BP

GO:0001570

vasculogenesis

The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.

ISS

BP

GO:0001980

regulation of systemic arterial blood pressure by ischemic conditions

The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system.

ISS

BP

GO:0003009

skeletal muscle contraction

A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.

IBA

BP

GO:0006874

cellular calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.

ISS

BP

GO:0006940

regulation of smooth muscle contraction

Any process that modulates the frequency, rate or extent of smooth muscle contraction.

IEA

BP

GO:0007507

heart development

The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

ISS

BP

GO:0030049

muscle filament sliding

The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.

TAS

BP

GO:0032780

negative regulation of ATPase activity

Any process that stops or reduces the rate of ATP hydrolysis by an ATPase.

IDA|IMP

BP

GO:0055010

ventricular cardiac muscle tissue morphogenesis

The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.

IMP

BP

GO:0060047

heart contraction

The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.

IMP

BP

GO:0060048

cardiac muscle contraction

Muscle contraction of cardiac muscle tissue.

IMP

BP

GO:1903779

regulation of cardiac conduction

Any process that modulates the frequency, rate or extent of cardiac conduction.

TAS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005861

troponin complex

A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.

IDA

CC

GO:0030017

sarcomere

The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

TAS

MF

GO:0003779

actin binding

Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0019855

calcium channel inhibitor activity

Stops, prevents, or reduces the activity of a calcium channel.

IPI

MF

GO:0019901

protein kinase binding

Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

IPI

MF

GO:0019904

protein domain specific binding

Interacting selectively and non-covalently with a specific domain of a protein.

IPI

MF

GO:0030172

troponin C binding

Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex.

IPI

MF

GO:0031014

troponin T binding

Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex.

IPI

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

MF

GO:0048306

calcium-dependent protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.

IPI