PCOSBase

Protein Description

Gene Symbol	TUBA4A
Entrez ID	7277
Uniprot ID	P68366
Description	tubulin alpha 4a
Chromosomal Location	chr2: 219,249,711-219,278,170

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0000086	G2/M transition of mitotic cell cycle	The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.	TAS
BP	GO:0002576	platelet degranulation	The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.	TAS
BP	GO:0007010	cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.	IEA
BP	GO:0007017	microtubule-based process	Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.	IEA
CC	GO:0005576	extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.	TAS
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	TAS
CC	GO:0005874	microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.	IDA
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
MF	GO:0003924	GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + phosphate.	IEA
MF	GO:0005200	structural constituent of cytoskeleton	The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.	IEA
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0005525	GTP binding	Interacting selectively and non-covalently with GTP, guanosine triphosphate.	IEA
MF	GO:0019899	enzyme binding	Interacting selectively and non-covalently with any enzyme.	IEA

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Domain ID	Description
IPR000217	Tubulin
IPR002452	Alpha tubulin
IPR003008	Tubulin/FtsZ, GTPase domain
IPR008280	Tubulin/FtsZ, C-terminal
IPR017975	Tubulin, conserved site
IPR018316	Tubulin/FtsZ, 2-layer sandwich domain

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Pathway ID	Pathway Term	Pathway Source
hsa04145	Phagosome	KEGG
hsa04210	Apoptosis	KEGG
hsa04530	Tight junction	KEGG
hsa04540	Gap junction	KEGG
hsa05130	Pathogenic Escherichia coli infection	KEGG
WP2272	Pathogenic Escherichia coli infection	WikiPathways
WP2359	Parkin-Ubiquitin Proteasomal System pathway	WikiPathways
h_mta3Pathway	Downregulated of MTA-3 in ER-negative Breast Tumors	BioCarta

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No diseases found.

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
appendix	lymphoid tissue
bone marrow	hematopoietic cells
breast	glandular cells
breast	myoepithelial cells
bronchus	respiratory epithelial cells
caudate	neuronal cells
cerebral cortex	neuronal cells
cerebral cortex	neuropil
cervix, uterine	glandular cells
colon	endothelial cells
colon	glandular cells
colon	peripheral nerve/ganglion
duodenum	glandular cells
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
hippocampus	neuronal cells
lung	macrophages
lung	pneumocytes
lymph node	germinal center cells
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
ovary	follicle cells
ovary	ovarian stroma cells
pancreas	exocrine glandular cells
pancreas	islets of Langerhans
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skin	fibroblasts
skin	keratinocytes
skin	Langerhans
skin	melanocytes
skin	epidermal cells
small intestine	glandular cells
soft tissue	chondrocytes
soft tissue	fibroblasts
soft tissue	peripheral nerve
stomach	glandular cells
testis	cells in seminiferous ducts
thyroid gland	glandular cells
tonsil	germinal center cells
tonsil	non-germinal center cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells

No databases found.

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Pubmed ID	Author	Year	Title
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome
25393639	Ambekar et al.	2014	Proteomics of follicular fluid from women with polycystic ovary syndrome suggests molecular defects in follicular development

