BP

GO:0002576

platelet degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.

TAS

BP

GO:0003300

cardiac muscle hypertrophy

The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.

IMP

BP

GO:0006936

muscle contraction

A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.

NAS|TAS

BP

GO:0006941

striated muscle contraction

A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.

TAS

BP

GO:0007076

mitotic chromosome condensation

The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.

IEP

BP

GO:0018108

peptidyl-tyrosine phosphorylation

The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.

IEA

BP

GO:0030049

muscle filament sliding

The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.

TAS

BP

GO:0030240

skeletal muscle thin filament assembly

The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle.

IMP

BP

GO:0030241

skeletal muscle myosin thick filament assembly

The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle.

IMP

BP

GO:0035995

detection of muscle stretch

The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal.

IDA|TAS

BP

GO:0045214

sarcomere organization

The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

IMP

BP

GO:0045859

regulation of protein kinase activity

Any process that modulates the frequency, rate or extent of protein kinase activity.

IMP

BP

GO:0048739

cardiac muscle fiber development

The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure.

IMP

BP

GO:0048769

sarcomerogenesis

The process in which sarcomeres are added in series within a fiber.

IMP

BP

GO:0050790

regulation of catalytic activity

Any process that modulates the activity of an enzyme.

IMP

BP

GO:0051592

response to calcium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.

IDA

BP

GO:0055003

cardiac myofibril assembly

The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.

IMP

BP

GO:0055008

cardiac muscle tissue morphogenesis

The process in which the anatomical structures of cardiac muscle tissue are generated and organized.

IMP

BP

GO:0060048

cardiac muscle contraction

Muscle contraction of cardiac muscle tissue.

IMP

CC

GO:0000794

condensed nuclear chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.

IDA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

TAS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005859

muscle myosin complex

A filament of myosin found in a muscle cell of any type.

IBA

CC

GO:0030018

Z disc

Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

IDA

CC

GO:0031674

I band

A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.

IDA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0002020

protease binding

Interacting selectively and non-covalently with any protease or peptidase.

IPI

MF

GO:0004674

protein serine/threonine kinase activity

Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

IDA

MF

GO:0004713

protein tyrosine kinase activity

Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

IDA

MF

GO:0005509

calcium ion binding

Interacting selectively and non-covalently with calcium ions (Ca2+).

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005516

calmodulin binding

Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.

IPI|TAS

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0008307

structural constituent of muscle

The action of a molecule that contributes to the structural integrity of a muscle fiber.

IMP|TAS

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IPI

MF

GO:0019901

protein kinase binding

Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

IPI

MF

GO:0031433

telethonin binding

Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase.

IPI|ISS

MF

GO:0042802

identical protein binding

Interacting selectively and non-covalently with an identical protein or proteins.

IPI

MF

GO:0042805

actinin binding

Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin.

IDA|IPI

MF

GO:0043621

protein self-association

Interacting selectively and non-covalently with a domain within the same polypeptide.

IDA

MF

GO:0051015

actin filament binding

Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.

IDA

MF

GO:0051371

muscle alpha-actinin binding

Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.

IPI

MF

GO:0097493

structural molecule activity conferring elasticity

The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling.

TAS