Protein Description

Gene Symbol CALD1
Entrez ID 800
Uniprot ID Q05682
Description caldesmon 1
Chromosomal Location chr7: 134,744,252-134,970,728
Ontology GO ID GO Term Definition Evidence

BP

GO:0006928

movement of cell or subcellular component

The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.

TAS

BP

GO:0006936

muscle contraction

A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.

TAS

BP

GO:0098609

cell-cell adhesion

The attachment of one cell to another cell via adhesion molecules.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005856

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA

CC

GO:0005913

cell-cell adherens junction

An adherens junction which connects a cell to another cell.

IDA

CC

GO:0015629

actin cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.

IDA

CC

GO:0030016

myofibril

The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.

IEA

CC

GO:0030478

actin cap

Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae.

IEA

MF

GO:0003779

actin binding

Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.

IEA

MF

GO:0005516

calmodulin binding

Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.

IEA

MF

GO:0005523

tropomyosin binding

Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle.

TAS

MF

GO:0017022

myosin binding

Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.

IEA

MF

GO:0098641

cadherin binding involved in cell-cell adhesion

Any cadherin binding that occurs as part of the process of cell-cell adhesion.

IDA

Domain ID Description

IPR006017

Caldesmon

IPR006018

Caldesmon/lymphocyte specific protein

Pathway ID Pathway Term Pathway Source

hsa04270

Vascular smooth muscle contraction

KEGG

WP289

Myometrial Relaxation and Contraction Pathways

WikiPathways

UMLS CUI UMLS Term

C0003873

Rheumatoid Arthritis

C3495559

Juvenile Arthritis

Tissue Cell Type

endometrium

cells in endometrial stroma

ovary

ovarian stroma cells

placenta

decidual cells

smooth muscle

smooth muscle cells

No databases found.

Pubmed ID Author Year Title

15291743

Diao et al.

2004

The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22789864

Yan et al.

2012

Expression of apoptosis-related genes in the endometrium of polycystic ovary syndrome patients during the window of implantation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

GRB2

2885

P62993

0.62

CSNK2A1

1457

P68400

0.63

PCYT1A

5130

P49585

0.63

RPL31

6160

P62899

0.63

CALM2

805

P62158

0.73

CALM3

808

P62158

0.73

ACTN1

87

P12814

0.49

PRKACA

5566

P17612

0.52

EPB41L2

2037

O43491

0.63

FH

2271

P07954

0.63

JUN

3725

P05412

0.63

MYC

4609

P01106

0.63

NTRK1

4914

P04629

0.63

PCMT1

5110

P22061

0.63

RPA1

6117

P27694

0.63

RPA2

6118

P15927

0.63

RPA3

6119

P35244

0.63

TERF2

7014

Q15554

0.63

TP53

7157

P04637

0.63

ISG15

9636

P05161

0.63

CUL7

9820

Q14999

0.63

PAN2

9924

Q504Q3

0.63

OBSL1

23363

O75147

0.63

LUZP4

51213

Q9P127

0.63

PHAX

51808

Q9H814

0.63

OTUB1

55611

Q96FW1

0.63

ARRB1

408

P49407

0.72

HSP90AA1

3320

P07900

0.72

KIF11

3832

P52732

0.72

MYH9

4627

P35579

0.72

NEFM

4741

P07197

0.72

TM9SF4

9777

Q92544

0.72

TACC3

10460

Q9Y6A5

0.72

GPSM2

29899

P81274

0.72

LIMA1

51474

Q9UHB6

0.72

FIGNL1

63979

Q6PIW4

0.72

MYO19

80179

Q96H55

0.72

LRCH3

84859

Q96II8

0.72

TERF1

7013

P54274

0.73

TINF2

26277

Q9BSI4

0.75

SHC1

6464

P29353

0.83

POT1

25913

Q9NUX5

0.86