Gene Symbol | TLE3 |
Entrez ID | 7090 |
Uniprot ID | Q04726 |
Description | transducin like enhancer of split 3 |
Chromosomal Location | chr15: 70,047,790-70,098,176 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006351 |
transcription, DNA-templated |
The cellular synthesis of RNA on a template of DNA. |
IEA |
BP |
GO:0006355 |
regulation of transcription, DNA-templated |
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
IEA |
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
TAS |
BP |
GO:0009887 |
animal organ morphogenesis |
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. |
TAS |
BP |
GO:0016055 |
Wnt signaling pathway |
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
IEA |
BP |
GO:1904837 |
beta-catenin-TCF complex assembly |
The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex. |
TAS |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
TAS |
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
TAS |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
Domain ID | Description |
---|---|
IPR001680 |
WD40 repeat |
IPR005617 |
Groucho/TLE, N-terminal Q-rich domain |
IPR009146 |
Groucho/transducin-like enhancer |
IPR015943 |
WD40/YVTN repeat-like-containing domain |
IPR017986 |
WD40-repeat-containing domain |
IPR019775 |
WD40 repeat, conserved site |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
WP3946 |
White fat cell differentiation |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0003873 |
Rheumatoid Arthritis |
C1458155 |
Mammary Neoplasms |
Tissue | Cell Type |
---|---|
vagina |
squamous epithelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
SIX4 |
51804 |
Q9UIU6 |
0.00 |
AHCY |
191 |
P23526 |
0.49 |
PPA1 |
5464 |
Q15181 |
0.49 |
RPE |
6120 |
Q96AT9 |
0.49 |
STAM |
8027 |
Q92783 |
0.49 |
FOXG1 |
2290 |
P55316 |
0.52 |
APP |
351 |
P05067 |
0.56 |
ARCN1 |
372 |
P48444 |
0.63 |
COPB1 |
1315 |
P53618 |
0.63 |
KLC1 |
3831 |
Q07866 |
0.63 |
COPZ1 |
22818 |
P61923 |
0.63 |
COPG1 |
22820 |
Q9Y678 |
0.63 |
CREBBP |
1387 |
Q92793 |
0.49 |
FKBP5 |
2289 |
Q13451 |
0.49 |
IGBP1 |
3476 |
P78318 |
0.49 |
PPM1G |
5496 |
O15355 |
0.49 |
S100A9 |
6280 |
P06702 |
0.49 |
UBA2 |
10054 |
Q9UBT2 |
0.49 |
ALYREF |
10189 |
Q86V81 |
0.49 |
SSSCA1 |
10534 |
O60232 |
0.49 |
AHCYL1 |
10768 |
O43865 |
0.49 |
SEC24A |
10802 |
O95486 |
0.49 |
SRXN1 |
140809 |
Q9BYN0 |
0.49 |
HDAC1 |
3065 |
Q13547 |
0.56 |
ANXA1 |
301 |
P04083 |
0.63 |
FGL1 |
2267 |
Q08830 |
0.63 |
GRN |
2896 |
P28799 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
PEX7 |
5191 |
O00628 |
0.63 |
TBC1D4 |
9882 |
O60343 |
0.63 |
UBD |
10537 |
O15205 |
0.63 |
QPRT |
23475 |
Q15274 |
0.63 |
HINFP |
25988 |
Q9BQA5 |
0.63 |
AUTS2 |
26053 |
Q8WXX7 |
0.63 |
LHX6 |
26468 |
Q9UPM6 |
0.63 |
STARD7 |
56910 |
Q9NQZ5 |
0.63 |
TBX20 |
57057 |
Q9UMR3 |
0.63 |
SIX3 |
6496 |
O95343 |
0.65 |
PIN1 |
5300 |
Q13526 |
0.68 |
FOXL1 |
2300 |
Q12952 |
0.72 |
FOXA3 |
3171 |
P55318 |
0.72 |
CUL4B |
8450 |
Q13620 |
0.72 |
FOXB1 |
27023 |
Q99853 |
0.72 |
NLK |
51701 |
Q9UBE8 |
0.72 |
FOXQ1 |
94234 |
Q9C009 |
0.72 |
NDRG1 |
10397 |
Q92597 |
0.73 |
AES |
166 |
Q08117 |
0.76 |