BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

IEA

BP

GO:0010613

positive regulation of cardiac muscle hypertrophy

Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.

IEA

BP

GO:0030823

regulation of cGMP metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP.

IEA

BP

GO:0042130

negative regulation of T cell proliferation

Any process that stops, prevents or reduces the rate or extent of T cell proliferation.

IEA

BP

GO:0043406

positive regulation of MAP kinase activity

Any process that activates or increases the frequency, rate or extent of MAP kinase activity.

IEA

BP

GO:0046069

cGMP catabolic process

The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate.

IDA|IEA

BP

GO:0055118

negative regulation of cardiac muscle contraction

Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction.

IEA

BP

GO:0055119

relaxation of cardiac muscle

The process in which the extent of cardiac muscle contraction is reduced.

IEA

BP

GO:0060282

positive regulation of oocyte development

Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.

IEA

CC

GO:0005575

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

ND

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

MF

GO:0004114

3',5'-cyclic-nucleotide phosphodiesterase activity

Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

NAS

MF

GO:0030553

cGMP binding

Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).

TAS

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

MF

GO:0047555

3',5'-cyclic-GMP phosphodiesterase activity

Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

TAS