PCOSBase

Protein Description

Gene Symbol	IRS4
Entrez ID	8471
Uniprot ID	O14654
Description	insulin receptor substrate 4
Chromosomal Location	chrX: 108,732,482-108,736,409

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0007165	signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.	TAS
BP	GO:0008286	insulin receptor signaling pathway	The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.	IBA
BP	GO:0009967	positive regulation of signal transduction	Any process that activates or increases the frequency, rate or extent of signal transduction.	IEA
BP	GO:0019216	regulation of lipid metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.	IBA
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	IBA
CC	GO:0005886	plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.	TAS
MF	GO:0004871	signal transducer activity	Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.	IEA
MF	GO:0005070	SH3/SH2 adaptor activity	Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).	TAS
MF	GO:0005158	insulin receptor binding	Interacting selectively and non-covalently with the insulin receptor.	IBA
MF	GO:0043548	phosphatidylinositol 3-kinase binding	Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.	IBA

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Domain ID	Description
IPR001849	Pleckstrin homology domain
IPR002404	IRS-type PTB domain
IPR011993	PH domain-like

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Pathway ID	Pathway Term	Pathway Source
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04068	FoxO signaling pathway	KEGG
hsa04140	Autophagy - animal	KEGG
hsa04152	AMPK signaling pathway	KEGG
hsa04211	Longevity regulating pathway	KEGG
hsa04213	Longevity regulating pathway - multiple species	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa04920	Adipocytokine signaling pathway	KEGG
hsa04923	Regulation of lipolysis in adipocytes	KEGG
hsa04930	Type II diabetes mellitus	KEGG
WP3915	Angiopoietin Like Protein 8 Regulatory Pathway	WikiPathways
WP481	Insulin Signaling	WikiPathways
WP236	Adipogenesis	WikiPathways
WP3935	Leptin Insulin Overlap	WikiPathways
WP3932	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway	WikiPathways

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No diseases found.

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No tissues found.

Database Name
DGA

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No sources found.

