Protein Description

Gene Symbol TACC1
Entrez ID 6867
Uniprot ID O75410
Description transforming, acidic coiled-coil containing protein 1
Chromosomal Location chr8: 38,728,186-38,853,028
Ontology GO ID GO Term Definition Evidence

BP

GO:0000226

microtubule cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

IBA

BP

GO:0007049

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

IEA

BP

GO:0008283

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

IBA

BP

GO:0021987

cerebral cortex development

The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.

IBA

BP

GO:0051301

cell division

The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

IEA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IEA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IBA|IDA

CC

GO:0005815

microtubule organizing center

An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.

IEA

CC

GO:0015630

microtubule cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

IBA|IDA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IEA

CC

GO:0030496

midbody

A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.

IEA

CC

GO:0045111

intermediate filament cytoskeleton

Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

Domain ID Description

IPR007707

Transforming acidic coiled-coil-containing protein

No pathways found.

UMLS CUI UMLS Term

C0206726

Gliosarcoma

C0334588

Giant Cell Glioblastoma

Tissue Cell Type

bone marrow

hematopoietic cells

bronchus

respiratory epithelial cells

colon

glandular cells

colon

peripheral nerve/ganglion

fallopian tube

glandular cells

gallbladder

glandular cells

lung

macrophages

pancreas

exocrine glandular cells

placenta

decidual cells

placenta

trophoblastic cells

rectum

glandular cells

testis

cells in seminiferous ducts

No databases found.

Pubmed ID Author Year Title

17148555

Wood et al.

2007

Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

BTRC

8945

Q9Y297

0.63

TACC2

10579

O95359

0.63

SH2D4A

63898

Q9H788

0.63

TACC1

6867

O75410

0.67

LYST

1130

Q99698

0.72

BRD3

8019

Q15059

0.72

RB1CC1

9821

Q8TDY2

0.72

BAIAP2L1

55971

Q9UHR4

0.72

AURKB

9212

Q96GD4

0.77

YEATS4

8089

O95619

0.78

SNRPG

6637

P62308

0.89

LSM7

51690

Q9UK45

0.89

CKAP5

9793

Q14008

0.90

S100A11

6282

P31949

0.49

SLC9A3R1

9368

O14745

0.49

PLXNB2

23654

O15031

0.49

NIF3L1

60491

Q9GZT8

0.49

C12orf57

113246

Q99622

0.49

KAT2A

2648

Q92830

0.59

THAP12

5612

O43422

0.63

STX5

6811

Q13190

0.63

VAPB

9217

O95292

0.63

ITSN2

50618

Q9NZM3

0.63

DTNBP1

84062

Q96EV8

0.63

BARD1

580

Q99728

0.72

VAPA

9218

Q9P0L0

0.72

KDM1A

23028

O60341

0.72

HTT

3064

P42858

0.73

FBXW11

23291

Q9UKB1

0.73

MEMO1

51072

Q9Y316

0.73

TDRD7

23424

Q8NHU6

0.79

AURKA

6790

O14965

0.88