PCOSBase

Protein Description

Gene Symbol	CALU
Entrez ID	813
Uniprot ID	O43852
Description	calumenin
Chromosomal Location	chr7: 128,739,292-128,771,807

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0008150	biological_process	Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.	ND
CC	GO:0005576	extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.	IEA
CC	GO:0005783	endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).	IDA
CC	GO:0005789	endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.	IEA
CC	GO:0005794	Golgi apparatus	A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.	IEA
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0033018	sarcoplasmic reticulum lumen	The volume enclosed by the membranes of the sarcoplasmic reticulum.	IEA
CC	GO:0042470	melanosome	A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.	IEA
MF	GO:0005509	calcium ion binding	Interacting selectively and non-covalently with calcium ions (Ca2+).	IDA
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI

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Domain ID	Description
IPR002048	EF-hand domain
IPR011992	EF-hand domain pair
IPR018247	EF-Hand 1, calcium-binding site
IPR027239	Calumenin

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Pathway ID	Pathway Term	Pathway Source
WP3413	NOTCH1 regulation of human endothelial cell calcification	WikiPathways

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UMLS CUI	UMLS Term
C0027626	Neoplasm Invasiveness

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Tissue	Cell Type
adrenal gland	glandular cells
breast	glandular cells
breast	myoepithelial cells
caudate	glial cells
caudate	neuronal cells
cerebral cortex	glial cells
cerebral cortex	neuronal cells
endometrium	glandular cells
endometrium	cells in endometrial stroma
hippocampus	glial cells
hippocampus	neuronal cells
liver	bile duct cells
lung	macrophages
placenta	decidual cells
placenta	trophoblastic cells
seminal vesicle	glandular cells
soft tissue	fibroblasts
spleen	cells in red pulp
stomach	glandular cells
thyroid gland	glandular cells

No databases found.

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Pubmed ID	Author	Year	Title
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
CALR	811	P27797	0.49
DBN1	1627	Q16643	0.49
EGFR	1956	P00533	0.49
GAA	2548	P10253	0.49
ICT1	3396	Q14197	0.49
PRPH	5630	P41219	0.49
RPL21	6144	P46778	0.49
RPL32	6161	P62910	0.49
TKT	7086	P29401	0.49
HSP90B1	7184	P14625	0.49
PPT2	9374	Q9UMR5	0.49
PTBP3	9991	O95758	0.49
HSPA4L	22824	O95757	0.49
EMC1	23065	Q8N766	0.49
FAF2	23197	Q96CS3	0.49
SARS2	54938	Q9NP81	0.49
IARS2	55699	Q9NSE4	0.49
TMEM165	55858	Q9HC07	0.49
PRKCDBP	112464	Q969G5	0.49
TMEM256	254863	Q8N2U0	0.49
NACA2	342538	Q9H009	0.49
AARS	16	P49588	0.63
HSF1	3297	Q00613	0.63
MTR	4548	Q99707	0.63
PRKACA	5566	P17612	0.63
PRKAR1B	5575	P31321	0.63
RANGAP1	5905	P46060	0.63
RPA2	6118	P15927	0.63
SH3GL1	6455	Q99961	0.63
TPD52L2	7165	O43399	0.63
SAE1	10055	Q9UBE0	0.63
ARPC4	10093	P59998	0.63
ARPC3	10094	O15145	0.63
ARPC1B	10095	O15143	0.63
ARPC2	10109	O15144	0.63
ZPBP	11055	Q9BS86	0.63
OBSL1	23363	O75147	0.63
KIF1BP	26128	Q96EK5	0.63
EEF2K	29904	O00418	0.63
UBQLN1	29979	Q9UMX0	0.63
TPRKB	51002	Q9Y3C4	0.63
SH3GLB1	51100	Q9Y371	0.63
IPO11	51194	Q9UI26	0.63
DPP8	54878	Q6V1X1	0.63
NSUN2	54888	Q08J23	0.63
THG1L	54974	Q9NWX6	0.63
SH3GLB2	56904	Q9NR46	0.63
RPRD1B	58490	Q9NQG5	0.63
NIF3L1	60491	Q9GZT8	0.63
AARSD1	80755	Q9BTE6	0.63
ARPC5L	81873	Q9BPX5	0.63
TRMT10A	93587	Q8TBZ6	0.63
CSNK2A1	1457	P68400	0.70
PRMT5	10419	O14744	0.72
TP53RK	112858	Q96S44	0.73
APCS	325	P02743	0.85
CLGN	1047	O14967	0.49
EIF2D	1939	P41214	0.49
HSD17B10	3028	Q99714	0.49
MSN	4478	P26038	0.49
NUCB2	4925	P80303	0.49
RDX	5962	P35241	0.49
TPD52	7163	P55327	0.49
VCP	7415	P55072	0.49
PTGES3	10728	Q15185	0.49
TCTN3	26123	Q6NUS6	0.49
TCTN1	79600	Q2MV58	0.49
UBE2I	7329	P63279	0.52
CDK2	1017	P24941	0.63
CDK5	1020	Q00535	0.63
CLN3	1201	Q13286	0.63
CLN5	1203	O75503	0.63
HARS	3035	P12081	0.63
HSPA5	3309	P11021	0.63
MCM2	4171	P49736	0.63
NOS2	4843	P35228	0.63
NPM1	4869	P06748	0.63
NTRK1	4914	P04629	0.63
PARK2	5071	O60260	0.63
PCNA	5111	P12004	0.63
PHKG2	5261	P15735	0.63
PRKACB	5567	P22694	0.63
STK4	6789	Q13043	0.63
UMPS	7372	P11172	0.63
WARS	7453	P23381	0.63
CTNNAL1	8727	Q9UBT7	0.63
UBA2	10054	Q9UBT2	0.63
ACTR3	10096	P61158	0.63
ACTR2	10097	P61160	0.63
PLIN3	10226	O60664	0.63
ARPC1A	10552	Q92747	0.63
PDLIM5	10611	Q96HC4	0.63
CEP250	11190	Q9BV73	0.63
FBXO6	26270	Q9NRD1	0.63
UBQLN2	29978	Q9UHD9	0.63
OTUB1	55611	Q96FW1	0.63
OSGEP	55644	Q9NPF4	0.63
DUS3L	56931	Q96G46	0.63
CEP76	79959	Q8TAP6	0.63
MAP1LC3A	84557	Q9H492	0.63
ARAF	369	P10398	0.72
CFTR	1080	P13569	0.72
ATF2	1386	P15336	0.72
IRAK1	3654	P51617	0.72
LIMK2	3985	P53671	0.72
AURKA	6790	O14965	0.72
XRCC3	7517	O43542	0.72
BAG6	7917	P46379	0.72
IRS4	8471	O14654	0.72
IQCB1	9657	Q15051	0.72
MAST3	23031	O60307	0.72
GOLT1B	51026	Q9Y3E0	0.72
SUCO	51430	Q9UBS9	0.72
GTSE1	51512	Q9NYZ3	0.72
HDAC11	79885	Q96DB2	0.72
CNTROB	116840	Q8N137	0.72
ASPM	259266	Q8IZT6	0.72
P4HB	5034	P07237	0.73
ILK	3611	Q13418	0.82
RAF1	5894	P04049	0.82