Gene Symbol	Entrez ID	Uniprot ID	Score
EEF1A1	1915	P68104	0.49
HNRNPK	3190	P61978	0.49
SMAD2	4087	Q15796	0.49
RUVBL1	8607	Q9Y265	0.49
PRPF8	10594	Q6P2Q9	0.49
LTA	4049	P01374	0.52
SKA1	220134	Q96BD8	0.55
RUVBL2	10856	Q9Y230	0.56
TUBB2B	347733	Q9BVA1	0.56
TCP1	6950	P17987	0.59
TUBB3	10381	Q13509	0.59
CALB2	794	P22676	0.62
ZAP70	7535	P43403	0.62
HSPA1A	3303	P0DMV8	0.63
HSPA1B	3304	P0DMV9	0.63
PRPS1	5631	P60891	0.63
RPS27A	6233	P62979	0.63
TXNRD1	7296	Q16881	0.63
MAGED1	9500	Q9Y5V3	0.63
BCAR1	9564	P56945	0.63
RBM23	55147	Q86U06	0.63
C4orf17	84103	Q53FE4	0.63
SIMC1	375484	Q8NDZ2	0.63
MGRN1	23295	O60291	0.65
FYN	2534	P06241	0.66
TUBB4B	10383	P68371	0.73
TUBB2A	7280	Q13885	0.74
TUBB	203068	P07437	0.74
PARK2	5071	O60260	0.75
MAPT	4137	P10636	0.83
MYC	4609	P01106	0.85
GJA1	2697	P17302	0.0
E2F1	1869	Q01094	0.49
HSPB1	3315	P04792	0.49
ILF3	3609	Q12906	0.49
MYH9	4627	P35579	0.49
PGK1	5230	P00558	0.49
PKM	5315	P14618	0.49
TUBB4A	10382	P04350	0.49
BRCA1	672	P38398	0.52
B4GALT1	2683	P15291	0.52
LGALS2	3957	P05162	0.52
PFDN4	5203	Q9NQP4	0.52
SYK	6850	P43405	0.52
VDAC1	7416	P21796	0.52
YWHAG	7532	P61981	0.52
TAOK2	9344	Q9UL54	0.52
SIRT2	22933	Q8IXJ6	0.52
RAB8B	51762	Q92930	0.52
RTN4	57142	Q9NQC3	0.52
EPB41	2035	P11171	0.55
GRM7	2917	Q14831	0.55
RBBP5	5929	Q15291	0.55
VAV1	7409	P15498	0.55
HDAC6	10013	Q9UBN7	0.55
GPHN	10243	Q9NQX3	0.55
MARK4	57787	Q96L34	0.55
NCALD	83988	P61601	0.55
GRB2	2885	P62993	0.56
TNPO1	3842	Q92973	0.56
PEX14	5195	O75381	0.56
PSMC4	5704	P43686	0.56
UCHL5	51377	Q9Y5K5	0.56
CAD	790	P27708	0.59
POLR2B	5431	P30876	0.59
PSMD1	5707	Q99460	0.59
RAC1	5879	P63000	0.62
RACGAP1	29127	Q9H0H5	0.62
ACTN2	88	P35609	0.63
CD81	975	P60033	0.63
CDC5L	988	Q99459	0.63
CDC20	991	Q12834	0.63
CRYZ	1429	Q08257	0.63
ENO2	2026	P09104	0.63
GNAI2	2771	P04899	0.63
HSPA5	3309	P11021	0.63
HTR7	3363	P34969	0.63
ICAM1	3383	P05362	0.63
IL12RB1	3594	P42701	0.63
ISLR	3671	O14498	0.63
JUN	3725	P05412	0.63
TM4SF1	4071	P30408	0.63
SMAD1	4086	Q15797	0.63
MCM2	4171	P49736	0.63
MDM2	4193	Q00987	0.63
MOV10	4343	Q9HCE1	0.63
NEDD8	4738	Q15843	0.63
NFKB1	4790	P19838	0.63
YBX1	4904	P67809	0.63
PPP2R2A	5520	P63151	0.63
PRG2	5553	P13727	0.63
RPA1	6117	P27694	0.63
RPA2	6118	P15927	0.63
RPA3	6119	P35244	0.63
RPL12	6136	P30050	0.63
S100A8	6279	P05109	0.63
SKI	6497	P12755	0.63
SLAMF1	6504	Q13291	0.63
SUMO2	6613	P61956	0.63
SOX2	6657	P48431	0.63
STAU1	6780	O95793	0.63
STK4	6789	Q13043	0.63
THBS3	7059	P49746	0.63
TP53	7157	P04637	0.63
TUBG1	7283	P23258	0.63
VHL	7428	P40337	0.63
CUL5	8065	Q93034	0.63
CUL4B	8450	Q13620	0.63
CUL4A	8451	Q13619	0.63
CUL3	8452	Q13618	0.63
CUL2	8453	Q13617	0.63
CUL1	8454	Q13616	0.63
CDK13	8621	Q14004	0.63
CEP57	9702	Q86XR8	0.63
KIAA0101	9768	Q15004	0.63
CUL7	9820	Q14999	0.63
DDX39A	10212	O00148	0.63
NXF1	10482	Q9UBU9	0.63
B3GNT2	10678	Q9NY97	0.63
TUBGCP2	10844	Q9BSJ2	0.63
MAGED2	10916	Q9UNF1	0.63
COPS6	10980	Q7L5N1	0.63
COPS5	10987	Q92905	0.63
KLK11	11012	Q9UBX7	0.63
NXPH3	11248	O95157	0.63
GABARAP	11337	O95166	0.63
GABARAPL2	11345	P60520	0.63
SNW1	22938	Q13573	0.63
OBSL1	23363	O75147	0.63
SRRM2	23524	Q9UQ35	0.63
GABARAPL1	23710	Q9H0R8	0.63
KLK5	25818	Q9Y337	0.63
FBXO25	26260	Q8TCJ0	0.63
TRAC	28755	P01848	0.63
DNAJB11	51726	Q9UBS4	0.63
DCUN1D1	54165	Q96GG9	0.63
HAUS2	55142	Q9NVX0	0.63
CAND1	55832	Q86VP6	0.63
CTDSP1	58190	Q9GZU7	0.63
DNASE2B	58511	Q8WZ79	0.63
NYX	60506	Q9GZU5	0.63
CCNJL	79616	Q8IV13	0.63
TXNDC15	79770	Q96J42	0.63
CEP76	79959	Q8TAP6	0.63
TUBA4B	80086	Q9H853	0.63
MAP1LC3B	81631	Q9GZQ8	0.63
ANTXR1	84168	Q9H6X2	0.63
TUBB6	84617	Q9BUF5	0.63
TMEM25	84866	Q86YD3	0.63
IGSF8	93185	Q969P0	0.63
HAUS1	115106	Q96CS2	0.63
ARHGAP1	392	Q07960	0.65
MAP1A	4130	P78559	0.65
PLK1	5347	P53350	0.65
BTK	695	Q06187	0.68
TBCE	6905	Q15813	0.68
TBCB	1155	Q99426	0.7
XPO1	7514	O14980	0.7
ARAF	369	P10398	0.72
ARRB1	408	P49407	0.72
ARRB2	409	P32121	0.72
ASCL2	430	Q99929	0.72
ILK	3611	Q13418	0.72
JAK3	3718	P52333	0.72
LIMK2	3985	P53671	0.72
STXBP1	6812	P61764	0.72
TYK2	7297	P29597	0.72
IQCB1	9657	Q15051	0.72
SIK2	23235	Q9H0K1	0.72
TUBA1A	7846	Q71U36	0.73
HSPH1	10808	Q92598	0.73
TUBA1C	84790	Q9BQE3	0.73
STARD13	90627	Q9Y3M8	0.73
SIAH1	6477	Q8IUQ4	0.74
NCOA6	23054	Q14686	0.74
MAP1LC3A	84557	Q9H492	0.75
APC	324	P25054	0.76
ERBB3	2065	P21860	0.82
CLIP1	6249	P30622	0.83
EGFR	1956	P00533	0.88