Gene Symbol | AP1G2 |
Entrez ID | 8906 |
Uniprot ID | O75843 |
Description | adaptor related protein complex 1 gamma 2 subunit |
Chromosomal Location | chr14: 23,559,565-23,568,070 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006886 |
intracellular protein transport |
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
IEA |
BP |
GO:0016032 |
viral process |
A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle. |
IEA |
BP |
GO:0016192 |
vesicle-mediated transport |
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
NAS |
CC |
GO:0000139 |
Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
TAS |
CC |
GO:0005794 |
Golgi apparatus |
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. |
TAS |
CC |
GO:0005798 |
Golgi-associated vesicle |
Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. |
IDA |
CC |
GO:0010008 |
endosome membrane |
The lipid bilayer surrounding an endosome. |
IEA |
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
CC |
GO:0030121 |
AP-1 adaptor complex |
A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). |
TAS |
CC |
GO:0030133 |
transport vesicle |
Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. |
IDA |
MF |
GO:0008565 |
protein transporter activity |
Enables the directed movement of proteins into, out of or within a cell, or between cells. |
IEA |
Domain ID | Description |
---|---|
IPR002553 |
Clathrin/coatomer adaptor, adaptin-like, N-terminal |
IPR008152 |
Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain |
IPR008153 |
Gamma-adaptin ear (GAE) domain |
IPR011989 |
Armadillo-like helical |
IPR013041 |
Coatomer/clathrin adaptor appendage, Ig-like subdomain |
IPR016024 |
Armadillo-type fold |
IPR017107 |
Adaptor protein complex AP-1, gamma subunit |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04142 |
Lysosome |
KEGG |
UMLS CUI | UMLS Term |
---|---|
C1720824 |
Sudden Cardiac Arrest |
Tissue | Cell Type |
---|---|
colon |
glandular cells |
small intestine |
glandular cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
19141487 |
Kenigsberg et al. |
2009 |
Gene expression microarray profiles of cumulus cells in lean and overweightobese polycystic ovary syndrome patients |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
CENPK |
64105 |
Q9BS16 |
0.63 |
UBE2Z |
65264 |
Q9H832 |
0.63 |
ATXN1L |
342371 |
P0C7T5 |
0.63 |
NEDD4 |
4734 |
P46934 |
0.77 |
AP1S1 |
1174 |
P61966 |
0.82 |
AP1S2 |
8905 |
P56377 |
0.96 |
IST1 |
9798 |
P53990 |
0.49 |
AP2M1 |
1173 |
Q96CW1 |
0.63 |
EGFR |
1956 |
P00533 |
0.63 |
RAB5A |
5868 |
P20339 |
0.63 |
SUMO1 |
7341 |
P63165 |
0.63 |
XPO1 |
7514 |
O14980 |
0.63 |
AAGAB |
79719 |
Q6PD74 |
0.63 |
LRRK2 |
120892 |
Q5S007 |
0.63 |
SYNE4 |
163183 |
Q8N205 |
0.63 |
AP1M2 |
10053 |
Q9Y6Q5 |
0.70 |
KDM1A |
23028 |
O60341 |
0.72 |
PRMT6 |
55170 |
Q96LA8 |
0.72 |
XRN1 |
54464 |
Q8IZH2 |
0.73 |
AFTPH |
54812 |
Q6ULP2 |
0.73 |
SYNRG |
11276 |
Q9UMZ2 |
0.76 |
RABEP1 |
9135 |
Q15276 |
0.84 |