Gene Symbol | SRPK1 |
Entrez ID | 6732 |
Uniprot ID | Q96SB4 |
Description | SRSF protein kinase 1 |
Chromosomal Location | chr6: 35,832,966-35,921,342 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006397 |
mRNA processing |
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
IEA |
BP |
GO:0006468 |
protein phosphorylation |
The process of introducing a phosphate group on to a protein. |
IDA |
BP |
GO:0007059 |
chromosome segregation |
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. |
IDA |
BP |
GO:0008380 |
RNA splicing |
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
IEA |
BP |
GO:0016032 |
viral process |
A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle. |
IEA |
BP |
GO:0035092 |
sperm chromatin condensation |
The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication. |
TAS |
BP |
GO:0035556 |
intracellular signal transduction |
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
IDA |
BP |
GO:0045070 |
positive regulation of viral genome replication |
Any process that activates or increases the frequency, rate or extent of viral genome replication. |
IDA |
BP |
GO:0045071 |
negative regulation of viral genome replication |
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication. |
IDA |
BP |
GO:0045087 |
innate immune response |
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
IC |
BP |
GO:0048024 |
regulation of mRNA splicing, via spliceosome |
Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism. |
TAS |
BP |
GO:0050684 |
regulation of mRNA processing |
Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide. |
IDA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0005783 |
endoplasmic reticulum |
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
IEA |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IDA |
CC |
GO:0016363 |
nuclear matrix |
The dense fibrillar network lying on the inner side of the nuclear membrane. |
IEA |
MF |
GO:0000287 |
magnesium ion binding |
Interacting selectively and non-covalently with magnesium (Mg) ions. |
IDA |
MF |
GO:0004672 |
protein kinase activity |
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
TAS |
MF |
GO:0004674 |
protein serine/threonine kinase activity |
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
IDA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IDA |
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
Domain ID | Description |
---|---|
IPR000719 |
