Protein Description

Gene Symbol SRPK1
Entrez ID 6732
Uniprot ID Q96SB4
Description SRSF protein kinase 1
Chromosomal Location chr6: 35,832,966-35,921,342
Ontology GO ID GO Term Definition Evidence

BP

GO:0006397

mRNA processing

Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.

IEA

BP

GO:0006468

protein phosphorylation

The process of introducing a phosphate group on to a protein.

IDA

BP

GO:0007059

chromosome segregation

The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.

IDA

BP

GO:0008380

RNA splicing

The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

IEA

BP

GO:0016032

viral process

A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.

IEA

BP

GO:0035092

sperm chromatin condensation

The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication.

TAS

BP

GO:0035556

intracellular signal transduction

The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

IDA

BP

GO:0045070

positive regulation of viral genome replication

Any process that activates or increases the frequency, rate or extent of viral genome replication.

IDA

BP

GO:0045071

negative regulation of viral genome replication

Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.

IDA

BP

GO:0045087

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

IC

BP

GO:0048024

regulation of mRNA splicing, via spliceosome

Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism.

TAS

BP

GO:0050684

regulation of mRNA processing

Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005783

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA

CC

GO:0016363

nuclear matrix

The dense fibrillar network lying on the inner side of the nuclear membrane.

IEA

MF

GO:0000287

magnesium ion binding

Interacting selectively and non-covalently with magnesium (Mg) ions.

IDA

MF

GO:0004672

protein kinase activity

Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

TAS

MF

GO:0004674

protein serine/threonine kinase activity

Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IDA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

Domain ID Description

IPR000719

Protein kinase domain

IPR008271

Serine/threonine-protein kinase, active site

IPR011009

Protein kinase-like domain

IPR017441

Protein kinase, ATP binding site

Pathway ID Pathway Term Pathway Source

hsa05168

Herpes simplex infection

KEGG

WP411

mRNA Processing

WikiPathways

No diseases found.

Tissue Cell Type

appendix

glandular cells

breast

glandular cells

bronchus

respiratory epithelial cells

cerebellum

Purkinje cells

cerebral cortex

neuronal cells

cervix, uterine

squamous epithelial cells

colon

glandular cells

duodenum

glandular cells

endometrium

glandular cells

epididymis

glandular cells

esophagus

squamous epithelial cells

gallbladder

glandular cells

lymph node

germinal center cells

nasopharynx

respiratory epithelial cells

ovary

follicle cells

placenta

trophoblastic cells

rectum

glandular cells

seminal vesicle

glandular cells

skin

epidermal cells

small intestine

glandular cells

stomach

glandular cells

testis

cells in seminiferous ducts

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

15598877

Wood et al.

