BP

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA

BP

GO:0001525

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

IDA

BP

GO:0001541

ovarian follicle development

The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.

ISS

BP

GO:0001569

patterning of blood vessels

The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.

ISS

BP

GO:0001570

vasculogenesis

The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.

TAS

BP

GO:0001666

response to hypoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.

IDA

BP

GO:0001701

in utero embryonic development

The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.

ISS

BP

GO:0001822

kidney development

The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.

ISS

BP

GO:0001934

positive regulation of protein phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

IDA

BP

GO:0001938

positive regulation of endothelial cell proliferation

Any process that activates or increases the rate or extent of endothelial cell proliferation.

IDA|ISS

BP

GO:0002042

cell migration involved in sprouting angiogenesis

The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.

IDA

BP

GO:0002052

positive regulation of neuroblast proliferation

Any process that activates or increases the rate of neuroblast proliferation.

ISS

BP

GO:0002053

positive regulation of mesenchymal cell proliferation

The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.

ISS

BP

GO:0002092

positive regulation of receptor internalization

Any process that activates or increases the frequency, rate or extent of receptor internalization.

IDA

BP

GO:0002576

platelet degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.

TAS

BP

GO:0002687

positive regulation of leukocyte migration

Any process that activates or increases the frequency, rate, or extent of leukocyte migration.

TAS

BP

GO:0003007

heart morphogenesis

The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

ISS

BP

GO:0003151

outflow tract morphogenesis

The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.

ISS

BP

GO:0003169

coronary vein morphogenesis

The process in which the anatomical structures of veins of the heart are generated and organized.

ISS

BP

GO:0007399

nervous system development

The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

TAS

BP

GO:0007498

mesoderm development

The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.

ISS

BP

GO:0007595

lactation

The secretion of milk by the mammary gland.

ISS

BP

GO:0008284

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

IDA|IMP

BP

GO:0008360

regulation of cell shape

Any process that modulates the surface configuration of a cell.

IDA

BP

GO:0010595

positive regulation of endothelial cell migration

Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.

IDA

BP

GO:0010628

positive regulation of gene expression

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

IDA

BP

GO:0030224

monocyte differentiation

The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte.

IDA

BP

GO:0030225

macrophage differentiation

The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.

IDA

BP

GO:0030324

lung development

The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.

ISS

BP

GO:0030335

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

IDA

BP

GO:0030823

regulation of cGMP metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP.

IDA

BP

GO:0030855

epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.

ISS

BP

GO:0030949

positive regulation of vascular endothelial growth factor receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.

IDA

BP

GO:0031077

post-embryonic camera-type eye development

The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure.

ISS

BP

GO:0031334

positive regulation of protein complex assembly

Any process that activates or increases the frequency, rate or extent of protein complex assembly.

IDA

BP

GO:0031954

positive regulation of protein autophosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues.

IDA

BP

GO:0032147

activation of protein kinase activity

Any process that initiates the activity of an inactive protein kinase.

IDA

BP

GO:0032793

positive regulation of CREB transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.

IDA

BP

GO:0033138

positive regulation of peptidyl-serine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.

IDA

BP

GO:0035148

tube formation

Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.

IDA

BP

GO:0035767

endothelial cell chemotaxis

The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

IDA

BP

GO:0035924

cellular response to vascular endothelial growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.

IDA

BP

GO:0036303

lymph vessel morphogenesis

The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph.

ISS

BP

GO:0038033

positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a VEGFR on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis.

IDA

BP

GO:0038091

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of cell proliferation.

IDA

BP

GO:0038190

VEGF-activated neuropilin signaling pathway

A series of molecular signals initiated by the binding of vascular endothelial growth factor (VEGF) to a neuropilin protein on the surface of a target cell, followed by transmission of the signal, and ending with regulation of a downstream cellular process, e.g. transcription.

ISS

BP

GO:0040007

growth

The increase in size or mass of an entire organism, a part of an organism or a cell.

ISS

BP

GO:0042462

eye photoreceptor cell development

Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.

ISS

BP

GO:0043066

negative regulation of apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

IMP

BP

GO:0043129

surfactant homeostasis

Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli.

ISS

BP

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.

IDA

BP

GO:0043406

positive regulation of MAP kinase activity

Any process that activates or increases the frequency, rate or extent of MAP kinase activity.

IDA

BP

GO:0043536

positive regulation of blood vessel endothelial cell migration

Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.

IDA

BP

GO:0045766

positive regulation of angiogenesis

Any process that activates or increases angiogenesis.

IDA|IMP

BP

GO:0045785

positive regulation of cell adhesion

Any process that activates or increases the frequency, rate or extent of cell adhesion.

IDA

BP

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA|IMP

BP

GO:0048010

vascular endothelial growth factor receptor signaling pathway

Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IDA|TAS

BP

GO:0048469

cell maturation

A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.

