Gene Symbol | TXN |
Entrez ID | 7295 |
Uniprot ID | P10599 |
Description | thioredoxin |
Chromosomal Location | chr9: 110,243,811-110,256,640 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000103 |
sulfate assimilation |
The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. |
IBA |
BP |
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IEA |
BP |
GO:0000302 |
response to reactive oxygen species |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. |
TAS |
BP |
GO:0006351 |
transcription, DNA-templated |
The cellular synthesis of RNA on a template of DNA. |
IEA |
BP |
GO:0006457 |
protein folding |
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
IBA |
BP |
GO:0006662 |
glycerol ether metabolic process |
The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. |
IEA |
BP |
GO:0006928 |
movement of cell or subcellular component |
The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore. |
TAS |
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
TAS |
BP |
GO:0007267 |
cell-cell signaling |
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. |
TAS |
BP |
GO:0008283 |
cell proliferation |
The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
TAS |
BP |
GO:0009314 |
response to radiation |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. |
IDA |
BP |
GO:0015949 |
nucleobase-containing small molecule interconversion |
The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. |
TAS |
BP |
GO:0030091 |
protein repair |
The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues. |
TAS |
BP |
GO:0032148 |
activation of protein kinase B activity |
Any process that initiates the activity of the inactive enzyme protein kinase B. |
IC |
BP |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. |
IGI |
BP |
GO:0033158 |
regulation of protein import into nucleus, translocation |
Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. |
IDA |
BP |
GO:0043388 |
positive regulation of DNA binding |
Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). |
IDA |
BP |
GO:0045454 |
cell redox homeostasis |
Any process that maintains the redox environment of a cell or compartment within a cell. |
IBA |
BP |
GO:0046826 |
negative regulation of protein export from nucleus |
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm. |
IEA |
BP |
GO:0051897 |
positive regulation of protein kinase B signaling |
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
IC |
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
IDA |
BP |
GO:1903206 |
negative regulation of hydrogen peroxide-induced cell death |
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death. |
IGI |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
TAS |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IBA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0015035 |
protein disulfide oxidoreductase activity |
Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. |
IBA |
MF |
GO:0015037 |
peptide disulfide oxidoreductase activity |
Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide bonds. |
IEA |
MF |
GO:0016671 |
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor |
Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. |
IBA |
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
Domain ID | Description |
---|---|
IPR005746 |
Thioredoxin |
IPR012336 |
Thioredoxin-like fold |
IPR013766 |
Thioredoxin domain |
IPR017937 |
Thioredoxin, conserved site |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04621 |
NOD-like receptor signaling pathway |
KEGG |
hsa05418 |
Fluid shear stress and atherosclerosis |
KEGG |
WP15 |
Selenium Micronutrient Network |
WikiPathways |
WP2884 |
NRF2 pathway |
WikiPathways |
WP231 |
TNF alpha Signaling Pathway |
WikiPathways |
WP3888 |
VEGFA-VEGFR2 Signaling Pathway |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0006287 |
Bronchopulmonary Dysplasia |
C0011616 |
Contact Dermatitis |
C0023895 |
Liver Diseases |
C0027626 |
Neoplasm Invasiveness |
C0242488 |
Acute Lung Injury |
Tissue | Cell Type |
---|---|
duodenum |
glandular cells |
fallopian tube |
glandular cells |
gallbladder |
glandular cells |
kidney |
cells in tubules |
placenta |
decidual cells |
rectum |
glandular cells |
small intestine |
glandular cells |
testis |
Leydig cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
15598877 |
Wood et al. |
2005 |
Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects |
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
ARHGDIA |
396 |
P52565 |
0.49 |
EEF2 |
1938 |
P13639 |
0.49 |
EIF4EBP2 |
1979 |
Q13542 |
0.49 |
UBE2K |
3093 |
P61086 |
0.49 |
HINT1 |
3094 |
P49773 |
0.49 |
HSPE1 |
3336 |
P61604 |
0.49 |
IMPA2 |
3613 |
O14732 |
0.49 |
RAB1A |
5861 |
P62820 |
0.49 |
SOD1 |
6647 |
P00441 |
0.49 |
TYMS |
7298 |
P04818 |
0.49 |
UBE2D2 |
7322 |
P62837 |
0.49 |
TAGLN2 |
8407 |
P37802 |
0.49 |
AKR7A2 |
8574 |
O43488 |
0.49 |
ATP6V1F |
9296 |
Q16864 |
0.49 |
GSTO1 |
9446 |
P78417 |
0.49 |
WDR1 |
9948 |
O75083 |
0.49 |
CCS |
9973 |
O14618 |
0.49 |
PDCD6 |
10016 |
O75340 |
0.49 |
STIP1 |
10963 |
P31948 |
0.49 |
TAGLN3 |
29114 |
Q9UI15 |
0.49 |
TAX1BP3 |
30851 |
O14907 |
0.49 |
GLOD4 |
51031 |
Q9HC38 |
0.49 |
UBQLN4 |
56893 |
Q9NRR5 |
0.49 |
UBL5 |
59286 |
Q9BZL1 |
0.49 |
UBE2V1 |
387522 |
Q13404 |
0.49 |
GFER |
2671 |
P55789 |
0.55 |
CDKN1A |
1026 |
P38936 |
0.63 |
FLNC |
2318 |
Q14315 |
0.63 |
MLH1 |
4292 |
P40692 |
0.63 |
PTPN6 |
5777 |
P29350 |
0.63 |
DYNLT1 |
6993 |
P63172 |
0.63 |
VIM |
7431 |
P08670 |
0.63 |
FST |
10468 |
P19883 |
0.63 |
SRP9 |
653226 |
P49458 |
0.63 |
DNAJA1 |
3301 |
P31689 |
0.65 |
SIAH1 |
6477 |
Q8IUQ4 |
0.65 |
HMGB1 |
3146 |
P09429 |
0.72 |
TP53 |
7157 |
P04637 |
0.75 |
COL1A1 |
1277 |
P02452 |
0.78 |
PRDX2 |
7001 |
P32119 |
0.79 |
PRDX1 |
5052 |
Q06830 |
0.83 |
NR3C1 |
