Gene Symbol | SPTBN1 |
Entrez ID | 6711 |
Uniprot ID | Q01082 |
Description | spectrin, beta, non-erythrocytic 1 |
Chromosomal Location | chr2: 54,456,285-54,671,445 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000165 |
MAPK cascade |
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
TAS |
BP |
GO:0000281 |
mitotic cytokinesis |
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. |
IMP |
BP |
GO:0006888 |
ER to Golgi vesicle-mediated transport |
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. |
TAS |
BP |
GO:0007009 |
plasma membrane organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. |
IMP |
BP |
GO:0007010 |
cytoskeleton organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
IEA |
BP |
GO:0007182 |
common-partner SMAD protein phosphorylation |
The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus. |
IEA |
BP |
GO:0007184 |
SMAD protein import into nucleus |
The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. |
IEA |
BP |
GO:0007411 |
axon guidance |
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
TAS |
BP |
GO:0043001 |
Golgi to plasma membrane protein transport |
The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. |
IMP |
BP |
GO:0043547 |
positive regulation of GTPase activity |
Any process that activates or increases the activity of a GTPase. |
IEA |
BP |
GO:0051693 |
actin filament capping |
The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. |
IEA |
BP |
GO:0071709 |
membrane assembly |
The aggregation, arrangement and bonding together of a set of components to form a membrane. |
IMP |
BP |
GO:0072661 |
protein targeting to plasma membrane |
The process of directing proteins towards the plasma membrane; usually uses signals contained within the protein. |
IMP |
BP |
GO:0098609 |
cell-cell adhesion |
The attachment of one cell to another cell via adhesion molecules. |
IEA |
BP |
GO:1900042 |
positive regulation of interleukin-2 secretion |
Any process that activates or increases the frequency, rate or extent of interleukin-2 secretion. |
IMP |
BP |
GO:1903076 |
regulation of protein localization to plasma membrane |
Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. |
IGI |
BP |
GO:1903078 |
positive regulation of protein localization to plasma membrane |
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. |
IMP |
CC |
GO:0005730 |
nucleolus |
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
IDA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0005913 |
cell-cell adherens junction |
An adherens junction which connects a cell to another cell. |
IDA |
CC |
GO:0008091 |
spectrin |
Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins. |
IEA |
CC |
GO:0014731 |
spectrin-associated cytoskeleton |
The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane. |
NAS |
CC |
GO:0030673 |
axolemma |
The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness. |
ISS |
CC |
GO:0031430 |
M band |
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines. |
IEA |
CC |
GO:0032437 |
cuticular plate |
A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted. |
IEA |
CC |
GO:0043234 |
protein complex |
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical. |
IEA |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0003779 |
actin binding |
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. |
IEA |
MF |
GO:0005088 |
Ras guanyl-nucleotide exchange factor activity |
