Protein Description

Gene Symbol SLC35A2
Entrez ID 7355
Uniprot ID P78381
Description solute carrier family 35 (UDP-galactose transporter), member A2
Chromosomal Location chrX: 48,903,180-48,911,958
Ontology GO ID GO Term Definition Evidence

BP

GO:0006012

galactose metabolic process

The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.

TAS

BP

GO:0015785

UDP-galactose transport

The directed movement of UDP-galactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate.

TAS

BP

GO:0015992

proton transport

The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IEA

BP

GO:0072334

UDP-galactose transmembrane transport

The directed movement of UDP-galactose across a membrane into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IEA

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

TAS

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005783

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

IDA

CC

GO:0005794

Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

IDA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0005351

sugar:proton symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in).

IEA

MF

GO:0005459

UDP-galactose transmembrane transporter activity

Catalysis of the transfer of a UDP-galactose from one side of the membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate.

TAS

Domain ID Description

IPR007271

Nucleotide-sugar transporter

No pathways found.

No diseases found.

Tissue Cell Type

appendix

glandular cells

breast

myoepithelial cells

bronchus

respiratory epithelial cells

cerebral cortex

neuronal cells

cervix, uterine

squamous epithelial cells

colon

endothelial cells

duodenum

glandular cells

endometrium

glandular cells

epididymis

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

nasopharynx

respiratory epithelial cells

oral mucosa

squamous epithelial cells

pancreas

exocrine glandular cells

rectum

glandular cells

salivary gland

glandular cells

seminal vesicle

glandular cells

skin

keratinocytes

skin

Langerhans

skin

melanocytes

smooth muscle

smooth muscle cells

soft tissue

adipocytes

soft tissue

chondrocytes

stomach

glandular cells

urinary bladder

urothelial cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

SLC35A2

7355

P78381

0.63

KRTAP10-3

386682

P60369

0.63

MDFI

4188

Q99750

0.73

PLSCR1

5359

O15162

0.73

SLC35A3

23443

Q9Y2D2

0.73

B3GALT1

8708

Q9Y5Z6

0.63