Protein kinase domain |
IPR008271 |
Serine/threonine-protein kinase, active site |
IPR011009 |
Protein kinase-like domain |
IPR017441 |
Protein kinase, ATP binding site |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa05168 |
Herpes simplex infection |
KEGG |
WP411 |
mRNA Processing |
WikiPathways |
Tissue | Cell Type |
---|---|
appendix |
glandular cells |
breast |
glandular cells |
bronchus |
respiratory epithelial cells |
cerebellum |
Purkinje cells |
cerebral cortex |
neuronal cells |
cervix, uterine |
squamous epithelial cells |
colon |
glandular cells |
duodenum |
glandular cells |
endometrium |
glandular cells |
epididymis |
glandular cells |
esophagus |
squamous epithelial cells |
gallbladder |
glandular cells |
lymph node |
germinal center cells |
nasopharynx |
respiratory epithelial cells |
ovary |
follicle cells |
placenta |
trophoblastic cells |
rectum |
glandular cells |
seminal vesicle |
glandular cells |
skin |
epidermal cells |
small intestine |
glandular cells |
stomach |
glandular cells |
testis |
cells in seminiferous ducts |
urinary bladder |
urothelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
15598877 |
Wood et al. |
2005 |
Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects |
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
HSP90AB1 |
3326 |
P08238 |
0.49 |
NOP2 |
4839 |
P46087 |
0.49 |
PPM1G |
5496 |
O15355 |
0.49 |
SSRP1 |
6749 |
Q08945 |
0.49 |
PRPF8 |
10594 |
Q6P2Q9 |
0.49 |
NAT10 |
55226 |
Q9H0A0 |
0.49 |
CACNB1 |
782 |
Q02641 |
0.52 |
MBP |
4155 |
P02686 |
0.52 |
SRRM1 |
10250 |
Q8IYB3 |
0.52 |
SRPK2 |
6733 |
P78362 |
0.55 |
APP |
351 |
P05067 |
0.56 |
SAFB2 |
9667 |
Q14151 |
0.56 |
PEX19 |
5824 |
P40855 |
0.63 |
TJP2 |
9414 |
Q9UDY2 |
0.63 |
ALYREF |
10189 |
Q86V81 |
0.63 |
FERMT1 |
55612 |
Q9BQL6 |
0.63 |
LUC7L3 |
51747 |
O95232 |
0.65 |
ABCF1 |
23 |
Q8NE71 |
0.68 |
FGF1 |
2246 |
P05230 |
0.68 |
FOS |
2353 |
P01100 |
0.68 |
PSMA7 |
5688 |
O14818 |
0.68 |
ZKSCAN8 |
7745 |
Q15776 |
0.68 |
P2RX6 |
9127 |
O15547 |
0.68 |
SRSF10 |
10772 |
O75494 |
0.68 |
METTL14 |
57721 |
Q9HCE5 |
0.68 |
DUS1L |
64118 |
Q6P1R4 |
0.68 |
FBXO15 |
201456 |
Q8NCQ5 |
0.68 |
C6orf201 |
404220 |
Q7Z4U5 |
0.68 |
PRM1 |
5619 |
P04553 |
0.69 |
ADPRH |
141 |
P54922 |
0.70 |
CDK7 |
1022 |
P50613 |
0.70 |
MAPK14 |
1432 |
Q16539 |
0.70 |
DUSP6 |
1848 |
Q16828 |
0.70 |
ECM1 |
1893 |
Q16610 |
0.70 |
ESRRG |
2104 |
P62508 |
0.70 |
FHL1 |
2273 |
Q13642 |
0.70 |
FKBP3 |
2287 |
Q00688 |
