PCOSBase

Protein Description

Gene Symbol	TPM3
Entrez ID	7170
Uniprot ID	P06753
Description	tropomyosin 3
Chromosomal Location	chr1: 154,155,304-154,194,648

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0006928	movement of cell or subcellular component	The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.	TAS
BP	GO:0006936	muscle contraction	A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.	TAS
BP	GO:0030049	muscle filament sliding	The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.	TAS
CC	GO:0001725	stress fiber	A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.	IDA
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	TAS
CC	GO:0005856	cytoskeleton	Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.	NAS\|TAS
CC	GO:0005862	muscle thin filament tropomyosin	A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments.	TAS
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
MF	GO:0003674	molecular_function	Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.	ND
MF	GO:0003779	actin binding	Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.	IEA
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI

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Domain ID	Description
IPR000533	Tropomyosin

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Pathway ID	Pathway Term	Pathway Source
hsa04260	Cardiac muscle contraction	KEGG
hsa04261	Adrenergic signaling in cardiomyocytes	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05216	Thyroid cancer	KEGG
hsa05410	Hypertrophic cardiomyopathy (HCM)	KEGG
hsa05414	Dilated cardiomyopathy	KEGG
WP383	Striated Muscle Contraction	WikiPathways

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UMLS CUI	UMLS Term
C0001418	Adenocarcinoma
C0009375	Colonic Neoplasms
C0024667	Animal Mammary Neoplasms
C0024668	Mammary Neoplasms, Experimental
C0038356	Stomach Neoplasms
C0040136	Thyroid Neoplasm
C0334121	Inflammatory Myofibroblastic Tumor
C0546264	Congenital Fiber Type Disproportion

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Tissue	Cell Type
colon	endothelial cells
skeletal muscle	myocytes
skin	fibroblasts
soft tissue	fibroblasts

No databases found.