ISS

BP

GO:0048593

camera-type eye morphogenesis

The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.

ISS

BP

GO:0048739

cardiac muscle fiber development

The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure.

ISS

BP

GO:0048754

branching morphogenesis of an epithelial tube

The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.

ISS

BP

GO:0048842

positive regulation of axon extension involved in axon guidance

Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance.

ISS

BP

GO:0048844

artery morphogenesis

The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.

ISS

BP

GO:0050679

positive regulation of epithelial cell proliferation

Any process that activates or increases the rate or extent of epithelial cell proliferation.

ISS

BP

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.

IDA

BP

GO:0050918

positive chemotaxis

The directed movement of a motile cell or organism towards a higher concentration of a chemical.

IDA

BP

GO:0050927

positive regulation of positive chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.

IDA

BP

GO:0050930

induction of positive chemotaxis

Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.

NAS

BP

GO:0051272

positive regulation of cellular component movement

Any process that activates or increases the frequency, rate or extent of the movement of a cellular component.

IDA

BP

GO:0051781

positive regulation of cell division

Any process that activates or increases the frequency, rate or extent of cell division.

IEA

BP

GO:0051894

positive regulation of focal adhesion assembly

Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.

IDA

BP

GO:0060319

primitive erythrocyte differentiation

Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis.

ISS

BP

GO:0060749

mammary gland alveolus development

The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland.

ISS

BP

GO:0060948

cardiac vascular smooth muscle cell development

The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state.

ISS

BP

GO:0060982

coronary artery morphogenesis

The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle.

ISS

BP

GO:0061418

regulation of transcription from RNA polymerase II promoter in response to hypoxia

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.

TAS

BP

GO:0061419

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.

IMP

BP

GO:0071456

cellular response to hypoxia

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.

IDA

BP

GO:0071542

dopaminergic neuron differentiation

The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.

ISS

BP

GO:0071679

commissural neuron axon guidance

The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues.

ISS

BP

GO:0090037

positive regulation of protein kinase C signaling

Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.

IDA

BP

GO:0090050

positive regulation of cell migration involved in sprouting angiogenesis

Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.

IDA

BP

GO:0090190

positive regulation of branching involved in ureteric bud morphogenesis

Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.

ISS

BP

GO:0090259

regulation of retinal ganglion cell axon guidance

Any process that modulates the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.

ISS

BP

GO:1900086

positive regulation of peptidyl-tyrosine autophosphorylation

Any process that activates or increases the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.

IDA

BP

GO:1900745

positive regulation of p38MAPK cascade

Any process that activates or increases the frequency, rate or extent of p38MAPK cascade.

IDA

BP

GO:1901727

positive regulation of histone deacetylase activity

Any process that activates or increases the frequency, rate or extent of histone deacetylase activity.

IDA

BP

GO:1902336

positive regulation of retinal ganglion cell axon guidance

Any process that activates or increases the frequency, rate or extent of retinal ganglion cell axon guidance.

ISS

BP

GO:1903572

positive regulation of protein kinase D signaling

Any process that activates or increases the frequency, rate or extent of protein kinase D signaling.

IDA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

TAS

CC

GO:0005578

proteinaceous extracellular matrix

A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.

NAS

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA|ISS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

IDA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IEA

CC

GO:0030141

secretory granule

A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.

IDA

CC

GO:0031093

platelet alpha granule lumen

The volume enclosed by the membrane of the platelet alpha granule.

TAS

MF

GO:0001968

fibronectin binding

Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.

IDA

MF

GO:0005125

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

IDA|ISS

MF

GO:0005161

platelet-derived growth factor receptor binding

Interacting selectively and non-covalently with the platelet-derived growth factor receptor.

IPI

MF

GO:0005172

vascular endothelial growth factor receptor binding

Interacting selectively and non-covalently with any vascular endothelial growth factor receptor.

IPI

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008083

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

IDA|ISS

MF

GO:0008201

heparin binding

Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.

IDA|IMP

MF

GO:0042056

chemoattractant activity

Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.

IDA

MF

GO:0042802

identical protein binding

Interacting selectively and non-covalently with an identical protein or proteins.

IPI

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

ISS

MF

GO:0043183

vascular endothelial growth factor receptor 1 binding

Interacting selectively and non-covalently with vascular endothelial growth factor receptor 1.

IPI

MF

GO:0043184

vascular endothelial growth factor receptor 2 binding

Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2.

IPI

MF

GO:0046982

protein heterodimerization activity

Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.

IDA

MF

GO:0048018

receptor agonist activity

Interacts with receptors such that the proportion of receptors in the active form is increased.

IPI

MF

GO:0050840

extracellular matrix binding

Interacting selectively and non-covalently with a component of the extracellular matrix.

IC