PCOSBase

Protein Description

Gene Symbol	TRAF1
Entrez ID	7185
Uniprot ID	Q13077
Description	TNF receptor associated factor 1
Chromosomal Location	chr9: 120,902,393-120,929,173

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0006461	protein complex assembly	The aggregation, arrangement and bonding together of a set of components to form a protein complex.	TAS
BP	GO:0006915	apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.	IEA
BP	GO:0007165	signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.	IEA
BP	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.	TAS
BP	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.	IDA
BP	GO:2001236	regulation of extrinsic apoptotic signaling pathway	Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway.	IDA
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	TAS
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	TAS
MF	GO:0005164	tumor necrosis factor receptor binding	Interacting selectively and non-covalently with the tumor necrosis factor receptor.	IPI
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0008270	zinc ion binding	Interacting selectively and non-covalently with zinc (Zn) ions.	IEA
MF	GO:0031625	ubiquitin protein ligase binding	Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.	IPI
MF	GO:0031996	thioesterase binding	Interacting selectively and non-covalently with any thioesterase enzyme.	IPI

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Domain ID	Description
IPR002083	MATH/TRAF domain
IPR008974	TRAF-like
IPR012227	TNF receptor-associated factor TRAF
IPR027136	TNF receptor-associated factor 1
IPR032070	TNF receptor-associated factor, BIRC3 binding domain

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Pathway ID	Pathway Term	Pathway Source
hsa04064	NF-kappa B signaling pathway	KEGG
hsa04210	Apoptosis	KEGG
hsa04668	TNF signaling pathway	KEGG
hsa05168	Herpes simplex infection	KEGG
hsa05169	Epstein-Barr virus infection	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05202	Transcriptional misregulation in cancer	KEGG
hsa05203	Viral carcinogenesis	KEGG
hsa05222	Small cell lung cancer	KEGG
WP3941	Oxidative Damage	WikiPathways
WP262	EBV LMP1 signaling	WikiPathways
WP2036	TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway	WikiPathways
WP254	Apoptosis	WikiPathways
WP231	TNF alpha Signaling Pathway	WikiPathways
WP2018	RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway	WikiPathways
WP2864	Apoptosis-related network due to altered Notch3 in ovarian cancer	WikiPathways
h_HivnefPathway	HIV-I Nef: negative effector of Fas and TNF	BioCarta
h_tnfr2Pathway	TNFR2 Signaling Pathway	BioCarta

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UMLS CUI	UMLS Term
C0000786	Spontaneous Abortion
C0003873	Rheumatoid Arthritis
C0013274	Patent Ductus Arteriosus
C0033578	Prostatic Neoplasms

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Tissue	Cell Type
appendix	lymphoid tissue
lymph node	germinal center cells
lymph node	non-germinal center cells
spleen	cells in white pulp
tonsil	germinal center cells
tonsil	non-germinal center cells

No databases found.

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Pubmed ID	Author	Year	Title
22789864	Yan et al.	2012	Expression of apoptosis-related genes in the endometrium of polycystic ovary syndrome patients during the window of implantation

