| Gene Symbol | SOD2 |
| Entrez ID | 6648 |
| Uniprot ID | P04179 |
| Description | superoxide dismutase 2, mitochondrial |
| Chromosomal Location | chr6: 159,669,057-159,762,529 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0000302 | response to reactive oxygen species |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. | TAS |
BP | GO:0000303 | response to superoxide |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. | IMP |
BP | GO:0001315 | age-dependent response to reactive oxygen species |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism. | IMP |
BP | GO:0001836 | release of cytochrome c from mitochondria |
The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. | ISS |
BP | GO:0003069 | vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure |
The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure. | ISS |
BP | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. | IMP |
BP | GO:0006801 | superoxide metabolic process |
The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. | IDA |
BP | GO:0008217 | regulation of blood pressure |
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. | ISS |
BP | GO:0008285 | negative regulation of cell proliferation |
Any process that stops, prevents or reduces the rate or extent of cell proliferation. | IMP |
BP | GO:0019430 | removal of superoxide radicals |
Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2). | IMP |
BP | GO:0032364 | oxygen homeostasis |
A homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell. | IMP |
BP | GO:0043524 | negative regulation of neuron apoptotic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. | IGI |
BP | GO:0051289 | protein homotetramerization |
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. | IPI |
BP | GO:0055114 | oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. | IEA |
BP | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. | IMP |
CC | GO:0005739 | mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. | IDA |
CC | GO:0005759 | mitochondrial matrix |
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. | TAS |
CC | GO:0070062 | extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. | IDA |
MF | GO:0004784 | superoxide dismutase activity |
Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide. | IDA|TAS |
MF | GO:0030145 | manganese ion binding |
Interacting selectively and non-covalently with manganese (Mn) ions. | IDA|TAS |
| Domain ID | Description |
|---|---|
IPR001189 | Manganese/iron superoxide dismutase |
IPR019831 | Manganese/iron superoxide dismutase, N-terminal |
IPR019832 | Manganese/iron superoxide dismutase, C-terminal |
IPR019833 | Manganese/iron superoxide dismutase, binding site |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa04068 | FoxO signaling pathway | KEGG |
hsa04146 | Peroxisome | KEGG |
hsa04211 | Longevity regulating pathway | KEGG |
hsa04213 | Longevity regulating pathway - multiple species | KEGG |
hsa05016 | Huntington's disease | KEGG |
WP1533 | Vitamin B12 Metabolism | WikiPathways |
WP15 | Selenium Micronutrient Network | WikiPathways |
WP710 | DNA Damage Response (only ATM dependent) | WikiPathways |
WP176 | Folate Metabolism | WikiPathways |
WP408 | Oxidative Stress | WikiPathways |
WP3940 | One carbon metabolism and related pathways | WikiPathways |
WP3888 | VEGFA-VEGFR2 Signaling Pathway | WikiPathways |
h_eponfkbPathway | Erythropoietin mediated neuroprotection through NF-kB | BioCarta |
