PCOSBase

Protein Description

Gene Symbol	UBA1
Entrez ID	7317
Uniprot ID	P22314
Description	ubiquitin-like modifier activating enzyme 1
Chromosomal Location	chrX: 47,190,861-47,215,128

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0006974	cellular response to DNA damage stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.	IDA
BP	GO:0016567	protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.	IEA
BP	GO:0019941	modification-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.	IBA
CC	GO:0000792	heterochromatin	A compact and highly condensed form of chromatin.	IDA
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	IDA
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IDA
CC	GO:0005739	mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.	IDA
CC	GO:0005765	lysosomal membrane	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.	IDA
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	IBA
CC	GO:0010008	endosome membrane	The lipid bilayer surrounding an endosome.	IDA
CC	GO:0030057	desmosome	A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.	IDA
CC	GO:0030867	rough endoplasmic reticulum membrane	The lipid bilayer surrounding the rough endoplasmic reticulum.	IDA
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
MF	GO:0004839	ubiquitin activating enzyme activity	Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.	IDA
MF	GO:0004842	ubiquitin-protein transferase activity	Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.	IBA
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0005524	ATP binding	Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.	IEA
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA

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Domain ID	Description
IPR000011	Ubiquitin/SUMO-activating enzyme E1
IPR000594	THIF-type NAD/FAD binding fold
IPR018074	Ubiquitin-activating enzyme E1, conserved site
IPR018075	Ubiquitin-activating enzyme E1
IPR018965	Ubiquitin-activating enzyme E1, C-terminal
IPR019572	Ubiquitin-activating enzyme, catalytic cysteine domain
IPR032418	Ubiquitin-activating enzyme E1, FCCH domain
IPR032420	Ubiquitin-activating enzyme E1, four-helix bundle
IPR033127	Ubiquitin-activating enzyme E1, Cys active site

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Pathway ID	Pathway Term	Pathway Source
hsa04120	Ubiquitin mediated proteolysis	KEGG
hsa05012	Parkinson's disease	KEGG
WP2371	Parkinsons Disease Pathway	WikiPathways
WP183	Proteasome Degradation	WikiPathways
WP2359	Parkin-Ubiquitin Proteasomal System pathway	WikiPathways

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No diseases found.

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Tissue	Cell Type
adrenal gland	glandular cells
bronchus	respiratory epithelial cells
cerebellum	Purkinje cells
cervix, uterine	glandular cells
cervix, uterine	squamous epithelial cells
colon	peripheral nerve/ganglion
endometrium	glandular cells
fallopian tube	glandular cells
gallbladder	glandular cells
kidney	cells in tubules
lung	macrophages
oral mucosa	squamous epithelial cells
pancreas	exocrine glandular cells
pancreas	islets of Langerhans
parathyroid gland	glandular cells
placenta	decidual cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skin	epidermal cells
testis	cells in seminiferous ducts
testis	Leydig cells
thyroid gland	glandular cells

No databases found.

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Pubmed ID	Author	Year	Title
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

