PCOSBase

Protein Description

Gene Symbol	TKT
Entrez ID	7086
Uniprot ID	P29401
Description	transketolase
Chromosomal Location	chr3: 53,224,707-53,256,052

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0005999	xylulose biosynthetic process	The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose.	TAS
BP	GO:0006098	pentose-phosphate shunt	The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses.	TAS
BP	GO:0009052	pentose-phosphate shunt, non-oxidative branch	The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P.	NAS
BP	GO:0040008	regulation of growth	Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.	IEA
BP	GO:0046166	glyceraldehyde-3-phosphate biosynthetic process	The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis.	IDA
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	IDA
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	IDA
CC	GO:0005777	peroxisome	A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.	ISS
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	TAS
CC	GO:0031982	vesicle	Any small, fluid-filled, spherical organelle enclosed by membrane.	IDA
CC	GO:0043209	myelin sheath	An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.	IEA
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
MF	GO:0004802	transketolase activity	Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor.	EXP\|IDA
MF	GO:0042803	protein homodimerization activity	Interacting selectively and non-covalently with an identical protein to form a homodimer.	IDA
MF	GO:0046872	metal ion binding	Interacting selectively and non-covalently with any metal ion.	IEA
MF	GO:0048037	cofactor binding	Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.	IDA

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Domain ID	Description
IPR005474	Transketolase, N-terminal
IPR005475	Transketolase-like, pyrimidine-binding domain
IPR009014	Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
IPR020826	Transketolase binding site
IPR029061	Thiamin diphosphate-binding fold
IPR033248	Transketolase, C-terminal domain

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Pathway ID	Pathway Term	Pathway Source
hsa00030	Pentose phosphate pathway	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01230	Biosynthesis of amino acids	KEGG
WP134	Pentose Phosphate Pathway	WikiPathways

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UMLS CUI	UMLS Term
C0003130	Anoxia
C0024667	Animal Mammary Neoplasms
C0024668	Mammary Neoplasms, Experimental
C0027626	Neoplasm Invasiveness
C0043121	Wernicke Encephalopathy
C0349464	Wernicke-Korsakoff Syndrome

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Tissue	Cell Type
bone marrow	hematopoietic cells
bronchus	respiratory epithelial cells
caudate	glial cells
esophagus	squamous epithelial cells
gallbladder	glandular cells
kidney	cells in tubules
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
pancreas	exocrine glandular cells
salivary gland	glandular cells
testis	Leydig cells
thyroid gland	glandular cells
urinary bladder	urothelial cells

No databases found.

