Protein Description

Gene Symbol SPTBN1
Entrez ID 6711
Uniprot ID Q01082
Description spectrin, beta, non-erythrocytic 1
Chromosomal Location chr2: 54,456,285-54,671,445
Ontology GO ID GO Term Definition Evidence

BP

GO:0000165

MAPK cascade

An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

TAS

BP

GO:0000281

mitotic cytokinesis

A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.

IMP

BP

GO:0006888

ER to Golgi vesicle-mediated transport

The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.

TAS

BP

GO:0007009

plasma membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.

IMP

BP

GO:0007010

cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.

IEA

BP

GO:0007182

common-partner SMAD protein phosphorylation

The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus.

IEA

BP

GO:0007184

SMAD protein import into nucleus

The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

IEA

BP

GO:0007411

axon guidance

The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.

TAS

BP

GO:0043001

Golgi to plasma membrane protein transport

The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.

IMP

BP

GO:0043547

positive regulation of GTPase activity

Any process that activates or increases the activity of a GTPase.

IEA

BP

GO:0051693

actin filament capping

The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.

IEA

BP

GO:0071709

membrane assembly

The aggregation, arrangement and bonding together of a set of components to form a membrane.

IMP

BP

GO:0072661

protein targeting to plasma membrane

The process of directing proteins towards the plasma membrane; usually uses signals contained within the protein.

IMP

BP

GO:0098609

cell-cell adhesion

The attachment of one cell to another cell via adhesion molecules.

IEA

BP

GO:1900042

positive regulation of interleukin-2 secretion

Any process that activates or increases the frequency, rate or extent of interleukin-2 secretion.

IMP

BP

GO:1903076

regulation of protein localization to plasma membrane

Any process that modulates the frequency, rate or extent of protein localization to plasma membrane.

IGI

BP

GO:1903078

positive regulation of protein localization to plasma membrane

Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.

IMP

CC

GO:0005730

nucleolus

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005913

cell-cell adherens junction

An adherens junction which connects a cell to another cell.

IDA

CC

GO:0008091

spectrin

Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.

IEA

CC

GO:0014731

spectrin-associated cytoskeleton

The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane.

NAS

CC

GO:0030673

axolemma

The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness.

ISS

CC

GO:0031430

M band

The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.

IEA

CC

GO:0032437

cuticular plate

A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted.

IEA

CC

GO:0043234

protein complex

A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0003779

actin binding

Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.

IEA

MF

GO:0005088

Ras guanyl-nucleotide exchange factor activity

Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

TAS

MF

GO:0005200

structural constituent of cytoskeleton

The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.

IMP

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005516

calmodulin binding

Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.

IEA

MF

GO:0005543

phospholipid binding

Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.

IEA

MF

GO:0030506

ankyrin binding

Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.

IPI|NAS

MF

GO:0032403

protein complex binding

Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IEA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

MF

GO:0051020

GTPase binding

Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP.

IPI

MF

GO:0098641

cadherin binding involved in cell-cell adhesion

Any cadherin binding that occurs as part of the process of cell-cell adhesion.