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Gene Symbol	Entrez ID	Uniprot ID	Score
AP1G1	164	O43747	0.49
ARHGAP1	392	Q07960	0.49
AP1S1	1174	P61966	0.49
GFPT1	2673	Q06210	0.49
MAPK3	5595	P27361	0.49
UCHL3	7347	P15374	0.49
EEF1E1	9521	O43324	0.49
NUP93	9688	Q8N1F7	0.49
LCMT2	9836	O60294	0.49
DPP3	10072	Q9NY33	0.49
USH1C	10083	Q9Y6N9	0.49
NPLOC4	55666	Q8TAT6	0.49
WDR73	84942	Q6P4I2	0.49
ARMC6	93436	Q6NXE6	0.49
UBA1	7317	P22314	0.52
UBE2L6	9246	O14933	0.52
UBE2D4	51619	Q9Y2X8	0.52
CREB3L2	64764	Q70SY1	0.52
CREB3L1	90993	Q96BA8	0.52
UBE2Q2	92912	Q8WVN8	0.52
UBE2L1	283556	N/A	0.52
UBE2G1	7326	P62253	0.56
UBE2H	7328	P62256	0.56
UBE2T	29089	Q9NPD8	0.56
UBE2R2	54926	Q712K3	0.56
SAPCD2	89958	Q86UD0	0.63
CTPS1	1503	P17812	0.63
FUS	2521	P35637	0.63
GRB2	2885	P62993	0.63
IPO5	3843	O00410	0.63
MC1R	4157	Q01726	0.63
MTNR1A	4543	P48039	0.63
NEDD8	4738	Q15843	0.63
TAF9	6880	Q16594	0.63
EZR	7430	P15311	0.63
XPNPEP1	7511	Q9NQW7	0.63
PDCD6IP	10015	Q8WUM4	0.63
CHTF8	54921	P0CG12	0.63
CHTF8	54921	P0CG13	0.63
RIC8A	60626	Q9NPQ8	0.63
MGMT	4255	P16455	0.65
UBE2G2	7327	P60604	0.69
UBE2E3	10477	Q969T4	0.69
UBE2W	55284	Q96B02	0.69
ATIC	471	P31939	0.70
CDC34	997	P49427	0.70
UBE2K	3093	P61086	0.70
UBE2D1	7321	P51668	0.70
UBE2D2	7322	P62837	0.70
UBE2D3	7323	P61077	0.70
UBE2E1	7324	P51965	0.70
UBE2E2	7325	Q96LR5	0.70
UBE2L3	7332	P68036	0.70
UBE2C	11065	O00762	0.70
PABPC1	26986	P11940	0.70
UBE2S	27338	Q16763	0.70
UBE2J2	118424	Q8N2K1	0.70
NDUFV3	4731	P56181	0.72
NVL	4931	O15381	0.72
TMCC2	9911	O75069	0.73
TSSC4	10078	Q9Y5U2	0.73
UBD	10537	O15205	0.74
UBE2A	7319	P49459	0.77
UBE2B	7320	P63146	0.77
ISG15	9636	P05161	0.78
ACOX1	51	Q15067	0.49
AP1B1	162	Q10567	0.49
TRIM23	373	P36406	0.49
ASNS	440	P08243	0.49
CBLB	868	Q13191	0.49
CD74	972	P04233	0.49
DUSP7	1849	Q16829	0.49
EPHA1	2041	P21709	0.49
EPRS	2058	P07814	0.49
HSD17B10	3028	Q99714	0.49
HIP1	3092	O00291	0.49
DNAJB2	3300	P25686	0.49
MDM4	4194	O15151	0.49
ATXN3	4287	P54252	0.49
PTEN	5728	P60484	0.49
QARS	5859	P47897	0.49
RBP2	5948	P50120	0.49
RNF4	6047	P78317	0.49
TRIM21	6737	P19474	0.49
AURKA	6790	O14965	0.49
THRA	7067	P10827	0.49
TLN1	7094	Q9Y490	0.49
EPM2A	7957	O95278	0.49
BAP1	8314	Q92560	0.49
CUL1	8454	Q13616	0.49
FKBP6	8468	O75344	0.49
KRT36	8689	O76013	0.49
RIOK3	8780	O14730	0.49
AP1M1	8907	Q9BXS5	0.49
HIP1R	9026	O75146	0.49
GDA	9615	Q9Y2T3	0.49
DNAJB6	10049	O75190	0.49
DNPH1	10591	O43598	0.49
HBS1L	10767	Q9Y450	0.49
NUDT6	11162	P53370	0.49
POLI	11201	Q9UNA4	0.49
RNF13	11342	O43567	0.49
GGA2	23062	Q9UJY4	0.49
SEPT6	23157	Q14141	0.49
FAF2	23197	Q96CS3	0.49
APPL1	26060	Q9UKG1	0.49
CCDC69	26112	A6NI79	0.49
TSPAN17	26262	Q96FV3	0.49
APEX2	27301	Q9UBZ4	0.49
EPN1	29924	Q9Y6I3	0.49
MAGEC2	51438	Q9UBF1	0.49
DCUN1D1	54165	Q96GG9	0.49
RNF111	54778	Q6ZNA4	0.49
MFSD6	54842	Q6ZSS7	0.49
NSUN2	54888	Q08J23	0.49
RFWD3	55159	Q6PCD5	0.49
