Protein Description

Gene Symbol IL18R1
Entrez ID 8809
Uniprot ID Q13478
Description interleukin 18 receptor 1
Chromosomal Location chr2: 102,311,529-102,398,775
Ontology GO ID GO Term Definition Evidence

BP

GO:0006955

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

TAS

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0030101

natural killer cell activation

The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.

IEA

BP

GO:0032729

positive regulation of interferon-gamma production

Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.

IEA

BP

GO:0035655

interleukin-18-mediated signaling pathway

A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IEA

BP

GO:0042346

positive regulation of NF-kappaB import into nucleus

Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.

IEA

BP

GO:0045063

T-helper 1 cell differentiation

The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0004872

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

TAS

MF

GO:0004908

interleukin-1 receptor activity

Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.

IEA

MF

GO:0042008

interleukin-18 receptor activity

Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IEA

Domain ID Description

IPR000157

Toll/interleukin-1 receptor homology (TIR) domain

IPR003599

Immunoglobulin subtype

IPR004074

Interleukin-1 receptor type I/II

IPR007110

Immunoglobulin-like domain

IPR013783

Immunoglobulin-like fold

IPR015621

Interleukin-1 receptor family

Pathway ID Pathway Term Pathway Source

hsa04060

Cytokine-cytokine receptor interaction

KEGG

hsa04668

TNF signaling pathway

KEGG

hsa05321

Inflammatory bowel disease (IBD)

KEGG

h_IL12Pathway

IL12 and Stat4 Dependent Signaling Pathway in Th1 Development

BioCarta

h_nktPathway

Selective expression of chemokine receptors during T-cell polarization

BioCarta

h_th1th2Pathway

Th1/Th2 Differentiation

BioCarta

UMLS CUI UMLS Term

C0004096

Asthma

C0007570

Celiac Disease

C0011615

Dermatitis, Atopic

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

bone marrow

hematopoietic cells

bronchus

respiratory epithelial cells

cerebellum

Purkinje cells

cerebral cortex

neuronal cells

cervix, uterine

glandular cells

endometrium

glandular cells

fallopian tube

glandular cells

gallbladder

glandular cells

hippocampus

neuronal cells

lung

macrophages

nasopharynx

respiratory epithelial cells

parathyroid gland

glandular cells

placenta

trophoblastic cells

prostate

glandular cells

seminal vesicle

glandular cells

skin

epidermal cells

testis

cells in seminiferous ducts

testis

Leydig cells

tonsil

germinal center cells

tonsil

non-germinal center cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

IL37

27178

Q9NZH6

0.56

IL1RAP

3556

Q9NPH3

0.76

IL18

3606

Q14116

0.85

CD48

962

P09326

0.55