Protein Description

Gene Symbol AP1G2
Entrez ID 8906
Uniprot ID O75843
Description adaptor related protein complex 1 gamma 2 subunit
Chromosomal Location chr14: 23,559,565-23,568,070
Ontology GO ID GO Term Definition Evidence

BP

GO:0006886

intracellular protein transport

The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.

IEA

BP

GO:0016032

viral process

A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.

IEA

BP

GO:0016192

vesicle-mediated transport

A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

NAS

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

TAS

CC

GO:0005794

Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

TAS

CC

GO:0005798

Golgi-associated vesicle

Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.

IDA

CC

GO:0010008

endosome membrane

The lipid bilayer surrounding an endosome.

IEA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0030121

AP-1 adaptor complex

A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).

TAS

CC

GO:0030133

transport vesicle

Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.

IDA

MF

GO:0008565

protein transporter activity

Enables the directed movement of proteins into, out of or within a cell, or between cells.

IEA

Domain ID Description

IPR002553

Clathrin/coatomer adaptor, adaptin-like, N-terminal

IPR008152

Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain

IPR008153

Gamma-adaptin ear (GAE) domain

IPR011989

Armadillo-like helical

IPR013041

Coatomer/clathrin adaptor appendage, Ig-like subdomain

IPR016024

Armadillo-type fold

IPR017107

Adaptor protein complex AP-1, gamma subunit

Pathway ID Pathway Term Pathway Source

hsa04142

Lysosome

KEGG

UMLS CUI UMLS Term

C1720824

Sudden Cardiac Arrest

Tissue Cell Type

colon

glandular cells

small intestine

glandular cells

No databases found.

Pubmed ID Author Year Title

19141487

Kenigsberg et al.

2009

Gene expression microarray profiles of cumulus cells in lean and overweightobese polycystic ovary syndrome patients

Gene Symbol Entrez ID Uniprot ID Score

CENPK

64105

Q9BS16

0.63

UBE2Z

65264

Q9H832

0.63

ATXN1L

342371

P0C7T5

0.63

NEDD4

4734

P46934

0.77

AP1S1

1174

P61966

0.82

AP1S2

8905

P56377

0.96

IST1

9798

P53990

0.49

AP2M1

1173

Q96CW1

0.63

EGFR

1956

P00533

0.63

RAB5A

5868

P20339

0.63

SUMO1

7341

P63165

0.63

XPO1

7514

O14980

0.63

AAGAB

79719

Q6PD74

0.63

LRRK2

120892

Q5S007

0.63

SYNE4

163183

Q8N205

0.63

AP1M2

10053

Q9Y6Q5

0.70

KDM1A

23028

O60341

0.72

PRMT6

55170

Q96LA8

0.72

XRN1

54464

Q8IZH2

0.73

AFTPH

54812

Q6ULP2

0.73

SYNRG

11276

Q9UMZ2

0.76

RABEP1

9135

Q15276

0.84