PCOSBase

Protein Description

Gene Symbol	STAU1
Entrez ID	6780
Uniprot ID	O95793
Description	staufen double-stranded RNA binding protein 1
Chromosomal Location	chr20: 49,113,339-49,188,367

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0034599	cellular response to oxidative stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.	IEA
BP	GO:0045070	positive regulation of viral genome replication	Any process that activates or increases the frequency, rate or extent of viral genome replication.	IMP
BP	GO:0046726	positive regulation by virus of viral protein levels in host cell	Any process where the infecting virus increases the levels of viral proteins in a cell.	IMP
BP	GO:1900273	positive regulation of long-term synaptic potentiation	Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation.	IEA
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IDA
CC	GO:0005783	endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).	IDA
CC	GO:0005791	rough endoplasmic reticulum	The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.	IEA
CC	GO:0005875	microtubule associated complex	Any multimeric complex connected to a microtubule.	TAS
CC	GO:0005886	plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.	IDA
CC	GO:0010494	cytoplasmic stress granule	A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.	ISS
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0030425	dendrite	A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.	IDA
CC	GO:0036464	cytoplasmic ribonucleoprotein granule	A ribonucleoprotein granule located in the cytoplasm.	IDA
CC	GO:0043025	neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.	IEA
CC	GO:0044297	cell body	The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.	IDA
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
MF	GO:0003725	double-stranded RNA binding	Interacting selectively and non-covalently with double-stranded RNA.	IEA
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0008157	protein phosphatase 1 binding	Interacting selectively and non-covalently with the enzyme protein phosphatase 1.	IEA
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA

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Domain ID	Description
IPR014720	Double-stranded RNA-binding domain
IPR032478	Staufen, C-terminal

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No pathways found.

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No diseases found.

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Tissue	Cell Type
bronchus	respiratory epithelial cells
cerebellum	Purkinje cells
endometrium	glandular cells
esophagus	squamous epithelial cells
nasopharynx	respiratory epithelial cells
skin	fibroblasts
thyroid gland	glandular cells
urinary bladder	urothelial cells

No databases found.

