| Gene Symbol | TPM2 |
| Entrez ID | 7169 |
| Uniprot ID | P07951 |
| Description | tropomyosin 2 (beta) |
| Chromosomal Location | chr9: 35,681,992-35,691,020 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006936 |
muscle contraction |
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. |
TAS |
|
BP |
GO:0030049 |
muscle filament sliding |
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated. |
TAS |
|
BP |
GO:0043462 |
regulation of ATPase activity |
Any process that modulates the rate of ATP hydrolysis by an ATPase. |
IDA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
CC |
GO:0005862 |
muscle thin filament tropomyosin |
A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments. |
TAS |
|
MF |
GO:0003779 |
actin binding |
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. |
IDA |
|
MF |
GO:0008307 |
structural constituent of muscle |
The action of a molecule that contributes to the structural integrity of a muscle fiber. |
TAS |
| Domain ID | Description |
|---|---|
|
IPR000533 |
Tropomyosin |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa04260 |
Cardiac muscle contraction |
KEGG |
|
hsa04261 |
Adrenergic signaling in cardiomyocytes |
KEGG |
|
hsa05410 |
Hypertrophic cardiomyopathy (HCM) |
KEGG |
|
hsa05414 |
Dilated cardiomyopathy |
KEGG |
|
WP383 |
Striated Muscle Contraction |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0546264 |
Congenital Fiber Type Disproportion |
| Tissue | Cell Type |
|---|---|
|
colon |
endothelial cells |
|
heart muscle |
myocytes |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
fibroblasts |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
12734205 |
Wood et al. |
2003 |
The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis |
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ACTN4 |
81 |
O43707 |
0.49 |
|
ACTN1 |
87 |
P12814 |
0.49 |
|
PSMD5 |
5711 |
Q16401 |
0.49 |
|
TPM3 |
7170 |
P06753 |
0.49 |
|
TPM4 |
7171 |
P67936 |
0.49 |
|
CKMT1A; CKMT1B |
1159 |
P12532 |
0.49 |
|
ACTB |
60 |
P60709 |
0.52 |
|
ADRBK1 |
156 |
P25098 |
0.55 |
|
S100A2 |
6273 |
P29034 |
0.55 |
|
ACTA1 |
58 |
P68133 |
0.56 |
|
MAST2 |
23139 |
Q6P0Q8 |
0.63 |
|
HECTD1 |
25831 |
Q9ULT8 |
0.63 |
|
JUN |
3725 |
P05412 |
0.65 |
|
RRAD |
6236 |
P55042 |
0.79 |
|
TPM1 |
7168 |
P09493 |
0.89 |
|
TPM2 |
7169 |
P07951 |
0.89 |
|
PDLIM7 |
9260 |
Q9NR12 |
0.90 |
|
TNNI3 |
7137 |
P19429 |
0.00 |
|
ACTN2 |
88 |
P35609 |
0.49 |
|
ATP5F1 |
515 |
P24539 |
0.49 |
|
CAPZB |
832 |
P47756 |
0.49 |
|
COX4I1 |
1327 |
P13073 |
0.49 |
|
DDX3X |
1654 |
O00571 |
0.49 |
|
DYNC1H1 |
1778 |
Q14204 |
0.49 |
|
MYH3 |
4621 |
P11055 |
0.49 |
|
MYH6 |
4624 |
P13533 |
0.49 |
|
MYH7 |
4625 |
P12883 |
0.49 |
|
MYL6 |
4637 |
P60660 |
0.49 |
|
NDUFB10 |
4716 |
O96000 |
0.49 |
|
NONO |
4841 |
Q15233 |
0.49 |
|
SSB |
6741 |
P05455 |
0.49 |
|
SULT1A1 |
6817 |
P50225 |
0.49 |
|
TNNI1 |
7135 |
P19237 |
0.49 |
|
UQCRC2 |
7385 |
P22695 |
0.49 |
|
STAM |
8027 |
Q92783 |
0.49 |
|
TAF15 |
8148 |
Q92804 |
0.49 |
|
DDX46 |
9879 |
Q7L014 |
0.49 |
|
BCAP31 |
10134 |
P51572 |
0.49 |
|
AHCYL1 |
10768 |
O43865 |
0.49 |
|
SUB1 |
10923 |
P53999 |
0.49 |
|
SF3B2 |
10992 |
Q13435 |
0.49 |
|
DSTN |
11034 |
P60981 |
0.49 |
|
SLC4A1AP |
22950 |
Q9BWU0 |
0.49 |
|
CCAR1 |
55749 |
Q8IX12 |
0.49 |
|
CORO1B |
57175 |
Q9BR76 |
0.49 |
|
CPSF7 |
79869 |
Q8N684 |
0.49 |
|
SRXN1 |
140809 |
Q9BYN0 |
0.49 |
|
DDB1 |
100290337 |
Q16531 |
0.49 |
|
S100A4 |
6275 |
P26447 |
0.52 |
|
PIK3CG |
5294 |
P48736 |
0.55 |
|
GRB2 |
2885 |
P62993 |
0.56 |
|
NEB |
4703 |
P20929 |
0.56 |
|
STMN1 |
3925 |
P16949 |
0.59 |
|
EPB41 |
2035 |
P11171 |
0.63 |
|
FLNC |
2318 |
Q14315 |
0.63 |
|
MAGEA10 |
4109 |
P43363 |
0.63 |
|
MCC |
4163 |
P23508 |
0.63 |
|
RPA1 |
6117 |
P27694 |
0.63 |
|
RPA2 |
6118 |
P15927 |
0.63 |
|
RPA3 |
6119 |
P35244 |
0.63 |
|
SKIL |
6498 |
P12757 |
0.63 |
|
SOD1 |
6647 |
P00441 |
0.63 |
|
SP1 |
6667 |
P08047 |
0.63 |
|
CDK5R1 |
8851 |
Q15078 |
0.63 |
|
FAM189B |
10712 |
P81408 |
0.63 |
|
EBNA1BP2 |
10969 |
Q99848 |
0.63 |
|
SNAPIN |
23557 |
O95295 |
0.63 |
|
ATP6V1H |
51606 |
Q9UI12 |
0.63 |
|
ZNF250 |
58500 |
P15622 |
0.63 |
|
C11orf70 |
85016 |
Q9BRQ4 |
0.63 |
|
LRRK2 |
120892 |
Q5S007 |
0.63 |
|
CIART |
148523 |
Q8N365 |
0.63 |
|
ASPDH |
554235 |
A6ND91 |
0.63 |
|
ADD1 |
118 |
P35611 |
0.72 |
|
AKT1 |
207 |
P31749 |
0.72 |
|
CAPZA2 |
830 |
P47755 |
0.72 |
|
CDK2 |
1017 |
P24941 |
0.72 |
|
FLNA |
2316 |
P21333 |
0.72 |
|
RBPJ |
3516 |
Q06330 |
0.72 |
|
MYH9 |
4627 |
P35579 |
0.72 |
|
PPP1CB |
5500 |
P62140 |
0.72 |
|
MAPK3 |
5595 |
P27361 |
0.72 |
|
IQGAP1 |
8826 |
P46940 |
0.72 |
|
SYNPO |
11346 |
Q8N3V7 |
0.72 |
|
ANLN |
54443 |
Q9NQW6 |
0.72 |
|
MYO5C |
55930 |
Q9NQX4 |
0.72 |
|
MYO19 |
80179 |
Q96H55 |
0.72 |
|
MYO18A |
399687 |
Q92614 |
0.72 |