IDA

Domain ID Description

IPR001589

Actinin-type actin-binding domain, conserved site

IPR001605

Pleckstrin homology domain, spectrin-type

IPR001715

Calponin homology domain

IPR001849

Pleckstrin homology domain

IPR002017

Spectrin repeat

IPR011993

PH domain-like

IPR016343

Spectrin, beta subunit

IPR018159

Spectrin/alpha-actinin

Pathway ID Pathway Term Pathway Source

WP706

Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways

WikiPathways

WP366

TGF-beta Signaling Pathway

WikiPathways

h_PDZsPathway

Synaptic Proteins at the Synaptic Junction

BioCarta

UMLS CUI UMLS Term

C0027092

Myopia

C0043094

Weight Gain

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

bronchus

respiratory epithelial cells

cerebral cortex

endothelial cells

cerebral cortex

neuropil

colon

endothelial cells

colon

glandular cells

duodenum

glandular cells

endometrium

glandular cells

fallopian tube

glandular cells

gallbladder

glandular cells

kidney

cells in glomeruli

kidney

cells in tubules

lung

pneumocytes

ovary

ovarian stroma cells

pancreas

exocrine glandular cells

parathyroid gland

glandular cells

rectum

glandular cells

salivary gland

glandular cells

seminal vesicle

glandular cells

small intestine

glandular cells

stomach

glandular cells

thyroid gland

glandular cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

NCAPD3

23310

P42695

0.49

TXN2

25828

Q99757

0.49

EPB41

2035

P11171

0.52

ANK1

286

P16157

0.63

MAP3K8

1326

P41279

0.63

GRIA2

2891

P42262

0.63

SMAD2

4087

Q15796

0.63

SMAD9

4093

O15198

0.63

MEF2C

4208

Q06413

0.63

PDE4D

5144

Q08499

0.63

STAT1

6772

P42224

0.63

TGFBR1

7046

P36897

0.63

TPM1

7168

P09493

0.63

PLCB1

23236

Q9NQ66

0.63

ATF7IP

55729

Q6VMQ6

0.63

TNKS1BP1

85456

Q9C0C2

0.63

DCTN1

1639

Q14203

0.72

TNIK

23043

Q9UKE5

0.73

TRAF3IP1

26146

Q8TDR0

0.73

DISC1

27185

Q9NRI5

0.73

RINT1

60561

Q6NUQ1

0.73

CEP63

80254

Q96MT8

0.73

EPB41L3

23136

Q9Y2J2

0.75

CDC5L

988

Q99459

0.83

CDH2

1000

P19022

0.49

EWSR1

2130

Q01844

0.49

HSPA5

3309

P11021

0.49

MCM5

4174

P33992

0.49

NFKB1

4790

P19838

0.49

POU2F1

5451

P14859

0.49

PRKAR1A

5573

P10644

0.49

PSMA7

5688

O14818

0.49

SOD1

6647

P00441

0.49

RBM8A

9939

Q9Y5S9

0.49

NXF1

10482

Q9UBU9

0.49

RABL2A

11159

Q9UBK7

0.49

NENF

29937

Q9UMX5

0.49

DDX19A

55308

Q9NUU7

0.49

PRKCDBP

112464

Q969G5

0.49

CAPN1

823

P07384

0.52

YWHAG

7532

P61981

0.52

CPNE1

8904

Q99829

0.52

ACTR1A

10121

P61163

0.52

CAMSAP1

157922

Q5T5Y3

0.52

PRKACA

5566

P17612

0.55

PTEN

5728

P60484

0.56

ANK2

287

Q01484

0.63

APC

324

P25054

0.63

CBL

867

P22681

0.63

CD81

975

P60033

0.63

CEBPA

1050

P49715

0.63

AP2M1

1173

Q96CW1

0.63

MAPK14

1432

Q16539

0.63

ESR1

2099

P03372

0.63

GRK5

2869

P34947

0.63

HSPB1

3315

P04792

0.63

MAGOH

4116

P61326

0.63

MYBL2

4605

P10244

0.63

NEDD8

4738

Q15843

0.63

NTRK1

4914

P04629

0.63

PIK3R2

5296

O00459

0.63

RPA1

6117

P27694

0.63

RPA2

6118

P15927

0.63

RPA3

6119

P35244

0.63

SHC1

6464

P29353

0.63

SUMO3

6612

P55854

0.63

SREBF2

6721

Q12772

0.63

SVIL

6840

O95425

0.63

TUBG1

7283

P23258

0.63

VCAM1

7412

P19320

0.63

UBL4A

8266

P11441

0.63

HIST1H3A

8350

P68431

0.63

CUL3

8452

Q13618

0.63

CUL1

8454

Q13616

0.63

EIF2B2

8892

P49770

0.63

SH3BP5

9467

O60239

0.63

KIAA0101

9768

Q15004

0.63

EIF4A3

9775

P38919

0.63

PAN2

9924

Q504Q3

0.63

UBD

10537

O15205

0.63

COPS5

10987

Q92905

0.63

GABARAPL2

11345

P60520

0.63

SNW1

22938

Q13573

0.63

SRRM2

23524

Q9UQ35

0.63

SNAPIN

23557

O95295

0.63

GABARAPL1

23710

Q9H0R8

0.63

MOB4

25843

Q9Y3A3

0.63

PYGO1

26108

Q9Y3Y4

0.63

FBXO6

26270

Q9NRD1

0.63

PACSIN1

29993

Q9BY11

0.63

SIRT7

51547

Q9NRC8

0.63

PLEKHA5

54477

Q9HAU0

0.63

SMURF1

57154

Q9HCE7

0.63

ZNF512B

57473

Q96KM6

0.63

LRRK1

79705

Q38SD2

0.63

MAP1LC3B

81631

Q9GZQ8

0.63

MAP1LC3A

84557

Q9H492

0.63

UBASH3B

84959

Q8TF42

0.63

UNK

85451

Q9C0B0

0.63

CPNE4

131034

Q96A23

0.65

YWHAZ

7534

P63104

0.68

PJA1

64219

Q8NG27

0.68

CSNK2A1

1457

P68400

0.71

ADD1

118

P35611

0.72

ARRB2

409

P32121

0.72

CAPZA2

830

P47755

0.72

FLNA

2316

P21333

0.72

FN1

2335

P02751

0.72

MAP3K3

4215

Q99759

0.72

MYH9

4627

P35579

0.72

MYO1C

4641

O00159

0.72

PPP1CB

5500

P62140

0.72

WEE1

7465

P30291

0.72

IQGAP1

8826

P46940

0.72

PDLIM7

9260

Q9NR12

0.72

IKBKE

9641

Q14164

0.72

RIPK3

11035

Q9Y572

0.72

KATNA1

11104

O75449

0.72

SYNPO

11346

Q8N3V7

0.72

MAPRE1

22919

Q15691

0.72

LIMA1

51474

Q9UHB6

0.72

ANLN

54443

Q9NQW6

0.72

MYO5C

55930

Q9NQX4

0.72

MYO19

80179

Q96H55

0.72

AGO3

192669

Q9H9G7

0.72

MYO18A

399687

Q92614

0.72

SUMO2

6613

P61956

0.73

SMAD3

4088

P84022

0.74

SMAD4

4089

Q13485

0.74

CTNNA1

1495

P35221

0.75

SPTA1

6708

P02549

0.75

GRB2

2885

P62993

0.78

SUMO1

7341

P63165

0.78

NF2

4771

P35240

0.79

SNCA

6622

P37840

0.80

CDK2

1017

P24941

0.82

DBN1

1627

Q16643

0.82

SPTAN1

6709

Q13813

0.93