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
TAS |
MF |
GO:0005200 |
structural constituent of cytoskeleton |
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
IMP |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0005516 |
calmodulin binding |
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
IEA |
MF |
GO:0005543 |
phospholipid binding |
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. |
IEA |
MF |
GO:0030506 |
ankyrin binding |
Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. |
IPI|NAS |
MF |
GO:0032403 |
protein complex binding |
Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IEA |
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
MF |
GO:0051020 |
GTPase binding |
Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP. |
IPI |
MF |
GO:0098641 |
cadherin binding involved in cell-cell adhesion |
Any cadherin binding that occurs as part of the process of cell-cell adhesion. |
IDA |
Domain ID | Description |
---|---|
IPR001589 |
Actinin-type actin-binding domain, conserved site |
IPR001605 |
Pleckstrin homology domain, spectrin-type |
IPR001715 |
Calponin homology domain |
IPR001849 |
Pleckstrin homology domain |
IPR002017 |
Spectrin repeat |
IPR011993 |
PH domain-like |
IPR016343 |
Spectrin, beta subunit |
IPR018159 |
Spectrin/alpha-actinin |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
WP706 |
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
WikiPathways |
WP366 |
TGF-beta Signaling Pathway |
WikiPathways |
h_PDZsPathway |
Synaptic Proteins at the Synaptic Junction |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0027092 |
Myopia |
C0043094 |
Weight Gain |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
appendix |
glandular cells |
bronchus |
respiratory epithelial cells |
cerebral cortex |
endothelial cells |
cerebral cortex |
neuropil |
colon |
endothelial cells |
colon |
glandular cells |
duodenum |
glandular cells |
endometrium |
glandular cells |
fallopian tube |
glandular cells |
gallbladder |
glandular cells |
kidney |
cells in glomeruli |
kidney |
cells in tubules |
lung |
pneumocytes |
ovary |
ovarian stroma cells |
pancreas |
exocrine glandular cells |
parathyroid gland |
glandular cells |
rectum |
glandular cells |
salivary gland |
glandular cells |
seminal vesicle |
glandular cells |
small intestine |
glandular cells |
stomach |
glandular cells |
thyroid gland |
glandular cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
NCAPD3 |
23310 |
P42695 |
0.49 |
TXN2 |
25828 |
Q99757 |
0.49 |
EPB41 |
2035 |
P11171 |
0.52 |
ANK1 |
286 |
P16157 |
0.63 |
MAP3K8 |
1326 |
P41279 |
0.63 |
GRIA2 |
2891 |
P42262 |
0.63 |
SMAD2 |
4087 |
Q15796 |
0.63 |
SMAD9 |
4093 |
O15198 |
0.63 |
MEF2C |
4208 |
Q06413 |
0.63 |
PDE4D |
5144 |
Q08499 |
0.63 |
STAT1 |
6772 |
P42224 |
0.63 |
TGFBR1 |
7046 |
P36897 |
0.63 |
TPM1 |
7168 |
P09493 |
0.63 |
PLCB1 |
23236 |
Q9NQ66 |
0.63 |
ATF7IP |
55729 |
Q6VMQ6 |
0.63 |
TNKS1BP1 |
85456 |
Q9C0C2 |
0.63 |
DCTN1 |
1639 |
Q14203 |
0.72 |
TNIK |
23043 |
Q9UKE5 |
0.73 |
TRAF3IP1 |
26146 |
Q8TDR0 |
0.73 |
DISC1 |
27185 |
Q9NRI5 |
0.73 |
RINT1 |
60561 |
Q6NUQ1 |
0.73 |
CEP63 |
80254 |
Q96MT8 |
0.73 |
EPB41L3 |
23136 |
Q9Y2J2 |
0.75 |
CDC5L |
988 |
Q99459 |
0.83 |
CDH2 |
1000 |
P19022 |
0.49 |
EWSR1 |
2130 |
Q01844 |
0.49 |
HSPA5 |
3309 |
P11021 |
0.49 |
MCM5 |
4174 |
P33992 |
0.49 |
NFKB1 |
4790 |
P19838 |
0.49 |
POU2F1 |
5451 |
P14859 |
0.49 |
PRKAR1A |
5573 |
P10644 |
