Gene Symbol | TGFB1 |
Entrez ID | 7040 |
Uniprot ID | P01137 |
Description | transforming growth factor beta 1 |
Chromosomal Location | chr19: 41,301,587-41,353,911 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000060 |
protein import into nucleus, translocation |
A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope. |
IDA |
BP |
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IEA |
BP |
GO:0000165 |
MAPK cascade |
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
IMP |
BP |
GO:0001570 |
vasculogenesis |
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. |
ISS |
BP |
GO:0001657 |
ureteric bud development |
The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure. |
IEA |
BP |
GO:0001666 |
response to hypoxia |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
IEA |
BP |
GO:0001837 |
epithelial to mesenchymal transition |
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
IDA |
BP |
GO:0001843 |
neural tube closure |
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. |
ISS |
BP |
GO:0001933 |
negative regulation of protein phosphorylation |
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein. |
IDA |
BP |
GO:0001934 |
positive regulation of protein phosphorylation |
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
IDA |
BP |
GO:0002028 |
regulation of sodium ion transport |
Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
IEA |
BP |
GO:0002062 |
chondrocyte differentiation |
The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. |
IDA |
BP |
GO:0002244 |
hematopoietic progenitor cell differentiation |
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. |
IDA |
BP |
GO:0002248 |
connective tissue replacement involved in inflammatory response wound healing |
The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response. |
TAS |
BP |
GO:0002460 |
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus. |
IEA |
BP |
GO:0002513 |
tolerance induction to self antigen |
Tolerance induction directed at self antigens. |
IEA |
BP |
GO:0002576 |
platelet degranulation |
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. |
TAS |
BP |
GO:0003179 |
heart valve morphogenesis |
The process in which the structure of a heart valve is generated and organized. |
ISS |
BP |
GO:0006468 |
protein phosphorylation |
The process of introducing a phosphate group on to a protein. |
ISS |
BP |
GO:0006611 |
protein export from nucleus |
The directed movement of a protein from the nucleus into the cytoplasm. |
IDA |
BP |
GO:0006754 |
ATP biosynthetic process |
The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IDA |
BP |
GO:0006796 |
phosphate-containing compound metabolic process |
The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. |
IDA |
BP |
GO:0006874 |
cellular calcium ion homeostasis |
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell. |
IEA |
BP |
GO:0006954 |
inflammatory response |
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
IDA |
BP |
GO:0007050 |
cell cycle arrest |
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M). |
IDA |
BP |
GO:0007093 |
mitotic cell cycle checkpoint |
A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. |
IDA |
BP |
GO:0007173 |
epidermal growth factor receptor signaling pathway |
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
IDA |
BP |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
IDA|TAS |
BP |
GO:0007182 |
common-partner SMAD protein phosphorylation |
The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus. |
IDA |
BP |
GO:0007183 |
SMAD protein complex assembly |
The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins. |
IDA |
BP |
GO:0007184 |
SMAD protein import into nucleus |
The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
IDA |
BP |
GO:0007219 |
Notch signaling pathway |
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
IEA |
BP |
GO:0007406 |
negative regulation of neuroblast proliferation |
Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts. |
IEA |
BP |
GO:0007435 |
salivary gland morphogenesis |
The process in which the anatomical structures of the salivary gland are generated and organized. |
IEP |
BP |
GO:0007492 |
endoderm development |
The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. |
IEA |
BP |
GO:0007507 |
heart development |
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
ISS |
BP |
GO:0007565 |
female pregnancy |
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. |
IEA |
BP |
GO:0007568 |
aging |
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). |
IEA |
BP |
GO:0008156 |
negative regulation of DNA replication |
