0.63
PPAN	56342	Q9NQ55	0.63
DDX24	57062	Q9GZR7	0.63
REXO4	57109	Q9GZR2	0.63
SCAF1	58506	Q9H7N4	0.63
NOC3L	64318	Q8WTT2	0.63
GZF1	64412	Q9H116	0.63
DDX31	64794	Q9H8H2	0.63
C8orf33	65265	Q9H7E9	0.63
DDX54	79039	Q8TDD1	0.63
TAF1D	79101	Q9H5J8	0.63
ZNF768	79724	Q9H5H4	0.63
ZNF668	79759	Q96K58	0.63
TLE6	79816	Q9H808	0.63
RPF1	80135	Q9H9Y2	0.63
RPF2	84154	Q9H7B2	0.63
ZCCHC7	84186	Q8N3Z6	0.63
FYTTD1	84248	Q96QD9	0.63
LLPH	84298	Q9BRT6	0.63
NIFK	84365	Q9BYG3	0.63
ZNF512	84450	Q96ME7	0.63
BUD13	84811	Q9BRD0	0.63
MINA	84864	Q8IUF8	0.63
ZSCAN25	221785	Q6NSZ9	0.63
RSBN1L	222194	Q6PCB5	0.63
CCDC137	339230	Q6PK04	0.63
ZFP62	643836	Q8NB50	0.63
RBM5	10181	P52756	0.70
RPL32	6161	P62910	0.73
RPL13A	23521	P40429	0.73
RPL26L1	51121	Q9UNX3	0.73
FTSJ3	117246	Q8IY81	0.73
RPL3	6122	P39023	0.74
RPL15	6138	P61313	0.74
RPS8	6202	P62241	0.74
PHLDA1	22822	Q8WV24	0.88
ACTA2	59	P62736	0.49
SLC25A5	292	P05141	0.49
CDH2	1000	P19022	0.49
EEF2	1938	P13639	0.49
HSP90AB1	3326	P08238	0.49
ICT1	3396	Q14197	0.49
ILF2	3608	Q12905	0.49
ILF3	3609	Q12906	0.49
HNRNPM	4670	P52272	0.49
NAP1L1	4673	P55209	0.49
NCL	4691	P19338	0.49
NDUFS4	4724	O43181	0.49
REV3L	5980	O60673	0.49
RPL3L	6123	Q92901	0.49
RPL26	6154	P61254	0.49
RPLP1	6176	P05386	0.49
RPS9	6203	P46781	0.49
SCD	6319	O00767	0.49
TUFM	7284	P49411	0.49
UQCRB	7381	P14927	0.49
GNL3	26354	Q9BVP2	0.49
PABPC1	26986	P11940	0.49
NENF	29937	Q9UMX5	0.49
RPL10L	140801	Q96L21	0.49
PPP2R2B	5521	Q00005	0.56
RPL34	6164	P49207	0.58
RPL10A	4736	P62906	0.59
RPL11	6135	P62913	0.59
RPL12	6136	P30050	0.59
RPL13	6137	P26373	0.59
PARP1	142	P09874	0.63
CDK2	1017	P24941	0.63
CSNK1A1	1452	P48729	0.63
CSNK1E	1454	P49674	0.63
ESR2	2100	Q92731	0.63
FUS	2521	P35637	0.63
GRSF1	2926	Q12849	0.63
ITGA4	3676	P13612	0.63
JUN	3725	P05412	0.63
KRT18	3875	P05783	0.63
NTRK1	4914	P04629	0.63
PCK1	5105	P35558	0.63
EIF2AK2	5610	P19525	0.63
PEX5	5830	P50542	0.63
RNF2	6045	Q99496	0.63
RPS6KB2	6199	Q9UBS0	0.63
SGK1	6446	O00141	0.63
SKI	6497	P12755	0.63
TCF3	6929	P15923	0.63
KLF10	7071	Q13118	0.63
TP53	7157	P04637	0.63
TUBG1	7283	P23258	0.63
VHL	7428	P40337	0.63
UBL4A	8266	P11441	0.63
HIST1H3A	8350	P68431	0.63
CUL4B	8450	Q13620	0.63
CUL3	8452	Q13618	0.63
CUL2	8453	Q13617	0.63
CUL1	8454	Q13616	0.63
EED	8726	O75530	0.63
KIAA0101	9768	Q15004	0.63
CUL7	9820	Q14999	0.63
PAN2	9924	Q504Q3	0.63
NOP56	10528	O00567	0.63
EBNA1BP2	10969	Q99848	0.63
COPS5	10987	Q92905	0.63
CEP250	11190	Q9BV73	0.63
GABARAP	11337	O95166	0.63
GABARAPL2	11345	P60520	0.63
ZBTB1	22890	Q9Y2K1	0.63
OBSL1	23363	O75147	0.63
TARDBP	23435	Q13148	0.63
GABARAPL1	23710	Q9H0R8	0.63
AGO1	26523	Q9UL18	0.63
TUBGCP4	27229	Q9UGJ1	0.63
SIRT7	51547	Q9NRC8	0.63
RIOK2	55781	Q9BVS4	0.63
CAND1	55832	Q86VP6	0.63
NOL12	79159	Q9UGY1	0.63
CCDC8	83987	Q9H0W5	0.63
MAP1LC3A	84557	Q9H492	0.63
TP53RK	112858	Q96S44	0.63
PI16	221476	Q6UXB8	0.63
ESR1	2099	P03372	0.67
ARRB2	409	P32121	0.72
FN1	2335	P02751	0.72
FOSL2	2355	P15408	0.72
MAP3K1	4214	Q13233	0.72
MAP3K14	9020	Q99558	0.72
STAU1	6780	O95793	0.74
LRRK2	120892	Q5S007	0.75
PTEN	5728	P60484	0.78
NPM1	4869	P06748	0.82
VCAM1	7412	P19320	0.82
RPL10	6134	P27635	0.83