0.70 |
FLT1 |
2321 |
P17948 |
0.70 |
KPNA2 |
3838 |
P52292 |
0.70 |
LAMC1 |
3915 |
P11047 |
0.70 |
MAGEB1 |
4112 |
P43366 |
0.70 |
NOVA1 |
4857 |
P51513 |
0.70 |
PDPK1 |
5170 |
O15530 |
0.70 |
PFN1 |
5216 |
P07737 |
0.70 |
SERPINB10 |
5273 |
P48595 |
0.70 |
PPIA |
5478 |
P62937 |
0.70 |
RBMS2 |
5939 |
Q15434 |
0.70 |
RPS6KB2 |
6199 |
Q9UBS0 |
0.70 |
AURKA |
6790 |
O14965 |
0.70 |
UBE2E2 |
7325 |
Q96LR5 |
0.70 |
VDR |
7421 |
P11473 |
0.70 |
KCNAB1 |
7881 |
Q14722 |
0.70 |
NCK2 |
8440 |
O43639 |
0.70 |
TAF1B |
9014 |
Q53T94 |
0.70 |
CIAO1 |
9391 |
O76071 |
0.70 |
ZRANB2 |
9406 |
O95218 |
0.70 |
FLOT1 |
10211 |
O75955 |
0.70 |
PAK4 |
10298 |
O96013 |
0.70 |
CHERP |
10523 |
Q8IWX8 |
0.70 |
UBD |
10537 |
O15205 |
0.70 |
CDC42EP3 |
10602 |
Q9UKI2 |
0.70 |
HBS1L |
10767 |
Q9Y450 |
0.70 |
ZMYND11 |
10771 |
Q15326 |
0.70 |
KPTN |
11133 |
Q9Y664 |
0.70 |
CHEK2 |
11200 |
O96017 |
0.70 |
DNAJC8 |
22826 |
O75937 |
0.70 |
SLC4A1AP |
22950 |
Q9BWU0 |
0.70 |
LARP1 |
23367 |
Q6PKG0 |
0.70 |
IFIT5 |
24138 |
Q13325 |
0.70 |
LINC00312 |
29931 |
Q9Y6C7 |
0.70 |
SFMBT1 |
51460 |
Q9UHJ3 |
0.70 |
PPIL1 |
51645 |
Q9Y3C6 |
0.70 |
CLIC5 |
53405 |
Q9NZA1 |
0.70 |
WDR55 |
54853 |
Q9H6Y2 |
0.70 |
ARGLU1 |
55082 |
Q9NWB6 |
0.70 |
RBM23 |
55147 |
Q86U06 |
0.70 |
ZNF444 |
55311 |
Q8N0Y2 |
0.70 |
PELI2 |
57161 |
Q9HAT8 |
0.70 |
PELI1 |
57162 |
Q96FA3 |
0.70 |
CLK4 |
57396 |
Q9HAZ1 |
0.70 |
SLAIN2 |
57606 |
Q9P270 |
0.70 |
EPB41L4A |
64097 |
Q9HCS5 |
0.70 |
MRPS11 |
64963 |
P82912 |
0.70 |
RSRC2 |
65117 |
Q7L4I2 |
0.70 |
NKAP |
79576 |
Q8N5F7 |
0.70 |
OCEL1 |
79629 |
Q9H607 |
0.70 |
VANGL1 |
81839 |
Q8TAA9 |
0.70 |
KIAA1841 |
84542 |
Q6NSI8 |
0.70 |
MRPL43 |
84545 |
Q8N983 |
0.70 |
MAP1LC3A |
84557 |
Q9H492 |
0.70 |
C11orf52 |
91894 |
Q96A22 |
0.70 |
ARHGAP12 |
94134 |
Q8IWW6 |
0.70 |
C16orf78 |
123970 |
Q8WTQ4 |
0.70 |
SRSF12 |
135295 |
Q8WXF0 |
0.70 |
CSAG1 |
158511 |
Q6PB30 |
0.70 |
DAW1 |
164781 |
Q8N136 |
0.70 |
ASXL1 |
171023 |
Q8IXJ9 |
0.70 |
TRIM65 |
201292 |
Q6PJ69 |
0.70 |
C9orf72 |
203228 |
Q96LT7 |
0.70 |
ALKBH3 |
221120 |
Q96Q83 |
0.70 |
YPEL2 |
388403 |
Q96QA6 |
0.70 |
C11orf87 |
399947 |
Q6NUJ2 |
0.70 |
DDX5 |
1655 |
P17844 |
0.72 |
EWSR1 |
2130 |
Q01844 |
0.72 |
FUS |
2521 |
P35637 |
0.72 |
ILF3 |
3609 |
Q12906 |
0.72 |
MAGOH |
4116 |
P61326 |
0.72 |
HNRNPM |
4670 |
P52272 |
0.72 |
PCBP1 |
5093 |
Q15365 |
0.72 |
PNN |
5411 |
Q9H307 |
0.72 |
RPL37 |
6167 |
P61927 |
0.72 |
SON |
6651 |
P18583 |
0.72 |
YBX3 |
