Protein Description

Gene Symbol PEX11B
Entrez ID 8799
Uniprot ID O96011
Description peroxisomal biogenesis factor 11 beta
Chromosomal Location chr1: 145,911,350-145,918,837
Ontology GO ID GO Term Definition Evidence

BP

GO:0007031

peroxisome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.

IDA|ISS

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

ISS

BP

GO:0016559

peroxisome fission

The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments.

IDA

BP

GO:0044375

regulation of peroxisome size

Any process that modulates the volume of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.

IDA

BP

GO:0051260

protein homooligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

IDA

CC

GO:0005777

peroxisome

A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

IDA

CC

GO:0005778

peroxisomal membrane

The lipid bilayer surrounding a peroxisome.

IDA

CC

GO:0005779

integral component of peroxisomal membrane

The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IDA|ISS

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0043234

protein complex

A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.

IDA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

IDA

Domain ID Description

IPR008733

Peroxisomal biogenesis factor 11

IPR011990

Tetratricopeptide-like helical domain

Pathway ID Pathway Term Pathway Source

hsa04146

Peroxisome

KEGG

UMLS CUI UMLS Term

C0043459

Zellweger Syndrome

C0282525

Adrenoleukodystrophy, Neonatal

C0282527

Infantile Refsum Disease (Disorder)

Tissue Cell Type

endometrium

glandular cells

liver

hepatocytes

lung

pneumocytes

tonsil

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

PEX11B

8799

O96011

0.63

FIS1

51024

Q9Y3D6

0.63

PEX19

5824

P40855

0.90

HTT

3064

P42858

0.63

PEX11A

8800

O75192

0.63

FAF2

23197

Q96CS3

0.63

HECW2

57520

Q9P2P5

0.63

PEX11G

92960

Q96HA9

0.63