BP

GO:0001525

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

IEA

BP

GO:0001945

lymph vessel development

The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.

ISS

BP

GO:0002092

positive regulation of receptor internalization

Any process that activates or increases the frequency, rate or extent of receptor internalization.

IEA

BP

GO:0002223

stimulatory C-type lectin receptor signaling pathway

Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.

TAS

BP

GO:0002250

adaptive immune response

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).

IBA|ISS

BP

GO:0002281

macrophage activation involved in immune response

A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.

IBA|ISS

BP

GO:0002283

neutrophil activation involved in immune response

The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.

IBA|ISS

BP

GO:0002366

leukocyte activation involved in immune response

A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.

ISS

BP

GO:0002554

serotonin secretion by platelet

The regulated release of serotonin by a platelet or group of platelets.

ISS

BP

GO:0006468

protein phosphorylation

The process of introducing a phosphate group on to a protein.

IDA|ISS

BP

GO:0006954

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

IBA

BP

GO:0007159

leukocyte cell-cell adhesion

The attachment of a leukocyte to another cell via adhesion molecules.

IDA

BP

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.

IBA

BP

GO:0007229

integrin-mediated signaling pathway

A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

ISS|NAS

BP

GO:0007257

activation of JUN kinase activity

The initiation of the activity of the inactive enzyme JUN kinase (JNK).

IEA

BP

GO:0008283

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

TAS

BP

GO:0009887

animal organ morphogenesis

Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

TAS

BP

GO:0010543

regulation of platelet activation

Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.

ISS

BP

GO:0010803

regulation of tumor necrosis factor-mediated signaling pathway

Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.

IMP

BP

GO:0016032

viral process

A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.

IEA

BP

GO:0018105

peptidyl-serine phosphorylation

The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

IEA

BP

GO:0019370

leukotriene biosynthetic process

The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.

IEA

BP

GO:0030168

platelet activation

A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.

TAS

BP

GO:0030593

neutrophil chemotaxis

The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.

IDA

BP

GO:0031623

receptor internalization

A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.

ISS

BP

GO:0032481

positive regulation of type I interferon production

Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

IEA

BP

GO:0032928

regulation of superoxide anion generation

Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell.

ISS

BP

GO:0033630

positive regulation of cell adhesion mediated by integrin

Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.

IBA|ISS

BP

GO:0038083

peptidyl-tyrosine autophosphorylation

The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein.

IBA

BP

GO:0038095

Fc-epsilon receptor signaling pathway

A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.

TAS

BP

GO:0038096

Fc-gamma receptor signaling pathway involved in phagocytosis

An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.

TAS

BP

GO:0042742

defense response to bacterium

Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.

ISS

BP

GO:0042991

transcription factor import into nucleus

The directed movement of a transcription factor from the cytoplasm to the nucleus.

IMP

BP

GO:0043306

positive regulation of mast cell degranulation

Any process that activates or increases the frequency, rate or extent of mast cell degranulation.

IBA

BP

GO:0043313

regulation of neutrophil degranulation

Any process that modulates the frequency, rate, or extent of neutrophil degranulation.

ISS

BP

GO:0043366

beta selection

The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell.

IEA

BP

GO:0045087

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

IBA|ISS

BP

GO:0045401

positive regulation of interleukin-3 biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3.

IEA

BP

GO:0045425

positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor.

IEA

BP

GO:0045579

positive regulation of B cell differentiation

Any process that activates or increases the frequency, rate or extent of B cell differentiation.

IMP

BP

GO:0045588

positive regulation of gamma-delta T cell differentiation

Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation.

IEA

BP

GO:0045780

positive regulation of bone resorption

Any process that activates or increases the frequency, rate or extent of bone resorption.

ISS

BP

GO:0046638

positive regulation of alpha-beta T cell differentiation

Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation.

IEA

BP

GO:0046641

positive regulation of alpha-beta T cell proliferation

Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation.

IBA

BP

GO:0048514

blood vessel morphogenesis

The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.

ISS

BP

GO:0050715

positive regulation of cytokine secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.

IEA

BP

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.

IEA

BP

GO:0050764

regulation of phagocytosis

Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.

ISS

BP

GO:0050850

positive regulation of calcium-mediated signaling

Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.

IEA

BP

GO:0050853

B cell receptor signaling pathway

A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.

IBA|ISS

BP

GO:0051090

regulation of sequence-specific DNA binding transcription factor activity

Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

IMP

BP

GO:0070372

regulation of ERK1 and ERK2 cascade

Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

ISS

BP

GO:0071226

cellular response to molecule of fungal origin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide.

ISS

BP

GO:0071404

cellular response to low-density lipoprotein particle stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.

ISS

BP

GO:0090237

regulation of arachidonic acid secretion

Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue.

ISS

BP

GO:0090330

regulation of platelet aggregation

Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.

IBA|ISS

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IC|TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0019815

B cell receptor complex

An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.

IEA

CC

GO:0031234

extrinsic component of cytoplasmic side of plasma membrane

The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.

IBA

CC

GO:0032009

early phagosome

A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.

ISS

CC

GO:0042101

T cell receptor complex

A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.

IDA

CC

GO:0043234

protein complex

A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.

IDA

MF

GO:0004672

protein kinase activity

Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

IDA|NAS

MF

GO:0004674

protein serine/threonine kinase activity

Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

IDA

MF

GO:0004713

protein tyrosine kinase activity

Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

EXP|TAS

MF

GO:0004715

non-membrane spanning protein tyrosine kinase activity

Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate.

IDA|TAS

MF

GO:0004716

receptor signaling protein tyrosine kinase activity

Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

IEA

MF

GO:0005178

integrin binding

Interacting selectively and non-covalently with an integrin.

IPI

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0019901

protein kinase binding

Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

IEA