| Gene Symbol | UQCRB |
| Entrez ID | 7381 |
| Uniprot ID | P14927 |
| Description | ubiquinol-cytochrome c reductase binding protein |
| Chromosomal Location | chr8: 96,225,920-96,235,634 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006119 |
oxidative phosphorylation |
The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. |
TAS |
|
BP |
GO:0006122 |
mitochondrial electron transport, ubiquinol to cytochrome c |
The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. |
IBA|TAS |
|
BP |
GO:0009060 |
aerobic respiration |
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. |
TAS |
|
BP |
GO:0034551 |
mitochondrial respiratory chain complex III assembly |
The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane. |
IBA |
|
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
TAS |
|
BP |
GO:1902600 |
hydrogen ion transmembrane transport |
The directed movement of hydrogen ion (proton) across a membrane. |
IEA |
|
CC |
GO:0005743 |
mitochondrial inner membrane |
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
TAS |
|
CC |
GO:0005746 |
mitochondrial respiratory chain |
The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. |
TAS |
|
CC |
GO:0005750 |
mitochondrial respiratory chain complex III |
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. |
IBA |
|
MF |
GO:0008121 |
ubiquinol-cytochrome-c reductase activity |
Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. |
IBA |
| Domain ID | Description |
|---|---|
|
IPR003197 |
Cytochrome b-c1 complex subunit 7 |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00190 |
Oxidative phosphorylation |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
hsa04260 |
Cardiac muscle contraction |
KEGG |
|
hsa04932 |
Non-alcoholic fatty liver disease (NAFLD) |
KEGG |
|
hsa05010 |
Alzheimer's disease |
KEGG |
|
hsa05012 |
Parkinson's disease |
KEGG |
|
hsa05016 |
Huntington's disease |
KEGG |
|
WP111 |
Electron Transport Chain |
WikiPathways |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
neuronal cells |
|
kidney |
cells in tubules |
|
liver |
hepatocytes |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
parathyroid gland |
glandular cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
15598877 |
Wood et al. |
2005 |
Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
|
25393639 |
Ambekar et al. |
2014 |
Proteomics of follicular fluid from women with polycystic ovary syndrome suggests molecular defects in follicular development |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ACAT1 |
38 |
P24752 |
0.49 |
|
DDOST |
1650 |
P39656 |
0.49 |
|
NDUFA8 |
4702 |
P51970 |
0.49 |
|
NDUFV1 |
4723 |
P49821 |
0.49 |
|
RPL6 |
6128 |
Q02878 |
0.49 |
|
RPL11 |
6135 |
P62913 |
0.49 |
|
RPS2 |
6187 |
P15880 |
0.49 |
|
RPS10 |
6204 |
P46783 |
0.49 |
|
RPS16 |
6217 |
P62249 |
0.49 |
|
VDAC1 |
7416 |
P21796 |
0.49 |
|
RPL14 |
9045 |
P50914 |
0.49 |
|
RPL23 |
9349 |
P62829 |
0.49 |
|
TIMM10 |
26519 |
P62072 |
0.49 |
|
NDUFA12 |
55967 |
Q9UI09 |
0.49 |
|
RPL9; RPL9P7; RPL9P8; RPL9P9 |
6133 |
P32969 |
0.49 |
|
UQCRFS1 |
7386 |
P47985 |
0.56 |
|
COX6B1 |
1340 |
P14854 |
0.63 |
|
MT-CO1 |
4512 |
P00395 |
0.63 |
|
PRKCA |
5578 |
P17252 |
0.63 |
|
S100A10 |
6281 |
P60903 |
0.63 |
|
UQCRC2 |
7385 |
P22695 |
0.63 |
|
UQCRH |
7388 |
P07919 |
0.63 |
|
COX7A2L |
9167 |
O14548 |
0.63 |
|
UQCRQ |
27089 |
O14949 |
0.63 |
|
UHRF1 |
29128 |
Q96T88 |
0.63 |
|
UQCR10 |
29796 |
Q9UDW1 |
0.63 |
|
RABL6 |
55684 |
Q3YEC7 |
0.63 |
|
ACCS |
84680 |
Q96QU6 |
0.63 |
|
MYO18A |
399687 |
Q92614 |
0.63 |
|
MT-CYB |
4519 |
P00156 |
0.70 |
|
ALDH1B1 |
219 |
P30837 |
0.49 |
|
ATP1B1 |
481 |
P05026 |
0.49 |
|
ATP1B3 |
483 |
P54709 |
0.49 |
|
ATP5F1 |
515 |
P24539 |
0.49 |
|
COX4I1 |
1327 |
P13073 |
0.49 |
|
NDUFA10 |
4705 |
O95299 |
0.49 |
|
NDUFB8 |
4714 |
O95169 |
0.49 |
|
NDUFS1 |
4719 |
P28331 |
0.49 |
|
SDHB |
6390 |
P21912 |
0.49 |
|
VAPA |
9218 |
Q9P0L0 |
0.49 |
|
SLC25A17 |
10478 |
O43808 |
0.49 |
|
MYL12A |
10627 |
P19105 |
0.49 |
|
NDUFB11 |
54539 |
Q9NX14 |
0.49 |
|
NDUFS4 |
4724 |
O43181 |
0.59 |
|
SDHA |
6389 |
P31040 |
0.59 |
|
COX5A |
9377 |
P20674 |
0.59 |
|
HSPB1 |
3315 |
P04792 |
0.63 |
|
MAGEA1 |
4100 |
P43355 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
PHLPP2 |
23035 |
Q6ZVD8 |
0.63 |
|
CEP76 |
79959 |
Q8TAP6 |
0.63 |
|
NDUFA11 |
126328 |
Q86Y39 |
0.72 |
|
UQCRC1 |
7384 |
P31930 |
0.79 |
|
MAGEA4 |
4103 |
P43358 |
0.83 |
|
CYC1 |
1537 |
P08574 |
0.85 |