Gene Symbol | TYMS |
Entrez ID | 7298 |
Uniprot ID | P04818 |
Description | thymidylate synthetase |
Chromosomal Location | chr18: 657,604-673,578 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000082 |
G1/S transition of mitotic cell cycle |
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. |
TAS |
BP |
GO:0000083 |
regulation of transcription involved in G1/S transition of mitotic cell cycle |
Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle. |
TAS |
BP |
GO:0006139 |
nucleobase-containing compound metabolic process |
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. |
TAS |
BP |
GO:0006231 |
dTMP biosynthetic process |
The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). |
IDA |
BP |
GO:0006235 |
dTTP biosynthetic process |
The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate. |
IEA |
BP |
GO:0006417 |
regulation of translation |
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA. |
IEA |
BP |
GO:0007568 |
aging |
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). |
IEA |
BP |
GO:0007623 |
circadian rhythm |
Any biological process in an organism that recurs with a regularity of approximately 24 hours. |
IEA |
BP |
GO:0008283 |
cell proliferation |
The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
NAS |
BP |
GO:0009157 |
deoxyribonucleoside monophosphate biosynthetic process |
The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar. |
TAS |
BP |
GO:0009636 |
response to toxic substance |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. |
IEA |
BP |
GO:0016049 |
cell growth |
The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. |
NAS |
BP |
GO:0019088 |
immortalization of host cell by virus |
A virus-induced cellular transformation arising in immortalized cells, or cells capable of indefinite replication, due to their ability to produce their own telomerase. |
IEA |
BP |
GO:0019860 |
uracil metabolic process |
The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. |
IEA |
BP |
GO:0032259 |
methylation |
The process in which a methyl group is covalently attached to a molecule. |
IEA |
BP |
GO:0032570 |
response to progesterone |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. |
IEA |
BP |
GO:0033189 |
response to vitamin A |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus. |
IEA |
BP |
GO:0034097 |
response to cytokine |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. |
IEA |
BP |
GO:0035999 |
tetrahydrofolate interconversion |
The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. |
IDA |
BP |
GO:0042493 |
response to drug |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. |
IEA |
BP |
GO:0045471 |
response to ethanol |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. |
IEA |
BP |
GO:0046078 |
dUMP metabolic process |
The chemical reactions and pathways involving dUMP, deoxyuridine (5'-)monophosphate (2'-deoxyuridine 5'-phosphate). |
IEA |
BP |
GO:0046134 |
pyrimidine nucleoside biosynthetic process |
The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). |
TAS |
BP |
GO:0046683 |
response to organophosphorus |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors. |
IEP |
BP |
GO:0048589 |
developmental growth |
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. |
IEA |
BP |
GO:0051216 |
cartilage development |
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. |
IEA |
BP |
GO:0051384 |
response to glucocorticoid |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. |
IEA |
BP |
GO:0051593 |
response to folic acid |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. |
IEA |
BP |
GO:0060574 |
intestinal epithelial cell maturation |
The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus. |
IEA |
BP |
GO:0071897 |
DNA biosynthetic process |
The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. |
IC |
BP |
GO:0097421 |
liver regeneration |
The regrowth of lost or destroyed liver. |
IEA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
TAS |
CC |
GO:0005730 |
nucleolus |
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
IEA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IDA |
CC |
GO:0005743 |
mitochondrial inner membrane |
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
IDA |
CC |
GO:0005759 |
mitochondrial matrix |
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
IDA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
MF |
GO:0000166 |
nucleotide binding |
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