2005

Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

HSP90AB1

3326

P08238

0.49

NOP2

4839

P46087

0.49

PPM1G

5496

O15355

0.49

SSRP1

6749

Q08945

0.49

PRPF8

10594

Q6P2Q9

0.49

NAT10

55226

Q9H0A0

0.49

CACNB1

782

Q02641

0.52

MBP

4155

P02686

0.52

SRRM1

10250

Q8IYB3

0.52

SRPK2

6733

P78362

0.55

APP

351

P05067

0.56

SAFB2

9667

Q14151

0.56

PEX19

5824

P40855

0.63

TJP2

9414

Q9UDY2

0.63

ALYREF

10189

Q86V81

0.63

FERMT1

55612

Q9BQL6

0.63

LUC7L3

51747

O95232

0.65

ABCF1

23

Q8NE71

0.68

FGF1

2246

P05230

0.68

FOS

2353

P01100

0.68

PSMA7

5688

O14818

0.68

ZKSCAN8

7745

Q15776

0.68

P2RX6

9127

O15547

0.68

SRSF10

10772

O75494

0.68

METTL14

57721

Q9HCE5

0.68

DUS1L

64118

Q6P1R4

0.68

FBXO15

201456

Q8NCQ5

0.68

C6orf201

404220

Q7Z4U5

0.68

PRM1

5619

P04553

0.69

ADPRH

141

P54922

0.70

CDK7

1022

P50613

0.70

MAPK14

1432

Q16539

0.70

DUSP6

1848

Q16828

0.70

ECM1

1893

Q16610

0.70

ESRRG

2104

P62508

0.70

FHL1

2273

Q13642

0.70

FKBP3

2287

Q00688

0.70

FLT1

2321

P17948

0.70

KPNA2

3838

P52292

0.70

LAMC1

3915

P11047

0.70

MAGEB1

4112

P43366

0.70

NOVA1

4857

P51513

0.70

PDPK1

5170

O15530

0.70

PFN1

5216

P07737

0.70

SERPINB10

5273

P48595

0.70

PPIA

5478

P62937

0.70

RBMS2

5939

Q15434

0.70

RPS6KB2

6199

Q9UBS0

0.70

AURKA

6790

O14965

0.70

UBE2E2

7325

Q96LR5

0.70

VDR

7421

P11473

0.70

KCNAB1

7881

Q14722

0.70

NCK2

8440

O43639

0.70

TAF1B

9014

Q53T94

0.70

CIAO1

9391

O76071

0.70

ZRANB2

9406

O95218

0.70

FLOT1

10211

O75955

0.70

PAK4

10298

O96013

0.70

CHERP

10523

Q8IWX8

0.70

UBD

10537

O15205

0.70

CDC42EP3

10602

Q9UKI2

0.70

HBS1L

10767

Q9Y450

0.70

ZMYND11

10771

Q15326

0.70

KPTN

11133

Q9Y664

0.70

CHEK2

11200

O96017

0.70

DNAJC8

22826

O75937

0.70

SLC4A1AP

22950

Q9BWU0

0.70

LARP1

23367

Q6PKG0

0.70

IFIT5

24138

Q13325

0.70

LINC00312

29931

Q9Y6C7

0.70

SFMBT1

51460

Q9UHJ3

0.70

PPIL1

51645

Q9Y3C6

0.70

CLIC5

53405

Q9NZA1

0.70

WDR55

54853

Q9H6Y2

0.70

ARGLU1

55082

Q9NWB6

0.70

RBM23

55147

Q86U06

0.70

ZNF444

55311

Q8N0Y2

0.70

PELI2

57161

Q9HAT8

0.70

PELI1

57162

Q96FA3

0.70

CLK4

57396

Q9HAZ1

0.70

SLAIN2

57606

Q9P270

0.70

EPB41L4A

64097

Q9HCS5

0.70

MRPS11

64963

P82912

0.70

RSRC2

65117

Q7L4I2

0.70

NKAP

79576

Q8N5F7

0.70

OCEL1

79629

Q9H607

0.70

VANGL1

81839

Q8TAA9

0.70

KIAA1841

84542

Q6NSI8

0.70

MRPL43

84545

Q8N983

0.70

MAP1LC3A

84557

Q9H492

0.70

C11orf52

91894

Q96A22

0.70

ARHGAP12

94134

Q8IWW6

0.70

C16orf78

123970

Q8WTQ4

0.70

SRSF12

135295

Q8WXF0

0.70

CSAG1

158511

Q6PB30

0.70

DAW1

164781

Q8N136

0.70

ASXL1

171023

Q8IXJ9

0.70

TRIM65

201292

Q6PJ69

0.70

C9orf72

203228

Q96LT7

0.70

ALKBH3

221120

Q96Q83

0.70

YPEL2

388403

Q96QA6

0.70

C11orf87

399947

Q6NUJ2

0.70

DDX5

1655

P17844

0.72

EWSR1

2130

Q01844

0.72

FUS

2521

P35637

0.72

ILF3

3609

Q12906

0.72

MAGOH

4116

P61326

0.72

HNRNPM

4670

P52272

0.72

PCBP1

5093

Q15365

0.72

PNN

5411

Q9H307

0.72

RPL37

6167

P61927

0.72

SON

6651

P18583

0.72

YBX3

8531

P16989

0.72

PPIG

9360

Q13427

0.72

BCLAF1

9774

Q9NYF8

0.72

EIF4A3

9775

P38919

0.72

THRAP3

9967

Q9Y2W1

0.72

ACIN1

22985

Q9UKV3

0.72

CHTOP

26097

Q9Y3Y2

0.72

PABPC1

26986

P11940

0.72

NSG1

27065

P42857

0.72

MMTAG2

79169

Q9BU76

0.72

PYM1

84305

Q9BRP8

0.72

U2AF2

11338

P26368

0.75

SRSF7

6432

Q16629

0.78

SRPK1

6732

Q96SB4

0.78

RBM39

9584

Q14498

0.78

RBM8A

9939

Q9Y5S9

0.78

SRSF8

10929

Q9BRL6

0.78

SRPK3

26576

Q9UPE1

0.78

DGCR8

54487

Q8WYQ5

0.79

YTHDC1