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Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
ACTN2	88	P35609	0.49
ATP1A1	476	P05023	0.49
CKB	1152	P12277	0.49
CYC1	1537	P08574	0.49
COX5A	9377	P20674	0.49
AHCYL1	10768	O43865	0.49
OSTF1	26578	Q92882	0.49
CKMT1A; CKMT1B	1159	P12532	0.49
S100A2	6273	P29034	0.55
TPM4	7171	P67936	0.56
ACTB	60	P60709	0.62
DVL2	1856	O14641	0.63
FASN	2194	P49327	0.63
FKBP4	2288	Q02790	0.63
FKBP5	2289	Q13451	0.63
TRIP6	7205	Q15654	0.63
TLK1	9874	Q9UKI8	0.63
MAGED2	10916	Q9UNF1	0.63
OIP5	11339	O43482	0.63
BLOC1S6	26258	Q9UL45	0.63
FBXO5	26271	Q9UKT4	0.63
HOOK2	29911	Q96ED9	0.63
CCHCR1	54535	Q8TD31	0.63
THAP1	55145	Q9NVV9	0.63
CCDC146	57639	Q8IYE0	0.63
CCDC102B	79839	Q68D86	0.63
CCDC114	93233	Q96M63	0.63
SYCE1	93426	Q8N0S2	0.63
LCA5L	150082	O95447	0.63
FAM9C	171484	Q8IZT9	0.63
HDDC3	374659	Q8N4P3	0.63
WASH3P	374666	C4AMC7	0.63
LURAP1	541468	Q96LR2	0.63
ACTA1	58	P68133	0.65
IFIT3	3437	O14879	0.73
MAD1L1	8379	Q9Y6D9	0.73
TFPT	29844	P0C1Z6	0.73
KXD1	79036	Q9BQD3	0.73
IKBIP	121457	Q70UQ0	0.73
C1orf216	127703	Q8TAB5	0.73
IKBKE	9641	Q14164	0.86
TPM3	7170	P06753	0.95
TNNI3	7137	P19429	0.00
TNNT2	7139	P45379	0.00
ACTN4	81	O43707	0.49
ACTN1	87	P12814	0.49
ATP5F1	515	P24539	0.49
COX4I1	1327	P13073	0.49
HSPB1	3315	P04792	0.49
STMN1	3925	P16949	0.49
NDUFB10	4716	O96000	0.49
PRDX1	5052	Q06830	0.49
PSMA2	5683	P25787	0.49
PSMA6	5687	P60900	0.49
TBCD	6904	Q9BTW9	0.49
TPM2	7169	P07951	0.49
UQCRC2	7385	P22695	0.49
SF3A2	8175	Q15428	0.49
CDC123	8872	O75794	0.49
KYNU	8942	Q16719	0.49
THOC1	9984	Q96FV9	0.49
SEPT9	10801	Q9UHD8	0.49
SEC23IP	11196	Q9Y6Y8	0.49
MTCH1	23787	Q9NZJ7	0.49
MYH7B	57644	A7E2Y1	0.49
S100A4	6275	P26447	0.52
TMOD1	7111	P28289	0.52
TMOD2	29767	Q9NZR1	0.52
SMAD3	4088	P84022	0.59
BRCA1	672	P38398	0.63
CFTR	1080	P13569	0.63
ATF2	1386	P15336	0.63
EGFR	1956	P00533	0.63
ELAVL1	1994	Q15717	0.63
HLA-B	3106	P30480	0.63
HSF2	3298	Q03933	0.63
EIF6	3692	P56537	0.63
KCNE1	3753	P15382	0.63
KIFC3	3801	Q9BVG8	0.63
MAGEA11	4110	P43364	0.63
MCM2	4171	P49736	0.63
MCM3	4172	P25205	0.63
MDM2	4193	Q00987	0.63
MOV10	4343	Q9HCE1	0.63
NEK2	4751	P51955	0.63
NTRK1	4914	P04629	0.63
PARK2	5071	O60260	0.63
PBX3	5090	P40426	0.63
RAD21	5885	O60216	0.63
TRIM27	5987	P14373	0.63
RNF2	6045	Q99496	0.63
VPS52	6293	Q8N1B4	0.63
SHMT2	6472	P34897	0.63
SP1	6667	P08047	0.63
TNNT1	7138	P13805	0.63
TP53	7157	P04637	0.63
TP73	7161	O15350	0.63
VDAC1	7416	P21796	0.63
BCAR3	8412	O75815	0.63
CUL3	8452	Q13618	0.63
MDC1	9656	Q14676	0.63
KIAA0101	9768	Q15004	0.63
CUL7	9820	Q14999	0.63
PAN2	9924	Q504Q3	0.63
TRAP1	10131	Q12931	0.63
EIF1B	10289	O60739	0.63
NXF1	10482	Q9UBU9	0.63
CAP1	10487	Q01518	0.63
MGEA5	10724	O60502	0.63
PAXIP1	22976	Q6ZW49	0.63
MAST2	23139	Q6P0Q8	0.63
OBSL1	23363	O75147	0.63
FTSJ1	24140	Q9UET6	0.63
RRAGD	58528	Q9NQL2	0.63
LRRK2	120892	Q5S007	0.63
SUMO4	387082	Q6EEV6	0.65
CNN1	1264	P51911	0.66
ADD1	118	P35611	0.72
CAPZA2	830	P47755	0.72
CHUK	1147	O15111	0.72
DAPK1	1612	P53355	0.72
FN1	2335	P02751	0.72
HSP90AB1	3326	P08238	0.72
MYH9	4627	P35579	0.72
PPP1CB	5500	P62140	0.72
PPP1CC	5501	P36873	0.72
IQGAP1	8826	P46940	0.72
PDLIM7	9260	Q9NR12	0.72
RIPK3	11035	Q9Y572	0.72
ANLN	54443	Q9NQW6	0.72
HDAC8	55869	Q9BY41	0.72
MYO19	80179	Q96H55	0.72
MYO18A	399687	Q92614	0.72
HSP90AA1	3320	P07900	0.73
EIF4A2	1974	Q14240	0.76
MCC	4163	P23508	0.76
MYO5C	55930	Q9NQX4	0.79
TPM1	7168	P09493	0.80
CDK2	1017	P24941	0.82