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication. |
IMP |
BP |
GO:0008284 |
positive regulation of cell proliferation |
Any process that activates or increases the rate or extent of cell proliferation. |
IDA|IMP |
BP |
GO:0008285 |
negative regulation of cell proliferation |
Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
IDA |
BP |
GO:0008354 |
germ cell migration |
The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form. |
IEA |
BP |
GO:0009611 |
response to wounding |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. |
IEP |
BP |
GO:0009749 |
response to glucose |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. |
IEA |
BP |
GO:0009817 |
defense response to fungus, incompatible interaction |
A response of an organism to a fungus that prevents the occurrence or spread of disease. |
IEA |
BP |
GO:0010575 |
positive regulation of vascular endothelial growth factor production |
Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor. |
TAS |
BP |
GO:0010628 |
positive regulation of gene expression |
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. |
IDA|IGI|IMP |
BP |
GO:0010629 |
negative regulation of gene expression |
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. |
IDA|IGI |
BP |
GO:0010716 |
negative regulation of extracellular matrix disassembly |
Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. |
IC |
BP |
GO:0010718 |
positive regulation of epithelial to mesenchymal transition |
Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
IDA|NAS |
BP |
GO:0010742 |
macrophage derived foam cell differentiation |
The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. |
IC |
BP |
GO:0010763 |
positive regulation of fibroblast migration |
Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. |
IDA |
BP |
GO:0010800 |
positive regulation of peptidyl-threonine phosphorylation |
Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
IDA |
BP |
GO:0010862 |
positive regulation of pathway-restricted SMAD protein phosphorylation |
Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
IDA |
BP |
GO:0010936 |
negative regulation of macrophage cytokine production |
Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. |
IDA |
BP |
GO:0014003 |
oligodendrocyte development |
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system. |
IEA |
BP |
GO:0016049 |
cell growth |
The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. |
IEA |
BP |
GO:0016202 |
regulation of striated muscle tissue development |
Any process that modulates the frequency, rate or extent of striated muscle development. |
ISS |
BP |
GO:0016477 |
cell migration |
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
IDA |
BP |
GO:0017015 |
regulation of transforming growth factor beta receptor signaling pathway |
Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway. |
IDA |
BP |
GO:0019049 |
evasion or tolerance of host defenses by virus |
Any process, either active or passive, by which a virus avoids or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction. |
IDA |
BP |
GO:0021915 |
neural tube development |
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. |
ISS |
BP |
GO:0022408 |
negative regulation of cell-cell adhesion |
Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. |
IDA |
BP |
GO:0030214 |
hyaluronan catabolic process |
The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. |
IDA |
BP |
GO:0030279 |
negative regulation of ossification |
Any process that stops, prevents, or reduces the frequency, rate or extent of bone formation. |
IEA |
BP |
GO:0030308 |
negative regulation of cell growth |
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. |
IDA |
BP |
GO:0030334 |
regulation of cell migration |
Any process that modulates the frequency, rate or extent of cell migration. |
TAS |
BP |
GO:0030335 |
positive regulation of cell migration |
Any process that activates or increases the frequency, rate or extent of cell migration. |
IDA|IMP |
BP |
GO:0030501 |
positive regulation of bone mineralization |
Any process that activates or increases the frequency, rate or extent of bone mineralization. |
IEP |
BP |
GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. |
TAS |
BP |
GO:0031065 |
positive regulation of histone deacetylation |
Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones. |
IEA |
BP |
GO:0031334 |
positive regulation of protein complex assembly |
Any process that activates or increases the frequency, rate or extent of protein complex assembly. |
IDA |
BP |
GO:0031536 |
positive regulation of exit from mitosis |
Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity). |
IEA |
BP |
GO:0031663 |
lipopolysaccharide-mediated signaling pathway |
A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. |
IDA |
BP |
GO:0032270 |
positive regulation of cellular protein metabolic process |
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. |
IDA |
BP |
GO:0032355 |
response to estradiol |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. |
IDA |
BP |
GO:0032570 |
response to progesterone |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. |
IDA |
BP |
GO:0032667 |
regulation of interleukin-23 production |
Any process that modulates the frequency, rate, or extent of interleukin-23 production. |
IEA |
BP |
GO:0032700 |
negative regulation of interleukin-17 production |
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. |
IEA |
BP |
GO:0032740 |
positive regulation of interleukin-17 production |
Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. |
IDA |
BP |
GO:0032801 |
receptor catabolic process |
The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
IDA |
BP |
GO:0032930 |
positive regulation of superoxide anion generation |
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell. |
IDA |
BP |
GO:0032943 |
mononuclear cell proliferation |
The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form. |
IEA |
BP |
GO:0032967 |
positive regulation of collagen biosynthetic process |
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. |
IDA|IGI|IMP |
BP |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. |
IDA |
BP |
GO:0033280 |
response to vitamin D |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. |
IEA |
BP |
GO:0034616 |
response to laminar fluid shear stress |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls. |
IEA |
BP |
GO:0035066 |
positive regulation of histone acetylation |
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein. |
IEA |
BP |
GO:0035307 |
positive regulation of protein dephosphorylation |
Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein. |
IDA |
BP |
GO:0035902 |
response to immobilization stress |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. |
IEA |
BP |
GO:0042130 |
negative regulation of T cell proliferation |
Any process that stops, prevents or reduces the rate or extent of T cell proliferation. |
IEA |
BP |
GO:0042306 |
regulation of protein import into nucleus |
Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus. |
ISS |
BP |
GO:0042307 |
positive regulation of protein import into nucleus |
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus. |
IDA |
BP |
GO:0042482 |
positive regulation of odontogenesis |
Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth. |
IEA |
BP |
GO:0042493 |
response to drug |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. |
IEA |
BP |
GO:0042552 |
myelination |
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. |
IEA |
BP |
GO:0042981 |
regulation of apoptotic process |
Any process that modulates the occurrence or rate of cell death by apoptotic process. |
IBA |
BP |
GO:0043011 |
myeloid dendritic cell differentiation |
The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. |
IEA |
BP |
GO:0043029 |
T cell homeostasis |
The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. |
IEA |
BP |
GO:0043065 |
positive regulation of apoptotic process |
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
IEA |
BP |
GO:0043117 |
positive regulation of vascular permeability |
Any process that increases the extent to which blood vessels can be pervaded by fluid. |
IDA |
BP |
GO:0043406 |
positive regulation of MAP kinase activity |
Any process that activates or increases the frequency, rate or extent of MAP kinase activity. |
IDA |
BP |
GO:0043491 |
protein kinase B signaling |
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. |
IMP |
BP |
GO:0043536 |
positive regulation of blood vessel endothelial cell migration |
Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. |
IDA |
BP |
GO:0043537 |
negative regulation of blood vessel endothelial cell migration |
Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. |
IDA |
BP |
GO:0043552 |
positive regulation of phosphatidylinositol 3-kinase activity |
Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity. |
IDA |
BP |
GO:0043932 |
ossification involved in bone remodeling |
The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli. |
IEP |
BP |
GO:0045066 |
regulatory T cell differentiation |
The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types. |
IEA |
BP |
GO:0045216 |
cell-cell junction organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells. |