DCUN1D2	55208	Q6PH85	0.49
IMPACT	55364	Q9P2X3	0.49
TXLNG	55787	Q9NUQ3	0.49
GRIPAP1	56850	Q4V328	0.49
CIAPIN1	57019	Q6FI81	0.49
SMURF1	57154	Q9HCE7	0.49
PELI2	57161	Q9HAT8	0.49
PELI1	57162	Q96FA3	0.49
HACE1	57531	Q8IYU2	0.49
C6orf106	64771	Q9H6K1	0.49
CEP85	64793	Q6P2H3	0.49
INTS3	65123	Q68E01	0.49
CRELD1	78987	Q96HD1	0.49
CARD14	79092	Q9BXL6	0.49
BIRC7	79444	Q96CA5	0.49
FAM184A	79632	Q8NB25	0.49
RNF122	79845	Q9H9V4	0.49
FAM188A	80013	Q9H8M7	0.49
DBF4B	80174	Q8NFT6	0.49
RNF34	80196	Q969K3	0.49
TRIM11	81559	Q96F44	0.49
ASCC2	84164	Q9H1I8	0.49
RHBDD1	84236	Q8TEB9	0.49
RNF135	84282	Q8IUD6	0.49
TRIM52	84851	Q96A61	0.49
ANKRD13A	88455	Q8IZ07	0.49
LRSAM1	90678	Q6UWE0	0.49
SLC9B2	133308	Q86UD5	0.49
MTPN	136319	P58546	0.49
RNF182	221687	Q8N6D2	0.49
ANKRD13D	338692	Q6ZTN6	0.49
NHLRC1	378884	Q6VVB1	0.49
UBE2V1	387522	Q13404	0.49
CUEDC1	404093	Q9NWM3	0.49
DENND6B	414918	Q8NEG7	0.49
MAGEA2; MAGEA2B	266740	P43356	0.49
CDKN1B	1027	P46527	0.52
CTNNB1	1499	P35222	0.52
RNF20	56254	Q5VTR2	0.52
AARS	16	P49588	0.56
CALM2	805	P62158	0.56
CALM3	808	P62158	0.56
GARS	2617	P41250	0.56
KARS	3735	Q15046	0.56
MTHFD1	4522	P11586	0.56
UBE2I	7329	P63279	0.56
AHSA1	10598	O95433	0.56
SUN2	25777	Q9UH99	0.56
AIMP2	7965	Q13155	0.59
TRIP13	9319	Q15645	0.59
NMD3	51068	Q96D46	0.59
LARS	51520	Q9P2J5	0.59
CDK2	1017	P24941	0.63
CRY1	1407	Q16526	0.63
ECHS1	1892	P30084	0.63
FH	2271	P07954	0.63
HSP90AA1	3320	P07900	0.63
JUN	3725	P05412	0.63
SMAD5	4090	Q99717	0.63
MDM2	4193	Q00987	0.63
MYC	4609	P01106	0.63
NTRK1	4914	P04629	0.63
MAPK13	5603	O15264	0.63
RAD21	5885	O60216	0.63
RAD23A	5886	P54725	0.63
RAD23B	5887	P54727	0.63
SUMO3	6612	P55854	0.63
AK6	6880	Q9Y3D8	0.63
TRIM25	7706	Q14258	0.63
USP5	8078	P45974	0.63
CUL3	8452	Q13618	0.63
BUB3	9184	O43684	0.63
BAG3	9531	O95817	0.63
CUL7	9820	Q14999	0.63
HDAC5	10014	Q9UQL6	0.63
HUWE1	10075	Q7Z6Z7	0.63
PSMD14	10213	O00487	0.63
PIAS3	10401	Q9Y6X2	0.63
COPS5	10987	Q92905	0.63
FBXW11	23291	Q9UKB1	0.63
OBSL1	23363	O75147	0.63
METTL21B	25895	Q96AZ1	0.63
IBTK	25998	Q9P2D0	0.63
MCTS1	28985	Q9ULC4	0.63
TTC19	54902	Q6DKK2	0.63
HEMGN	55363	Q9BXL5	0.63
OTUB1	55611	Q96FW1	0.63
CCDC8	83987	Q9H0W5	0.63
UNK	85451	Q9C0B0	0.63
DDB1	100290337	Q16531	0.63
IARS	3376	P41252	0.65
STUB1	10273	Q9UNE7	0.66
RBCK1	10616	Q9BYM8	0.66
YWHAZ	7534	P63104	0.68
BIRC2	329	Q13490	0.72
FANCD2	2177	Q9BXW9	0.72
HSP90AB1	3326	P08238	0.72
USP11	8237	P51784	0.72
USP14	9097	P54578	0.72
CEP290	80184	O15078	0.72
SEMA3F	6405	Q13275	0.73
SUMO2	6613	P61956	0.74
CBL	867	P22681	0.75
BTRC	8945	Q9Y297	0.75
DZIP3	9666	Q86Y13	0.75
NEDD4L	23327	Q96PU5	0.75
UBTD2	92181	Q8WUN7	0.77
GAN	8139	Q9H2C0	0.78
UBE2J1	51465	Q9Y385	0.78
POLR2A	5430	P24928	0.81
BIRC3	330	Q13489	0.82
UBE2N	7334	P61088	0.83
NEDD4	4734	P46934	0.84
HGS	9146	O14964	0.84
BARD1	580	Q99728	0.85
BRCA1	672	P38398	0.85
HSPH1	10808	Q92598	0.92