| Gene Symbol | AKAP1 |
| Entrez ID | 8165 |
| Uniprot ID | Q92667 |
| Description | A-kinase anchoring protein 1 |
| Chromosomal Location | chr17: 57,085,092-57,121,349 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0007596 |
blood coagulation |
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. |
TAS |
|
BP |
GO:0010738 |
regulation of protein kinase A signaling |
Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. |
IEA |
|
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IDA |
|
CC |
GO:0005741 |
mitochondrial outer membrane |
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
IEA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
|
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
|
MF |
GO:0003723 |
RNA binding |
Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
TAS |
|
MF |
GO:0034237 |
protein kinase A regulatory subunit binding |
Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A. |
IPI |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR002999 |
Tudor domain |
|
IPR004087 |
K Homology domain |
|
IPR004088 |
K Homology domain, type 1 |
|
IPR033104 |
A-kinase anchor protein 1, mitochondrial |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
WP35 |
G Protein Signaling Pathways |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0028754 |
Obesity |
| Tissue | Cell Type |
|---|---|
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
caudate |
glial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
endothelial cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
follicle cells |
|
pancreas |
exocrine glandular cells |
|
parathyroid gland |
glandular cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
CAV1 |
857 |
Q03135 |
0.52 |
|
APP |
351 |
P05067 |
0.56 |
|
FLNB |
2317 |
O75369 |
0.63 |
|
TNNI3 |
7137 |
P19429 |
0.63 |
|
PHB |
5245 |
P35232 |
0.72 |
|
RPL12 |
6136 |
P30050 |
0.72 |
|
CKAP5 |
9793 |
Q14008 |
0.72 |
|
FARP1 |
10160 |
Q9Y4F1 |
0.72 |
|
PHB2 |
11331 |
Q99623 |
0.72 |
|
PYM1 |
84305 |
Q9BRP8 |
0.72 |
|
LARP4 |
113251 |
Q71RC2 |
0.72 |
|
PRKAR1B |
5575 |
P31321 |
0.77 |
|
PRKAR2B |
5577 |
P31323 |
0.78 |
|
PRKAR2A |
5576 |
P13861 |
0.90 |
|
FGFR1OP |
11116 |
O95684 |
0.49 |
|
TMEM67 |
91147 |
Q5HYA8 |
0.49 |
|
PPP1CA |
5499 |
P62136 |
0.55 |
|
APBB2 |
323 |
Q92870 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
TP73 |
7161 |
O15350 |
0.63 |
|
DYSF |
8291 |
O75923 |
0.63 |
|
ZFP41 |
286128 |
Q8N8Y5 |
0.63 |
|
PTPN21 |
11099 |
Q16825 |
0.67 |
|
PRKACB |
5567 |
P22694 |
0.72 |
|
AMY1A; AMY1B; AMY1C |
276 |
P04745 |
0.74 |
|
USP7 |
7874 |
Q93009 |
0.76 |
|
SIAH2 |
6478 |
O43255 |
0.79 |
|
MAATS1 |
89876 |
Q7Z4T9 |
0.79 |
|
PRKACA |
5566 |
P17612 |
0.86 |
|
PRKAR1A |
5573 |
P10644 |
0.89 |
|
MYCBP |
26292 |
Q99417 |
0.90 |