8531 |
P16989 |
0.72 |
PPIG |
9360 |
Q13427 |
0.72 |
BCLAF1 |
9774 |
Q9NYF8 |
0.72 |
EIF4A3 |
9775 |
P38919 |
0.72 |
THRAP3 |
9967 |
Q9Y2W1 |
0.72 |
ACIN1 |
22985 |
Q9UKV3 |
0.72 |
CHTOP |
26097 |
Q9Y3Y2 |
0.72 |
PABPC1 |
26986 |
P11940 |
0.72 |
NSG1 |
27065 |
P42857 |
0.72 |
MMTAG2 |
79169 |
Q9BU76 |
0.72 |
PYM1 |
84305 |
Q9BRP8 |
0.72 |
U2AF2 |
11338 |
P26368 |
0.75 |
SRSF7 |
6432 |
Q16629 |
0.78 |
SRPK1 |
6732 |
Q96SB4 |
0.78 |
RBM39 |
9584 |
Q14498 |
0.78 |
RBM8A |
9939 |
Q9Y5S9 |
0.78 |
SRSF8 |
10929 |
Q9BRL6 |
0.78 |
SRPK3 |
26576 |
Q9UPE1 |
0.78 |
DGCR8 |
54487 |
Q8WYQ5 |
0.79 |
YTHDC1 |
91746 |
Q96MU7 |
0.79 |
LBR |
3930 |
Q14739 |
0.81 |
HNRNPC |
3183 |
P07910 |
0.82 |
DROSHA |
29102 |
Q9NRR4 |
0.82 |
YWHAG |
7532 |
P61981 |
0.83 |
SRSF2 |
6427 |
Q01130 |
0.84 |
DHX8 |
1659 |
Q14562 |
0.85 |
ARL6IP4 |
51329 |
Q66PJ3 |
0.85 |
SRRM2 |
23524 |
Q9UQ35 |
0.86 |
SAFB |
6294 |
Q15424 |
0.87 |
LUC7L2 |
51631 |
Q9Y383 |
0.87 |
LUC7L |
55692 |
Q9NQ29 |
0.87 |
U2AF1 |
7307 |
Q01081 |
0.88 |
SNRNP70 |
6625 |
P08621 |
0.90 |
SART1 |
9092 |
O43290 |
0.49 |
CEP135 |
9662 |
Q66GS9 |
0.49 |
SF3A3 |
10946 |
Q12874 |
0.49 |
CEP19 |
84984 |
Q96LK0 |
0.49 |
DHX9 |
1660 |
Q08211 |
0.52 |
TOP2A |
7153 |
P11388 |
0.52 |
DDX21 |
9188 |
Q9NR30 |
0.52 |
BARD1 |
580 |
Q99728 |
0.63 |
ELAVL1 |
1994 |
Q15717 |
0.63 |
ESR1 |
2099 |
P03372 |
0.63 |
GRK5 |
2869 |
P34947 |
0.63 |
HSP90AA1 |
3320 |
P07900 |
0.63 |
IFI16 |
3428 |
Q16666 |
0.63 |
JUN |
3725 |
P05412 |
0.63 |
MAOB |
4129 |
P27338 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
SF1 |
7536 |
Q15637 |
0.63 |
CUL3 |
8452 |
Q13618 |
0.63 |
KIAA0101 |
9768 |
Q15004 |
0.63 |
COPS5 |
10987 |
Q92905 |
0.63 |
PAXIP1 |
22976 |
Q6ZW49 |
0.63 |
TARDBP |
23435 |
Q13148 |
0.63 |
SIRT7 |
51547 |
Q9NRC8 |
0.63 |
WWOX |
51741 |
Q9NZC7 |
0.63 |
LYAR |
55646 |
Q9NX58 |
0.63 |
CAND1 |
55832 |
Q86VP6 |
0.63 |
HECW2 |
57520 |
Q9P2P5 |
0.63 |
ZBTB38 |
253461 |
Q8NAP3 |
0.63 |
MKNK2 |
2872 |
Q9HBH9 |
0.68 |
TULP2 |
7288 |
O00295 |
0.68 |
IKBKG |
8517 |
Q9Y6K9 |
0.68 |
WDR1 |
9948 |
O75083 |
0.68 |
SPAG11B |
10407 |
Q08648 |
0.68 |
EMILIN1 |
11117 |
Q9Y6C2 |
0.68 |
CDC42EP4 |
23580 |
Q9H3Q1 |
0.68 |
ADI1 |
55256 |
Q9BV57 |
0.68 |
C15orf39 |
56905 |
Q6ZRI6 |
0.68 |
APMAP |
57136 |
Q9HDC9 |
0.68 |
CAB39L |
81617 |
Q9H9S4 |
0.68 |
TAAR8 |
83551 |
Q969N4 |
0.68 |
YPEL3 |
83719 |
P61236 |
0.68 |
GNPTG |
84572 |
Q9UJJ9 |
0.68 |
TCEAL2 |
140597 |
Q9H3H9 |
0.68 |
ZNF321P |
