BP

GO:0002215

defense response to nematode

A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

ISS

BP

GO:0002526

acute inflammatory response

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

ISS

BP

GO:0002726

positive regulation of T cell cytokine production

Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.

ISS

BP

GO:0002819

regulation of adaptive immune response

Any process that modulates the frequency, rate, or extent of an adaptive immune response.

ISS

BP

GO:0002830

positive regulation of type 2 immune response

Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.

ISS

BP

GO:0002891

positive regulation of immunoglobulin mediated immune response

Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response.

ISS

BP

GO:0006955

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

IEA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0008203

cholesterol metabolic process

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.

IEA

BP

GO:0008284

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

TAS

BP

GO:0009615

response to virus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.

ISS

BP

GO:0032689

negative regulation of interferon-gamma production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.

ISS

BP

GO:0032700

negative regulation of interleukin-17 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.

IDA

BP

GO:0032729

positive regulation of interferon-gamma production

Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.

IDA

BP

GO:0032733

positive regulation of interleukin-10 production

Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.

ISS

BP

GO:0032735

positive regulation of interleukin-12 production

Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.

ISS

BP

GO:0032736

positive regulation of interleukin-13 production

Any process that activates or increases the frequency, rate, or extent of interleukin-13 production.

ISS

BP

GO:0032743

positive regulation of interleukin-2 production

Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.

IEA

BP

GO:0032753

positive regulation of interleukin-4 production

Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.

IDA

BP

GO:0032755

positive regulation of interleukin-6 production

Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.

IDA

BP

GO:0033209

tumor necrosis factor-mediated signaling pathway

A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

TAS

BP

GO:0035709

memory T cell activation

The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

ISS

BP

GO:0035712

T-helper 2 cell activation

The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

ISS

BP

GO:0035713

response to nitrogen dioxide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus.

ISS

BP

GO:0035714

cellular response to nitrogen dioxide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus.

IEA

BP

GO:0035783

CD4-positive, alpha-beta T cell costimulation

The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha-beta T cell activation.

IEA

BP

GO:0042098

T cell proliferation

The expansion of a T cell population by cell division. Follows T cell activation.

IEA

BP

GO:0042102

positive regulation of T cell proliferation

Any process that activates or increases the rate or extent of T cell proliferation.

IBA

BP

GO:0042104

positive regulation of activated T cell proliferation

Any process that activates or increases the rate or extent of activated T cell proliferation.

IEA

BP

GO:0043372

positive regulation of CD4-positive, alpha-beta T cell differentiation

Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation.

ISS

BP

GO:0043382

positive regulation of memory T cell differentiation

Any process that activates or increases the frequency, rate or extent of memory T cell differentiation.

ISS

BP

GO:0043433

negative regulation of sequence-specific DNA binding transcription factor activity

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

ISS

BP

GO:0045590

negative regulation of regulatory T cell differentiation

Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells.

ISS

BP

GO:0045626

negative regulation of T-helper 1 cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation.

ISS

BP

GO:0045630

positive regulation of T-helper 2 cell differentiation

Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation.

ISS

BP

GO:0045892

negative regulation of transcription, DNA-templated

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

ISS

BP

GO:0046641

positive regulation of alpha-beta T cell proliferation

Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation.

ISS

BP

GO:0050710

negative regulation of cytokine secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.

IEA

BP

GO:0050727

regulation of inflammatory response

Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.

ISS

BP

GO:0050729

positive regulation of inflammatory response

Any process that activates or increases the frequency, rate or extent of the inflammatory response.

IDA

BP

GO:0050871

positive regulation of B cell activation

Any process that activates or increases the frequency, rate or extent of B cell activation.

ISS

BP

GO:0051024

positive regulation of immunoglobulin secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell.

ISS

BP

GO:0071222

cellular response to lipopolysaccharide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.

IDA

BP

GO:0071380

cellular response to prostaglandin E stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.

IDA

BP

GO:0071954

chemokine (C-C motif) ligand 11 production

The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

ISS

BP

GO:1900281

positive regulation of CD4-positive, alpha-beta T cell costimulation

Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation.

ISS

BP

GO:2000568

positive regulation of memory T cell activation

Any process that activates or increases the frequency, rate or extent of memory T cell activation.

IEA

BP

GO:2000570

positive regulation of T-helper 2 cell activation

Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation.

IEA

BP

GO:2000572

positive regulation of interleukin-4-dependent isotype switching to IgE isotypes

Any process that activates or increases the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes.

ISS

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

NAS

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

IDA

MF

GO:0005102

receptor binding

Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

TAS

MF

GO:0005125

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

IEA

MF

GO:0005164

tumor necrosis factor receptor binding

Interacting selectively and non-covalently with the tumor necrosis factor receptor.

IEA

MF

GO:0032813

tumor necrosis factor receptor superfamily binding

Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily.

IBA|ISS