Gene Symbol | IL18R1 |
Entrez ID | 8809 |
Uniprot ID | Q13478 |
Description | interleukin 18 receptor 1 |
Chromosomal Location | chr2: 102,311,529-102,398,775 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006955 |
immune response |
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. |
TAS |
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
TAS |
BP |
GO:0030101 |
natural killer cell activation |
The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. |
IEA |
BP |
GO:0032729 |
positive regulation of interferon-gamma production |
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. |
IEA |
BP |
GO:0035655 |
interleukin-18-mediated signaling pathway |
A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
IEA |
BP |
GO:0042346 |
positive regulation of NF-kappaB import into nucleus |
Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. |
IEA |
BP |
GO:0045063 |
T-helper 1 cell differentiation |
The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma. |
IEA |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
TAS |
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
MF |
GO:0004872 |
receptor activity |
Combining with an extracellular or intracellular messenger to initiate a change in cell activity. |
TAS |
MF |
GO:0004908 |
interleukin-1 receptor activity |
Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response. |
IEA |
MF |
GO:0042008 |
interleukin-18 receptor activity |
Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IEA |
Domain ID | Description |
---|---|
IPR000157 |
Toll/interleukin-1 receptor homology (TIR) domain |
IPR003599 |
Immunoglobulin subtype |
IPR004074 |
Interleukin-1 receptor type I/II |
IPR007110 |
Immunoglobulin-like domain |
IPR013783 |
Immunoglobulin-like fold |
IPR015621 |
Interleukin-1 receptor family |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04060 |
Cytokine-cytokine receptor interaction |
KEGG |
hsa04668 |
TNF signaling pathway |
KEGG |
hsa05321 |
Inflammatory bowel disease (IBD) |
KEGG |
h_IL12Pathway |
IL12 and Stat4 Dependent Signaling Pathway in Th1 Development |
BioCarta |
h_nktPathway |
Selective expression of chemokine receptors during T-cell polarization |
BioCarta |
h_th1th2Pathway |
Th1/Th2 Differentiation |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0004096 |
Asthma |
C0007570 |
Celiac Disease |
C0011615 |
Dermatitis, Atopic |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
appendix |
glandular cells |
bone marrow |
hematopoietic cells |
bronchus |
respiratory epithelial cells |
cerebellum |
Purkinje cells |
cerebral cortex |
neuronal cells |
cervix, uterine |
glandular cells |
endometrium |
glandular cells |
fallopian tube |
glandular cells |
gallbladder |
glandular cells |
hippocampus |
neuronal cells |
lung |
macrophages |
nasopharynx |
respiratory epithelial cells |
parathyroid gland |
glandular cells |
placenta |
trophoblastic cells |
prostate |
glandular cells |
seminal vesicle |
glandular cells |
skin |
epidermal cells |
testis |
cells in seminiferous ducts |
testis |
Leydig cells |
tonsil |
germinal center cells |
tonsil |
non-germinal center cells |
tonsil |
squamous epithelial cells |
urinary bladder |
urothelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
IL37 |
27178 |
Q9NZH6 |
0.56 |
IL1RAP |
3556 |
Q9NPH3 |
0.76 |
IL18 |
3606 |
Q14116 |
0.85 |
CD48 |
962 |
P09326 |
0.55 |