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Pubmed ID	Author	Year	Title
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
ACP1	52	P24666	0.49
ALDOA	226	P04075	0.49
AKR1B1	231	P15121	0.49
CALR	811	P27797	0.49
AKR1C2	1646	P52895	0.49
DUT	1854	P33316	0.49
ENO1	2023	P06733	0.49
ENO2	2026	P09104	0.49
ENO3	2027	P13929	0.49
ESD	2098	P10768	0.49
FABP5	2171	Q01469	0.49
FABP7	2173	O15540	0.49
FH	2271	P07954	0.49
XRCC6	2547	P12956	0.49
GAPDH	2597	P04406	0.49
GLRX	2745	P35754	0.49
GPI	2821	P06744	0.49
GPX4	2879	P36969	0.49
HINT1	3094	P49773	0.49
HSPE1	3336	P61604	0.49
IDH1	3417	O75874	0.49
ITPA	3704	Q9BY32	0.49
LDHA	3939	P00338	0.49
LDHB	3945	P07195	0.49
MIF	4282	P14174	0.49
NME2	4831	P22392	0.49
P4HB	5034	P07237	0.49
PCBP1	5093	Q15365	0.49
PCMT1	5110	P22061	0.49
PGK1	5230	P00558	0.49
PLS3	5358	P13797	0.49
PMP2	5375	P02689	0.49
RPE	6120	Q96AT9	0.49
SOD2	6648	P04179	0.49
STAT4	6775	Q14765	0.49
UBE2D1	7321	P51668	0.49
UBE2I	7329	P63279	0.49
UGDH	7358	O60701	0.49
VCP	7415	P55072	0.49
VDAC3	7419	Q9Y277	0.49
SF1	7536	Q15637	0.49
ALDH4A1	8659	P30038	0.49
PDCD6IP	10015	Q8WUM4	0.49
PDCD6	10016	O75340	0.49
COX17	10063	Q14061	0.49
AKR1A1	10327	P14550	0.49
ACAA2	10449	P42765	0.49
RAB10	10890	P61026	0.49
STIP1	10963	P31948	0.49
LYPLA2	11313	O95372	0.49
HSPA4L	22824	O95757	0.49
PITPNB	23760	P48739	0.49
UFC1	51506	Q9Y3C8	0.49
NANS	54187	Q9NR45	0.49
PGM2	55276	Q96G03	0.49
SCYL2	55681	Q6P3W7	0.49
LDHAL6B	92483	Q9BYZ2	0.49
AKR1B15	441282	C9JRZ8	0.49
TPI1	7167	P60174	0.59
UFM1	51569	P61960	0.59
TKT	7086	P29401	0.92
AK2	204	P54819	0.49
ANXA7	310	P20073	0.49
ASS1	445	P00966	0.49
CALU	813	O43852	0.49
CAPG	822	P40121	0.49
CFL1	1072	P23528	0.49
GLO1	2739	Q04760	0.49
HSD17B10	3028	Q99714	0.49
HSPA9	3313	P38646	0.49
HSPB1	3315	P04792	0.49
IGBP1	3476	P78318	0.49
MSN	4478	P26038	0.49
PRDX1	5052	Q06830	0.49
PKM	5315	P14618	0.49
RDX	5962	P35241	0.49
RSU1	6251	Q15404	0.49
FSCN1	6624	Q16658	0.49
SOD1	6647	P00441	0.49
SPR	6697	P35270	0.49
SRI	6717	P30626	0.49
EZR	7430	P15311	0.49
TAGLN2	8407	P37802	0.49
PIR	8544	O00625	0.49
VAPA	9218	Q9P0L0	0.49
WDR1	9948	O75083	0.49
SSSCA1	10534	O60232	0.49
PAICS	10606	P22234	0.49
YKT6	10652	O15498	0.49
PTGES3	10728	Q15185	0.49
AHCYL1	10768	O43865	0.49
RPIA	22934	P49247	0.49
COTL1	23406	Q14019	0.49
DAZAP1	26528	Q96EP5	0.49
C11orf54	28970	Q9H0W9	0.49
TAGLN3	29114	Q9UI15	0.49
GLOD4	51031	Q9HC38	0.49
LAP3	51056	P28838	0.49
DYNC1LI1	51143	Q9Y6G9	0.49
FKBP7	51661	Q9Y680	0.49
SLC2A9	56606	Q9NRM0	0.49
TIGAR	57103	Q9NQ88	0.49
ABHD14B	84836	Q96IU4	0.49
SQSTM1	8878	Q13501	0.56
CDK2	1017	P24941	0.63
ESR1	2099	P03372	0.63
FUS	2521	P35637	0.63
GH1	2688	P01241	0.63
HLA-B	3106	P30480	0.63
IFI16	3428	Q16666	0.63
JUN	3725	P05412	0.63
MCC	4163	P23508	0.63
MCM2	4171	P49736	0.63
MDM2	4193	Q00987	0.63
NTRK1	4914	P04629	0.63
PIK3C2A	5286	O00443	0.63
RPL31	6160	P62899	0.63
SUMO1	7341	P63165	0.63
VHL	7428	P40337	0.63
CUL3	8452	Q13618	0.63
TNFRSF10D	8793	Q9UBN6	0.63
ISG15	9636	P05161	0.63
IKBKE	9641	Q14164	0.63
HDAC5	10014	Q9UQL6	0.63
EIF1B	10289	O60739	0.63
GABARAPL2	11345	P60520	0.63
FTSJ1	24140	Q9UET6	0.63
FBXO6	26270	Q9NRD1	0.63
ITGB1BP2	26548	Q9UKP3	0.63
PPME1	51400	Q9Y570	0.63
ACTR6	64431	Q9GZN1	0.63
FBXO11	80204	Q86XK2	0.63
MYOC	4653	Q99972	0.65
TALDO1	6888	P37837	0.65
YWHAZ	7534	P63104	0.68
FN1	2335	P02751	0.72
H2AFX	3014	P16104	0.72
MYC	4609	P01106	0.72
EXOSC9	5393	Q06265	0.72
PRKCD	5580	Q05655	0.72
MAPK8	5599	P45983	0.72
ATG5	9474	Q9H1Y0	0.72
NEDD8	4738	Q15843	0.73
TERF1	7013	P54274	0.75