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Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
RASA1	5921	P20936	0.52
APP	351	P05067	0.56
ACLY	47	P53396	0.63
ADAR	103	P55265	0.63
SLC25A5	292	P05141	0.63
ARF4	378	P18085	0.63
ARF5	381	P84085	0.63
ARF6	382	P62330	0.63
ARL1	400	P40616	0.63
ATP1A1	476	P05023	0.63
ATP5A1	498	P25705	0.63
ATP5B	506	P06576	0.63
ATP5C1	509	P36542	0.63
ATP5O	539	P48047	0.63
CAD	790	P27708	0.63
CANX	821	P27824	0.63
SERPINH1	871	P50454	0.63
CDK1	983	P06493	0.63
CDC5L	988	Q99459	0.63
AP2M1	1173	Q96CW1	0.63
AP3S1	1176	Q92572	0.63
CLTC	1213	Q00610	0.63
COPA	1314	P53621	0.63
CSE1L	1434	P55060	0.63
DARS	1615	P14868	0.63
DDOST	1650	P39656	0.63
DDX1	1653	Q92499	0.63
DDX3X	1654	O00571	0.63
DDX5	1655	P17844	0.63
DHX15	1665	O43143	0.63
DHCR7	1717	Q9UBM7	0.63
DNM2	1785	P50570	0.63
EEF1A1	1915	P68104	0.63
EEF1D	1936	P29692	0.63
EEF1G	1937	P26641	0.63
EIF4A1	1973	P60842	0.63
ENO1	2023	P06733	0.63
EPRS	2058	P07814	0.63
ETFB	2109	P38117	0.63
ACSL3	2181	O95573	0.63
FASN	2194	P49327	0.63
FLNA	2316	P21333	0.63
GAPDH	2597	P04406	0.63
GARS	2617	P41250	0.63
GOLGA2	2801	Q08379	0.63
GOLGA3	2802	Q08378	0.63
HK1	3098	P19367	0.63
HNRNPA1	3178	P09651	0.63
HNRNPA2B1	3181	P22626	0.63
HNRNPAB	3182	Q99729	0.63
HNRNPC	3183	P07910	0.63
HNRNPF	3185	P52597	0.63
HNRNPH1	3187	P31943	0.63
HNRNPH2	3188	P55795	0.63
HNRNPH3	3189	P31942	0.63
HNRNPK	3190	P61978	0.63
HSD17B4	3295	P51659	0.63
HSPA1A	3303	P0DMV8	0.63
HSPA1B	3304	P0DMV9	0.63
HSPA1L	3305	P34931	0.63
HSPA5	3309	P11021	0.63
HSPA8	3312	P11142	0.63
HSPA9	3313	P38646	0.63
HSPD1	3329	P10809	0.63
IARS	3376	P41252	0.63
IDH3A	3419	P50213	0.63
EIF3E	3646	P60228	0.63
ITIH4	3700	Q14624	0.63
KIF5A	3798	Q12840	0.63
KIF5B	3799	P33176	0.63
KPNB1	3837	Q14974	0.63
IPO5	3843	O00410	0.63
LDHA	3939	P00338	0.63
LDHB	3945	P07195	0.63
LYZ	4069	P61626	0.63
CAPRIN1	4076	Q14444	0.63
MCM7	4176	P33993	0.63
RAB8A	4218	P61006	0.63
MOV10	4343	Q9HCE1	0.63
HNRNPM	4670	P52272	0.63
DRG1	4733	Q9Y295	0.63
NONO	4841	Q15233	0.63
NPM1	4869	P06748	0.63
NSF	4905	P46459	0.63
OAT	4942	P04181	0.63
PCBP1	5093	Q15365	0.63
PDHB	5162	P11177	0.63
PFKL	5211	P17858	0.63
PHB	5245	P35232	0.63
PKM	5315	P14618	0.63
PLS3	5358	P13797	0.63
PRKDC	5591	P78527	0.63
PSMC6	5706	P62333	0.63
PSMD2	5708	Q13200	0.63
PSMD3	5709	O43242	0.63
ALDH18A1	5832	P54886	0.63
PYGL	5836	P06737	0.63
QARS	5859	P47897	0.63
RAB5C	5878	P51148	0.63
RAN	5901	P62826	0.63
RARS	5917	P54136	0.63
ABCE1	6059	P61221	0.63
RPL3	6122	P39023	0.63
RPL4	6124	P36578	0.63
RPL5	6125	P46777	0.63
