| Gene Symbol | UROD |
| Entrez ID | 7389 |
| Uniprot ID | P06132 |
| Description | uroporphyrinogen decarboxylase |
| Chromosomal Location | chr1: 45,012,147-45,015,575 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006782 |
protoporphyrinogen IX biosynthetic process |
The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. |
IEA |
|
BP |
GO:0006783 |
heme biosynthetic process |
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. |
IBA|IC|TAS |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
IBA|TAS |
|
MF |
GO:0004853 |
uroporphyrinogen decarboxylase activity |
Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. |
IDA|TAS |
| Domain ID | Description |
|---|---|
|
IPR000257 |
Uroporphyrinogen decarboxylase (URO-D) |
|
IPR006361 |
Uroporphyrinogen decarboxylase HemE |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00860 |
Porphyrin and chlorophyll metabolism |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
WP561 |
Heme Biosynthesis |
WikiPathways |
|
h_ahspPathway |
Hemoglobin's Chaperone |
BioCarta |
| UMLS CUI | UMLS Term |
|---|---|
|
C0018671 |
Head And Neck Neoplasms |
|
C0162566 |
Porphyria Cutanea Tarda |
|
C0162569 |
Hepatoerythropoietic Porphyria |
| Tissue | Cell Type |
|---|---|
|
appendix |
glandular cells |
|
breast |
glandular cells |
|
bronchus |
respiratory epithelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
kidney |
cells in tubules |
|
liver |
bile duct cells |
|
lung |
pneumocytes |
|
nasopharynx |
respiratory epithelial cells |
|
pancreas |
exocrine glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
|
urinary bladder |
urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
NME1 |
4830 |
P15531 |
0.49 |
|
MYCBP |
26292 |
Q99417 |
0.49 |
|
TIPRL |
261726 |
O75663 |
0.49 |
|
CHD3 |
1107 |
Q12873 |
0.63 |
|
MTAP |
4507 |
Q13126 |
0.63 |
|
VIM |
7431 |
P08670 |
0.63 |
|
HMGXB4 |
10042 |
Q9UGU5 |
0.63 |
|
FAF1 |
11124 |
Q9UNN5 |
0.63 |
|
CHRAC1 |
54108 |
Q9NRG0 |
0.63 |
|
WDR45B |
56270 |
Q5MNZ6 |
0.63 |
|
FAM84B |
157638 |
Q96KN1 |
0.63 |
|
POTEF |
728378 |
A5A3E0 |
0.63 |
|
EGFR |
1956 |
P00533 |
0.72 |
|
UROD |
7389 |
P06132 |
0.95 |
|
MOV10 |
4343 |
Q9HCE1 |
0.63 |
|
BAG3 |
9531 |
O95817 |
0.63 |
|
NXF1 |
10482 |
Q9UBU9 |
0.63 |