Protein Description

Gene Symbol TXN
Entrez ID 7295
Uniprot ID P10599
Description thioredoxin
Chromosomal Location chr9: 110,243,811-110,256,640
Ontology GO ID GO Term Definition Evidence

BP

GO:0000103

sulfate assimilation

The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds.

IBA

BP

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IEA

BP

GO:0000302

response to reactive oxygen species

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.

TAS

BP

GO:0006351

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

IEA

BP

GO:0006457

protein folding

The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

IBA

BP

GO:0006662

glycerol ether metabolic process

The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol.

IEA

BP

GO:0006928

movement of cell or subcellular component

The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.

TAS

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0007267

cell-cell signaling

Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.

TAS

BP

GO:0008283

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

TAS

BP

GO:0009314

response to radiation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.

IDA

BP

GO:0015949

nucleobase-containing small molecule interconversion

The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule.

TAS

BP

GO:0030091

protein repair

The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues.

TAS

BP

GO:0032148

activation of protein kinase B activity

Any process that initiates the activity of the inactive enzyme protein kinase B.

IC

BP

GO:0033138

positive regulation of peptidyl-serine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.

IGI

BP

GO:0033158

regulation of protein import into nucleus, translocation

Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane.

IDA

BP

GO:0043388

positive regulation of DNA binding

Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).

IDA

BP

GO:0045454

cell redox homeostasis

Any process that maintains the redox environment of a cell or compartment within a cell.

IBA

BP

GO:0046826

negative regulation of protein export from nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm.

IEA

BP

GO:0051897

positive regulation of protein kinase B signaling

Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.

IC

BP

GO:0055114

oxidation-reduction process

A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

IDA

BP

GO:1903206

negative regulation of hydrogen peroxide-induced cell death

Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death.

IGI

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

TAS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

IBA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0015035

protein disulfide oxidoreductase activity

Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.

IBA

MF

GO:0015037

peptide disulfide oxidoreductase activity

Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide bonds.

IEA

MF

GO:0016671

oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide.

IBA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

Domain ID Description

IPR005746

Thioredoxin

IPR012336

Thioredoxin-like fold

IPR013766

Thioredoxin domain

IPR017937

Thioredoxin, conserved site

Pathway ID Pathway Term Pathway Source

hsa04621

NOD-like receptor signaling pathway

KEGG

hsa05418

Fluid shear stress and atherosclerosis

KEGG

WP15

Selenium Micronutrient Network

WikiPathways

WP2884

NRF2 pathway

WikiPathways

WP231

TNF alpha Signaling Pathway

WikiPathways

WP3888

VEGFA-VEGFR2 Signaling Pathway

WikiPathways

UMLS CUI UMLS Term

C0006287

Bronchopulmonary Dysplasia

C0011616

Contact Dermatitis

C0023895

Liver Diseases

C0027626

Neoplasm Invasiveness

C0242488

Acute Lung Injury

Tissue Cell Type

duodenum

glandular cells

fallopian tube

glandular cells

gallbladder

glandular cells

kidney

cells in tubules

placenta

decidual cells

rectum

glandular cells

small intestine

glandular cells

testis

Leydig cells

No databases found.

Pubmed ID Author Year Title

15598877

Wood et al.