RPL7	6129	P18124	0.63
RPL13	6137	P26373	0.63
RPL15	6138	P61313	0.63
RPL17	6139	P18621	0.63
RPL18	6141	Q07020	0.63
RPL19	6143	P84098	0.63
RPL21	6144	P46778	0.63
RPL24	6152	P83731	0.63
RPL29	6159	P47914	0.63
RPN1	6184	P04843	0.63
RPS3	6188	P23396	0.63
RPS3A	6189	P61247	0.63
RPS9	6203	P46781	0.63
SAFB	6294	Q15424	0.63
SFPQ	6421	P23246	0.63
SRSF1	6426	Q07955	0.63
SRSF4	6429	Q08170	0.63
SRSF7	6432	Q16629	0.63
SPTAN1	6709	Q13813	0.63
SRP68	6730	Q9UHB9	0.63
SRP72	6731	O76094	0.63
TCP1	6950	P17987	0.63
TPR	7175	P12270	0.63
TUBA4A	7277	P68366	0.63
VARS	7407	P26640	0.63
VIM	7431	P08670	0.63
XPO1	7514	O14980	0.63
YWHAZ	7534	P63104	0.63
MOGS	7841	Q13724	0.63
DDX39B	7919	Q13838	0.63
SMC1A	8243	Q14683	0.63
SLC25A11	8402	Q02978	0.63
IRS4	8471	O14654	0.63
KHSRP	8570	Q92945	0.63
PRKRA	8575	O75569	0.63
EIF3A	8661	Q14152	0.63
EIF3B	8662	P55884	0.63
EIF3D	8664	O15371	0.63
PABPC4	8761	Q13310	0.63
CPNE3	8895	O75131	0.63
AP3D1	8943	O14617	0.63
SART1	9092	O43290	0.63
ATP6V0D1	9114	P61421	0.63
AIFM1	9131	O95831	0.63
DDX21	9188	Q9NR30	0.63
DDX23	9416	Q9BUQ8	0.63
NPEPPS	9520	P55786	0.63
PRDX6	9588	P30041	0.63
NUP155	9631	O75694	0.63
EIF4A3	9775	P38919	0.63
MATR3	9782	P43243	0.63
PTDSS1	9791	P48651	0.63
TOMM70	9868	O94826	0.63
ARPC4	10093	P59998	0.63
LRPPRC	10128	P42704	0.63
TRIM28	10155	Q13263	0.63
ALYREF	10189	Q86V81	0.63
HNRNPR	10236	O43390	0.63
SF3B4	10262	Q15427	0.63
TUBB3	10381	Q13509	0.63
RACK1	10399	P63244	0.63
CDIPT	10423	O14735	0.63
SYNCRIP	10492	O60506	0.63
MYBBP1A	10514	Q9BQG0	0.63
DDX17	10521	Q92841	0.63
IPO7	10527	O95373	0.63
GLRX3	10539	O76003	0.63
CCT4	10575	P50991	0.63
CCT2	10576	P78371	0.63
PRPF8	10594	Q6P2Q9	0.63
IGF2BP1	10642	Q9NZI8	0.63
IGF2BP3	10643	O00425	0.63
IGF2BP2	10644	Q9Y6M1	0.63
RRAGA	10670	Q7L523	0.63
KIF1C	10749	O43896	0.63
SRSF10	10772	O75494	0.63
RAB10	10890	P61026	0.63
HNRNPA0	10949	Q13151	0.63
YWHAQ	10971	P27348	0.63
GCN1	10985	Q92616	0.63
SF3B2	10992	Q13435	0.63
NUDT21	11051	O43809	0.63
KRR1	11103	Q13601	0.63
PHB2	11331	Q99623	0.63
COPZ1	22818	P61923	0.63
DHX30	22907	Q7L2E3	0.63
SNRNP200	23020	O75643	0.63
FAM120A	23196	Q9NZB2	0.63
SCFD1	23256	Q8WVM8	0.63
SF3B1	23451	O75533	0.63
COPG2	26958	Q9UBF2	0.63
CYFIP2	26999	Q96F07	0.63
RBMX	27316	P38159	0.63
NXT1	29107	Q9UKK6	0.63
CPSF1	29894	Q10570	0.63
SEC61A1	29927	P61619	0.63
HACD3	51495	Q9P035	0.63
LARS	51520	Q9P2J5	0.63
LUC7L2	51631	Q9Y383	0.63
ZFR	51663	Q96KR1	0.63
PTCD3	55037	Q96EY7	0.63
LRRC59	55379	Q96AG4	0.63
PRPF40A	55660	O75400	0.63
DDX27	55661	Q96GQ7	0.63
ZC3H15	55854	Q8WU90	0.63
NKRF	55922	O15226	0.63
