BP

GO:0000187

activation of MAPK activity

The initiation of the activity of the inactive enzyme MAP kinase (MAPK).

IMP

BP

GO:0001666

response to hypoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.

NAS

BP

GO:0001937

negative regulation of endothelial cell proliferation

Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.

IDA|IMP

BP

GO:0001953

negative regulation of cell-matrix adhesion

Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.

IDA

BP

GO:0002040

sprouting angiogenesis

The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells.

IMP

BP

GO:0002544

chronic inflammatory response

Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response.

IEP

BP

GO:0002576

platelet degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.

TAS

BP

GO:0002581

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.

IDA

BP

GO:0002605

negative regulation of dendritic cell antigen processing and presentation

Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation.

IDA

BP

GO:0006954

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

IDA

BP

GO:0006955

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

IEP

BP

GO:0006986

response to unfolded protein

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

IEA

BP

GO:0007050

cell cycle arrest

A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).

IDA

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

NAS

BP

GO:0008284

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

IDA

BP

GO:0009612

response to mechanical stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.

IEA

BP

GO:0009749

response to glucose

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.

IDA

BP

GO:0010595

positive regulation of endothelial cell migration

Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.

IDA

BP

GO:0010596

negative regulation of endothelial cell migration

Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.

IDA

BP

GO:0010748

negative regulation of plasma membrane long-chain fatty acid transport

Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane.

IDA

BP

GO:0010751

negative regulation of nitric oxide mediated signal transduction

Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO).

IDA

BP

GO:0010754

negative regulation of cGMP-mediated signaling

Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.

IDA

BP

GO:0010757

negative regulation of plasminogen activation

Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.

IDA

BP

GO:0010759

positive regulation of macrophage chemotaxis

Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.

ISS

BP

GO:0010763

positive regulation of fibroblast migration

Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.

IDA

BP

GO:0016477

cell migration

The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.

IDA

BP

GO:0016525

negative regulation of angiogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.

IDA

BP

GO:0018149

peptide cross-linking

The formation of a covalent cross-link between or within protein chains.

IDA

BP

GO:0030194

positive regulation of blood coagulation

Any process that activates or increases the frequency, rate or extent of blood coagulation.

IDA

BP

GO:0030198

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

TAS

BP

GO:0030335

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

IDA|IMP

BP

GO:0030511

positive regulation of transforming growth factor beta receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.

IDA

BP

GO:0030823

regulation of cGMP metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP.

IDA

BP

GO:0032026

response to magnesium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.

IDA

BP

GO:0032570

response to progesterone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.

TAS

BP

GO:0032695

negative regulation of interleukin-12 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.

IDA

BP

GO:0032914

positive regulation of transforming growth factor beta1 production

Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1.

ISS

BP

GO:0033574

response to testosterone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.

IEA

BP

GO:0034605

cellular response to heat

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

NAS

BP

GO:0034976

response to endoplasmic reticulum stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.

ISS

BP

GO:0036066

protein O-linked fucosylation

The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage.

TAS

BP

GO:0040037

negative regulation of fibroblast growth factor receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.

IDA

BP

GO:0042327

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

IMP

BP

GO:0042493

response to drug

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

IEP

BP

GO:0042535

positive regulation of tumor necrosis factor biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.

IDA

BP

GO:0043032

positive regulation of macrophage activation

Any process that stimulates, induces or increases the rate of macrophage activation.

IDA

BP

GO:0043066

negative regulation of apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

IDA

BP

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.

IDA

BP

GO:0043536

positive regulation of blood vessel endothelial cell migration

Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.

IDA

BP

GO:0043537

negative regulation of blood vessel endothelial cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.

IDA

BP

GO:0043652

engulfment of apoptotic cell

The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.

IDA

BP

GO:0045727

positive regulation of translation

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.

IDA

BP

GO:0045766

positive regulation of angiogenesis

Any process that activates or increases angiogenesis.

IMP

BP

GO:0048266

behavioral response to pain

Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.

ISS

BP

GO:0048661

positive regulation of smooth muscle cell proliferation

Any process that activates or increases the rate or extent of smooth muscle cell proliferation.

IDA

BP

GO:0050921

positive regulation of chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

IDA

BP

GO:0051592

response to calcium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.

IDA

BP

GO:0051895

negative regulation of focal adhesion assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.

TAS

BP

GO:0051897

positive regulation of protein kinase B signaling

Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.

IDA

BP

GO:0051918

negative regulation of fibrinolysis

Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

IDA

BP

GO:0071356

cellular response to tumor necrosis factor

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.

IEA

BP

GO:0071363

cellular response to growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.

IEA

BP

GO:1902043

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.

IDA

BP

GO:2000353

positive regulation of endothelial cell apoptotic process

Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process.

IDA

BP

GO:2000379

positive regulation of reactive oxygen species metabolic process

Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.

IDA

BP

GO:2001027

negative regulation of endothelial cell chemotaxis

Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis.

IDA

BP

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.

TAS

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

TAS

CC

GO:0005577

fibrinogen complex

A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.

IDA

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA

CC

GO:0005783

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

ISS

CC

GO:0005788

endoplasmic reticulum lumen

The volume enclosed by the membranes of the endoplasmic reticulum.

TAS

CC

GO:0009897

external side of plasma membrane

The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.

IDA

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

IDA

CC

GO:0016529

sarcoplasmic reticulum

A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.

ISS

CC

GO:0030141

secretory granule

A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.

IDA

CC

GO:0031012

extracellular matrix

A structure lying external to one or more cells, which provides structural support for cells or tissues.

IDA|ISS|TAS

CC

GO:0031091

platelet alpha granule

A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).

IDA

CC

GO:0031093

platelet alpha granule lumen

The volume enclosed by the membrane of the platelet alpha granule.

TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0001786

phosphatidylserine binding

Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.

IDA

MF

GO:0001948

glycoprotein binding

Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans.

NAS

MF

GO:0001968

fibronectin binding

Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.

IDA

MF

GO:0005178

integrin binding

Interacting selectively and non-covalently with an integrin.

IMP

MF

GO:0005509

calcium ion binding

Interacting selectively and non-covalently with calcium ions (Ca2+).

NAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008201

heparin binding

Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.

IDA

MF

GO:0017134

fibroblast growth factor binding

Interacting selectively and non-covalently with a fibroblast growth factor.

IDA

MF

GO:0030169

low-density lipoprotein particle binding

Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.

IDA

MF

GO:0042802

identical protein binding

Interacting selectively and non-covalently with an identical protein or proteins.

NAS

MF

GO:0043236

laminin binding

Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.

IDA

MF

GO:0043394

proteoglycan binding

Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans.

TAS

MF

GO:0050431

transforming growth factor beta binding

Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types.

ISS|TAS

MF

GO:0070051

fibrinogen binding

Interacting selectively and non-covalently with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade.

IDA

MF

GO:0070052

collagen V binding

Interacting selectively and non-covalently with a type V collagen trimer.

IDA