BP

GO:0002027

regulation of heart rate

Any process that modulates the frequency or rate of heart contraction.

IMP

BP

GO:0006936

muscle contraction

A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.

TAS

BP

GO:0060307

regulation of ventricular cardiac muscle cell membrane repolarization

Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.

IMP

BP

GO:0086005

ventricular cardiac muscle cell action potential

An action potential that occurs in a ventricular cardiac muscle cell.

IMP

BP

GO:1902083

negative regulation of peptidyl-cysteine S-nitrosylation

Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-cysteine S-nitrosylation.

IMP

BP

GO:1902305

regulation of sodium ion transmembrane transport

Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport.

IMP

CC

GO:0005622

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IEA

CC

GO:0005856

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

IEA

CC

GO:0016013

syntrophin complex

A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase.

TAS

CC

GO:0016328

lateral plasma membrane

The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.

TAS

CC

GO:0030054

cell junction

A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.

IEA

CC

GO:0031594

neuromuscular junction

The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.

IEA

CC

GO:0042383

sarcolemma

The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.

IEA

CC

GO:0043234

protein complex

A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.

IDA

MF

GO:0003779

actin binding

Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.

IEA

MF

GO:0005198

structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005516

calmodulin binding

Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.

IEA

MF

GO:0017080

sodium channel regulator activity

Modulates the activity of a sodium channel.

IMP

MF

GO:0030165

PDZ domain binding

Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.

IEA

MF

GO:0044325

ion channel binding

Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

IPI

MF

GO:0050998

nitric-oxide synthase binding

Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.

IPI

MF

GO:0051117

ATPase binding

Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.

IPI