IEA |
MF |
GO:0003729 |
mRNA binding |
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
IEA |
MF |
GO:0004799 |
thymidylate synthase activity |
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. |
IDA|TAS |
MF |
GO:0005542 |
folic acid binding |
Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. |
IC |
MF |
GO:0008144 |
drug binding |
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. |
IEA |
MF |
GO:0042803 |
protein homodimerization activity |
Interacting selectively and non-covalently with an identical protein to form a homodimer. |
IEA |
MF |
GO:0048037 |
cofactor binding |
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. |
IEA |
Domain ID | Description |
---|---|
IPR000398 |
Thymidylate synthase |
IPR020940 |
Thymidylate synthase, active site |
IPR023451 |
Thymidylate synthase/dCMP hydroxymethylase domain |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00240 |
Pyrimidine metabolism |
KEGG |
hsa00670 |
One carbon pool by folate |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
hsa01523 |
Antifolate resistance |
KEGG |
WP241 |
One Carbon Metabolism |
WikiPathways |
WP3594 |
Circadian rythm related genes |
WikiPathways |
WP1601 |
Fluoropyrimidine Activity |
WikiPathways |
WP2446 |
Retinoblastoma (RB) in Cancer |
WikiPathways |
WP2525 |
Trans-sulfuration and one carbon metabolism |
WikiPathways |
WP3940 |
One carbon metabolism and related pathways |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0002871 |
Anemia |
C0006111 |
Brain Diseases |
C0007137 |
Squamous Cell Carcinoma |
C0008924 |
Cleft Lip |
C0008925 |
Cleft Palate |
C0009375 |
Colonic Neoplasms |
C0009404 |
Colorectal Neoplasms |
C0012243 |
Digestive System Neoplasms |
C0017661 |
Iga Glomerulonephritis |
C0018671 |
Head And Neck Neoplasms |
C0024121 |
Lung Neoplasms |
C0024301 |
Lymphoma, Follicular |
C0024305 |
Lymphoma, Non-Hodgkin |
C0027643 |
Neoplasm Recurrence, Local |
C0027765 |
Nervous System Disorder |
C0030297 |
Pancreatic Neoplasm |
C0033578 |
Prostatic Neoplasms |
C0034885 |
Rectal Neoplasms |
C0038356 |
Stomach Neoplasms |
C0040411 |
Tongue Neoplasms |
C0041755 |
Adverse Reaction To Drug |
C0206754 |
Neuroendocrine Tumors |
C0220994 |
Hyperammonemia |
C0919267 |
Ovarian Neoplasm |
C1458155 |
Mammary Neoplasms |
C2239176 |
Liver Carcinoma |
Tissue | Cell Type |
---|---|
bone marrow |
hematopoietic cells |
lymph node |
germinal center cells |
tonsil |
germinal center cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
12734205 |
Wood et al. |
2003 |
The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis |
19141577 |
Kim et al. |
2009 |
Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome |
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
23824412 |
Piltonen et al. |
2013 |
Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
ATP6V1C1 |
528 |
P21283 |
0.49 |
ATP6V1E1 |
529 |
P36543 |
0.49 |
UBE2K |
3093 |
P61086 |
0.49 |
UBE2A |
7319 |
P49459 |
0.49 |
UBE2B |
7320 |
P63146 |
0.49 |
UBE2M |
9040 |
P61081 |
0.49 |
ZRANB2 |
9406 |
O95218 |
0.49 |
VPS4B |
9525 |
O75351 |
0.49 |
WDR1 |
9948 |
O75083 |
0.49 |
PDCD6 |
10016 |
O75340 |
0.49 |
UBE2C |
11065 |
O00762 |
0.49 |
UBXN7 |
26043 |
O94888 |
0.49 |
UFC1 |
51506 |
Q9Y3C8 |
0.49 |
WDR45B |
56270 |
Q5MNZ6 |
0.49 |
UBQLN4 |
56893 |
Q9NRR5 |
0.49 |
ZFYVE21 |
79038 |
Q9BQ24 |
0.49 |
ZFYVE19 |
84936 |
Q96K21 |
0.49 |
UNK |
85451 |
Q9C0B0 |
0.49 |
EIF5A |
1984 |
P63241 |
0.63 |
TYMS |
7298 |
P04818 |
0.70 |
ADSL |
158 |
P30566 |
0.49 |
ATIC |
471 |
P31939 |
0.49 |
DUT |
1854 |
P33316 |
0.49 |
IGBP1 |
3476 |
P78318 |
0.49 |
STMN1 |
3925 |
P16949 |
0.49 |
PGAM1 |
5223 |
P18669 |
0.49 |
PPAT |
5471 |
Q06203 |
0.49 |
PSMA5 |
5686 |
P28066 |
0.49 |
TXN |
7295 |
P10599 |
0.49 |
SAE1 |
10055 |
Q9UBE0 |
0.49 |
SSSCA1 |
10534 |
O60232 |
0.49 |
AHCYL1 |
10768 |
O43865 |
0.49 |
RPGRIP1L |
23322 |
Q68CZ1 |
0.49 |
REXO2 |
25996 |
Q9Y3B8 |
0.49 |
PHGDH |
26227 |
O43175 |
0.49 |
TXNDC17 |
84817 |
Q9BRA2 |
0.49 |
POC5 |
134359 |
Q8NA72 |
0.49 |
POC1B |
282809 |
Q8TC44 |
0.49 |
MAPK14 |
1432 |
Q16539 |
0.63 |
DCK |
1633 |
P27707 |
0.63 |
GOT1 |
2805 |
P17174 |
0.63 |
ITGA4 |
3676 |
P13612 |
0.63 |
LIMS1 |
3987 |
P48059 |
0.63 |
NEDD8 |
4738 |
Q15843 |
0.63 |
PLS3 |
5358 |
P13797 |
0.63 |
SH3GL2 |
6456 |
Q99962 |
0.63 |
SUMO2 |
6613 |
P61956 |
0.63 |
TNIK |
23043 |
Q9UKE5 |
0.63 |
UPF2 |
26019 |
Q9HAU5 |
0.63 |
SBDS |
51119 |
Q9Y3A5 |
0.63 |
VCAM1 |
7412 |
P19320 |
0.82 |