| Gene Symbol | SOD2 |
| Entrez ID | 6648 |
| Uniprot ID | P04179 |
| Description | superoxide dismutase 2, mitochondrial |
| Chromosomal Location | chr6: 159,669,057-159,762,529 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000302 |
response to reactive oxygen species |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. |
TAS |
|
BP |
GO:0000303 |
response to superoxide |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. |
IMP |
|
BP |
GO:0001315 |
age-dependent response to reactive oxygen species |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism. |
IMP |
|
BP |
GO:0001836 |
release of cytochrome c from mitochondria |
The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. |
ISS |
|
BP |
GO:0003069 |
vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure |
The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure. |
ISS |
|
BP |
GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IMP |
|
BP |
GO:0006801 |
superoxide metabolic process |
The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. |
IDA |
|
BP |
GO:0008217 |
regulation of blood pressure |
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. |
ISS |
|
BP |
GO:0008285 |
negative regulation of cell proliferation |
Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
IMP |
|
BP |
GO:0019430 |
removal of superoxide radicals |
Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2). |
IMP |
|
BP |
GO:0032364 |
oxygen homeostasis |
A homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell. |
IMP |
|
BP |
GO:0043524 |
negative regulation of neuron apoptotic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. |
IGI |
|
BP |
GO:0051289 |
protein homotetramerization |
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. |
IPI |
|
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
IEA |
|
BP |
GO:1902176 |
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. |
IMP |
|
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IDA |
|
CC |
GO:0005759 |
mitochondrial matrix |
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
TAS |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0004784 |
superoxide dismutase activity |
Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide. |
IDA|TAS |
|
MF |
GO:0030145 |
manganese ion binding |
Interacting selectively and non-covalently with manganese (Mn) ions. |
IDA|TAS |
| Domain ID | Description |
|---|---|
|
IPR001189 |
Manganese/iron superoxide dismutase |
|
IPR019831 |
Manganese/iron superoxide dismutase, N-terminal |
|
IPR019832 |
Manganese/iron superoxide dismutase, C-terminal |
|
IPR019833 |
Manganese/iron superoxide dismutase, binding site |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa04068 |
FoxO signaling pathway |
KEGG |
|
hsa04146 |
Peroxisome |
KEGG |
|
hsa04211 |
Longevity regulating pathway |
KEGG |
|
hsa04213 |
Longevity regulating pathway - multiple species |
KEGG |
|
hsa05016 |
Huntington's disease |
KEGG |
|
WP1533 |
Vitamin B12 Metabolism |
WikiPathways |
|
WP15 |
Selenium Micronutrient Network |
WikiPathways |
|
WP710 |
DNA Damage Response (only ATM dependent) |
WikiPathways |
|
WP176 |
Folate Metabolism |
WikiPathways |
|
WP408 |
Oxidative Stress |
WikiPathways |
|
WP3940 |
One carbon metabolism and related pathways |
WikiPathways |
|
WP3888 |
VEGFA-VEGFR2 Signaling Pathway |
WikiPathways |
|
h_eponfkbPathway |
Erythropoietin mediated neuroprotection through NF-kB |
BioCarta |
|
h_longevityPathway |
The IGF-1 Receptor and Longevity |
BioCarta |
| UMLS CUI | UMLS Term |
|---|---|
|
C0001418 |
Adenocarcinoma |
|
