BP

GO:0001731

formation of translation preinitiation complex

The joining of the small ribosomal subunit, ternary complex, and mRNA.

IEA

BP

GO:0002181

cytoplasmic translation

The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.

IBA

BP

GO:0006413

translational initiation

The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.

IC|TAS

BP

GO:0006446

regulation of translational initiation

Any process that modulates the frequency, rate or extent of translational initiation.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005852

eukaryotic translation initiation factor 3 complex

A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.

IDA

CC

GO:0016282

eukaryotic 43S preinitiation complex

A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.

IEA

CC

GO:0033290

eukaryotic 48S preinitiation complex

A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.

IEA

MF

GO:0003743

translation initiation factor activity

Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

IBA|IC