IDA |
BP |
GO:0045591 |
positive regulation of regulatory T cell differentiation |
Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells. |
IEA |
BP |
GO:0045596 |
negative regulation of cell differentiation |
Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. |
IEP |
BP |
GO:0045599 |
negative regulation of fat cell differentiation |
Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. |
IDA |
BP |
GO:0045662 |
negative regulation of myoblast differentiation |
Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
IDA |
BP |
GO:0045786 |
negative regulation of cell cycle |
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. |
IDA |
BP |
GO:0045892 |
negative regulation of transcription, DNA-templated |
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
IDA |
BP |
GO:0045893 |
positive regulation of transcription, DNA-templated |
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
IDA|ISS |
BP |
GO:0045930 |
negative regulation of mitotic cell cycle |
Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. |
IDA |
BP |
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IDA |
BP |
GO:0046732 |
active induction of host immune response by virus |
The intentional, virally-encoded stimulation of a host defense response to viral infection. |
TAS |
BP |
GO:0048146 |
positive regulation of fibroblast proliferation |
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. |
IEA |
BP |
GO:0048298 |
positive regulation of isotype switching to IgA isotypes |
Any process that activates or increases the frequency, rate or extent of isotype switching to IgA isotypes. |
IDA |
BP |
GO:0048535 |
lymph node development |
The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes. |
ISS |
BP |
GO:0048565 |
digestive tract development |
The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. |
IEA |
BP |
GO:0048642 |
negative regulation of skeletal muscle tissue development |
Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development. |
IDA |
BP |
GO:0048839 |
inner ear development |
The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure. |
IEA |
BP |
GO:0050679 |
positive regulation of epithelial cell proliferation |
Any process that activates or increases the rate or extent of epithelial cell proliferation. |
IEA |
BP |
GO:0050680 |
negative regulation of epithelial cell proliferation |
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. |
IDA|IMP |
BP |
GO:0050714 |
positive regulation of protein secretion |
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. |
IDA |
BP |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. |
IDA |
BP |
GO:0050765 |
negative regulation of phagocytosis |
Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis. |
IEA |
BP |
GO:0050921 |
positive regulation of chemotaxis |
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. |
IDA |
BP |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. |
IEA |
BP |
GO:0051098 |
regulation of binding |
Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. |
ISS |
BP |
GO:0051101 |
regulation of DNA binding |
Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). |
ISS |
BP |
GO:0051152 |
positive regulation of smooth muscle cell differentiation |
Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation. |
IEA |
BP |
GO:0051280 |
negative regulation of release of sequestered calcium ion into cytosol |
Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. |
IEA |
BP |
GO:0051781 |
positive regulation of cell division |
Any process that activates or increases the frequency, rate or extent of cell division. |
IEA |
BP |
GO:0051897 |
positive regulation of protein kinase B signaling |
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
IDA |
BP |
GO:0055010 |
ventricular cardiac muscle tissue morphogenesis |
The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. |
ISS |
BP |
GO:0060312 |
regulation of blood vessel remodeling |
Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels. |
IC|NAS |
BP |
GO:0060325 |
face morphogenesis |
The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head. |
IEA |
BP |
GO:0060364 |
frontal suture morphogenesis |
The process in which the frontal suture is generated and organized. |
IEA |
BP |
GO:0060389 |
pathway-restricted SMAD protein phosphorylation |
The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor. |
IDA |
BP |
GO:0060390 |
regulation of SMAD protein import into nucleus |
Any process that modulates the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
IDA |
BP |
GO:0060391 |
positive regulation of SMAD protein import into nucleus |