RNF20	56254	Q5VTR2	0.63
THOC2	57187	Q8NI27	0.63
SRPRB	58477	Q9Y5M8	0.63
ZMAT3	64393	Q9HA38	0.63
UPF3B	65109	Q9BZI7	0.63
DDX50	79009	Q9BQ39	0.63
CPSF7	79869	Q8N684	0.63
FIP1L1	81608	Q6UN15	0.63
DOCK7	85440	Q96N67	0.63
ZNF622	90441	Q969S3	0.63
LONRF1	91694	Q17RB8	0.63
SFXN1	94081	Q9H9B4	0.63
RAVER1	125950	Q8IY67	0.63
HNRNPA3	220988	P51991	0.63
TINCR	257000	N/A	0.63
RPL9; RPL9P7; RPL9P8; RPL9P9	6133	P32969	0.63
CDC42	998	P60953	0.67
MAPT	4137	P10636	0.67
SRPK1	6732	Q96SB4	0.70
SNF8	11267	Q96H20	0.72
ILF2	3608	Q12905	0.73
ILF3	3609	Q12906	0.73
RPL8	6132	P62917	0.73
RPL10	6134	P27635	0.73
RPS8	6202	P62241	0.73
RPS2	6187	P15880	0.74
RPL14	9045	P50914	0.74
RPL7A	6130	P62424	0.75
STAU1	6780	O95793	0.75
ACTB	60	P60709	0.82
RPS4X	6191	P62701	0.82
TUBA1A	7846	Q71U36	0.83
FMR1	2332	Q06787	0.84
NCL	4691	P19338	0.85
RPS6	6194	P62753	0.85
TUBB	203068	P07437	0.85
RPLP0	6175	P05388	0.88
UPF1	5976	Q92900	0.89
PCM1	5108	Q15154	0.49
CC2D2A	57545	Q9P2K1	0.49
SCLT1	132320	Q96NL6	0.49
MAP1B	4131	P46821	0.55
BMI1	648	P35226	0.63
CDC20	991	Q12834	0.63
CSNK2B	1460	P67870	0.63
FLNB	2317	O75369	0.63
GJA1	2697	P17302	0.63
HIST1H1A	3024	Q02539	0.63
HDAC1	3065	Q13547	0.63
HNRNPD	3184	Q14103	0.63
IFI16	3428	Q16666	0.63
ILK	3611	Q13418	0.63
JUN	3725	P05412	0.63
MCM2	4171	P49736	0.63
MNDA	4332	P41218	0.63
NTRK1	4914	P04629	0.63
PPP1R7	5510	Q15435	0.63
SPP1	6696	P10451	0.63
UBE2D3	7323	P61077	0.63
CUL3	8452	Q13618	0.63
CUL1	8454	Q13616	0.63
MDC1	9656	Q14676	0.63
KIAA0101	9768	Q15004	0.63
CUL7	9820	Q14999	0.63
IVNS1ABP	10625	Q9Y6Y0	0.63
PAXIP1	22976	Q6ZW49	0.63
GTPBP4	23560	Q9BZE4	0.63
FZR1	51343	Q9UM11	0.63
SIRT7	51547	Q9NRC8	0.63
PRR11	55771	Q96HE9	0.63
RIOK2	55781	Q9BVS4	0.63
CAND1	55832	Q86VP6	0.63
NOL12	79159	Q9UGY1	0.63
RBM4B	83759	Q9BQ04	0.63
SPRTN	83932	Q9H040	0.63
CCDC8	83987	Q9H0W5	0.63
ZBTB38	253461	Q8NAP3	0.63
MYH1	4619	P12882	0.65
NCBP1	4686	Q09161	0.65
RPL28	6158	P46779	0.65
ROCK2	9475	O75116	0.65
KIF2B	84643	Q8N4N8	0.65
ESR2	2100	Q92731	0.67
RAC1	5879	P63000	0.67
PPP1CC	5501	P36873	0.70
HDGF	3068	P51858	0.72
MAP3K14	9020	Q99558	0.72
SRPK3	26576	Q9UPE1	0.72
CBX8	57332	Q9HC52	0.72
DHX58	79132	Q96C10	0.72
ELAVL1	1994	Q15717	0.73
TARDBP	23435	Q13148	0.73
TAX1BP3	30851	O14907	0.73
PABPN1	8106	Q86U42	0.75
ESR1	2099	P03372	0.78
YBX1	4904	P67809	0.82
EIF2AK2	5610	P19525	0.82
CASC3	22794	O15234	0.82
DYNC1I1	1780	O14576	0.84
HNRNPU	3192	Q00839	0.84
RPL6	6128	Q02878	0.84
IQGAP1	8826	P46940	0.84
INA	9118	Q16352	0.84
DHX9	1660	Q08211	0.85
PABPC1	26986	P11940	0.85
PPP1CA	5499	P62136	0.92