2005

Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

ARHGDIA

396

P52565

0.49

EEF2

1938

P13639

0.49

EIF4EBP2

1979

Q13542

0.49

UBE2K

3093

P61086

0.49

HINT1

3094

P49773

0.49

HSPE1

3336

P61604

0.49

IMPA2

3613

O14732

0.49

RAB1A

5861

P62820

0.49

SOD1

6647

P00441

0.49

TYMS

7298

P04818

0.49

UBE2D2

7322

P62837

0.49

TAGLN2

8407

P37802

0.49

AKR7A2

8574

O43488

0.49

ATP6V1F

9296

Q16864

0.49

GSTO1

9446

P78417

0.49

WDR1

9948

O75083

0.49

CCS

9973

O14618

0.49

PDCD6

10016

O75340

0.49

STIP1

10963

P31948

0.49

TAGLN3

29114

Q9UI15

0.49

TAX1BP3

30851

O14907

0.49

GLOD4

51031

Q9HC38

0.49

UBQLN4

56893

Q9NRR5

0.49

UBL5

59286

Q9BZL1

0.49

UBE2V1

387522

Q13404

0.49

GFER

2671

P55789

0.55

CDKN1A

1026

P38936

0.63

FLNC

2318

Q14315

0.63

MLH1

4292

P40692

0.63

PTPN6

5777

P29350

0.63

DYNLT1

6993

P63172

0.63

VIM

7431

P08670

0.63

FST

10468

P19883

0.63

SRP9

653226

P49458

0.63

DNAJA1

3301

P31689

0.65

SIAH1

6477

Q8IUQ4

0.65

HMGB1

3146

P09429

0.72

TP53

7157

P04637

0.75

COL1A1

1277

P02452

0.78

PRDX2

7001

P32119

0.79

PRDX1

5052

Q06830

0.83

NR3C1

2908

P04150

0.87

APEX1

328

P27695

0.88

NFKB1

4790

P19838

0.88

COPS5

10987

Q92905

0.88

ASS1

445

P00966

0.49

ATIC

471

P31939

0.49

ENO1

2023

P06733

0.49

ENO2

2026

P09104

0.49

ENO3

2027

P13929

0.49

EWSR1

2130

Q01844

0.49

FKBP1A

2280

P62942

0.49

FKBP2

2286

P26885

0.49

HSPA5

3309

P11021

0.49

IMPA1

3612

P29218

0.49

LGALS3

3958

P17931

0.49

PGAM1

5223

P18669

0.49

PGAM2

5224

P15259

0.49

MAP2K2

5605

P36507

0.49

SFPQ

6421

P23246

0.49

RAE1

8480

P78406

0.49

PSMD14

10213

O00487

0.49

SYNCRIP

10492

O60506

0.49

SSSCA1

10534

O60232

0.49

AHCYL1

10768

O43865

0.49

TXN2

25828

Q99757

0.49

GLRX5

51218

Q86SX6

0.49

C4orf27

54969

Q9NWY4

0.49

TMX1

81542

Q9H3N1

0.49

SFXN1

94081

Q9H9B4

0.49

GSTO2

119391

Q9H4Y5

0.49

SRPK2

6733

P78362

0.52

PTEN

5728

P60484

0.56

UCHL5

51377

Q9Y5K5

0.56

CDK2

1017

P24941

0.63

CDK5

1020

Q00535

0.63

CRY1

1407

Q16526

0.63

EPB41

2035

P11171

0.63

GPX1

2876

P07203

0.63

HLA-B

3106

P30480

0.63

ILK

3611

Q13418

0.63

MCM2

4171

P49736

0.63

NFE2

4778

Q16621

0.63

NPM1

4869

P06748

0.63

NTRK1

4914

P04629

0.63

PARK2

5071

O60260

0.63

PSPH

5723

P78330

0.63

PTPN1

5770

P18031

0.63

SUMO2

6613

P61956

0.63

TRAF6

7189

Q9Y4K3

0.63

TSSC1

7260

Q53HC9

0.63

VCAM1

7412

P19320

0.63

UBL4A

8266

P11441

0.63

CUL4B

8450

Q13620

0.63

CUL2

8453

Q13617

0.63

CUL1

8454

Q13616

0.63

KIAA0101

9768

Q15004

0.63

PAN2

9924

Q504Q3

0.63

OXSR1

9943

O95747

0.63

PTBP3

9991

O95758

0.63

EIF1B

10289

O60739

0.63

UBD

10537

O15205

0.63

COPS6

10980

Q7L5N1

0.63

FAM107A

11170

O95990

0.63

GABARAP

11337

O95166

0.63

GABARAPL2

11345

P60520

0.63

GABARAPL1

23710

Q9H0R8

0.63

EEF2K

29904

O00418

0.63

TMBIM4

51643

Q9HC24

0.63

DCUN1D1

54165

Q96GG9

0.63

OTUB1

55611

Q96FW1

0.63

FBXO11

80204

Q86XK2

0.63

MAP1LC3B

81631

Q9GZQ8

0.63

MAP1LC3A

84557

Q9H492

0.63

UNK

85451

Q9C0B0

0.63

TP53RK

112858

Q96S44

0.63

GPRASP2

114928

Q96D09

0.63

ACTN4

81

O43707

0.65

NCF4

4689

Q15080

0.65

YWHAZ

7534

P63104

0.68

IFIT3

3437

O14879

0.72

MYC

4609

P01106

0.72

GEMIN5

25929

Q8TEQ6

0.72

TOR1AIP1

26092

Q5JTV8

0.72

CD40

958

P25942

0.76

VHL

7428

P40337

0.76

PINX1

54984

Q96BK5

0.76

MYD88

4615

Q99836

0.78

GAPDH

2597

P04406

0.83

EGFR

1956

P00533

0.89

MAP3K5

4217

Q99683

0.90

TXNIP

10628

Q9H3M7

0.90