Any process that increases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
IDA |
BP |
GO:0060395 |
SMAD protein signal transduction |
The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell. |
IBA |
BP |
GO:0060744 |
mammary gland branching involved in thelarche |
The process in which the branching structure of the mammary gland duct is generated and organized during the period of sexual maturity in mammals. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. |
IEA |
BP |
GO:0060751 |
branch elongation involved in mammary gland duct branching |
The developmental growth process in which a branch of a mammary gland duct elongates. |
IEA |
BP |
GO:0060762 |
regulation of branching involved in mammary gland duct morphogenesis |
Any process that modulates the rate, frequency, or extent of branching involved in mammary gland duct morphogenesis. |
IEA |
BP |
GO:0060965 |
negative regulation of gene silencing by miRNA |
Any process that decreases the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression. |
IGI |
BP |
GO:0061035 |
regulation of cartilage development |
Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. |
IEA |
BP |
GO:0070306 |
lens fiber cell differentiation |
The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities. |
IEA |
BP |
GO:0070723 |
response to cholesterol |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. |
IDA |
BP |
GO:0071158 |
positive regulation of cell cycle arrest |
Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. |
IEA |
BP |
GO:0071260 |
cellular response to mechanical stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. |
IEA |
BP |
GO:0071407 |
cellular response to organic cyclic compound |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. |
IDA |
BP |
GO:0071479 |
cellular response to ionizing radiation |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. |
IEA |
BP |
GO:0071549 |
cellular response to dexamethasone stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. |
IEA |
BP |
GO:0071560 |
cellular response to transforming growth factor beta stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. |
IDA|IGI |
BP |
GO:0071677 |
positive regulation of mononuclear cell migration |
Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. |
IEA |
BP |
GO:0085029 |
extracellular matrix assembly |
The aggregation, arrangement and bonding together of the extracellular matrix. |
IDA |
BP |
GO:0090190 |
positive regulation of branching involved in ureteric bud morphogenesis |
Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. |
IEA |
BP |
GO:0097191 |
extrinsic apoptotic signaling pathway |
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. |
IDA |
BP |
GO:0097421 |
liver regeneration |
The regrowth of lost or destroyed liver. |
IEA |
BP |
GO:1900126 |
negative regulation of hyaluronan biosynthetic process |
Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process. |
IDA |
BP |
GO:1901203 |
positive regulation of extracellular matrix assembly |
Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly. |
IC |
BP |
GO:1901666 |
positive regulation of NAD+ ADP-ribosyltransferase activity |
Any process that activates or increases the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity. |
IDA |
BP |
GO:1902895 |
positive regulation of pri-miRNA transcription from RNA polymerase II promoter |
Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter. |
IDA |
BP |
GO:1903077 |
negative regulation of protein localization to plasma membrane |
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. |
IDA |
BP |
GO:1903799 |
negative regulation of production of miRNAs involved in gene silencing by miRNA |
Any process that stops, prevents or reduces the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA. |
IGI |
BP |
GO:1903911 |
positive regulation of receptor clustering |
Any process that activates or increases the frequency, rate or extent of receptor clustering. |
IEA |
BP |
GO:1905313 |
transforming growth factor beta receptor signaling pathway involved in heart development |
Any transforming growth factor beta receptor signaling pathway that is involved in heart development. |
ISS |
BP |
GO:1990314 |
cellular response to insulin-like growth factor stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus. |
IEA |
BP |
GO:1990402 |
embryonic liver development |
The process occurring during the embryonic phase whose specific outcome is the progression of the liver over time, from its formation to the mature structure. |
ISS |
BP |
GO:2000249 |
regulation of actin cytoskeleton reorganization |
Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization. |
IEA |
BP |
GO:2000679 |
positive regulation of transcription regulatory region DNA binding |
Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding. |
IDA |
BP |
GO:2000727 |
positive regulation of cardiac muscle cell differentiation |
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. |
IDA |
CC |
GO:0005576 |
extracellular region |
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
TAS |
CC |
GO:0005578 |
proteinaceous extracellular matrix |
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. |
ISS |
CC |
GO:0005615 |
extracellular space |
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
IDA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0005796 |
Golgi lumen |
The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. |
TAS |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
TAS |
CC |
GO:0005902 |
microvillus |
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. |
IDA |
CC |
GO:0009986 |
cell surface |
The external part of the cell wall and/or plasma membrane. |
IMP |
CC |
GO:0030424 |
axon |
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
IEA |
CC |
GO:0031012 |
extracellular matrix |
A structure lying external to one or more cells, which provides structural support for cells or tissues. |
IDA |
CC |
GO:0031093 |
platelet alpha granule lumen |
The volume enclosed by the membrane of the platelet alpha granule. |
TAS |
CC |
GO:0043025 |
neuronal cell body |
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
IEA |
CC |
GO:0072562 |
blood microparticle |
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. |
IDA |
MF |
GO:0001948 |
glycoprotein binding |
Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans. |
IPI |
MF |
GO:0003823 |
antigen binding |
Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. |
IPI |
MF |
GO:0005114 |
type II transforming growth factor beta receptor binding |
Interacting selectively and non-covalently with a type II transforming growth factor beta receptor. |
IDA|IMP|IPI |
MF |
GO:0005125 |
cytokine activity |
Functions to control the survival, growth, differentiation and effector function of tissues and cells. |
TAS |
MF |
GO:0005160 |
transforming growth factor beta receptor binding |
Interacting selectively and non-covalently with the transforming growth factor beta receptor. |
TAS |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0008083 |
growth factor activity |
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. |
IEA |
MF |
GO:0019899 |
enzyme binding |
Interacting selectively and non-covalently with any enzyme. |
IPI |
MF |
GO:0034713 |
type I transforming growth factor beta receptor binding |
Interacting selectively and non-covalently with a type I transforming growth factor beta receptor. |
IMP|IPI |
MF |
GO:0034714 |
type III transforming growth factor beta receptor binding |
Interacting selectively and non-covalently with a type III transforming growth factor beta receptor. |
IMP|IPI |
MF |
GO:0042803 |
protein homodimerization activity |
Interacting selectively and non-covalently with an identical protein to form a homodimer. |
IEA |
MF |
GO:0043539 |
protein serine/threonine kinase activator activity |
Binds to and increases the activity of a protein serine/threonine kinase. |
IEA |
MF |
GO:0046982 |
protein heterodimerization activity |
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. |
IEA |
MF |
GO:0047485 |
protein N-terminus binding |
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
IEA |
Domain ID | Description |
---|---|
IPR001111 |
TGF-beta, propeptide |
IPR001839 |
Transforming growth factor-beta, C-terminal |
IPR003939 |
Transforming growth factor, beta 1 |
IPR015615 |
Transforming growth factor-beta-related |
IPR016319 |
Transforming growth factor-beta |
IPR017948 |
Transforming growth factor beta, conserved site |
IPR029034 |
Cystine-knot cytokine |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04010 |
MAPK signaling pathway |
KEGG |
hsa04060 |
Cytokine-cytokine receptor interaction |
KEGG |
hsa04068 |
FoxO signaling pathway |
KEGG |
hsa04110 |
Cell cycle |
KEGG |
hsa04144 |
Endocytosis |
KEGG |
hsa04350 |
TGF-beta signaling pathway |
KEGG |
hsa04380 |
Osteoclast differentiation |
KEGG |
hsa04390 |
Hippo signaling pathway |
KEGG |
hsa04659 |
Th17 cell differentiation |
KEGG |
hsa04672 |
Intestinal immune network for IgA production |
KEGG |
hsa04932 |
Non-alcoholic fatty liver disease (NAFLD) |
KEGG |
hsa04933 |
AGE-RAGE signaling pathway in diabetic complications |
KEGG |
hsa05140 |
Leishmaniasis |
KEGG |
hsa05142 |