C0001925 |
Albuminuria |
|
C0002390 |
Extrinsic Allergic Alveolitis |
|
C0002395 |
Alzheimer'S Disease |
|
C0002736 |
Amyotrophic Lateral Sclerosis |
|
C0002871 |
Anemia |
|
C0002896 |
Sideroblastic Anemia |
|
C0003130 |
Anoxia |
|
C0003493 |
Aortic Diseases |
|
C0003873 |
Rheumatoid Arthritis |
|
C0004045 |
Asphyxia Neonatorum |
|
C0004153 |
Atherosclerosis |
|
C0004364 |
Autoimmune Diseases |
|
C0005695 |
Bladder Neoplasm |
|
C0006118 |
Brain Neoplasms |
|
C0007131 |
Non-Small Cell Lung Carcinoma |
|
C0007134 |
Renal Cell Carcinoma |
|
C0007137 |
Squamous Cell Carcinoma |
|
C0007193 |
Cardiomyopathy, Dilated |
|
C0007621 |
Neoplastic Cell Transformation |
|
C0007682 |
Cns Disorder |
|
C0007786 |
Brain Ischemia |
|
C0007787 |
Transient Ischemic Attack |
|
C0009375 |
Colonic Neoplasms |
|
C0009404 |
Colorectal Neoplasms |
|
C0011853 |
Diabetes Mellitus, Experimental |
|
C0011860 |
Diabetes Mellitus, Non-Insulin-Dependent |
|
C0011881 |
Diabetic Nephropathy |
|
C0014859 |
Esophageal Neoplasms |
|
C0014866 |
Esophageal Stenosis |
|
C0014868 |
Esophagitis |
|
C0015695 |
Fatty Liver |
|
C0015967 |
Fever |
|
C0016059 |
Fibrosis |
|
C0018200 |
Granuloma, Respiratory Tract |
|
C0018800 |
Cardiomegaly |
|
C0018801 |
Heart Failure |
|
C0020538 |
Hypertensive Disease |
|
C0020542 |
Pulmonary Hypertension |
|
C0020550 |
Hyperthyroidism |
|
C0020615 |
Hypoglycemia |
|
C0021364 |
Male Infertility |
|
C0021655 |
Insulin Resistance |
|
C0022116 |
Ischemia |
|
C0022658 |
Kidney Diseases |
|
C0022665 |
Kidney Neoplasm |
|
C0022672 |
Acute Kidney Tubular Necrosis |
|
C0023891 |
Liver Cirrhosis, Alcoholic |
|
C0024115 |
Lung Diseases |
|
C0024232 |
Lymphatic Metastasis |
|
C0024668 |
Mammary Neoplasms, Experimental |
|
C0024796 |
Marfan Syndrome |
|
C0025312 |
Meningomyelocele |
|
C0025500 |
Mesothelioma |
|
C0026640 |
Mouth Neoplasms |
|
C0026764 |
Multiple Myeloma |
|
C0027051 |
Myocardial Infarction |
|
C0027540 |
Necrosis |
|
C0027626 |
Neoplasm Invasiveness |
|
C0027627 |
Neoplasm Metastasis |
|
C0027726 |
Nephrotic Syndrome |
|
C0027746 |
Nerve Degeneration |
|
C0028754 |
Obesity |
|
C0029408 |
Degenerative Polyarthritis |
|
C0029456 |
Osteoporosis |
|
C0030297 |
Pancreatic Neoplasm |
|
C0030354 |
Papilloma |
|
C0030567 |
Parkinson Disease |
|
C0031117 |
Peripheral Neuropathy |
|
C0032580 |
Adenomatous Polyposis Coli |
|
C0032927 |
Precancerous Conditions |
|
C0033578 |
Prostatic Neoplasms |
|
C0033860 |
Psoriasis |
|
C0033941 |
Psychoses, Substance-Induced |
|
C0035126 |
Reperfusion Injury |
|
C0036202 |
Sarcoidosis |
|
C0036572 |
Seizures |
|
C0036980 |
Shock, Cardiogenic |
|
C0037268 |
Skin Abnormalities |
|
C0037274 |
Dermatologic Disorders |
|
C0037286 |
Skin Neoplasms |
|
C0038356 |
Stomach Neoplasms |
|
C0040411 |
Tongue Neoplasms |
|
C0041408 |
Turner Syndrome |
|
C0042164 |
Uveitis |
|
C0042373 |
Vascular Diseases |
|
C0079744 |
Diffuse Large B-Cell Lymphoma |
|
C0085207 |
Gestational Diabetes |
|
C0151526 |
Premature Birth |
|
C0151744 |
Myocardial Ischemia |
|
C0162309 |
Adrenoleukodystrophy |
|
C0162671 |
Melas Syndrome |
|
C0162674 |
Chronic Progressive External Ophthalmoplegia |
|
C0162871 |
Aortic Aneurysm, Abdominal |
|
C0206062 |
Lung Diseases, Interstitial |
|
C0206160 |
Reticulocytosis |
|
C0238461 |
Anaplastic Thyroid Carcinoma |
|
C0242656 |
Disease Progression |
|
C0242698 |
Ventricular Dysfunction, Left |
|
C0242992 |
Multiple Chemical Sensitivity |
|
C0268255 |
Farber Lipogranulomatosis |
|
C0311375 |
Arsenic Poisoning |
|
C0376618 |
Endotoxemia |
|
C0520459 |
