BP

GO:0006955

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

TAS

BP

GO:0010955

negative regulation of protein processing

Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage.

IEA

BP

GO:0019221

cytokine-mediated signaling pathway

A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IEA

BP

GO:0050712

negative regulation of interleukin-1 alpha secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell.

IEA

BP

GO:1900016

negative regulation of cytokine production involved in inflammatory response

Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.

IEA

BP

GO:2000660

negative regulation of interleukin-1-mediated signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway.

IEA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

IEA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0004908

interleukin-1 receptor activity

Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.

TAS

MF

GO:0004910

interleukin-1, Type II, blocking receptor activity

Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0019966

interleukin-1 binding

Interacting selectively and non-covalently with interleukin-1.

IEA