2908 |
P04150 |
0.87 |
APEX1 |
328 |
P27695 |
0.88 |
NFKB1 |
4790 |
P19838 |
0.88 |
COPS5 |
10987 |
Q92905 |
0.88 |
ASS1 |
445 |
P00966 |
0.49 |
ATIC |
471 |
P31939 |
0.49 |
ENO1 |
2023 |
P06733 |
0.49 |
ENO2 |
2026 |
P09104 |
0.49 |
ENO3 |
2027 |
P13929 |
0.49 |
EWSR1 |
2130 |
Q01844 |
0.49 |
FKBP1A |
2280 |
P62942 |
0.49 |
FKBP2 |
2286 |
P26885 |
0.49 |
HSPA5 |
3309 |
P11021 |
0.49 |
IMPA1 |
3612 |
P29218 |
0.49 |
LGALS3 |
3958 |
P17931 |
0.49 |
PGAM1 |
5223 |
P18669 |
0.49 |
PGAM2 |
5224 |
P15259 |
0.49 |
MAP2K2 |
5605 |
P36507 |
0.49 |
SFPQ |
6421 |
P23246 |
0.49 |
RAE1 |
8480 |
P78406 |
0.49 |
PSMD14 |
10213 |
O00487 |
0.49 |
SYNCRIP |
10492 |
O60506 |
0.49 |
SSSCA1 |
10534 |
O60232 |
0.49 |
AHCYL1 |
10768 |
O43865 |
0.49 |
TXN2 |
25828 |
Q99757 |
0.49 |
GLRX5 |
51218 |
Q86SX6 |
0.49 |
C4orf27 |
54969 |
Q9NWY4 |
0.49 |
TMX1 |
81542 |
Q9H3N1 |
0.49 |
SFXN1 |
94081 |
Q9H9B4 |
0.49 |
GSTO2 |
119391 |
Q9H4Y5 |
0.49 |
SRPK2 |
6733 |
P78362 |
0.52 |
PTEN |
5728 |
P60484 |
0.56 |
UCHL5 |
51377 |
Q9Y5K5 |
0.56 |
CDK2 |
1017 |
P24941 |
0.63 |
CDK5 |
1020 |
Q00535 |
0.63 |
CRY1 |
1407 |
Q16526 |
0.63 |
EPB41 |
2035 |
P11171 |
0.63 |
GPX1 |
2876 |
P07203 |
0.63 |
HLA-B |
3106 |
P30480 |
0.63 |
ILK |
3611 |
Q13418 |
0.63 |
MCM2 |
4171 |
P49736 |
0.63 |
NFE2 |
4778 |
Q16621 |
0.63 |
NPM1 |
4869 |
P06748 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
PARK2 |
5071 |
O60260 |
0.63 |
PSPH |
5723 |
P78330 |
0.63 |
PTPN1 |
5770 |
P18031 |
0.63 |
SUMO2 |
6613 |
P61956 |
0.63 |
TRAF6 |
7189 |
Q9Y4K3 |
0.63 |
TSSC1 |
7260 |
Q53HC9 |
0.63 |
VCAM1 |
7412 |
P19320 |
0.63 |
UBL4A |
8266 |
P11441 |
0.63 |
CUL4B |
8450 |
Q13620 |
0.63 |
CUL2 |
8453 |
Q13617 |
0.63 |
CUL1 |
8454 |
Q13616 |
0.63 |
KIAA0101 |
9768 |
Q15004 |
0.63 |
PAN2 |
9924 |
Q504Q3 |
0.63 |
OXSR1 |
9943 |
O95747 |
0.63 |
PTBP3 |
9991 |
O95758 |
0.63 |
EIF1B |
10289 |
O60739 |
0.63 |
UBD |
10537 |
O15205 |
0.63 |
COPS6 |
10980 |
Q7L5N1 |
0.63 |
FAM107A |
11170 |
O95990 |
0.63 |
GABARAP |
11337 |
O95166 |
0.63 |
GABARAPL2 |
11345 |
P60520 |
0.63 |
GABARAPL1 |
23710 |
Q9H0R8 |
0.63 |
EEF2K |
29904 |
O00418 |
0.63 |
TMBIM4 |
51643 |
Q9HC24 |
0.63 |
DCUN1D1 |
54165 |
Q96GG9 |
0.63 |
OTUB1 |
55611 |
Q96FW1 |
0.63 |
FBXO11 |
80204 |
Q86XK2 |
0.63 |
MAP1LC3B |
81631 |
Q9GZQ8 |
0.63 |
MAP1LC3A |
84557 |
Q9H492 |
0.63 |
UNK |
85451 |
Q9C0B0 |
0.63 |
TP53RK |
112858 |
Q96S44 |
0.63 |
GPRASP2 |
114928 |
Q96D09 |
0.63 |
ACTN4 |
81 |
O43707 |
0.65 |
NCF4 |
4689 |
Q15080 |
0.65 |
YWHAZ |
7534 |
P63104 |
0.68 |
IFIT3 |
3437 |
O14879 |
0.72 |
MYC |
4609 |
P01106 |
0.72 |
GEMIN5 |
25929 |
Q8TEQ6 |
0.72 |
TOR1AIP1 |
26092 |
Q5JTV8 |
0.72 |
CD40 |
958 |
P25942 |
0.76 |
VHL |
7428 |
P40337 |
0.76 |
PINX1 |
54984 |
Q96BK5 |
0.76 |
MYD88 |
4615 |
Q99836 |
0.78 |
GAPDH |
2597 |
P04406 |
0.83 |
EGFR |
1956 |
P00533 |
0.89 |
MAP3K5 |
4217 |
Q99683 |
0.90 |
TXNIP |
10628 |
Q9H3M7 |
0.90 |