Chagas disease (American trypanosomiasis) |
KEGG |
hsa05144 |
Malaria |
KEGG |
hsa05145 |
Toxoplasmosis |
KEGG |
hsa05146 |
Amoebiasis |
KEGG |
hsa05152 |
Tuberculosis |
KEGG |
hsa05161 |
Hepatitis B |
KEGG |
hsa05166 |
HTLV-I infection |
KEGG |
hsa05200 |
Pathways in cancer |
KEGG |
hsa05205 |
Proteoglycans in cancer |
KEGG |
hsa05210 |
Colorectal cancer |
KEGG |
hsa05211 |
Renal cell carcinoma |
KEGG |
hsa05212 |
Pancreatic cancer |
KEGG |
hsa05220 |
Chronic myeloid leukemia |
KEGG |
hsa05321 |
Inflammatory bowel disease (IBD) |
KEGG |
hsa05323 |
Rheumatoid arthritis |
KEGG |
hsa05410 |
Hypertrophic cardiomyopathy (HCM) |
KEGG |
hsa05414 |
Dilated cardiomyopathy |
KEGG |
WP2431 |
Spinal Cord Injury |
WikiPathways |
WP560 |
TGF-beta Receptor Signaling |
WikiPathways |
WP3859 |
TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition |
WikiPathways |
WP2328 |
Allograft Rejection |
WikiPathways |
WP2572 |
Primary Focal Segmental Glomerulosclerosis FSGS |
WikiPathways |
WP3646 |
Hepatitis C and Hepatocellular Carcinoma |
WikiPathways |
WP2848 |
Differentiation Pathway |
WikiPathways |
WP1559 |
TFs Regulate miRNAs related to cardiac hypertrophy |
WikiPathways |
WP366 |
TGF-beta Signaling Pathway |
WikiPathways |
WP2355 |
Corticotropin-releasing hormone signaling pathway |
WikiPathways |
WP2884 |
NRF2 pathway |
WikiPathways |
WP3624 |
Lung fibrosis |
WikiPathways |
WP710 |
DNA Damage Response (only ATM dependent) |
WikiPathways |
WP236 |
Adipogenesis |
WikiPathways |
WP2870 |
Extracellular vesicle-mediated signaling in recipient cells |
WikiPathways |
WP2855 |
Dopaminergic Neurogenesis |
WikiPathways |
WP3670 |
Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway |
WikiPathways |
WP2853 |
Endoderm Differentiation |
WikiPathways |
WP382 |
MAPK Signaling Pathway |
WikiPathways |
WP2873 |
Aryl Hydrocarbon Receptor Pathway |
WikiPathways |
WP615 |
Senescence and Autophagy in Cancer |
WikiPathways |
WP1544 |
MicroRNAs in cardiomyocyte hypertrophy |
WikiPathways |
WP474 |
Endochondral Ossification |
WikiPathways |
WP179 |
Cell Cycle |
WikiPathways |
WP554 |
ACE Inhibitor Pathway |
WikiPathways |
WP2406 |
Cardiac Progenitor Differentiation |
WikiPathways |
WP2795 |
Cardiac Hypertrophic Response |
WikiPathways |
WP3874 |
Canonical and Non-Canonical TGF-B signaling |
WikiPathways |
WP530 |
Cytokines and Inflammatory Response |
WikiPathways |
WP2332 |
Interleukin-11 Signaling Pathway |
WikiPathways |
WP286 |
IL-3 Signaling Pathway |
WikiPathways |
WP69 |
T-Cell antigen Receptor (TCR) Signaling Pathway |
WikiPathways |
h_alkPathway |
ALK in cardiac myocytes |
BioCarta |
h_g1Pathway |
Cell Cycle: G1/S Check Point |
BioCarta |
h_ctcfPathway |
CTCF: First Multivalent Nuclear Factor |
BioCarta |
h_inflamPathway |
Cytokines and Inflammatory Response |
BioCarta |
h_erythPathway |
Erythrocyte Differentiation Pathway |
BioCarta |
h_slrp2Pathway |
Function of SLRP in Bone: An Integrated View |
BioCarta |
h_mapkPathway |
MAPKinase Signaling Pathway |
BioCarta |
h_p38mapkPathway |
p38 MAPK Signaling Pathway |
BioCarta |
h_tob1Pathway |
Role of Tob in T-cell activation |
BioCarta |
h_nktPathway |
Selective expression of chemokine receptors during T-cell polarization |
BioCarta |
h_il1rPathway |
Signal transduction through IL1R |
BioCarta |
h_tgfbPathway |
TGF beta signaling pathway |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0000786 |
Spontaneous Abortion |
C0001418 |
Adenocarcinoma |
C0003504 |
Aortic Valve Insufficiency |
C0004096 |
Asthma |
C0005138 |
Berylliosis |
C0007137 |
Squamous Cell Carcinoma |
C0007140 |
Carcinosarcoma |
C0007621 |
Neoplastic Cell Transformation |
C0008925 |
Cleft Palate |
C0009404 |
Colorectal Neoplasms |
C0010674 |
Cystic Fibrosis |
C0011853 |
Diabetes Mellitus, Experimental |
C0011860 |
Diabetes Mellitus, Non-Insulin-Dependent |
C0011881 |
Diabetic Nephropathy |
C0011882 |
Diabetic Neuropathies |
C0011989 |
Camurati-Engelmann Syndrome |
C0013238 |
Dry Eye Syndromes |
C0013264 |
Muscular Dystrophy, Duchenne |
C0013295 |
Duodenal Ulcer |
C0016059 |
Fibrosis |
C0017661 |
Iga Glomerulonephritis |
C0017668 |
Focal Glomerulosclerosis |
C0019189 |
Hepatitis, Chronic |
C0019284 |
Diaphragmatic Hernia |
C0020507 |
Hyperplasia |
C0020517 |
Hypersensitivity |
C0020538 |
Hypertensive Disease |
C0021368 |
Inflammation |
C0022658 |
Kidney Diseases |
C0022661 |
Kidney Failure, Chronic |
C0023890 |
Liver Cirrhosis |
C0023891 |
Liver Cirrhosis, Alcoholic |
C0023893 |
Liver Cirrhosis, Experimental |
C0024115 |
Lung Diseases |
C0024117 |
Chronic Obstructive Airway Disease |
C0024121 |
Lung Neoplasms |