h_longevityPathway | The IGF-1 Receptor and Longevity | BioCarta |
| UMLS CUI | UMLS Term |
|---|---|
C0001418 | Adenocarcinoma |
C0001925 | Albuminuria |
C0002390 | Extrinsic Allergic Alveolitis |
C0002395 | Alzheimer'S Disease |
C0002736 | Amyotrophic Lateral Sclerosis |
C0002871 | Anemia |
C0002896 | Sideroblastic Anemia |
C0003130 | Anoxia |
C0003493 | Aortic Diseases |
C0003873 | Rheumatoid Arthritis |
C0004045 | Asphyxia Neonatorum |
C0004153 | Atherosclerosis |
C0004364 | Autoimmune Diseases |
C0005695 | Bladder Neoplasm |
C0006118 | Brain Neoplasms |
C0007131 | Non-Small Cell Lung Carcinoma |
C0007134 | Renal Cell Carcinoma |
C0007137 | Squamous Cell Carcinoma |
C0007193 | Cardiomyopathy, Dilated |
C0007621 | Neoplastic Cell Transformation |
C0007682 | Cns Disorder |
C0007786 | Brain Ischemia |
C0007787 | Transient Ischemic Attack |
C0009375 | Colonic Neoplasms |
C0009404 | Colorectal Neoplasms |
C0011853 | Diabetes Mellitus, Experimental |
C0011860 | Diabetes Mellitus, Non-Insulin-Dependent |
C0011881 | Diabetic Nephropathy |
C0014859 | Esophageal Neoplasms |
C0014866 | Esophageal Stenosis |
C0014868 | Esophagitis |
C0015695 | Fatty Liver |
C0015967 | Fever |
C0016059 | Fibrosis |
C0018200 | Granuloma, Respiratory Tract |
C0018800 | Cardiomegaly |
C0018801 | Heart Failure |
C0020538 | Hypertensive Disease |
C0020542 | Pulmonary Hypertension |
C0020550 | Hyperthyroidism |
C0020615 | Hypoglycemia |
C0021364 | Male Infertility |
C0021655 | Insulin Resistance |
C0022116 | Ischemia |
C0022658 | Kidney Diseases |
C0022665 | Kidney Neoplasm |
C0022672 | Acute Kidney Tubular Necrosis |
C0023891 | Liver Cirrhosis, Alcoholic |
C0024115 | Lung Diseases |
C0024232 | Lymphatic Metastasis |
C0024668 | Mammary Neoplasms, Experimental |
C0024796 | Marfan Syndrome |
C0025312 | Meningomyelocele |
C0025500 | Mesothelioma |
C0026640 | Mouth Neoplasms |
C0026764 | Multiple Myeloma |
C0027051 | Myocardial Infarction |
C0027540 | Necrosis |
C0027626 | Neoplasm Invasiveness |
C0027627 | Neoplasm Metastasis |
C0027726 | Nephrotic Syndrome |
C0027746 | Nerve Degeneration |
C0028754 | Obesity |
C0029408 | Degenerative Polyarthritis |
C0029456 | Osteoporosis |
C0030297 | Pancreatic Neoplasm |
C0030354 | Papilloma |
C0030567 | Parkinson Disease |
C0031117 | Peripheral Neuropathy |
C0032580 | Adenomatous Polyposis Coli |
C0032927 | Precancerous Conditions |
C0033578 | Prostatic Neoplasms |
C0033860 | Psoriasis |
C0033941 | Psychoses, Substance-Induced |
C0035126 | Reperfusion Injury |
C0036202 | Sarcoidosis |
C0036572 | Seizures |
C0036980 | Shock, Cardiogenic |
C0037268 | Skin Abnormalities |
C0037274 | Dermatologic Disorders |
C0037286 | Skin Neoplasms |
C0038356 | Stomach Neoplasms |
C0040411 | Tongue Neoplasms |
C0041408 | Turner Syndrome |
C0042164 | Uveitis |
C0042373 | Vascular Diseases |
C0079744 | Diffuse Large B-Cell Lymphoma |
C0085207 | Gestational Diabetes |
C0151526 | Premature Birth |
C0151744 | Myocardial Ischemia |
C0162309 | Adrenoleukodystrophy |
C0162671 | Melas Syndrome |
C0162674 | Chronic Progressive External Ophthalmoplegia |
C0162871 | Aortic Aneurysm, Abdominal |
C0206062 | Lung Diseases, Interstitial |
C0206160 | Reticulocytosis |
C0238461 | Anaplastic Thyroid Carcinoma |
C0242656 | Disease Progression |
C0242698 | Ventricular Dysfunction, Left |
C0242992 | Multiple Chemical Sensitivity |
C0268255 | Farber Lipogranulomatosis |
C0311375 | Arsenic Poisoning |
C0376618 | Endotoxemia |
C0520459 | Necrotizing Enterocolitis |