Necrotizing Enterocolitis |
|
C0524851 |
Neurodegenerative Disorders |
|
C0740392 |
Infarction, Middle Cerebral Artery |
|
C0751651 |
Mitochondrial Diseases |
|
C0752347 |
Lewy Body Disease |
|
C0878544 |
Cardiomyopathies |
|
C0919267 |
Ovarian Neoplasm |
|
C0948089 |
Acute Coronary Syndrome |
|
C1134719 |
Invasive Ductal Breast Carcinoma |
|
C1269683 |
Major Depressive Disorder |
|
C1458155 |
Mammary Neoplasms |
|
C2239176 |
Liver Carcinoma |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
17900306 |
Borro et al. |
2007 |
Proteomic analysis of peripheral T lymphocytes, suitable circulating biosensors of strictly related diseases |
|
19820292 |
Misti et al. |
2010 |
Proteomic profiles in hyperandrogenic syndromes |
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22904171 |
Kaur et al. |
2012 |
Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ABAT |
18 |
P80404 |
0.49 |
|
ACO2 |
50 |
Q99798 |
0.49 |
|
ALDH2 |
217 |
P05091 |
0.49 |
|
ALDH1B1 |
219 |
P30837 |
0.49 |
|
CAT |
847 |
P04040 |
0.49 |
|
ENO3 |
2027 |
P13929 |
0.49 |
|
GOLGB1 |
2804 |
Q14789 |
0.49 |
|
GPX4 |
2879 |
P36969 |
0.49 |
|
HSPE1 |
3336 |
P61604 |
0.49 |
|
MDH1 |
4190 |
P40925 |
0.49 |
|
P4HB |
5034 |
P07237 |
0.49 |
|
PEBP1 |
5037 |
P30086 |
0.49 |
|
PEPD |
5184 |
P12955 |
0.49 |
|
TPI1 |
7167 |
P60174 |
0.49 |
|
UCHL3 |
7347 |
P15374 |
0.49 |
|
PRDM2 |
7799 |
Q13029 |
0.49 |
|
ALDH5A1 |
7915 |
P51649 |
0.49 |
|
UBL4A |
8266 |
P11441 |
0.49 |
|
STX7 |
8417 |
O15400 |
0.49 |
|
ALDH4A1 |
8659 |
P30038 |
0.49 |
|
VAPA |
9218 |
Q9P0L0 |
0.49 |
|
ZC3H11A |
9877 |
O75152 |
0.49 |
|
PRDX5 |
25824 |
P30044 |
0.49 |
|
TBL2 |
26608 |
Q9Y4P3 |
0.49 |
|
TCEAL9 |
51186 |
Q9UHQ7 |
0.49 |
|
NABP2 |
79035 |
Q9BQ15 |
0.49 |
|
FAM192A |
80011 |
Q9GZU8 |
0.49 |
|
APP |
351 |
P05067 |
0.56 |
|
FH |
2271 |
P07954 |
0.56 |
|
ATRX |
546 |
P46100 |
0.63 |
|
COL1A2 |
1278 |
P08123 |
0.63 |
|
SRP72 |
6731 |
O76094 |
0.63 |
|
STK4 |
6789 |
Q13043 |
0.63 |
|
TGFB1I1 |
7041 |
O43294 |
0.63 |
|
ZYX |
7791 |
Q15942 |
0.63 |
|
DCHS1 |
8642 |
Q96JQ0 |
0.63 |
|
UBR2 |
23304 |
Q8IWV8 |
0.63 |
|
MBD5 |
55777 |
Q9P267 |
0.63 |
|
BDH2 |
56898 |
Q9BUT1 |
0.63 |
|
KIAA1549 |
57670 |
Q9HCM3 |
0.63 |
|
CYP4F12 |
66002 |
Q9HCS2 |
0.63 |
|
NOL12 |
79159 |
Q9UGY1 |
0.63 |
|
HDHD2 |
84064 |
Q9H0R4 |
0.63 |
|
CCDC57 |
284001 |
Q2TAC2 |
0.63 |
|
SOD2 |
6648 |
P04179 |
0.76 |
|
ALDOA |
226 |
P04075 |
0.49 |
|
ALDOC |
230 |
P09972 |
0.49 |
|
OAT |
4942 |
P04181 |
0.49 |
|
RPL21 |
6144 |
P46778 |
0.49 |
|
SMARCA2 |
6595 |
P51531 |
0.49 |
|
TKT |
7086 |
P29401 |
0.49 |
|
HSP90B1 |
7184 |
P14625 |
0.49 |
|
SMARCA5 |
8467 |
O60264 |
0.49 |
|
SCRN1 |
9805 |
Q12765 |
0.49 |
|
TMEM131 |
23505 |
Q92545 |
0.49 |
|
DYNC1LI1 |
51143 |
Q9Y6G9 |
0.49 |
|
GET4 |
51608 |
Q7L5D6 |
0.49 |
|
GPT2 |
84706 |
Q8TD30 |
0.49 |
|
SOD1 |
6647 |
P00441 |
0.59 |
|
AMY1A; AMY1B; AMY1C |
276 |
P04745 |
0.63 |
|
ARF6 |
382 |
P62330 |
0.63 |
|
CST1 |
1469 |
P01037 |
0.63 |
|
CST4 |
1472 |
P01036 |
0.63 |
|
HLA-B |
3106 |
P30480 |
0.63 |
|
MCC |
4163 |
P23508 |
0.63 |
|
MPG |
4350 |
P29372 |
0.63 |
|
MYH8 |
4626 |
P13535 |
0.63 |
|
PAK2 |
5062 |
Q13177 |
0.63 |
|
RPS3A |
6189 |
P61247 |
0.63 |
|
SUMO1 |
7341 |
P63165 |
0.63 |
|
VHL |
7428 |
P40337 |
0.63 |
|
RIPK2 |
8767 |
O43353 |
0.63 |
|
IKBKE |
9641 |
Q14164 |
0.63 |
|
EIF1B |
10289 |
O60739 |
0.63 |
|
TNIK |
23043 |
Q9UKE5 |
0.63 |
|
RPL22L1 |
200916 |
Q6P5R6 |
0.63 |
|
RNF144B |
255488 |
Q7Z419 |
0.63 |
|
H2AFX |
3014 |
P16104 |
0.72 |
|
AURKA |
6790 |
O14965 |
0.72 |
|
USP36 |
57602 |
Q9P275 |
0.72 |
|
RAB4A |
5867 |
P20338 |
0.77 |