Gene Symbol | CALD1 |
Entrez ID | 800 |
Uniprot ID | Q05682 |
Description | caldesmon 1 |
Chromosomal Location | chr7: 134,744,252-134,970,728 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006928 |
movement of cell or subcellular component |
The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore. |
TAS |
BP |
GO:0006936 |
muscle contraction |
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. |
TAS |
BP |
GO:0098609 |
cell-cell adhesion |
The attachment of one cell to another cell via adhesion molecules. |
IEA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0005856 |
cytoskeleton |
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
TAS |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IDA |
CC |
GO:0005913 |
cell-cell adherens junction |
An adherens junction which connects a cell to another cell. |
IDA |
CC |
GO:0015629 |
actin cytoskeleton |
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
IDA |
CC |
GO:0030016 |
myofibril |
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. |
IEA |
CC |
GO:0030478 |
actin cap |
Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae. |
IEA |
MF |
GO:0003779 |
actin binding |
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. |
IEA |
MF |
GO:0005516 |
calmodulin binding |
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
IEA |
MF |
GO:0005523 |
tropomyosin binding |
Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. |
TAS |
MF |
GO:0017022 |
myosin binding |
Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. |
IEA |
MF |
GO:0098641 |
cadherin binding involved in cell-cell adhesion |
Any cadherin binding that occurs as part of the process of cell-cell adhesion. |
IDA |
Domain ID | Description |
---|---|
IPR006017 |
Caldesmon |
IPR006018 |
Caldesmon/lymphocyte specific protein |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04270 |
Vascular smooth muscle contraction |
KEGG |
WP289 |
Myometrial Relaxation and Contraction Pathways |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0003873 |
Rheumatoid Arthritis |
C3495559 |
Juvenile Arthritis |
Tissue | Cell Type |
---|---|
endometrium |
cells in endometrial stroma |
ovary |
ovarian stroma cells |
placenta |
decidual cells |
smooth muscle |
smooth muscle cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
15291743 |
Diao et al. |
2004 |
The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray |
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22789864 |
Yan et al. |
2012 |
Expression of apoptosis-related genes in the endometrium of polycystic ovary syndrome patients during the window of implantation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
GRB2 |
2885 |
P62993 |
0.62 |
CSNK2A1 |
1457 |
P68400 |
0.63 |
PCYT1A |
5130 |
P49585 |
0.63 |
RPL31 |
6160 |
P62899 |
0.63 |
CALM2 |
805 |
P62158 |
0.73 |
CALM3 |
808 |
P62158 |
0.73 |
ACTN1 |
87 |
P12814 |
0.49 |
PRKACA |
5566 |
P17612 |
0.52 |
EPB41L2 |
2037 |
O43491 |
0.63 |
FH |
2271 |
P07954 |
0.63 |
JUN |
3725 |
P05412 |
0.63 |
MYC |
4609 |
P01106 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
PCMT1 |
5110 |
P22061 |
0.63 |
RPA1 |
6117 |
P27694 |
0.63 |
RPA2 |
6118 |
P15927 |
0.63 |
RPA3 |
6119 |
P35244 |
0.63 |
TERF2 |
7014 |
Q15554 |
0.63 |
TP53 |
7157 |
P04637 |
0.63 |
ISG15 |
9636 |
P05161 |
0.63 |
CUL7 |
9820 |
Q14999 |
0.63 |
PAN2 |
9924 |
Q504Q3 |
0.63 |
OBSL1 |
23363 |
O75147 |
0.63 |
LUZP4 |
51213 |
Q9P127 |
0.63 |
PHAX |
51808 |
Q9H814 |
0.63 |
OTUB1 |
55611 |
Q96FW1 |
0.63 |
ARRB1 |
408 |
P49407 |
0.72 |
HSP90AA1 |
3320 |
P07900 |
0.72 |
KIF11 |
3832 |
P52732 |
0.72 |
MYH9 |
4627 |
P35579 |
0.72 |
NEFM |
4741 |
P07197 |
0.72 |
TM9SF4 |
9777 |
Q92544 |
0.72 |
TACC3 |
10460 |
Q9Y6A5 |
0.72 |
GPSM2 |
29899 |
P81274 |
0.72 |
LIMA1 |
51474 |
Q9UHB6 |
0.72 |
FIGNL1 |
63979 |
Q6PIW4 |
0.72 |
MYO19 |
80179 |
Q96H55 |
0.72 |
LRCH3 |
84859 |
Q96II8 |
0.72 |
TERF1 |
7013 |
P54274 |
0.73 |
TINF2 |
26277 |
Q9BSI4 |
0.75 |
SHC1 |
6464 |
P29353 |
0.83 |
POT1 |
25913 |
Q9NUX5 |
0.86 |