C0026848 |
Myopathy |
C0027051 |
Myocardial Infarction |
C0027626 |
Neoplasm Invasiveness |
C0027627 |
Neoplasm Metastasis |
C0027726 |
Nephrotic Syndrome |
C0029172 |
Oral Submucous Fibrosis |
C0029456 |
Osteoporosis |
C0029458 |
Osteoporosis, Postmenopausal |
C0030297 |
Pancreatic Neoplasm |
C0030354 |
Papilloma |
C0030848 |
Peyronie Disease |
C0032285 |
Pneumonia |
C0033578 |
Prostatic Neoplasms |
C0033687 |
Proteinuria |
C0034067 |
Pulmonary Emphysema |
C0034069 |
Pulmonary Fibrosis |
C0036202 |
Sarcoidosis |
C0037286 |
Skin Neoplasms |
C0038454 |
Cerebrovascular Accident |
C0040028 |
Thrombocythemia, Essential |
C0041948 |
Uremia |
C0041956 |
Ureteral Obstruction |
C0042109 |
Urticaria |
C0149931 |
Migraine Disorders |
C0158266 |
Intervertebral Disc Degeneration |
C0241910 |
Hepatitis, Autoimmune |
C0242488 |
Acute Lung Injury |
C0243026 |
Sepsis |
C0400966 |
Non-Alcoholic Fatty Liver Disease |
C0521607 |
Peritoneal Fibrosis |
C0553980 |
Endomyocardial Fibrosis |
C0600519 |
Ventricular Remodeling |
C1527249 |
Colorectal Cancer |
C2239176 |
Liver Carcinoma |
C2609414 |
Acute Kidney Injury |
Tissue | Cell Type |
---|---|
bone marrow |
hematopoietic cells |
Database Name |
---|
DisGeNET |
DGA |
Pubmed ID | Author | Year | Title |
---|---|---|---|
19141577 |
Kim et al. |
2009 |
Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
BMPR1A |
657 |
P36894 |
0.49 |
BUB1 |
699 |
O43683 |
0.49 |
MCC |
4163 |
P23508 |
0.49 |
AURKA |
6790 |
O14965 |
0.49 |
TLR2 |
7097 |
O60603 |
0.49 |
AXIN2 |
8313 |
Q9Y2T1 |
0.49 |
BCL10 |
8915 |
O95999 |
0.49 |
DLC1 |
10395 |
Q96QB1 |
0.49 |
FBXW7 |
55294 |
Q969H0 |
0.49 |
BMP2 |
650 |
P12643 |
0.52 |
BMP3 |
651 |
P12645 |
0.52 |
CTGF |
1490 |
P29279 |
0.52 |
ITGB6 |
3694 |
P18564 |
0.52 |
SMAD2 |
4087 |
Q15796 |
0.52 |
SMAD3 |
4088 |
P84022 |
0.52 |
CCL3 |
6348 |
P10147 |
0.52 |
CILP |
8483 |
O75339 |
0.55 |
EIF1AX |
1964 |
P47813 |
0.63 |
LAMB1 |
3912 |
P07942 |
0.63 |
LAMC1 |
3915 |
P11047 |
0.63 |
NMT1 |
4836 |
P30419 |
0.63 |
CCL5 |
6352 |
P13501 |
0.63 |
TGFB1 |
7040 |
P01137 |
0.63 |
THRSP |
7069 |
Q92748 |
0.63 |
NMT2 |
9397 |
O60551 |
0.63 |
FEM1B |
10116 |
Q9UK73 |
0.63 |
PARD6A |
50855 |
Q9NPB6 |
0.63 |
BCAS3 |
54828 |
Q9H6U6 |
0.63 |
RMND5A |
64795 |
Q9H871 |
0.63 |
CCDC33 |
80125 |
Q8N5R6 |
0.63 |
AGR3 |
155465 |
Q8TD06 |
0.63 |
UBR1 |
197131 |
Q8IWV7 |
0.63 |
C4orf48 |
401115 |
Q5BLP8 |
0.63 |
SPARC |
6678 |
P09486 |
0.65 |
THBS1 |
7057 |
P07996 |
0.70 |
TGFBRAP1 |
9392 |
Q8WUH2 |
0.72 |
WFIKKN1 |
117166 |
Q96NZ8 |
0.72 |
WFIKKN2 |
124857 |
Q8TEU8 |
0.72 |
FKBP1A |
2280 |
P62942 |
0.73 |
FNTA |
2339 |
P49354 |
0.73 |
FSTL1 |
11167 |
Q12841 |
0.76 |
MMP2 |
4313 |
P08253 |
0.81 |
COL2A1 |
1280 |
P02458 |
0.85 |
ENG |
2022 |
P17813 |
0.85 |
DCN |
1634 |
P07585 |
0.87 |
BMPR2 |
659 |
Q13873 |
0.00 |
INHBB |
3625 |
P09529 |
0.00 |
INHBC |
3626 |
P55103 |
0.00 |
MAPK3 |
5595 |
P27361 |
0.00 |
APC |
324 |
P25054 |
0.49 |
CDKN2A |
1029 |
Q8N726 |
0.49 |
EGFR |
1956 |
P00533 |
0.49 |
ERBB2 |
2064 |
P04626 |
0.49 |
PDGFRL |
5157 |
Q15198 |
0.49 |
MLH3 |
27030 |
Q9UHC1 |
0.49 |
DPT |
1805 |
Q07507 |
0.52 |
ITGAV |
3685 |
P06756 |
0.52 |
LTBP3 |
4054 |
Q9NS15 |
0.52 |
SDC2 |
6383 |
P34741 |
0.52 |
FCN1 |
2219 |
O00602 |
0.58 |
LTBP4 |
8425 |
Q8N2S1 |
0.62 |
CST6 |
1474 |
Q15828 |
0.63 |
HOXC6 |
3223 |
P09630 |
0.63 |
SMAD7 |
4092 |
O15105 |
0.63 |
MEOX2 |
4223 |
P50222 |
0.63 |
KLK7 |
5650 |
P49862 |
0.63 |
SNAI1 |
6615 |
O95863 |
0.63 |
ST14 |
6768 |
Q9Y5Y6 |
0.63 |
DIRAS3 |
9077 |
O95661 |
0.63 |
GREB1 |
9687 |
Q4ZG55 |
0.63 |
LAMTOR5 |
10542 |
O43504 |
0.63 |
KLK5 |
25818 |
Q9Y337 |
0.63 |
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
PRSS50 |
29122 |
Q9UI38 |
0.63 |
PSMC3IP |
29893 |
Q9P2W1 |
0.63 |
ANGPTL4 |
51129 |
Q9BY76 |
0.63 |
WHSC1L1 |
54904 |
Q9BZ95 |
0.63 |
MTA3 |
57504 |
Q9BTC8 |
0.63 |
PDLIM2 |
64236 |
Q96JY6 |
0.63 |
SLC35G2 |
80723 |
Q8TBE7 |
0.63 |
SCGB3A1 |
92304 |
Q96QR1 |
0.63 |
KLK9 |
284366 |
Q9UKQ9 |
0.63 |
BLID |
414899 |
Q8IZY5 |
0.63 |
EPS15 |
2060 |
P42566 |
0.65 |
ITGB8 |
3696 |
P26012 |
0.65 |
DIP2A |
23181 |
Q14689 |
0.72 |
SNIP1 |
79753 |
Q8TAD8 |
0.72 |
PZP |
5858 |
P20742 |
0.75 |
TGFB2 |
7042 |
P61812 |
0.75 |
VASN |
114990 |
Q6EMK4 |
0.76 |
DAXX |
1616 |
Q9UER7 |
0.77 |
MMP9 |
4318 |
P14780 |
0.77 |
EIF3I |
8668 |
Q13347 |
0.84 |
FMOD |
2331 |
Q06828 |
0.85 |
VTN |
7448 |
P04004 |
0.85 |
APP |
351 |
P05067 |
0.86 |
BGN |
633 |
P21810 |
0.86 |
ACVRL1 |
94 |
P37023 |
0.88 |
LTBP1 |
4052 |
Q14766 |
0.88 |
YWHAE |
7531 |
P62258 |
0.88 |
TGFBR2 |
7048 |
P37173 |
0.90 |
TGFBR1 |
7046 |
P36897 |
0.96 |
TGFBR3 |
7049 |
Q03167 |
0.96 |