BP

GO:0001701

in utero embryonic development

The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.

IEA

BP

GO:0003065

positive regulation of heart rate by epinephrine

The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction.

ISS

BP

GO:0006928

movement of cell or subcellular component

The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.

TAS

BP

GO:0006936

muscle contraction

A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.

TAS

BP

GO:0006937

regulation of muscle contraction

Any process that modulates the frequency, rate or extent of muscle contraction.

TAS

BP

GO:0007010

cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.

TAS

BP

GO:0008016

regulation of heart contraction

Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.

TAS

BP

GO:0008360

regulation of cell shape

Any process that modulates the surface configuration of a cell.

IMP

BP

GO:0030049

muscle filament sliding

The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.

ISS|TAS

BP

GO:0030336

negative regulation of cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.

ISS

BP

GO:0031529

ruffle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.

ISS

BP

GO:0032781

positive regulation of ATPase activity

Any process that activates or increases the rate of ATP hydrolysis by an ATPase.

ISS

BP

GO:0034614

cellular response to reactive oxygen species

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.

IEP

BP

GO:0042060

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

ISS

BP

GO:0045214

sarcomere organization

The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

IMP

BP

GO:0045785

positive regulation of cell adhesion

Any process that activates or increases the frequency, rate or extent of cell adhesion.

ISS

BP

GO:0051496

positive regulation of stress fiber assembly

Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.

ISS

BP

GO:0055010

ventricular cardiac muscle tissue morphogenesis

The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.

IMP

BP

GO:0060048

cardiac muscle contraction

Muscle contraction of cardiac muscle tissue.

IMP

BP

GO:1904706

negative regulation of vascular smooth muscle cell proliferation

Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.

IMP

BP

GO:1904753

negative regulation of vascular associated smooth muscle cell migration

Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration.

IMP

CC

GO:0001725

stress fiber

A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005856

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

TAS

CC

GO:0005862

muscle thin filament tropomyosin

A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments.

TAS

CC

GO:0030017

sarcomere

The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

TAS

CC

GO:0031941

filamentous actin

A two-stranded helical polymer of the protein actin.

IEA

CC

GO:0032059

bleb

A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.

IMP

CC

GO:0032587

ruffle membrane

The portion of the plasma membrane surrounding a ruffle.

IDA

MF

GO:0003779

actin binding

Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.

TAS

MF

GO:0005200

structural constituent of cytoskeleton

The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.

TAS

MF

GO:0008092

cytoskeletal protein binding

Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).

IPI

MF

GO:0008307

structural constituent of muscle

The action of a molecule that contributes to the structural integrity of a muscle fiber.

TAS