399669 |
Q8N8H1 |
0.68 |
SERF1A |
728492 |
O75920 |
0.68 |
APEX1 |
328 |
P27695 |
0.70 |
ASAH1 |
427 |
Q13510 |
0.70 |
CAMK2D |
817 |
Q13557 |
0.70 |
CHUK |
1147 |
O15111 |
0.70 |
CLK1 |
1195 |
P49759 |
0.70 |
CRHR1 |
1394 |
P34998 |
0.70 |
EPHA3 |
2042 |
P29320 |
0.70 |
ERBB2 |
2064 |
P04626 |
0.70 |
FGF12 |
2257 |
P61328 |
0.70 |
HNRNPA1 |
3178 |
P09651 |
0.70 |
KCNN2 |
3781 |
Q9H2S1 |
0.70 |
LIMK1 |
3984 |
P53667 |
0.70 |
PDGFRA |
5156 |
P16234 |
0.70 |
POLR2E |
5434 |
P19388 |
0.70 |
PTK2 |
5747 |
Q05397 |
0.70 |
MAPK12 |
6300 |
P53778 |
0.70 |
SRSF3 |
6428 |
P84103 |
0.70 |
SRSF6 |
6431 |
Q13247 |
0.70 |
TRA2B |
6434 |
P62995 |
0.70 |
STAU1 |
6780 |
O95793 |
0.70 |
AURKC |
6795 |
Q9UQB9 |
0.70 |
NELFE |
7936 |
P18615 |
0.70 |
TFEB |
7942 |
P19484 |
0.70 |
HIRIP3 |
8479 |
Q9BW71 |
0.70 |
MAPKAPK5 |
8550 |
Q8IW41 |
0.70 |
TNFRSF10C |
8794 |
O14798 |
0.70 |
HMGN3 |
9324 |
Q15651 |
0.70 |
H2AFY |
9555 |
O75367 |
0.70 |
EIF3M |
10480 |
Q7L2H7 |
0.70 |
SEC23B |
10483 |
Q15437 |
0.70 |
USP39 |
10713 |
Q53GS9 |
0.70 |
AHCYL1 |
10768 |
O43865 |
0.70 |
NUDT21 |
11051 |
O43809 |
0.70 |
KRR1 |
11103 |
Q13601 |
0.70 |
GABARAP |
11337 |
O95166 |
0.70 |
ARHGAP26 |
23092 |
Q9UNA1 |
0.70 |
CBX5 |
23468 |
P45973 |
0.70 |
GABARAPL1 |
23710 |
Q9H0R8 |
0.70 |
DDX47 |
51202 |
Q9H0S4 |
0.70 |
CDKL3 |
51265 |
Q8IVW4 |
0.70 |
RSRC1 |
51319 |
Q96IZ7 |
0.70 |
NOP16 |
51491 |
Q9Y3C1 |
0.70 |
PHF7 |
51533 |
Q9BWX1 |
0.70 |
STK26 |
51765 |
Q9P289 |
0.70 |
NSMCE4A |
54780 |
Q9NXX6 |
0.70 |
MBNL3 |
55796 |
Q9NUK0 |
0.70 |
NXT2 |
55916 |
Q9NPJ8 |
0.70 |
RSRP1 |
57035 |
Q9BUV0 |
0.70 |
SUDS3 |
64426 |
Q9H7L9 |
0.70 |
SPATS2 |
65244 |
Q86XZ4 |
0.70 |
C11orf63 |
79864 |
Q6NUN7 |
0.70 |
AMMECR1L |
83607 |
Q6DCA0 |
0.70 |
NSRP1 |
84081 |
Q9H0G5 |
0.70 |
SETD3 |
84193 |
Q86TU7 |
0.70 |
LCE3D |
84648 |
Q9BYE3 |
0.70 |
ZNF514 |
84874 |
Q96K75 |
0.70 |
NOL4L |
140688 |
Q96MY1 |
0.70 |
RIMS4 |
140730 |
Q9H426 |
0.70 |
FAM76B |
143684 |
Q5HYJ3 |
0.70 |
C18orf25 |
147339 |
Q96B23 |
0.70 |
OR6B3 |
150681 |
Q8NGW1 |
0.70 |
FAM124A |
220108 |
Q86V42 |
0.70 |
ODF3L2 |
284451 |
Q3SX64 |
0.70 |
SPANXN4 |
441525 |
Q5MJ08 |
0.70 |
HDGF |
3068 |
P51858 |
0.72 |
LRRK2 |
120892 |
Q5S007 |
0.72 |
SUMO2 |
6613 |
P61956 |
0.73 |
TP53 |
7157 |
P04637 |
0.78 |
YWHAB |
7529 |
P31946 |
0.82 |
ZRSR2 |
8233 |
Q15696 |
0.85 |
PRPF38A |
84950 |
Q8NAV1 |
0.85 |
SREK1 |
140890 |
Q8WXA9 |
0.85 |
SRSF1 |
6426 |
Q07955 |
0.89 |
RNPS1 |
10921 |
Q15287 |
0.89 |