91746

Q96MU7

0.79

LBR

3930

Q14739

0.81

HNRNPC

3183

P07910

0.82

DROSHA

29102

Q9NRR4

0.82

YWHAG

7532

P61981

0.83

SRSF2

6427

Q01130

0.84

DHX8

1659

Q14562

0.85

ARL6IP4

51329

Q66PJ3

0.85

SRRM2

23524

Q9UQ35

0.86

SAFB

6294

Q15424

0.87

LUC7L2

51631

Q9Y383

0.87

LUC7L

55692

Q9NQ29

0.87

U2AF1

7307

Q01081

0.88

SNRNP70

6625

P08621

0.90

SART1

9092

O43290

0.49

CEP135

9662

Q66GS9

0.49

SF3A3

10946

Q12874

0.49

CEP19

84984

Q96LK0

0.49

DHX9

1660

Q08211

0.52

TOP2A

7153

P11388

0.52

DDX21

9188

Q9NR30

0.52

BARD1

580

Q99728

0.63

ELAVL1

1994

Q15717

0.63

ESR1

2099

P03372

0.63

GRK5

2869

P34947

0.63

HSP90AA1

3320

P07900

0.63

IFI16

3428

Q16666

0.63

JUN

3725

P05412

0.63

MAOB

4129

P27338

0.63

NTRK1

4914

P04629

0.63

SF1

7536

Q15637

0.63

CUL3

8452

Q13618

0.63

KIAA0101

9768

Q15004

0.63

COPS5

10987

Q92905

0.63

PAXIP1

22976

Q6ZW49

0.63

TARDBP

23435

Q13148

0.63

SIRT7

51547

Q9NRC8

0.63

WWOX

51741

Q9NZC7

0.63

LYAR

55646

Q9NX58

0.63

CAND1

55832

Q86VP6

0.63

HECW2

57520

Q9P2P5

0.63

ZBTB38

253461

Q8NAP3

0.63

MKNK2

2872

Q9HBH9

0.68

TULP2

7288

O00295

0.68

IKBKG

8517

Q9Y6K9

0.68

WDR1

9948

O75083

0.68

SPAG11B

10407

Q08648

0.68

EMILIN1

11117

Q9Y6C2

0.68

CDC42EP4

23580

Q9H3Q1

0.68

ADI1

55256

Q9BV57

0.68

C15orf39

56905

Q6ZRI6

0.68

APMAP

57136

Q9HDC9

0.68

CAB39L

81617

Q9H9S4

0.68

TAAR8

83551

Q969N4

0.68

YPEL3

83719

P61236

0.68

GNPTG

84572

Q9UJJ9

0.68

TCEAL2

140597

Q9H3H9

0.68

ZNF321P

399669

Q8N8H1

0.68

SERF1A

728492

O75920

0.68

APEX1

328

P27695

0.70

ASAH1

427

Q13510

0.70

CAMK2D

817

Q13557

0.70

CHUK

1147

O15111

0.70

CLK1

1195

P49759

0.70

CRHR1

1394

P34998

0.70

EPHA3

2042

P29320

0.70

ERBB2

2064

P04626

0.70

FGF12

2257

P61328

0.70

HNRNPA1

3178

P09651

0.70

KCNN2

3781

Q9H2S1

0.70

LIMK1

3984

P53667

0.70

PDGFRA

5156

P16234

0.70

POLR2E

5434

P19388

0.70

PTK2

5747

Q05397

0.70

MAPK12

6300

P53778

0.70

SRSF3

6428

P84103

0.70

SRSF6

6431

Q13247

0.70

TRA2B

6434

P62995

0.70

STAU1

6780

O95793

0.70

AURKC

6795

Q9UQB9

0.70

NELFE

7936

P18615

0.70

TFEB

7942

P19484

0.70

HIRIP3

8479

Q9BW71

0.70

MAPKAPK5

8550

Q8IW41

0.70

TNFRSF10C

8794

O14798

0.70

HMGN3

9324

Q15651

0.70

H2AFY

9555

O75367

0.70

EIF3M

10480

Q7L2H7

0.70

SEC23B

10483

Q15437

0.70

USP39

10713

Q53GS9

0.70

AHCYL1

10768

O43865

0.70

NUDT21

11051

O43809

0.70

KRR1

11103

Q13601

0.70

GABARAP

11337

O95166

0.70

ARHGAP26

23092

Q9UNA1

0.70

CBX5

23468

P45973

0.70

GABARAPL1

23710

Q9H0R8

0.70

DDX47

51202

Q9H0S4

0.70

CDKL3

51265

Q8IVW4

0.70

RSRC1

51319

Q96IZ7

0.70

NOP16

51491

Q9Y3C1

0.70

PHF7

51533

Q9BWX1

0.70

STK26

51765

Q9P289

0.70

NSMCE4A

54780

Q9NXX6

0.70

MBNL3

55796

Q9NUK0

0.70

NXT2

55916

Q9NPJ8

0.70

RSRP1

57035

Q9BUV0

0.70

SUDS3

64426

Q9H7L9

0.70

SPATS2

65244

Q86XZ4

0.70

C11orf63

79864

Q6NUN7

0.70

AMMECR1L

83607

Q6DCA0

0.70

NSRP1

84081

Q9H0G5

0.70

SETD3

84193

Q86TU7

0.70

LCE3D

84648

Q9BYE3

0.70

ZNF514

84874

Q96K75

0.70

NOL4L

140688

Q96MY1

0.70

RIMS4

140730

Q9H426

0.70

FAM76B

143684

Q5HYJ3

0.70

C18orf25

147339

Q96B23

0.70

OR6B3

150681

Q8NGW1

0.70

FAM124A

220108

Q86V42

0.70

ODF3L2

284451

Q3SX64

0.70

SPANXN4

441525

Q5MJ08

0.70

HDGF

3068

P51858

0.72

LRRK2

120892

Q5S007

0.72

SUMO2

6613

P61956

0.73

TP53

7157

P04637

0.78

YWHAB

7529

P31946

0.82

ZRSR2

8233

Q15696

0.85

PRPF38A

84950

Q8NAV1

0.85

SREK1

140890

Q8WXA9

0.85

SRSF1

6426

Q07955

0.89

RNPS1

10921

Q15287

0.89