0.49 |
PSMA7 |
5688 |
O14818 |
0.49 |
SOD1 |
6647 |
P00441 |
0.49 |
RBM8A |
9939 |
Q9Y5S9 |
0.49 |
NXF1 |
10482 |
Q9UBU9 |
0.49 |
RABL2A |
11159 |
Q9UBK7 |
0.49 |
NENF |
29937 |
Q9UMX5 |
0.49 |
DDX19A |
55308 |
Q9NUU7 |
0.49 |
PRKCDBP |
112464 |
Q969G5 |
0.49 |
CAPN1 |
823 |
P07384 |
0.52 |
YWHAG |
7532 |
P61981 |
0.52 |
CPNE1 |
8904 |
Q99829 |
0.52 |
ACTR1A |
10121 |
P61163 |
0.52 |
CAMSAP1 |
157922 |
Q5T5Y3 |
0.52 |
PRKACA |
5566 |
P17612 |
0.55 |
PTEN |
5728 |
P60484 |
0.56 |
ANK2 |
287 |
Q01484 |
0.63 |
APC |
324 |
P25054 |
0.63 |
CBL |
867 |
P22681 |
0.63 |
CD81 |
975 |
P60033 |
0.63 |
CEBPA |
1050 |
P49715 |
0.63 |
AP2M1 |
1173 |
Q96CW1 |
0.63 |
MAPK14 |
1432 |
Q16539 |
0.63 |
ESR1 |
2099 |
P03372 |
0.63 |
GRK5 |
2869 |
P34947 |
0.63 |
HSPB1 |
3315 |
P04792 |
0.63 |
MAGOH |
4116 |
P61326 |
0.63 |
MYBL2 |
4605 |
P10244 |
0.63 |
NEDD8 |
4738 |
Q15843 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
PIK3R2 |
5296 |
O00459 |
0.63 |
RPA1 |
6117 |
P27694 |
0.63 |
RPA2 |
6118 |
P15927 |
0.63 |
RPA3 |
6119 |
P35244 |
0.63 |
SHC1 |
6464 |
P29353 |
0.63 |
SUMO3 |
6612 |
P55854 |
0.63 |
SREBF2 |
6721 |
Q12772 |
0.63 |
SVIL |
6840 |
O95425 |
0.63 |
TUBG1 |
7283 |
P23258 |
0.63 |
VCAM1 |
7412 |
P19320 |
0.63 |
UBL4A |
8266 |
P11441 |
0.63 |
HIST1H3A |
8350 |
P68431 |
0.63 |
CUL3 |
8452 |
Q13618 |
0.63 |
CUL1 |
8454 |
Q13616 |
0.63 |
EIF2B2 |
8892 |
P49770 |
0.63 |
SH3BP5 |
9467 |
O60239 |
0.63 |
KIAA0101 |
9768 |
Q15004 |
0.63 |
EIF4A3 |
9775 |
P38919 |
0.63 |
PAN2 |
9924 |
Q504Q3 |
0.63 |
UBD |
10537 |
O15205 |
0.63 |
COPS5 |
10987 |
Q92905 |
0.63 |
GABARAPL2 |
11345 |
P60520 |
0.63 |
SNW1 |
22938 |
Q13573 |
0.63 |
SRRM2 |
23524 |
Q9UQ35 |
0.63 |
SNAPIN |
23557 |
O95295 |
0.63 |
GABARAPL1 |
23710 |
Q9H0R8 |
0.63 |
MOB4 |
25843 |
Q9Y3A3 |
0.63 |
PYGO1 |
26108 |
Q9Y3Y4 |
0.63 |
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
PACSIN1 |
29993 |
Q9BY11 |
0.63 |
SIRT7 |
51547 |
Q9NRC8 |
0.63 |
PLEKHA5 |
54477 |
Q9HAU0 |
0.63 |
SMURF1 |
57154 |
Q9HCE7 |
0.63 |
ZNF512B |
57473 |
Q96KM6 |
0.63 |
LRRK1 |
79705 |
Q38SD2 |
0.63 |
MAP1LC3B |
81631 |
Q9GZQ8 |
0.63 |
MAP1LC3A |
84557 |
Q9H492 |
0.63 |
UBASH3B |
84959 |
Q8TF42 |
0.63 |
UNK |
85451 |
Q9C0B0 |
0.63 |
CPNE4 |
131034 |
Q96A23 |
0.65 |
YWHAZ |
7534 |
P63104 |
0.68 |
PJA1 |
64219 |
Q8NG27 |
0.68 |
CSNK2A1 |
1457 |
P68400 |
0.71 |
ADD1 |
118 |
P35611 |
0.72 |
ARRB2 |
409 |
P32121 |
0.72 |
CAPZA2 |
830 |
P47755 |
0.72 |
FLNA |
2316 |
P21333 |
0.72 |
FN1 |
2335 |
P02751 |
0.72 |
MAP3K3 |
4215 |
Q99759 |
0.72 |
MYH9 |
4627 |
P35579 |
0.72 |
MYO1C |
4641 |
O00159 |
0.72 |
PPP1CB |
5500 |
P62140 |
0.72 |
WEE1 |
7465 |
P30291 |
0.72 |
IQGAP1 |
8826 |
P46940 |
0.72 |
PDLIM7 |
9260 |
Q9NR12 |
0.72 |
IKBKE |
9641 |
Q14164 |
0.72 |
RIPK3 |
11035 |
Q9Y572 |
0.72 |
KATNA1 |
11104 |
O75449 |
0.72 |
SYNPO |
11346 |
Q8N3V7 |
0.72 |
MAPRE1 |
22919 |
Q15691 |
0.72 |
LIMA1 |
51474 |
Q9UHB6 |
0.72 |
ANLN |
54443 |
Q9NQW6 |
0.72 |
MYO5C |
55930 |
Q9NQX4 |
0.72 |
MYO19 |
80179 |
Q96H55 |
0.72 |
AGO3 |
192669 |
Q9H9G7 |
0.72 |
MYO18A |
399687 |
Q92614 |
0.72 |
SUMO2 |
6613 |
P61956 |
0.73 |
SMAD3 |
4088 |
P84022 |
0.74 |
SMAD4 |
4089 |
Q13485 |
0.74 |
CTNNA1 |
1495 |
P35221 |
0.75 |
SPTA1 |
6708 |
P02549 |
0.75 |
GRB2 |
2885 |
P62993 |
0.78 |
SUMO1 |
7341 |
P63165 |
0.78 |
NF2 |
4771 |
P35240 |
0.79 |
SNCA |
6622 |
P37840 |
0.80 |
CDK2 |
1017 |
P24941 |
0.82 |
DBN1 |
1627 |
Q16643 |
0.82 |
SPTAN1 |
6709 |
Q13813 |
0.93 |