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Gene Symbol	Entrez ID	Uniprot ID	Score
HSF2	3298	Q03933	0.49
SGTA	6449	O43765	0.49
NUDCD3	23386	Q8IVD9	0.49
FKBPL	63943	Q9UIM3	0.49
PRKCZ	5590	Q05513	0.52
PTPN6	5777	P29350	0.52
PTPN11	5781	Q06124	0.52
IRS4	8471	O14654	0.55
SOCS7	30837	O14512	0.55
ERBB2	2064	P04626	0.63
DNAH17	8632	Q9UFH2	0.63
BIN1	274	O00499	0.72
CALU	813	O43852	0.72
CTSB	1508	P07858	0.72
FKBP5	2289	Q13451	0.72
HSPA4	3308	P34932	0.72
HSPB1	3315	P04792	0.72
P4HA1	5033	P13674	0.72
PIK3R2	5296	O00459	0.72
PPP5C	5536	P53041	0.72
RAF1	5894	P04049	0.72
RCN1	5954	Q15293	0.72
RCN2	5955	Q14257	0.72
YWHAE	7531	P62258	0.72
YWHAH	7533	Q04917	0.72
YWHAZ	7534	P63104	0.72
TUBA1A	7846	Q71U36	0.72
USP9X	8239	Q93008	0.72
PIK3R3	8503	Q92569	0.72
GBF1	8729	Q92538	0.72
P4HA2	8974	O15460	0.72
DNAJA3	9093	Q96EY1	0.72
MAGED1	9500	Q9Y5V3	0.72
DNAJA2	10294	O60884	0.72
TUBB4A	10382	P04350	0.72
YWHAQ	10971	P27348	0.72
WDR6	11180	Q9NNW5	0.72
AKAP8L	26993	Q9ULX6	0.72
CACYBP	27101	Q9HB71	0.72
TBL1XR1	79718	Q9BZK7	0.72
CLPB	81570	Q9H078	0.72
TUBB6	84617	Q9BUF5	0.72
GPRASP2	114928	Q96D09	0.72
FAM27E3	100131997	Q08E93	0.72
PIK3CA	5290	P42336	0.73
CRKL	1399	P46109	0.76
EGFR	1956	P00533	0.82
MAGED2	10916	Q9UNF1	0.82
PIK3R1	5295	P27986	0.83
GRB2	2885	P62993	0.86
HSP90AA1	3320	P07900	0.86
CRK	1398	P46108	0.90
MLF1	4291	P58340	0.49
STIP1	10963	P31948	0.49
TMEM216	51259	Q9P0N5	0.49
TMEM17	200728	Q86X19	0.49
NPHP4	261734	O75161	0.49
TP53BP2	7159	Q13625	0.56
MEX3C	51320	Q5U5Q3	0.56
ADRBK1	156	P25098	0.63
ALK	238	Q9UM73	0.63
CDK2	1017	P24941	0.63
CDK5	1020	Q00535	0.63
CDK9	1025	P50750	0.63
CDKN1A	1026	P38936	0.63
CSK	1445	P41240	0.63
CSNK1A1	1452	P48729	0.63
CSNK1E	1454	P49674	0.63
CSNK2A2	1459	P19784	0.63
EMD	2010	P50402	0.63
JUN	3725	P05412	0.63
LGALS3BP	3959	Q08380	0.63
NFKB1	4790	P19838	0.63
PAK1	5058	Q13153	0.63
PCK1	5105	P35558	0.63
PHKG2	5261	P15735	0.63
PPP2R1A	5518	P30153	0.63
PRKAA1	5562	Q13131	0.63
PRKACA	5566	P17612	0.63
PRKACB	5567	P22694	0.63
PRKCD	5580	Q05655	0.63
PTEN	5728	P60484	0.63
RPS6KA1	6195	Q15418	0.63
STAU1	6780	O95793	0.63
STK3	6788	Q13188	0.63
STK4	6789	Q13043	0.63
AURKA	6790	O14965	0.63
TERF1	7013	P54274	0.63
TERF2	7014	Q15554	0.63
TP53	7157	P04637	0.63
TUBG1	7283	P23258	0.63
VCP	7415	P55072	0.63
VRK1	7443	Q99986	0.63
STK24	8428	Q9Y6E0	0.63
CUL4B	8450	Q13620	0.63
CUL3	8452	Q13618	0.63
CUL2	8453	Q13617	0.63
CUL1	8454	Q13616	0.63
AURKB	9212	Q96GD4	0.63
CEP57	9702	Q86XR8	0.63
PAN2	9924	Q504Q3	0.63
OXSR1	9943	O95747	0.63
HDAC5	10014	Q9UQL6	0.63
TUBGCP3	10426	Q96CW5	0.63
STK25	10494	O00506	0.63
COPS5	10987	Q92905	0.63
CEP250	11190	Q9BV73	0.63
SIRT7	51547	Q9NRC8	0.63
HAUS2	55142	Q9NVX0	0.63
LGR4	55366	Q9BXB1	0.63
OTUB1	55611	Q96FW1	0.63
RIOK2	55781	Q9BVS4	0.63
PINK1	65018	Q9BXM7	0.63
CEP76	79959	Q8TAP6	0.63
UBXN6	80700	Q9BZV1	0.63
CCDC8	83987	Q9H0W5	0.63
MAP1LC3A	84557	Q9H492	0.63
TP53RK	112858	Q96S44	0.63
NEDD1	121441	Q8NHV4	0.63
IGF1R	3480	P08069	0.65
SOCS6	9306	O14544	0.65
PPP2R2B	5521	Q00005	0.68
ILK	3611	Q13418	0.72
MAP3K1	4214	Q13233	0.72
MYC	4609	P01106	0.72
RELA	5970	Q04206	0.72
TNFRSF1B	7133	P20333	0.72
PTGES3	10728	Q15185	0.72
SAV1	60485	Q9H4B6	0.72
AARSD1	80755	Q9BTE6	0.72
MTNR1B	4544	P49286	0.75
YWHAB	7529	P31946	0.82
MTNR1A	4543	P48039	0.83
YWHAG	7532	P61981	0.83
NISCH	11188	Q9Y2I1	0.88