C0524851 | Neurodegenerative Disorders |
C0740392 | Infarction, Middle Cerebral Artery |
C0751651 | Mitochondrial Diseases |
C0752347 | Lewy Body Disease |
C0878544 | Cardiomyopathies |
C0919267 | Ovarian Neoplasm |
C0948089 | Acute Coronary Syndrome |
C1134719 | Invasive Ductal Breast Carcinoma |
C1269683 | Major Depressive Disorder |
C1458155 | Mammary Neoplasms |
C2239176 | Liver Carcinoma |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
17900306 | Borro et al. | 2007 | Proteomic analysis of peripheral T lymphocytes, suitable circulating biosensors of strictly related diseases |
19820292 | Misti et al. | 2010 | Proteomic profiles in hyperandrogenic syndromes |
22617121 | Ouandaogo et al. | 2012 | Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22904171 | Kaur et al. | 2012 | Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis |
22951915 | Haozi et al. | 2012 | Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
ABAT | 18 | P80404 | 0.49 |
ACO2 | 50 | Q99798 | 0.49 |
ALDH2 | 217 | P05091 | 0.49 |
ALDH1B1 | 219 | P30837 | 0.49 |
CAT | 847 | P04040 | 0.49 |
ENO3 | 2027 | P13929 | 0.49 |
GOLGB1 | 2804 | Q14789 | 0.49 |
GPX4 | 2879 | P36969 | 0.49 |
HSPE1 | 3336 | P61604 | 0.49 |
MDH1 | 4190 | P40925 | 0.49 |
P4HB | 5034 | P07237 | 0.49 |
PEBP1 | 5037 | P30086 | 0.49 |
PEPD | 5184 | P12955 | 0.49 |
TPI1 | 7167 | P60174 | 0.49 |
UCHL3 | 7347 | P15374 | 0.49 |
PRDM2 | 7799 | Q13029 | 0.49 |
ALDH5A1 | 7915 | P51649 | 0.49 |
UBL4A | 8266 | P11441 | 0.49 |
STX7 | 8417 | O15400 | 0.49 |
ALDH4A1 | 8659 | P30038 | 0.49 |
VAPA | 9218 | Q9P0L0 | 0.49 |
ZC3H11A | 9877 | O75152 | 0.49 |
PRDX5 | 25824 | P30044 | 0.49 |
TBL2 | 26608 | Q9Y4P3 | 0.49 |
TCEAL9 | 51186 | Q9UHQ7 | 0.49 |
NABP2 | 79035 | Q9BQ15 | 0.49 |
FAM192A | 80011 | Q9GZU8 | 0.49 |
APP | 351 | P05067 | 0.56 |
FH | 2271 | P07954 | 0.56 |
ATRX | 546 | P46100 | 0.63 |
COL1A2 | 1278 | P08123 | 0.63 |
SRP72 | 6731 | O76094 | 0.63 |
STK4 | 6789 | Q13043 | 0.63 |
TGFB1I1 | 7041 | O43294 | 0.63 |
ZYX | 7791 | Q15942 | 0.63 |
DCHS1 | 8642 | Q96JQ0 | 0.63 |
UBR2 | 23304 | Q8IWV8 | 0.63 |
MBD5 | 55777 | Q9P267 | 0.63 |
BDH2 | 56898 | Q9BUT1 | 0.63 |
KIAA1549 | 57670 | Q9HCM3 | 0.63 |
CYP4F12 | 66002 | Q9HCS2 | 0.63 |
NOL12 | 79159 | Q9UGY1 | 0.63 |
HDHD2 | 84064 | Q9H0R4 | 0.63 |
CCDC57 | 284001 | Q2TAC2 | 0.63 |
SOD2 | 6648 | P04179 | 0.76 |
ALDOA | 226 | P04075 | 0.49 |
ALDOC | 230 | P09972 | 0.49 |
OAT | 4942 | P04181 | 0.49 |
RPL21 | 6144 | P46778 | 0.49 |
SMARCA2 | 6595 | P51531 | 0.49 |
TKT | 7086 | P29401 | 0.49 |
HSP90B1 | 7184 | P14625 | 0.49 |
SMARCA5 | 8467 | O60264 | 0.49 |
SCRN1 | 9805 | Q12765 | 0.49 |
TMEM131 | 23505 | Q92545 | 0.49 |
DYNC1LI1 | 51143 | Q9Y6G9 | 0.49 |
GET4 | 51608 | Q7L5D6 | 0.49 |
GPT2 | 84706 | Q8TD30 | 0.49 |
SOD1 | 6647 | P00441 | 0.59 |
AMY1A; AMY1B; AMY1C | 276 | P04745 | 0.63 |
ARF6 | 382 | P62330 | 0.63 |
CST1 | 1469 | P01037 | 0.63 |
CST4 | 1472 | P01036 | 0.63 |
HLA-B | 3106 | P30480 | 0.63 |
MCC | 4163 | P23508 | 0.63 |
MPG | 4350 | P29372 | 0.63 |
MYH8 | 4626 | P13535 | 0.63 |
PAK2 | 5062 | Q13177 | 0.63 |
RPS3A | 6189 | P61247 | 0.63 |
SUMO1 | 7341 | P63165 | 0.63 |
VHL | 7428 | P40337 | 0.63 |
RIPK2 | 8767 | O43353 | 0.63 |
IKBKE | 9641 | Q14164 | 0.63 |
EIF1B | 10289 | O60739 | 0.63 |
TNIK | 23043 | Q9UKE5 | 0.63 |
RPL22L1 | 200916 | Q6P5R6 | 0.63 |
RNF144B | 255488 | Q7Z419 | 0.63 |
H2AFX | 3014 | P16104 | 0.72 |
AURKA | 6790 | O14965 | 0.72 |
USP36 | 57602 | Q9P275 | 0.72 |
RAB4A | 5867 | P20338 | 0.77 |