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Gene Symbol	Entrez ID	Uniprot ID	Score
POM121L1P	25812	Q3SYA9	0.49
TRAF3IP2	10758	O43734	0.55
TRAF3	7187	Q13114	0.63
UBB	7314	P0CG47	0.63
UBC	7316	P0CG48	0.63
ZNF20	7568	P17024	0.63
ZNF124	7678	Q15973	0.63
TCL1A	8115	P56279	0.63
AKAP17A	8227	Q02040	0.63
GFI1B	8328	Q5VTD9	0.63
LATS1	9113	O95835	0.63
RASAL2	9462	Q9UJF2	0.63
NUP58	9818	Q9BVL2	0.63
JOSD1	9929	Q15040	0.63
TSSC4	10078	Q9Y5U2	0.63
NEBL	10529	O76041	0.63
GLRX3	10539	O76003	0.63
MAPRE2	10982	Q15555	0.63
PRDM7	11105	Q9NQW5	0.63
SNW1	22938	Q13573	0.63
PPP1R13B	23368	Q96KQ4	0.63
SIK3	23387	Q9Y2K2	0.63
HEY2	23493	Q9UBP5	0.63
ZFYVE26	23503	Q68DK2	0.63
CARHSP1	23589	Q9Y2V2	0.63
GORASP2	26003	Q9H8Y8	0.63
A1CF	29974	Q9NQ94	0.63
SH3KBP1	30011	Q96B97	0.63
MYEF2	50804	Q9P2K5	0.63
PHF21A	51317	Q96BD5	0.63
WAC	51322	Q9BTA9	0.63
SPG21	51324	Q9NZD8	0.63
POP5	51367	Q969H6	0.63
ZNF581	51545	Q9P0T4	0.63
CYB5R2	51700	Q6BCY4	0.63
CCHCR1	54535	Q8TD31	0.63
QRICH1	54870	Q2TAL8	0.63
CHCHD3	54927	Q9NX63	0.63
C1orf109	54955	Q9NX04	0.63
C14orf105	55195	Q9NVL8	0.63
FAM86C1	55199	Q9NVL1	0.63
RBM41	55285	Q96IZ5	0.63
RYDEN	55337	Q9NUL5	0.63
TRPV6	55503	Q9H1D0	0.63
KIAA1217	56243	Q5T5P2	0.63
DIABLO	56616	Q9NR28	0.63
GATAD2B	57459	Q8WXI9	0.63
ZNF512B	57473	Q96KM6	0.63
NUFIP2	57532	Q7Z417	0.63
DMRT3	58524	Q9NQL9	0.63
UBE2O	63893	Q9C0C9	0.63
GMCL1P1	64396	Q8NEA9	0.63
METTL17	64745	Q9H7H0	0.63
DEPTOR	64798	Q8TB45	0.63
SCNM1	79005	Q9BWG6	0.63
ZFYVE21	79038	Q9BQ24	0.63
ARSJ	79642	Q5FYB0	0.63
ZC2HC1C	79696	Q53FD0	0.63
DOK3	79930	Q7L591	0.63
FBXL18	80028	Q96ME1	0.63
THAP7	80764	Q9BT49	0.63
CDCA3	83461	Q99618	0.63
RASSF5	83593	Q8WWW0	0.63
PLEKHN1	84069	Q494U1	0.63
FAM161A	84140	Q3B820	0.63
LCOR	84458	Q96JN0	0.63
BEX2	84707	Q9BXY8	0.63
NFATC2IP	84901	Q8NCF5	0.63
ZNF587	84914	Q96SQ5	0.63
RELT	84957	Q969Z4	0.63
CCDC120	90060	Q96HB5	0.63
C5orf30	90355	Q96GV9	0.63
ZNF697	90874	Q5TEC3	0.63
ZNF502	91392	Q8TBZ5	0.63
SYCE1	93426	Q8N0S2	0.63
HAUS1	115106	Q96CS2	0.63
TNFRSF13C	115650	Q96RJ3	0.63
TBC1D16	125058	Q8TBP0	0.63
C1orf216	127703	Q8TAB5	0.63
RBM45	129831	Q8IUH3	0.63
ZNF572	137209	Q7Z3I7	0.63
ZNF417	147687	Q8TAU3	0.63
LOC149950	149950	N/A	0.63
ALS2CR11	151254	Q53TS8	0.63
ZNF564	163050	Q8TBZ8	0.63
POM121L4P	266697	N/A	0.63
MORN3	283385	Q6PF18	0.63
RTP5	285093	Q14D33	0.63
TRIM42	287015	Q8IWZ5	0.63
KLHL38	340359	Q2WGJ6	0.63
ZNF662	389114	Q6ZS27	0.63
RBCK1	10616	Q9BYM8	0.68
RNF31	55072	Q96EP0	0.68
ACTG1	71	P63261	0.72
SLC25A5	292	P05141	0.72
C1QBP	708	Q07021	0.72
DDX3X	1654	O00571	0.72
DDX5	1655	P17844	0.72
GAPDH	2597	P04406	0.72
HSPA1A	3303	P0DMV8	0.72
HSPA1B	3304	P0DMV9	0.72
HSPA1L	3305	P34931	0.72
HSPA8	3312	P11142	0.72
HSPA9	3313	P38646	0.72
HSP90AA1	3320	P07900	0.72
IGHG1	3500	P01857	0.72
