BP

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IMP

BP

GO:0000165

MAPK cascade

An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

IMP|ISS

BP

GO:0000288

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.

IDA

BP

GO:0000289

nuclear-transcribed mRNA poly(A) tail shortening

Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.

IMP

BP

GO:0006402

mRNA catabolic process

The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.

IDA

BP

GO:0009611

response to wounding

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

IDA|ISS

BP

GO:0010837

regulation of keratinocyte proliferation

Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.

IMP

BP

GO:0031086

nuclear-transcribed mRNA catabolic process, deadenylation-independent decay

A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability.

IDA

BP

GO:0032680

regulation of tumor necrosis factor production

Any process that modulates the frequency, rate, or extent of tumor necrosis factor production.

IDA

BP

GO:0032897

negative regulation of viral transcription

Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription.

IMP

BP

GO:0035278

miRNA mediated inhibition of translation

The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs

ISS

BP

GO:0038066

p38MAPK cascade

An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

ISS

BP

GO:0042594

response to starvation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.

IDA

BP

GO:0043488

regulation of mRNA stability

Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.

IDA|IMP|TAS

BP

GO:0044344

cellular response to fibroblast growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.

IDA

BP

GO:0045085

negative regulation of interleukin-2 biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.

ISS

BP

GO:0045600

positive regulation of fat cell differentiation

Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.

ISS

BP

GO:0045616

regulation of keratinocyte differentiation

Any process that modulates the frequency, rate or extent of keratinocyte differentiation.

IMP

BP

GO:0045647

negative regulation of erythrocyte differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.

IDA

BP

GO:0051028

mRNA transport

The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IMP

BP

GO:0060213

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.

IDA

BP

GO:0061158

3'-UTR-mediated mRNA destabilization

An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.

IBA|IDA|IMP

BP

GO:0070935

3'-UTR-mediated mRNA stabilization

An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.

IDA

BP

GO:0071222

cellular response to lipopolysaccharide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.

IDA|IMP

BP

GO:0071356

cellular response to tumor necrosis factor

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.

IDA

BP

GO:0071364

cellular response to epidermal growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.

IDA

BP

GO:0071385

cellular response to glucocorticoid stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.

IDA

BP

GO:0097011

cellular response to granulocyte macrophage colony-stimulating factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.

IDA

BP

GO:1900153

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.

IDA|ISS

BP

GO:1901835

positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA

Any process that activates or increases the frequency, rate or extent of deadenylation-independent decapping of nuclear-transcribed mRNA.

IDA

BP

GO:1902172

regulation of keratinocyte apoptotic process

Any process that modulates the frequency, rate or extent of keratinocyte apoptotic process.

IMP

BP

GO:1904246

negative regulation of polynucleotide adenylyltransferase activity

Any process that stops, prevents or reduces the frequency, rate or extent of polynucleotide adenylyltransferase activity.

ISS

BP

GO:1904582

positive regulation of intracellular mRNA localization

Any process that activates or increases the frequency, rate or extent of intracellular mRNA localization.

IMP

BP

GO:2000637

positive regulation of gene silencing by miRNA

Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.

IMP

CC

GO:0000932

cytoplasmic mRNA processing body

A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IBA|IDA|TAS

CC

GO:0010494

cytoplasmic stress granule

A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.

IDA

CC

GO:0030014

CCR4-NOT complex

The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.

ISS

CC

GO:0030529

intracellular ribonucleoprotein complex

An intracellular macromolecular complex containing both protein and RNA molecules.

IDA

CC

GO:0070578

RISC-loading complex

A trimeric ribonucleoprotein complex that and is required for the formation of a mature RNA induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1) and TRBP (TARBP2) in association with the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.

IDA

CC

GO:0098745

Dcp1-Dcp2 complex

A protein complex consisting of a Dcp1 regulatory subunit and a Dcp2 catalytic subunit that has mRNA cap binding activity and is involved in decapping of nuclear-transcribed mRNA.

IDA

CC

GO:1990904

ribonucleoprotein complex

A macromolecular complex containing both protein and RNA molecules.

IDA

MF

GO:0003677

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

IEA

MF

GO:0003727

single-stranded RNA binding

Interacting selectively and non-covalently with single-stranded RNA.

TAS

MF

GO:0003729

mRNA binding

Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

IDA

MF

GO:0003730

mRNA 3'-UTR binding

Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.

IBA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0017091

AU-rich element binding

Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases.

IDA|IMP

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IPI

MF

GO:0019901

protein kinase binding

Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

IPI

MF

GO:0019957

C-C chemokine binding

Interacting selectively and non-covalently with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.

IPI

MF

GO:0031072

heat shock protein binding

Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.

IDA

MF

GO:0035925

mRNA 3'-UTR AU-rich region binding

Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.

IDA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

MF

GO:0070063

RNA polymerase binding

Interacting selectively and non-covalently with an RNA polymerase molecule or complex.

ISS

MF

GO:0071889

14-3-3 protein binding

Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.

IDA