Protein Description

Gene Symbol TLE3
Entrez ID 7090
Uniprot ID Q04726
Description transducin like enhancer of split 3
Chromosomal Location chr15: 70,047,790-70,098,176
Ontology GO ID GO Term Definition Evidence

BP

GO:0006351

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

IEA

BP

GO:0006355

regulation of transcription, DNA-templated

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

IEA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0009887

animal organ morphogenesis

Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

TAS

BP

GO:0016055

Wnt signaling pathway

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

IEA

BP

GO:1904837

beta-catenin-TCF complex assembly

The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex.

TAS

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

TAS

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

Domain ID Description

IPR001680

WD40 repeat

IPR005617

Groucho/TLE, N-terminal Q-rich domain

IPR009146

Groucho/transducin-like enhancer

IPR015943

WD40/YVTN repeat-like-containing domain

IPR017986

WD40-repeat-containing domain

IPR019775

WD40 repeat, conserved site

Pathway ID Pathway Term Pathway Source

WP3946

White fat cell differentiation

WikiPathways

UMLS CUI UMLS Term

C0003873

Rheumatoid Arthritis

C1458155

Mammary Neoplasms

Tissue Cell Type

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

SIX4

51804

Q9UIU6

0.00

AHCY

191

P23526

0.49

PPA1

5464

Q15181

0.49

RPE

6120

Q96AT9

0.49

STAM

8027

Q92783

0.49

FOXG1

2290

P55316

0.52

APP

351

P05067

0.56

ARCN1

372

P48444

0.63

COPB1

1315

P53618

0.63

KLC1

3831

Q07866

0.63

COPZ1

22818

P61923

0.63

COPG1

22820

Q9Y678

0.63

CREBBP

1387

Q92793

0.49

FKBP5

2289

Q13451

0.49

IGBP1

3476

P78318

0.49

PPM1G

5496

O15355

0.49

S100A9

6280

P06702

0.49

UBA2

10054

Q9UBT2

0.49

ALYREF

10189

Q86V81

0.49

SSSCA1

10534

O60232

0.49

AHCYL1

10768

O43865

0.49

SEC24A

10802

O95486

0.49

SRXN1

140809

Q9BYN0

0.49

HDAC1

3065

Q13547

0.56

ANXA1

301

P04083

0.63

FGL1

2267

Q08830

0.63

GRN

2896

P28799

0.63

NTRK1

4914

P04629

0.63

PEX7

5191

O00628

0.63

TBC1D4

9882

O60343

0.63

UBD

10537

O15205

0.63

QPRT

23475

Q15274

0.63

HINFP

25988

Q9BQA5

0.63

AUTS2

26053

Q8WXX7

0.63

LHX6

26468

Q9UPM6

0.63

STARD7

56910

Q9NQZ5

0.63

TBX20

57057

Q9UMR3

0.63

SIX3

6496

O95343

0.65

PIN1

5300

Q13526

0.68

FOXL1

2300

Q12952

0.72

FOXA3

3171

P55318

0.72

CUL4B

8450

Q13620

0.72

FOXB1

27023

Q99853

0.72

NLK

51701

Q9UBE8

0.72

FOXQ1

94234

Q9C009

0.72

NDRG1

10397

Q92597

0.73

AES

166

Q08117

0.76