MAP3K5	4217	Q99683	0.72
NAP1L1	4673	P55209	0.72
NONO	4841	Q15233	0.72
PPIB	5479	P23284	0.72
RCN2	5955	Q14257	0.72
RPS3	6188	P23396	0.72
SFPQ	6421	P23246	0.72
ANP32A	8125	P39687	0.72
BAG2	9532	O95816	0.72
TUBB4A	10382	P04350	0.72
ZMYND11	10771	Q15326	0.72
APIP	51074	Q96GX9	0.72
NT5DC2	64943	Q9H857	0.72
TIMM50	92609	Q3ZCQ8	0.72
TUBB	203068	P07437	0.72
TUBA3C; TUBA3D	113457	Q13748	0.72
CHUK	1147	O15111	0.73
CCDC146	57639	Q8IYE0	0.73
FBF1	85302	Q8TES7	0.73
CCDC116	164592	Q8IYX3	0.73
OLIG3	167826	Q7RTU3	0.73
CD40	958	P25942	0.78
TNFRSF17	608	Q02223	0.83
TNFRSF1A	7132	P19438	0.86
TNFAIP3	7128	P21580	0.88
TRAF1	7185	Q13077	0.89
TNFRSF8	943	P28908	0.90
TNFRSF1B	7133	P20333	0.90
TRAF2	7186	Q12933	0.90
SLC25A48	153328	Q6ZT89	0.63
YT011_HUMAN	N/A	Q5W150	0.49
MAP6	4135	Q96JE9	0.52
PKN1	5585	Q16512	0.52
EDAR	10913	Q9UNE0	0.52
BEX3	27018	Q00994	0.52
SSC5D	284297	A1L4H1	0.63
ACTN3	89	Q08043	0.63
ADRB2	154	P07550	0.63
AES	166	Q08117	0.63
SLC25A6	293	P12236	0.63
AQP1	358	P29972	0.63
TRIM23	373	P36406	0.63
KIF1A	547	Q12756	0.63
BARD1	580	Q99728	0.63
BCL6	604	P41182	0.63
CD40LG	959	P29965	0.63
CDKN1A	1026	P38936	0.63
CDKN2B	1030	P42772	0.63
COX5B	1329	P10606	0.63
CRYGA	1418	P11844	0.63
ECH1	1891	Q13011	0.63
EHHADH	1962	Q08426	0.63
EWSR1	2130	Q01844	0.63
FOSL2	2355	P15408	0.63
GATA2	2624	P23769	0.63
GEM	2669	P55040	0.63
GNG5	2787	P63218	0.63
HOXA1	3198	P49639	0.63
HOXD12	3238	P35452	0.63
KPNA2	3838	P52292	0.63
MOS	4342	P00540	0.63
PBX3	5090	P40426	0.63
PDE4D	5144	Q08499	0.63
PIN1	5300	Q13526	0.63
PSMA1	5682	P25786	0.63
PSMB1	5689	P20618	0.63
STK3	6788	Q13188	0.63
TEAD4	7004	Q15561	0.63
TFAP4	7023	Q01664	0.63
TP53	7157	P04637	0.63
DGCR6	8214	Q14129	0.63
ARNT2	9915	Q9HBZ2	0.63
HMG20B	10362	Q9P0W2	0.63
CDC40	51362	O60508	0.63
ZNF250	58500	P15622	0.63
EDA2R	60401	Q9HAV5	0.63
ABHD17A	81926	Q96GS6	0.63
TMC8	147138	Q8IU68	0.63
CASP6	839	P55212	0.67
CASP10	843	Q92851	0.67
SUMO2	6613	P61956	0.68
CASP3	836	P42574	0.69
CD27	939	P26842	0.72
DNAJA1	3301	P31689	0.72
NGFR	4804	P08138	0.72
ZNF440	126070	Q8IYI8	0.73
TRAF6	7189	Q9Y4K3	0.74
TANK	10010	Q92844	0.74
SPOP	8405	O43791	0.75
TNFRSF19	55504	Q9NS68	0.75
GIT2	9815	Q14161	0.76
TNFRSF4	7293	P43489	0.82
SRC	6714	P12931	0.84
TICAM1	148022	Q8IUC6	0.84
TRIM37	4591	O94972	0.85
USP7	7874	Q93009	0.85
TNFRSF14	8764	Q92956	0.85
IKBKB	3551	O14920	0.86
RIPK2	8767	O43353	0.86
HIVEP3	59269	Q5T1R4	0.86
LTBR	4055	P36941	0.87
TRADD	8717	Q15628	0.88
TNFRSF18	8784	Q9Y5U5	0.88
CFLAR	8837	O15519	0.88
TNFRSF12A	51330	Q9NP84	0.88
CASP8	841	Q14790	0.89
RIPK1	8737	Q13546	0.89
TNFSF9	8744	P41273	0.89
MAP3K14	9020	Q99558	0.89
TRAIP	10293	Q9BWF2	0.89
BIRC2	329	Q13490	0.90
BIRC3	330	Q13489	0.90
TNFRSF9	3604	Q07011	0.96
TNFRSF11A	8792	Q9Y6Q6	0.96