BP

GO:0000302

response to reactive oxygen species

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.

IDA

BP

GO:0001822

kidney development

The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.

ISS

BP

GO:0002244

hematopoietic progenitor cell differentiation

The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.

IEA

BP

GO:0005975

carbohydrate metabolic process

The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.

IEA

BP

GO:0006027

glycosaminoglycan catabolic process

The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars.

IDA

BP

GO:0009615

response to virus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.

IDA

BP

GO:0010259

multicellular organism aging

An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).

IEA

BP

GO:0010764

negative regulation of fibroblast migration

Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.

IDA

BP

GO:0019064

fusion of virus membrane with host plasma membrane

Fusion of a viral membrane with the host cell membrane during viral entry. Results in release of the virion contents into the cytoplasm.

IDA

BP

GO:0019087

transformation of host cell by virus

Any virus-induced change in the morphological, biochemical, or growth parameters of a cell.

IDA|ISS

BP

GO:0030214

hyaluronan catabolic process

The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.

IDA|TAS

BP

GO:0030308

negative regulation of cell growth

Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.

IDA

BP

GO:0035810

positive regulation of urine volume

Any process that increases the amount of urine excreted from the body over a unit of time.

ISS

BP

GO:0042117

monocyte activation

The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

IDA

BP

GO:0042307

positive regulation of protein import into nucleus

Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.

ISS

BP

GO:0043407

negative regulation of MAP kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.

IDA

BP

GO:0044344

cellular response to fibroblast growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.

IDA

BP

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

ISS

BP

GO:0046677

response to antibiotic

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

IEP

BP

GO:0046718

viral entry into host cell

The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.

ISS

BP

GO:0048705

skeletal system morphogenesis

The process in which the anatomical structures of the skeleton are generated and organized.

IEA

BP

GO:0050729

positive regulation of inflammatory response

Any process that activates or increases the frequency, rate or extent of the inflammatory response.

IDA

BP

GO:0051216

cartilage development

The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.

IEP

BP

GO:0051607

defense response to virus

Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

IEA

BP

GO:0051898

negative regulation of protein kinase B signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.

IDA

BP

GO:0060586

multicellular organismal iron ion homeostasis

Any process involved in the maintenance of the distribution of iron stores within tissues and organs of a multicellular organism.

IEA

BP

GO:0061099

negative regulation of protein tyrosine kinase activity

Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity.

IDA

BP

GO:0070295

renal water absorption

A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.

ISS

BP

GO:0071347

cellular response to interleukin-1

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.

IDA

BP

GO:0071356

cellular response to tumor necrosis factor

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.

IEP

BP

GO:0071493

cellular response to UV-B

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.

IDA

BP

GO:0071560

cellular response to transforming growth factor beta stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.

IDA

BP

GO:2000484

positive regulation of interleukin-8 secretion

Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion.

IDA

BP

GO:2000778

positive regulation of interleukin-6 secretion

Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion.

IDA

BP

GO:2001238

positive regulation of extrinsic apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.

ISS

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

ISS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005764

lysosome

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

IDA

CC

GO:0005783

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

NAS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IDA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0005902

microvillus

Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.

IDA

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

IDA|ISS

CC

GO:0016023

cytoplasmic, membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

IDA

CC

GO:0016324

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

IDA

CC

GO:0030139

endocytic vesicle

A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.

IDA

CC

GO:0031362

anchored component of external side of plasma membrane

The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.

IDA

CC

GO:0031410

cytoplasmic vesicle

A vesicle found in the cytoplasm of a cell.

IDA

CC

GO:0045121

membrane raft

Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.

IDA

CC

GO:0046658

anchored component of plasma membrane

The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.

IDA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IDA

CC

GO:0090575

RNA polymerase II transcription factor complex

A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II.

ISS

MF

GO:0001105

RNA polymerase II transcription coactivator activity

Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery.

IEA

MF

GO:0001618

virus receptor activity

Combining with a virus component and mediating entry of the virus into the cell.

IDA

MF

GO:0004415

hyalurononglucosaminidase activity

Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

IDA|TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005540

hyaluronic acid binding

Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.

IDA

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IPI

MF

GO:0030294

receptor signaling protein tyrosine kinase inhibitor activity

Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase.

IDA

MF

GO:0030971

receptor tyrosine kinase binding

Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.

IPI

MF

GO:0033906

hyaluronoglucuronidase activity

Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate.

IDA

MF

GO:0050431

transforming growth factor beta binding

Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types.

ISS